The International Nonproprietary Name dronabinol, also known under the trade names Marinol, Syndros, Reduvo and Adversa, is a generic name for the molecule of delta-9-tetrahydrocannabinol in the pharmaceutical context. (wikipedia.org)
This rescheduling constituted part of the argument for a 2002 petition for removal of cannabis from Schedule I of the Controlled Substances Act, in which petitioner Jon Gettman noted, "Cannabis is a natural source of dronabinol (THC), the ingredient of Marinol, a Schedule III drug. (wikipedia.org)
Dronabinol is marketed as Marinol and Syndros, a registered trademark of Solvay Pharmaceuticals. (wikipedia.org)
Dronabinol is also marketed, sold, and distributed by PAR Pharmaceutical Companies under the terms of a license and distribution agreement with SVC pharma LP, an affiliate of Rhodes Technologies for Marinol and Insys Pharmaceuticals for Syndros. (wikipedia.org)
citation needed] Dronabinol is available as a prescription drug (under Marinol and Syndros ) in several countries including the United States, Germany, South Africa and Australia. (wikipedia.org)
It included clinical trials related to oral cannabis extract, oromucosal cannabis extract (nabiximols [Sativex]), dronabinol (Marinol), and nabilone (Cesamet). (medpagetoday.com)
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). (drugbank.com)
After standard anti-nausea medications failed to alleviate his symptoms, Mr. Dobson's physicians prescribed dronabinol (brand name Marinol), which worked immediately. (medicareadvocacy.org)
The prescribing information for Marinol (active ingredient dronabinol) is similar with regard to drug interactions. (factcheck.org)
Some medicines, like Marinol (dronabinol), are carefully made in a lab to help sick people. (wikipedia.org)
Nabilone4
Dronabinol and nabilone are synthetic versions of THC. (medpagetoday.com)
Novel studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas. (springer.com)
Dronabinol and nabilone, a synthetic cannabinoid drug, are frequently used to treat some health conditions. (bolsademulher.com)
On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ 9 THC), an exogenous Cannabinoid type 1 and type 2 (CB1 and CB2) receptor agonist in patients with Obstructive Sleep Apnea (OSA). (frontiersin.org)
We recently reported that 4 out of 6 patients with refractory schizophrenia improved with the cannabinoid agonist dronabinol (synthetic Δ 9 -tetrahydrocannabinol). (psychiatrist.com)
Tetrahydrocannabinol3
Dronabinol is the principal psychoactive constituent enantiomer form, (−)-trans-Δ9-tetrahydrocannabinol, found in cannabis. (wikipedia.org)
Dronabinol does not include any other tetrahydrocannabinol (THC) isomers or any cannabidiol. (wikipedia.org)
Since 15 April 2020 , German pharmacies have been able to purchase the active ingredient dronabinol (also known as tetrahydrocannabinol or THC) directly from Cantourage - the new supplier of dronabinol, which is pure THC as an API (active pharmaceutical ingredient). (prnewswire.com)
Syndros1
One of these is dronabinol ( Syndros , Benuvia Therapeutics Inc), a synthetic oral formulation of THC approved for anorexia and weight loss in AIDS as well as nausea and vomiting related to chemotherapy. (medscape.com)
Active ingredient1
The active ingredient 'Dronabinol API Cantourage' is available for pharmacies to order directly from Cantourage and via wholesalers. (prnewswire.com)
Capsules14
While dronabinol was initially approved by the United States Food and Drug Administration on May 31, 1985, it was not until May 13, 1986, the Drug Enforcement Administration (DEA) issued a Final Rule and Statement of Policy authorizing the "rescheduling of synthetic dronabinol in sesame oil and encapsulated in soft gelatin capsules from Schedule I to Schedule II" (DEA 51 FR 17476-78). (wikipedia.org)
These highlights do not include all the information needed to use dronabinol capsules safely and effectively. (nih.gov)
Inform patients not to operate motor vehicles or other dangerous machinery until they are reasonably certain that dronabinol capsules do not affect them adversely. (nih.gov)
Avoid concomitant use of drugs with similar effects and monitor for hemodynamic changes after initiating or increasing the dosage of dronabinol capsules. (nih.gov)
Weigh the potential risk versus benefits before prescribing dronabinol capsules to patients with a history of seizures, including those requiring anti-epileptic medication or with other factors that lower the seizure threshold. (nih.gov)
Assess risk for abuse or misuse in patients with a history of substance abuse or dependence, prior to prescribing dronabinol capsules and monitor for the development of associated behaviors or conditions. (nih.gov)
monitor for adverse reactions to concomitant highly protein-bound drugs and narrow therapeutic index drugs (e.g., warfarin, cyclosporine, amphotericin B) when initiating or increasing the dosage of dronabinol capsules. (nih.gov)
Pharmacies process it mainly into either drops or capsules for patients according to the DAC monograph and dronabinol is therefore easier and more targeted to dose than cannabis flowers. (prnewswire.com)
The Harvard Drug Group, LLC d/b/a Major Pharmaceutical and Rugby Laboratories, based in La Vergne, Tennessee, is voluntarily recalling a single lot of Dronabinol Capsules, USP, 2.5 mg and Ziprasidone Hydrochloride Capsules, 20 mg because of a label mix-up, according to the FDA. (trulaw.com)
Company officials announced the consumer-level recall on June 13, 2023, after a distributor sent a customer complaint indicating that blister packages labeled and containing Dronabinol Capsules, USP, 2.5 mg for Lot T04769 were found in several unit dose cartons labeled Ziprasidone Hydrochloride Capsules, 20 mg. (trulaw.com)
All products under Lot T04769, Dronabinol Capsules, USP, 2.5 mg, which may be found in outer cartons bearing the label for either Dronabinol Capsules, USP, 2.5 mg or Ziprasidone Hydrochloride Capsules, 20 mg., are impacted. (trulaw.com)
Images of the outer carton for both products, as well as for the blister packages of Dronabinol Capsules, USP, 2.5 mg found in the Ziprasidone Hydrochloride Capsules, 20 mg carton, can also be referenced in the letter. (trulaw.com)
The mislabeling presents a risk to patients who ingest the Dronabinol Capsues, USP, 2.5 mg instead of the intended Ziprasidone Hydrochloride, 20 mg capsules. (trulaw.com)
Efficacy3
Dronabinol demonstrated analgesic efficacy in a majority of studies in chronic pain, the data in acute pain is less conclusive. (wikipedia.org)
monitor for potential dronabinol-related adverse reactions or loss of efficacy. (nih.gov)
In his own clinical practice, efficacy of dronabinol has been "hit and miss. (medscape.com)
Oral2
After oral administration, dronabinol has an onset of action of approximately 0.5 to 1 hours and peak effect at 2 to 4 hours. (cellphoneforums.net)
Prior studies have separately examined the effects of dronabinol (oral THC) on cannabis withdrawal, cognitive performance, and the acute effects of smoked cannabis. (erowid.org)
Capsule2
Pill with imprint RP 869 is Orange, Capsule-shape and has been identified as Dronabinol 10 mg. (drugs.com)
For example, as stated earlier, dronabinol is a gelatin capsule containing THC and is used to treat nausea and vomiting in cancer patients who are undergoing chemotherapy. (bolsademulher.com)
Therefore, by design, dose-escalation of dronabinol was permitted only if the lower dose was not associated with adverse events. (frontiersin.org)
In such an event, officials acknowledge there is "a reasonable probability" that patients could suffer a number of adverse events from both failing to take their prescribed ziprasidone dose and taking the unintended dose of Dronabinol. (trulaw.com)
Cannabis withdrawal1
Dronabinol may be useful in treating cannabis addiction as it has been shown to reduce cannabis withdrawal symptoms and the subjective effects of marijuana. (wikipedia.org)
Stimulate1
Dronabinol is used to stimulate appetite and therefore weight gain in patients with HIV/AIDS and cancer. (wikipedia.org)
Patients6
Dr. Florian Holzapfel sees the company as a think tank for cannabis: "Breaking the dronabinol monopoly is our first step towards creating added value for patients, pharmacists and health insurance companies. (prnewswire.com)
Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5-10 mg daily and significantly reduces AHI in the short-term. (frontiersin.org)
proof of concept study aimed to test the hypothesis that dronabinol, an exogenous CB 1 and CB 2 receptor agonist can reduce abnormal respiratory events and associated hypoxemia in patients with OSA. (frontiersin.org)
The primary objective was to assess the safety and tolerability of dronabinol in patients with moderate to severe OSA. (frontiersin.org)
In their article, Rosenberg and colleagues note that they are currently conducting a randomized, controlled trial to test the effects of dronabinol for agitation in patients with AD. (medscape.com)
Appetite2
Duration of action for psychoactive effects is 4 to 6 hours, but the appetite stimulant effect of dronabinol may continue for 24 hours or longer after administration. (cellphoneforums.net)
Dronabinol , a synthetic form of delta-9-THC, is used to relieve nausea and vomiting caused by chemotherapy drugs and to enhance appetite in people with AIDS. (merckmanuals.com)
Doses2
Another experimental objective was to test the effect of repeated doses of dronabinol on OSA severity measured by Apnea Hypopnea Index (AHI). (frontiersin.org)
His group is researching 10 mg/day of dronabinol, while other studies are experimenting with different doses of THC. (medscape.com)
Marijuana3
On the basis of the patient's report that he had felt calm when he took marijuana in high school, we added dronabinol 5 mg bid. (psychiatrist.com)
On the basis of the patient's report that marijuana 'put me to sleep beautifully at night,' we added dronabinol 5 mg bid. (psychiatrist.com)
On the basis of his history that 'daily marijuana was the only thing that kept me straight and helped me concentrate,' we added dronabinol 10 mg bid. (psychiatrist.com)
Medication2
Dronabinol use was approved by the joint institutional review board of the Rockland Psychiatric Center and Nathan S. Kline Institute for Psychiatric Research (Orangeburg, New York) and given according to our hospital's formal protocol for administering US Food and Drug Administration-approved medication for off-label use. (psychiatrist.com)
A single study examining these clinically relevant domains would benefit the continued evaluation of dronabinol as a potential medication for the treatment of cannabis use disorders. (erowid.org)
Apnea1
Dronabinol demonstrates significant improvement in sleep apnea scores. (wikipedia.org)
Clinical1
1 We have subsequently tried dronabinol in a purely clinical manner for 8 other inpatients with refractory psychosis in our tertiary care hospital. (psychiatrist.com)
Drugs1
Cantourage has its own exclusive production relationship with Israeli cannabis producer BOL (Breath of Life) Pharma for dronabinol, which pharmacies use to make patient-specific drugs. (prnewswire.com)
Drug1
an inhaled THC-based dronabinol drug and their mucoadhesive-delivery dronabinol drug Adversa®, which are both in the accelerated 505(b)(2) New Drug Application (NDA) pathway for the U.S. and Canadian markets. (wikipedia.org)
Medications1
Dronabinol is used to treat nausea and vomiting caused by chemotherapy in people who have already taken other medications to treat this type of nausea and vomiting without good results. (cellphoneforums.net)
Treatment2
Repeat PSG assessments were performed on nights 7, 14, and 21 of dronabinol treatment. (frontiersin.org)
Two weeks later, dronabinol treatment was restarted, and his behavior once again became calm, cooperative, and logical within 2 days. (psychiatrist.com)
State1
When the dronabinol was phased out 3 weeks later, his behavior deteriorated within 5 days to the pre-dronabinol state. (psychiatrist.com)
Trial2
At the time of the dronabinol trial, he was receiving daily clozapine 775 mg (serum level = 650 ng/mL), risperidone 5 mg, lithium carbonate 900 mg (serum level = 1.18 mEq/L), and clonazepam 4 mg for months with no significant benefit. (psychiatrist.com)
At the time of the dronabinol trial, he was receiving olanzapine 25 mg/d and clonazepam 2 mg/d for months with minimal response and had a CGI-S score of 5, markedly ill. (psychiatrist.com)
Label1
Using this commonsense meaning of the word "support," the court concluded that the listing in question requires Medicare to cover Mr. Dobson's off-label use of dronabinol. (medicareadvocacy.org)
Continue1
Based on past developments, the sales volume for dronabinol will continue to multiply over the coming years. (prnewswire.com)
Daily1
Dronabinol was administered after baseline PSG, starting at 2.5 mg once daily. (frontiersin.org)
Medical1
The dronabinol produced for Cantourage is the first commercial export to the EU from Israel , which is considered a pioneer in medical cannabis, which has been approved for medical purposes since 1992. (prnewswire.com)