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  • systolic blood pr
  • Physiologic determinants, such as pulse pressure [difference between systolic blood pressure (SBP) and diastolic BP (DBP)], mean arterial pressure (2/3 DBP + 1/3 SBP), and double product [beats per minute (bpm) × SBP], are linked to cardiovascular outcomes. (biomedcentral.com)
  • hepatic
  • The most probable mechanism leading to T2DM in thyroid dysfunction could be attributed to perturbed genetic expression of a constellation of genes along with physiological aberrations leading to impaired glucose utilization and disposal in muscles, overproduction of hepatic glucose output, and enhanced absorption of splanchnic glucose. (hindawi.com)
  • Ertugliflozin
  • In December 2017, ertugliflozin (Steglatro™), developed by Merck and Pfizer, received its first global approval in the US for use in conjunction with exercise and diet to improve glycaemic control in adults with type-2 diabetes mellitus (T2DM). (adisintouch.com)
  • At the same time the FDA also approved a fixed dose combination tablet formulation of ertugliflozin and sitagliptin (Steglujan™) [2] for the same indication, where use of each agent is appropriate. (adisintouch.com)
  • Subsequently in January 2018 the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion and recommended the Marketing Authorisation for fixed dose ertugliflozin plus metformin (Segluromet™) tablets be granted, also for use in conjunction with exercise and diet to improve glycaemic control in adults with T2DM. (adisintouch.com)
  • The purpose of this article is to review the pharmacological aspects of ertugliflozin and its clinical trials, which led to Food and Drug Administration (FDA) approval for the treatment of type 2 diabetes mellitus (T2DM). (readbyqxmd.com)
  • mechanism
  • Evidence from animal studies indicates that hyperinsulinemia, without changes in glucose, increases ventilation via a carotid body-mediated mechanism. (bioportfolio.com)
  • dipeptidyl
  • Linagliptin is an inhibitor of the enzyme, dipeptidyl peptidase-4 (DPP-4), which breaks down the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that are involved with regulating blood sugar. (bio-medicine.org)
  • metabolism
  • The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG tracers. (bioportfolio.com)
  • It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration. (bioportfolio.com)
  • Hyper- and hypothyroidism have been associated with insulin resistance which has been reported to be the major cause of impaired glucose metabolism in T2DM. (hindawi.com)
  • Outcomes
  • therefore, the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) issued a guidance to the pharmaceutical industry to specifically assess the CV outcomes and safety of new glucose-lowering drugs. (clinsci.org)
  • This cross sectional study compared the Kidney Disease: Improving Global Outcomes (KDIGO) and Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines in assessing the prevalence of CKD in Type 2 diabetes Mellitus (T2DM) patients.MethodsWe consecutively sampled a cross-section of 202 T2DM patients from the Ho municipality in the Volta region (Ghana). (medworm.com)
  • dysfunction
  • T 2 DM affects several major organs, including heart, blood vessels, nerves, eyes and kidneys leading to disabling or even life-threatening complications such as cardiac dysfunction, atherosclerosis, and nephropathy [ 7 ]. (ijbs.com)
  • Type 2 diabetes mellitus (T2DM) has an intersecting underlying pathology with thyroid dysfunction. (hindawi.com)
  • The state-of-art evidence suggests a pivotal role of insulin resistance in underlining the relation between T2DM and thyroid dysfunction. (hindawi.com)
  • There is a deep underlying relation between diabetes mellitus and thyroid dysfunction [ 2 ]. (hindawi.com)
  • Intervention
  • Further population-based and long-term human intervention studies are necessary to ultimately evaluate the use of anthocyanins for protection/prevention against the development of obesity and T2DM. (springer.com)
  • clinical
  • Recent consensus guidelines from the American Association of Clinical Endocrinologists (AACE) ( 2 ) described a similar algorithm with rather aggressive A1C criteria for initiating dual therapy. (diabetesjournals.org)
  • A plethora of preclinical, molecular, and clinical studies have evidenced an undeniable role of thyroid malfunctioning as a comorbid disorder of T2DM. (hindawi.com)