HIV Integrase InhibitorsIntegrase InhibitorsHIV IntegrasePyrrolidinonesHeterocyclic Compounds, 3-RingDrug Resistance, ViralVirus IntegrationHIV-1IntegrasesQuinolonesAnti-HIV AgentsHealthy VolunteersNaphthyridinesHIV InfectionsKeto AcidsAcetoacetatesQuantitative Structure-Activity RelationshipAttachment Sites, MicrobiologicalReverse Transcriptase InhibitorsMutation, MissenseDNA NucleotidyltransferasesDrug DesignDNA, ViralVirus ReplicationMolecular StructureModels, MolecularInhibitory Concentration 50Catalytic DomainStructure-Activity RelationshipHIV Protease InhibitorsAmino Acid SubstitutionQuinolinesMutationDrug InteractionsViral LoadArea Under Curve