• CAIRO: Egypt's Ministry of Health reported two new cases of the H1N1 virus on Wednesday as the World Health Organization (WHO) announced the appearance of a strain resistant to Tamiflu. (dailynewsegypt.com)
  • Meanwhile, the World Health Organization (WHO) said that it was informed by health officials in Denmark, Japan, Hong Kong and China of an H1N1 strain resistant to Tamiflu, the drug used to treat the virus. (dailynewsegypt.com)
  • U.S. health officials say almost 100% of the type A H1N1 strain showed resistance to the leading antiviral drug. (flutrackers.com)
  • Of samples tested since October, almost 100% of the strain -- known as type A H1N1 -- showed resistance to Tamiflu. (flutrackers.com)
  • Doctors were told to substitute an alternative antiviral, Relenza, for Tamiflu, or to combine Tamiflu with an older antiviral, rimantadine, if the H1N1 virus was the main strain circulating in their communities. (flutrackers.com)
  • Only the H1N1 virus is showing signs of Tamiflu resistance, CDC officials said, speaking at an influenza conference in Washington. (flutrackers.com)
  • the new 2009 H1N1 picking up the Tamiflu resistance. (flutrackers.com)
  • Yesterday the New York Times ran an article on the resistance to Tamiflu of current influenza H1N1 strains circulating in the US. (virology.ws)
  • Most of the flu in the US now is caused by H1N1 strains. (virology.ws)
  • The Tamiflu-resistant H1N1 strains are sensitive to another drug, Relenza (zanamivir). (virology.ws)
  • However, these H1N1 strains are sensitive to Rimantadine, so its use is a good alternative. (virology.ws)
  • Unless otherwise noted, references to terms like S-OIV, H1N1 and such, all refer to this new A(H1N1) strain and not to sundry other strains of H1N1 which are endemic in humans, birds and pigs. (wikipedia.org)
  • United States The CDC receives its first sample from California (from the ten-year-old boy in San Diego County), and identifies the virus as a strain of swine influenza A(H1N1). (wikipedia.org)
  • In the United States, the FDA approved two antiviral drugs for treatment and prophylaxis of the 2009 H1N1 influenza virus: Tamiflu and Relenza (zanamivir). (yourlawyer.com)
  • A spokesperson from the vaccine manufacturer Roche confirmed reports Monday that a Denmark patient with H1N1 (swine flu) developed resistance to the antiviral Tamiflu, a drug known to decrease the spread and severity of the virus, Reuters reports (Cage/Arnold, 6/29). (kff.org)
  • Tamiflu resistance did not appear in the tests of two hundred H1N1 samples in the U.S., Bridges added. (kff.org)
  • Roche scientists have ruled out the possibility that the Tamiflu-resistant strain is a combination of H1N1 and the seasonal flu virus. (kff.org)
  • Common seasonal flu can resist Tamiflu and [David Reddy, Roche's pandemic taskforce leader, told reporters] a case of resistance in H1N1 was not unexpected, adding Roche has been working on strategies to counter such a development," according to Reuters (6/29). (kff.org)
  • But with no other known instances of resistance, the CDC isn't ready to stop recommending Tamiflu or Relenza, a similar drug produced by U.K.-based GlaxoSmithKline PLC (GSK), as effective against A/H1N1" (Greil, 6/29). (kff.org)
  • The dominant flu strain this season is an H3N2 strain, which tends to be more severe than the H1N1 strains that usually dominate. (pharmacytimes.com)
  • As with other influenza strains, H1N1 flu can be expected to show signs of resistance to oseltamivir, and new treatments will be needed to respond to this and future pandemics. (tgen.org)
  • The World Health Organization has identified more than three-dozen instances of resistance to Tamiflu in the H1N1 swine flu virus. (tgen.org)
  • The authors cited antiviral resistance to other therapies as a threat, as evidenced by global circulation of oseltamivir-resistant seasonal influenza A (H1N1) viruses in 2008-2009, as well as community clusters of oseltamivir-resistant influenza A (H1N1) viruses. (medpagetoday.com)
  • Officials also asked people to think twice before asking doctors to prescribe Tamiflu as it is the only family of drugs that is effective in treating the H1N1 flu virus. (caymannewsservice.com)
  • Using it inappropriately is irresponsible as it increases the chance of the H1N1 flu virusbecoming resistant to the drug. (caymannewsservice.com)
  • A study of 410 young adults has found that a Chinese herbal combination called maxingshigan-yinqiaosan treats H1N1 virus infections more successfully than the conventional drug oseltamivir (Tamiflu). (plantmedicines.org)
  • The study, published in the medical journal Annals of Internal Medicine and conducted at the Capital Medical University in Beijing, gave infected adults aged from 15 to 59 years old either the Chinese herbal combination or the conventional drug Tamiflu in eleven hospitals throughout China during the 2009 H1N1 outbreak. (plantmedicines.org)
  • Oseltamivir, produced by Roche under the trademark Tamiflu, is considered by the CDC, the World Health Organization and other agencies as the 'go-to' medication for treating H1N1. (plantmedicines.org)
  • However, the H1N1 virus has become increasingly resistant to oseltamivir. (plantmedicines.org)
  • The World Health Organization reported that 314 strains of the H1N1 virus had become resistant to oseltamivir as of December 2010. (plantmedicines.org)
  • This correlates with the seeming disappearance of the previously circulating H1N1 strain (called "seasonal") that was resistant to oseltamivir. (chestervetclinic.com)
  • The Western Australia state government on Friday confirmed a 38-year-old Perth man to be the country's first Tamiflu-resistant case of H1N1, Reuters reports. (kffhealthnews.org)
  • Similarly, during the 2009-2010 novel influenza A H1N1 pandemic, preliminary data from a limited number of states indicated a high prevalence of virus strains resistant to oseltamivir. (medscape.com)
  • However, I suspect that the use of Tamiflu and Relenza is far more prevalent than desired. (virology.ws)
  • Tamiflu and Relenza should be used when necessary and must be used appropriately. (yourlawyer.com)
  • There are serious question marks hanging over the vaccine and two main anti-viral drugs, Osteltamivir (Tamiflu) and Zanivir (Relenza), carry some strong risks of unpleasant side effects[C1] ,the most common being vomiting, nausea and dizziness - and the most worrying being psychiatric side-effects in children. (helixhouse.co.uk)
  • Questions have been raised for some years about the efficacy and effectiveness of neuraminidase inhibitors (NAIs)Tamiflu and Relenza, the principal antiviral drugs used in treating flu, and whether this justifies their being part of the UK government's response to influenza. (sciencemediacentre.org)
  • The Cochrane Collaboration published an evidence review of Tamiflu (the antiviral drug oseltamivir) and Relenza (zanamivir) trials, reporting that Tamiflu shortens symptoms of influenza but other claims made for the drugs were not well supported by evidence from clinical study reports. (sciencemediacentre.org)
  • Overuse or misuse of the drugs could pave the way for resistant strains of the emerging swine flu, which could make control of a pandemic all the more problematic, noted the LA Times, previously. (yourlawyer.com)
  • Meanwhile, a Tamiflu-resistant strain of Swine Flu has already been reported. (yourlawyer.com)
  • Once Tamiflu started being used to treat H5N1 (bird flu) in 2003/4 resistant strains of the virus cropped up within months and Tamiflu-resistant strains of swine flu have emerged ALREADY, making it look like these anti-viral drugs will be little more than an expensive distraction. (helixhouse.co.uk)
  • No reason to abuse it, even though resistent strains do not seem to be resistant to zanamivir. (caymannewsservice.com)
  • CS-8958 was also believed to be effectual against extremely pathogenic and oseltamivir-resistant strains of H5N1 virus. (healthjockey.com)
  • Some studies have also reported that certain herbal extracts can inhibit the replication of oseltamivir-resistant strains. (herbs.news)
  • And the other strain currently circulating, H3N2? (virology.ws)
  • So although the H3N2 strains are sensitive to Tamiflu, it's not much help. (virology.ws)
  • Most H3N2 strains are resistant to Rimantadine, which is why it has not been used much in recent years. (virology.ws)
  • The 2003-2004 season, during which at least 48,000 people died of flu-related illnesses, was also dominated by an H3N2 strain. (pharmacytimes.com)
  • So far, however, no cases have been resistant to Tamiflu, and this year's flu shot is well-matched to the dominant H3N2 strain. (pharmacytimes.com)
  • No cases have been resistant to Tamiflu, which can ease symptoms if taken within 48 hours, and this year's flu shot is well-matched to the H3N2 strain, the C.D.C. said. (truthdig.com)
  • This season, influenza B is prominent in the Americas and Africa, and influenza A H3N2 comprises half the reported cases Prof. Emerita, Stanford University in Europe and Australia, and more than 75% of strains in ChinaA. (chestervetclinic.com)
  • In temperate South America, numbers of influenza cases began to increase in May, peaking around July with the largest numbers seen for A(H3N2), but showing a second peak in August with more influenza B strains and untyped influenza A strains (Figure 1). (chestervetclinic.com)
  • However, a new virus, variant H3N2 (H3N2v), associated with pigs and originally discovered in 2011, has cropped up this year in some human outbreaks periodically since July, 2012.1,B Although the strains of influenza circulating globally now are genetically slightly different from those in the current vaccine, the CDC feels that there will be significant cross-reactive protection, so they recommend that the vaccines not be changed. (chestervetclinic.com)
  • The worry here is this event could give rise to a more virulent influenza strain, such as a pandemic strain that is resistant to Tamiflu, and so needs to be monitored closely. (sciencemediacentre.co.nz)
  • Pandemic influenza tops the UK's National Risk Register due to the social and economic disruption that could result from a particularly virulent strain. (sciencemediacentre.org)
  • Influenza activity nationwide had taken a sudden jump , which was linked to poor vaccine matches with circulating influenza strains. (sott.net)
  • They noted that baloxavir showed nanomolar antiviral activity against influenza A and B viruses in preclinical models, including "strains resistant to current antiviral agents. (medpagetoday.com)
  • In addition, Roche, the maker of the antiviral Tamiflu (oseltamivir), has reported shortages of its liquid formulation, used primarily to treat children. (pharmacytimes.com)
  • Other flu viruses currently circulating are not Tamiflu-resistant. (flutrackers.com)
  • Drug-resistant viruses are not 'reactions' to overuse of the drug. (virology.ws)
  • Usually the drug-resistant mutants are already in the host, and outpace other drug-sensitive viruses. (virology.ws)
  • CS-8958 is highly effective for the treatment and prophylaxis of infection with H5N1 influenza viruses, including oseltamivir-resistant mutants. (healthjockey.com)
  • Health experts also warned that Tamiflu is not effective in treating the other seasonal flu viruses in circulation, and will therefore not help if you are ill with the seasonal flu. (caymannewsservice.com)
  • Viruses are identified to be resistant to pharmaceutical antibiotics. (bettingconfidence.com)
  • To the researchers' surprise, increased expression of IFITMs also blocked the replication of completely different viruses, including strains of West Nile and Dengue viruses. (drugdiscoveryopinion.com)
  • Antiviral drugs are the other option available for the treatment of influenza, which falls under three categories as M2 inhibitors, neuraminidase inhibitors, and nucleoprotein inhibitors [ 15 ] targeting the viral components, thwarted by newly emerging strains. (springeropen.com)
  • Circulating strains of influenza A virus with resistance to existing neuraminidase inhibitors have already been discovered, and new molecular targets would provide additional protection in the event of a fresh outbreak. (drugdiscoveryopinion.com)
  • Some isolates of influenza virus (H5N1) in Egypt are resistant to oseltamivir ( 3 ), and in others, virulent mutations have developed, leading to case-fatality rates of 100% ( 4 ). (cdc.gov)
  • A study headed by a University of Wisconsin-Madison virologist claims that a new compound could be extremely effectual against the pathogenic H5N1 avian influenza virus, counting a few drug-resistant strains. (healthjockey.com)
  • One form of the protein makes influenza virus resistant to Oseltamivir (Tamiflu®) Don't worry, these proteins aren't from H5N1, but they do come from a related influenza virus that also infects birds. (digitalworldbiology.com)
  • Actualización sobre el virus la influenza aviar A (H5N1) en los seres humanos. (cdc.gov)
  • Xofluza is said to be as effective as Tamiflu in alleviating symptoms. (wcpo.com)
  • Unlike earlier drugs, Xofluza is expected to work against drug-resistant strains. (wcpo.com)
  • Since the 2005-2006 influenza season, amantadine and rimantadine are no longer recommended by the Centers for Disease Control and Prevention (CDC) because circulating strains of influenza virus have proved resistant. (medscape.com)
  • Investigations have not found the resistant virus in the close contacts of these people, according to WHO's statement. (dailynewsegypt.com)
  • A cocktail of a vareity of drugs which it makes it very hard for the virus to become resistant to each specific drug. (flutrackers.com)
  • Thus, when this virus arrived in parts of the world where Tamiflu is used, the resistance was noted. (virology.ws)
  • With about 10 16 human immunodeficiency virus (HIV) genomes on the planet today, it is highly probable that somewhere there exist HIV genomes that are resistant to every one of the antiviral drugs that we have now or are likely to have in the future. (virology.ws)
  • Test results revealed an Influenza A virus but were negative for standard human strains. (wikipedia.org)
  • Scientists are eager to add new agents to their antiflu arsenal, especially as the virus shows increasing resistance to antiviral drugs like Tamiflu, and after the especially bad 2017 flu season. (acs.org)
  • Because it is a virus, it mutates easily and becomes resistant. (tgen.org)
  • Due to its high mutation rate, the influenza virus has rapidly and continuously evolved and has now generated new strains that are resistant to anti-viral medications commonly used today. (herbs.news)
  • Globally, influenza virus infections present a potential threat to human and animal health due to frequent reassortant and novel mutant strains [ 7 ]. (springeropen.com)
  • The influenza A subtypes are further classified into strains, and the names of the virus strains include the place where the strain was first found and the year of discovery. (bcm.edu)
  • A Nature Communications paper showed a mutation in newly emerged H7N9 influenza can render it resistant to the only class of drugs active against the virus, without affecting its ability to spread in animals. (sciencemediacentre.org)
  • A flu virus mutates often and at times a new strain emerges that humans have not been exposed to. (bettingconfidence.com)
  • How does a single nucleotide change make influenza virus resistant to a drug? (digitalworldbiology.com)
  • Antibiotic overuse contributes to the emergence of drug-resistant organisms. (medscape.com)
  • The single mutation that creates Tamiflu resistance appears to be spontaneous, and not a reaction to overuse of the drug. (virology.ws)
  • What apparently happened is that the mutation that causes drug-resistance, a change from histidine to tyrosine at position 274 of the viral NA protein, emerged in parts of the world were little Tamiflu is used. (virology.ws)
  • Numerous public well being authorities have pinned their hopes around the antiviral drug Tamiflu to fight the avian flu, by way of example, only to discover that resistent instances are emerging. (bettingconfidence.com)
  • Tamiflu, the most commonly used influenza antiviral and the mainstay of the federal government's emergency drug stockpile, no longer works for the dominant flu strain circulating in much of the country, government officials said Tuesday. (flutrackers.com)
  • The U.S. Food & Drug Administration (FDA) has issued a Public Health Alert advising pharmacists and pediatrics healthcare professionals about potential dosing errors with Tamiflu (oseltamivir) for Oral Suspension. (yourlawyer.com)
  • The AP/News & Observer writes: "It appears the strain developed in a patient who was taking the drug to prevent illness, and it has not spread to others. (kff.org)
  • That's a much better scenario than if the patient had not been taking Tamiflu and picked up a drug-resistant strain already spreading through the public, said Bridges. (kff.org)
  • Derivatives of naproxen protected mice against flu (left) and human cells against drug-resistant flu (right). (acs.org)
  • Such co-infection, though rare, has raised concerns that it could lead to new, more dangerous forms of flu, for example passing drug resistance from one flu strain to another. (sciencemediacentre.co.nz)
  • Health Advisory: Increase in Extensively Drug-Resistant (XDR) Shigellosis in the U.S. (snohd.org)
  • Of course, occasional resistance can arise and patients who fail to improve after a week of therapy should be evaluated for drug resistant strains, as well as for other complications. (chestervetclinic.com)
  • Tamiflu can be used to treat flu if administered within 48 hours of the appearance of symptoms. (pharmacytimes.com)
  • Researchers have published in the Lancet journal a meta-analysis of the effects of Tamiflu, reporting beneficial effects on alleviation of symptoms and risk of complications, but also on an increase in side effects such as nausea. (sciencemediacentre.org)
  • Upcoming strains resistant to present drugs, predominantly oseltamivir (Tamiflu), appear to be a threat and make the progress of alternate antivirals an imperative public health issue. (healthjockey.com)
  • The problem with influenza is that it is becoming resistant to the antiviral drugs that are out there,'' said Dr. Paul Keim, a Professor of Biology at Northern Arizona University and Director of TGen North. (tgen.org)
  • So, these viral-specific drugs are not able to become viral resisting drugs for new strains. (springeropen.com)
  • For the trivalent formulation influenza vaccines, two strains of influenza A and one of influenza B are included. (medscape.com)
  • Don't expect Tamiflu to be the magic pill that fixes everything. (shaneshirley.com)
  • On December 21, 2012, the FDA expanded the use of Tamiflu to treat children as young as 2 weeks old, although children under a year old must receive a dose calibrated to their weight. (pharmacytimes.com)
  • The initial guidelines said not to treat with Tamiflu except for high-risk and seriously sick individuals. (babydr.us)
  • Oseltamivir is an anti-viral neuraminidase inhibitor (Tamiflu) used to treat influenza infections. (herbs.news)
  • The group taking the Chinese herbal medication had 37% faster fever reduction over untreated patients, while oseltamivir (Tamiflu) reduced fevers by 34% over the untreated group. (plantmedicines.org)
  • Furthermore, combined treatment with oseltamivir (Tamiflu) and the Chinese herbal formula reduced fevers by 47%, and 19% sooner than oseltamivir alone. (plantmedicines.org)
  • None of the 11 people with co-infections - or two others who researchers believe also contracted both strains - were severely ill or admitted to hospital. (sciencemediacentre.co.nz)
  • Gene-swapping would not necessarily result in a more harmful flu strain forming, but a risk still existed, the researchers concluded. (sciencemediacentre.co.nz)
  • In the event the strain spreads simply in between humans, it can lead to widespread death and overwhelm global overall health resources. (bettingconfidence.com)
  • So far, it looks like this assay is very effective with strains in the U.S., and we expect it to have the same accuracy with strains around the world,'' said Engelthaler, the former State Epidemiologist for Arizona and former State of Arizona Biodefense Coordinator. (tgen.org)
  • In addition, Tamiflu is not always available to doctors in some parts of the world. (plantmedicines.org)
  • The FDA stated that U.S. health care providers typically write prescriptions for liquid medicines in milliliters (mL) or teaspoons, while Tamiflu is dosed in milligrams (mg). (yourlawyer.com)