Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2 Mecamylamine has been used as an orally-active ganglionic blocker in treating autonomic dysreflexia and hypertension, but, like most ganglionic blockers, it is more often used now as a research tool. (wikipedia.org)
Although fibrillation potential or an antidepressant (chapters 14 and 11), helps to prevent guesswork by the ganglionic blocker mecamylamine. (riversideortho.com)
Hydrochloride5
ZYRTEC-D 12 HOUR (cetirizine hydrochloride 5 mg and pseudoephedrine hydrochloride 120 mg) Extended Release Tablets for oral administration contain 5 mg of cetirizine hydrochloride for immediate release and 120 mg of pseudoephedrine hydrochloride for extended release in a bilayer tablet. (rxdrugnews.com)
Cetirizine hydrochloride, one of the two active components of ZYRTEC-D 12 HOUR Extended Release Tablets, is an orally active and selective H 1 -receptor antagonist. (rxdrugnews.com)
Pseudoephedrine hydrochloride, the other active ingredient of ZYRTEC-D 12 HOUR Extended Release Tablets, is an adrenergic (vasoconstrictor) agent with the chemical name (1S.2S)-2-methylamino-1-phenyl-1-propanol hydrochloride. (rxdrugnews.com)
The bioavailability of cetirizine hydrochloride and pseudoephedrine hydrochloride from ZYRTEC-D 12 HOUR Extended Release Tablets is not significantly different from that achieved with separate administration of a cetirizine 5 mg tablet and a pseudoephedrine 120 mg extended release caplet. (rxdrugnews.com)
When healthy volunteers were administered multiple doses of the ZYRTEC-D 12 HOUR Extended Release Tablet to reach steady-state concentrations (cetirizine hydrochloride 5 mg and pseudoephedrine hydrochloride 120 mg twice daily for seven days), a mean Cmax of 178 ng/mL was observed for cetirizine and 526 ng/mL for pseudoephedrine. (rxdrugnews.com)
Depression3
medical citation needed] In a recent double-blind, placebo-controlled Phase II trial in Indian patients with major depression, (S)-mecamylamine (TC-5214) appeared to have efficacy as an augmentation therapy. (wikipedia.org)
US authorities have approved the first generic version of Lexapro (escitalopram) tablets for treating depression and anxiety. (chemistryworld.com)
The two companies were interested in using TC-5214, an enantiomer of mecamylamine, as a treatment for depression. (chemistryworld.com)
Medications1
There is a possibility that this treatment will interact negatively with the following medications: atropine\sbethanechol\sdisopyramide edrophonium guanadrel\sguanethidine Medications containing mecamylamine that are used to block muscular or nerve discomfort It's probable that this list doesn't cover all of the possible interactions. (canadapharmacy-usa.com)
Bupropion1
A 23% sustained cessation rate is achieved with bupropion tablets at 1 year, compared with a 12% sustained cessation rate with placebo. (medscape.com)
Extended release1
Following a single dose of the ZYRTEC-D 12 HOUR Extended Release Tablet, a mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine and a mean Cmax of 309 ng/mL at a Tmax of 4.4 hours postdose was observed for pseudoephedrine. (rxdrugnews.com)
Cialis2
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Inversine1
Some clinicians and investigators have been exploring the value of nicotine patches or mecamylamine (Inversine®), a medication that blocks nicotine receptors in the brain. (depression-guide.com)
Nicotine2
The odds ratio for abstinence with NRT compared to control was 1.73 (95% confidence interval 1.62-1.85), The odds ratios for the different forms of NRT were 1.66 for gum, 1.76 for patches, 2.27 for nasal spray, 2.08 for inhaled nicotine and 1.73 for nicotine sublingual tablet. (medscape.com)
All of the commercially available forms of NRT (nicotine gum, transdermal patch, the nicotine nasal spray, nicotine inhaler and nicotine sublingual tablets) are effective as part of a strategy to promote smoking cessation. (medscape.com)
Slowly3
Mecamylamine HCl is excreted slowly in the urine in the unchanged form. (nih.gov)
S)-(+)-Mecamylamine dissociates more slowly from α4β2 and α3β4 receptors than does the (R)-(−)-enantiomer. (wikipedia.org)
Claritin-D 24 hour extended release tablets contain 10 mg loratadine in the tablet film coating for immediate release and 240 mg pseudoephedrine sulfate in the tablet core which is released slowly allowing for once-daily administration. (globalrph.com)
Dose1
The usual dose was one tablet every 12 hours for up to 28 days. (globalrph.com)
Secondary3
Mecamylamine HCl is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. (nih.gov)
Mecamylamine, a secondary amine, readily penetrates the brain and thus may produce central nervous system effects. (nih.gov)
Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2 Mecamylamine has been used as an orally-active ganglionic blocker in treating autonomic dysreflexia and hypertension, but, like most ganglionic blockers, it is more often used now as a research tool. (wikipedia.org)
Oral1
Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. (nih.gov)
Transdermal1
Clonidine is available in tablet and sustained-release (transdermal) patch form. (depression-guide.com)
Clinical1
pseudoephedrine sulfate extended release tablets should be administered when both the antihistaminic properties of loratadine and the nasal decongestant activity of pseudoephedrine are desired (see CLINICAL PHARMACOLOGY ). (globalrph.com)
Large2
These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency. (nih.gov)
A large SAR study of mecamylamine and its analogs was reported by a group from Merck in 1962. (wikipedia.org)
Effects2
On the other hand, the effects of Mecamylamine HCl sometimes may last from hours to days after therapy is discontinued. (nih.gov)
Food versus no food) crossover study to measure the effects of food on pharmacokinetics of TC-5214 (S-Mecamylamine) in healthy Subjects. (astrazenecaclinicaltrials.com)
Therapy3
When Mecamylamine HCl is withdrawn, this should be done gradually, and other antihypertensive therapy usually must be substituted. (nih.gov)
During therapy with Mecamylamine HCl, sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted. (nih.gov)
medical citation needed] In a recent double-blind, placebo-controlled Phase II trial in Indian patients with major depression, (S)-mecamylamine (TC-5214) appeared to have efficacy as an augmentation therapy. (wikipedia.org)
Drug1
Mecamylamine is also sometimes used as an antiaddictive drug to help people stop smoking tobacco, and is now more widely used for this application than it is for lowering blood pressure. (wikipedia.org)
Blood3
Mecamylamine HCl reduces blood pressure in both normotensive and hypertensive individuals. (nih.gov)
Mecamylamine HCl is almost completely absorbed from the gastrointestinal tract, resulting in consistent lowering of blood pressure in most patients with hypertensive cardiovascular disease. (nih.gov)
Mecamylamine HCl crosses the blood-brain and placental barriers. (nih.gov)
Water1
24 Hour Tablet: One tablet daily taken with a full glass of water (see PRECAUTIONS and ADVERSE REACTIONS ). (globalrph.com)