• Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. (wikipedia.org)
  • LEUKERAN (chlorambucil) can severely suppress bone marrow function. (nih.gov)
  • LEUKERAN (chlorambucil) was first synthesized by Everett et al. (nih.gov)
  • LEUKERAN (chlorambucil) is available in tablet form for oral administration. (nih.gov)
  • In a study of 12 patients given single oral doses of 0.2 mg/kg of LEUKERAN, the mean dose-adjusted (±SD) plasma chlorambucil C max was 492 ± 160 ng/mL, the AUC was 883 ± 329 ng.h/mL, the mean elimination half-life (t½) was 1.3 ± 0.5 hours, and the T max was 0.83 ± 0.53 hours. (nih.gov)
  • LEUKERAN (chlorambucil) is indicated in the treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease. (nih.gov)
  • Chlorambucil (Leukeran) is indicated in the treatment of chronic lymphatic (lymphocytic) leukemia. (thrivingpets.com)
  • Chemical Name: CHLORAMBUCIL (klor-AM-byoo-sill) Leukeran belongs to the group of medicines called alkylating agents. (canadapharmacy.com)
  • Leukeran (chlorambucil) is a brand-name prescription medication. (medicalnewstoday.com)
  • Alkylating agents , including chlorambucil (Leukeran) and cyclophosphamide (Cytoxan). (cancercare.org)
  • Most patients are treated with oral prednisone, with or without a cytotoxic/immunosuppressive agent, such as methotrexate, cyclophosphamide, or chlorambucil, or a tumor necrosis factor (TNF)-alpha antagonist. (medscape.com)
  • Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, inducing DNA damage via three different methods of covalent adduct generation with double-helical DNA: Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA. (wikipedia.org)
  • Chlorambucil alkylates and cross-links strands of DNA, inhibiting DNA replication and RNA transcription. (medscape.com)
  • Patients assigned to the combination of ibrutinib (Imbruvica) and venetoclax (Venclexta) had yet to reach median progression-free survival (PFS) after a median follow-up of 27 months, whereas the control regimen of obinutuzumab (Gazyva) and chlorambucil led to a median PFS of 21.0 months. (medpagetoday.com)
  • Patients in the control arm received 6 cycles of chlorambucil and obinutuzumab. (medpagetoday.com)
  • WASHINGTON -- The FDA has approved obinutuzumab (Gazyva) as a combination treatment with chlorambucil for patients with untreated lymphocytic leukemia. (medpagetoday.com)
  • CHLORAMBUCIL (clor AM byoo sil) treats leukemia and lymphoma. (chemocare.com)
  • Three studies investigated cyclosporin A (CSA) with or without prednisone versus prednisone or no treatment and one compared chlorambucil plus prednisone versus no treatment. (nih.gov)
  • The novel agent was again compared with rituximab at the 2013 American Society of Clinical Oncology meeting where, in combination with chlorambucil, the drug more than doubled the progression-free survival seen with chlorambucil monotherapy to 23 months versus 10.9 months. (medpagetoday.com)
  • Although partially refractory to local radiotherapy, the painful swelling of the fingers and toes resolved fully following systemic therapy with chlorambucil and rituximab. (medscape.com)
  • Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard, which has antineoplastic activity. (nih.gov)
  • Again, less than 1% of the urinary radioactivity is in the form of chlorambucil or phenylacetic acid mustard. (nih.gov)
  • butyl ester and its active metabolites chlorambucil and phenylacetic mustard in plasma and tissue. (uclahealth.org)
  • In the 1950s, aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, proving to be less electrophilic and react with DNA more slowly. (wikipedia.org)
  • Chlorambucil, an aromatic nitrogen mustard derivative, is an alkylating agent. (nih.gov)
  • Chlorambucil's current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients. (wikipedia.org)
  • The apparent volume of distribution averaged 0.31 L/kg following a single 0.2 mg/kg oral dose of chlorambucil in 11 cancer patients with chronic lymphocytic leukemia. (nih.gov)
  • Chlorambucil in indolent chronic lymphocytic leukemia. (bvsalud.org)
  • Each film-coated tablet contains 2 mg chlorambucil and the inactive ingredients colloidal silicon dioxide, hypromellose, lactose (anhydrous), macrogol/PEG 400, microcrystalline cellulose, red iron oxide, stearic acid, titanium dioxide, and yellow iron oxide. (nih.gov)
  • Chlorambucil tablet What does this drug do? (canadapharmacy-usa.com)
  • Chlorambucil and its metabolites are extensively bound to plasma and tissue proteins. (nih.gov)
  • Like many alkylating agents, chlorambucil has been associated with the development of other forms of cancer. (wikipedia.org)
  • Skin reactions Hepatotoxicity Infertility Hair Loss Chlorambucil produces its anti-cancer effects by interfering with DNA replication and damaging the DNA in a cell. (wikipedia.org)
  • A recent study has shown Chlorambucil to be detoxified by human glutathione transferase Pi (GST P1-1), an enzyme that is often found over-expressed in cancer tissues. (wikipedia.org)
  • CHLORAMBUCIL is a drug used to treat cancer. (canadapharmacy-usa.com)
  • RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
  • Les risques de cancer les plus élevés pour les Qatariens proviendraient de facteurs associés aux modes de vie, en particulier l'obésité, la sédentarité et le tabagisme. (who.int)
  • Chlorambucil produces human infertility (see WARNINGS and PRECAUTIONS). (nih.gov)
  • Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent. (nih.gov)
  • Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. (nih.gov)
  • After single oral doses of 0.6 to 1.2 mg/kg, peak plasma chlorambucil levels (C max ) are reached within 1 hour and the terminal elimination half-life (t ½ ) of the parent drug is estimated at 1.5 hours. (nih.gov)
  • This is important since chlorambucil, as an electrophile, is made less reactive by conjugation with glutathione, thereby making the drug less toxic to the cell. (wikipedia.org)
  • Consistent with the rapid, predictable absorption of chlorambucil, the inter-individual variability in the plasma pharmacokinetics of chlorambucil has been shown to be relatively small following oral dosages of between 15 and 70 mg (2-fold intra-patient variability, and a 2 to 4 fold interpatient variability in AUC). (nih.gov)
  • Alemtuzumab has been approved for use in CLL and has shown superior response rates compared with chlorambucil. (medscape.com)
  • Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. (uclahealth.org)
  • Chlorambucil is in the alkylating agent family of medications. (wikipedia.org)
  • chlorambucil decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • chlorambucil will increase the level or effect of gepirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)