• These agents are also indicated to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus who with either established cardiovascular disease or multiple cardiovascular risk factors. (medscape.com)
  • IntroductionRheumatic diseases are autoimmune, inflammatory diseases often associated with cardiovascular (CV) disease, a major cause of mortality in these patients. (researchgate.net)
  • Childhood obesity is one of the most serious public health challenges of the 21st century, placing children at high risk of diseases such as diabetes, cardiovascular disease and some cancers. (findaphd.com)
  • DKD - by itself and mostly during haemodialysis - also highly increases the risk of cardiovascular diseases such as heart attack, stroke, and others [ 1, 6 ]. (karger.com)
  • Recently, clinical trials and preclinical studies have shown that curcumin exerts protective effects against a variety of diseases, including diabetes and its cardiovascular complications. (frontiersin.org)
  • In 2016, the Global Burden of Diseases (GBD) study reported that T2DM and its complications accounted for a 22% increase in disability-adjusted life years (DALYs) during the last decade (2016), imposing enormous burden on individuals and public health ( GBD 2015 Risk Factors Collaborators, 2016 ). (frontiersin.org)
  • Many remain small to adulthood and are at an increased risk for developing metabolic diseases such as obesity and type 2 diabetes. (bcm.edu)
  • A recent population-based longitudinal study has shown that the relative risk of Alzheimer's diseases (AD) and vascular dementia (VaD) in the DM population was 1.46 (95% CI: 1.20-1.77) and 2.5 (95% CI: 2.1-3.0), respectively, when compared to people without DM [ 6 ]. (hindawi.com)
  • The prevalence of these diseases increases with age and they share common risk. (koreamed.org)
  • This study emphasizes the importance of screening of lipid profile as these abnormalities may lead to development of cardiovascular diseases. (heraldopenaccess.us)
  • Using Framingham risk scores, 61% of the subjects had elevated 10-year risk of developing cardiovascular diseases (CVDs), with no significant difference in gender prevalence. (hindawi.com)
  • Recent human epidemiological and animal experimentation studies have revealed that negative conditions occurring prenatally influence the appearance of metabolic and cardiovascular diseases, some of which are in turn risk factors for Alzheimer's disease (AD). (alzheimer-europe.org)
  • The discovery and the understanding of such conserved changes might ultimately pave the way for identifying people at risk for AD earlier than is currently possible, which could in turn improve patients' quality of life and help to reduce the social and economic impact of these diseases. (alzheimer-europe.org)
  • Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
  • Abdominal obesity has been strongly linked to cardiovascular disease, Alzheimer's disease, and other metabolic and vascular diseases. (wikipedia.org)
  • Conversely, people with cardiovascular diseases more frequently suffer from serious mental disorders. (bvsalud.org)
  • we also linked rotating night shift work , through its profound effects on metabolism and weight (i.e. obesity) with other major chronic diseases, including cardiovascular disease, metabolic syndrome, hypertension, stroke, endometriosis, type 2 diabetes (T2DM). (cdc.gov)
  • Obesity and sleep disorders have a combined effect on cardiovascular diseases and diabetes mellitus. (bvsalud.org)
  • This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, and screening of these diseases. (bvsalud.org)
  • Patients with NAFLD are at increased risk of cardiovascular disease. (medscape.com)
  • The metabolic syndrome (MetS) is a constellation of metabolic risk factors (including hypertension, dyslipidaemia, abdominal obesity and impaired glucose metabolism), which is associated with a twofold increased risk of cardiovascular disease (CVD) (Ford, 2005), and an even higher risk of T2DM (Grundy, 2008). (bhma.org)
  • Pre-diabetes is a high-risk state for the development of type 2 diabetes mellitus (T2DM) and cardiovascular disease. (nih.gov)
  • Introduction Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic disease in the Spanish population. (bmj.com)
  • Obesity increases the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). (wku.edu)
  • As the burden of disease from diabetes rises to epidemic proportions, RGA's Heather Lund asks in On the Risk whether the possibility of remission for Type 2 diabetes mellitus (T2DM) signals an opportunity to escape a major public health traffic jam. (rgare.com)
  • But in recent years, despite initial scanty evidence, there is mounting data that suggests some reversibility in established Type 2 diabetes mellitus (T2DM), particularly in those with short duration. (rgare.com)
  • Waist circumference (WC) is used to indirectly measure abdominal adipose tissue and the associated risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). (nih.gov)
  • As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events. (springer.com)
  • Eighty-two adult subjects with diagnosed T2DM were recruited from the Diabetes Mellitus Outpatient Clinic of the 3rd Department of Internal Medicine, situated at Papageorgiou General Hospital, Thessaloniki, Greece, and divided into two groups according to the presence or absence of DPN. (springer.com)
  • Next, type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular and renal disease. (healthydebate.ca)
  • Vitamin D deficiency and insufficiency are also more common across type 2 diabetes mellitus (T2DM) patients. (karger.com)
  • Vitamin D deficiency also contributes to many extraskeletal outcomes, including higher risk of type 1 or type 2 diabetes mellitus, allergy, autoimmunity, pregnancy complications, and many other pathologies. (karger.com)
  • We analyzed the association between adherence of a MeDiet in patients with type 2 diabetes mellitus (T2DM) and levels of HbA1c. (nuthealth.org)
  • Obesity is independently associated with an increased incidence of diabetes mellitus, hypertension, hyperlipidemia, cardiovascular disease (CVD), and certain cancers. (mims.com)
  • The aim of this study was to assess the quality of care for type 2 diabetes mellitus (T2DM) patients from these ethnic minority groups compared with the care received by Norwegians. (biomedcentral.com)
  • In the developing world, both urbanisation and a shift towards a westernised lifestyle are risk factors for developing type 2 diabetes mellitus (T2DM). (biomedcentral.com)
  • In Norway, the majority of T2DM patients are cared for in general practice whereas type 1 diabetes mellitus (T1DM) patients usually receive hospital based specialist care. (biomedcentral.com)
  • Globally, about one in eleven adults have diabetes, and 90% of whom are diagnosed as type 2 diabetes mellitus (T2DM). (frontiersin.org)
  • To prospectively assess the long-term safety of statins in patients with prediabetes/type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH). (medscape.com)
  • 2 , 3 Women diagnosed with gestational diabetes mellitus (GDM), defined as glucose intolerance of varying severity with onset and first recognition in pregnancy, have an increased lifetime risk of developing both T2DM and cardiovascular disease. (bmj.com)
  • There are two types of DM: type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). (hindawi.com)
  • The longitudinal changes in the fibrinolytic factors tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and tPA/PAI-1 complex have been inadequately studied in the general population and in relation to incident type 2 diabetes mellitus (T2DM). (avhandlingar.se)
  • Background: To investigate the efficacy and safety of moderate-intensity rosuvastatin/ezetimibe combination compared to highintensity rosuvastatin in high atherosclerotic cardiovascular disease (ASCVD) risk patients with type 2 diabetes mellitus (T2DM). (koreamed.org)
  • Background: This study investigates the long-term efficacy and safety of evogliptin add-on therapy in patients with inadequately controlled type 2 diabetes mellitus (T2DM) previously received dapagliflozin and metformin (DAPA/MET) combination. (koreamed.org)
  • Type 2 diabetes mellitus (T2DM) and sarcopenia (low skeletal muscle mass and function) share a bidirectional relationship. (koreamed.org)
  • Comparative predictiveness of major lipid and lipoprotein parameters for cardiovascular events in patients with type 2 diabetes mellitus. (koreamed.org)
  • Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid levels status. (heraldopenaccess.us)
  • Type1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM) are the commonest types of DM, this classification is important for both clinically in assessing the need for treatment, and also in understanding the causes of diabetes which are entirely different in the two groups [2]. (heraldopenaccess.us)
  • Diabetes mellitus is a common secondary cause of hyperlipidemia, particularly if glycemic control is poor, which in-turn is an important risk factor for atherosclerosis and coronary heart disease [12,13]. (heraldopenaccess.us)
  • About 4790 deaths recorded in the same year aside the many undiagnosed cases in Africa, type II diabetes mellitus (T2DM) accounted for 90-95% of all diagnosed cases [ 3 , 4 ]. (hindawi.com)
  • We illustrate our approach by modeling the divergence in childhood-to-adulthood body mass index (BMI) trajectories between two groups of adults with/without type 2 diabetes mellitus (T2DM) in the Cardiovascular Risk in Young Finns Study (YFS). (monash.edu)
  • A five-year follow- up study of Swedish men indicated that elevated plasma cortisol and low testosterone were prospectively associated with increased incidence of cardiovascular-related events and Type 2 Diabetes Mellitus (T2DM) (Rosmond et al, 2003). (bhma.org)
  • The aim of this proposal is to determine if and how early-life stress may precipitate dementias linked to AD and to type 2 diabetes mellitus (T2DM), two major causes of senile dementia worldwide. (alzheimer-europe.org)
  • Type 2 diabetes mellitus (T2DM) accounts for approximately 90% of the cases of diabetes. (ddw-online.com)
  • The micro and macrovascular complications of Type 2 diabetes mellitus are influenced by several well described cardiovascular risk factors such as hyperglycaemia, hypertension, hyperlipidaemia, and smoking alongside age, sex, and diabetes duration. (emjreviews.com)
  • Type 2 diabetes mellitus is associated with increased cardiovascular risk as documented in numerous observational studies. (emjreviews.com)
  • Several international guidelines have addressed the challenge of screening, diagnosing, and treating these risk factors, not only in patients with Type 2 diabetes mellitus but also in subjects with impaired fasting glucose or impaired glucose tolerance. (emjreviews.com)
  • 1 In the USA, the American Diabetes Association (ADA) published the annual 'Standards of Medical Care' in 2016, where updated recommendations for the treatment of Type 2 diabetes mellitus and risk factor control were stated. (emjreviews.com)
  • Table 1: Treatment goals for risk factor control in patients with Type 2 diabetes mellitus. (emjreviews.com)
  • During 2013-2016 several important new clinical intervention trials in patients with Type 2 diabetes mellitus have been published to expand the evidence base for how to deal with the risk factors regarding drug therapy. (emjreviews.com)
  • The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
  • BACKGROUND: Type 2 diabetes mellitus (T2DM) patients are at high risk of cardiovascular (CV) events. (bvsalud.org)
  • The aim of this study is to describe real-world clinical practice in terms of type 2 diabetes mellitus (T2DM) disease management and treatment patterns within Lebanon. (who.int)
  • to International Diabetes Federation report: in Lebanon, the prevalence of age-adjusted T2DM was reported to The worldwide prevalence of type 2 diabetes mellitus be at 12.6% ( 11 ). (who.int)
  • But adiponectin, an anti-inflammatory adipokine, which is found in lower concentration in obese and diabetic individuals has shown to be beneficial and protective in type 2 diabetes mellitus (T2DM). (wikipedia.org)
  • Insulin resistance is a major feature of diabetes mellitus type 2, and central obesity is correlated with both insulin resistance and T2DM itself. (wikipedia.org)
  • Children who are living with long-term medical conditions are a much greater risk for overweight and obesity compared to other children (Rimmer et al. (findaphd.com)
  • Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. (findaphd.com)
  • Review CV risk factors, their relationship, association and prevalence in persons with obesity. (pcna.net)
  • In sub-Saharan Africa, hypertension followed by obesity was the commonly known cardiometabolic risk factors associated with the general adult population [ 8 ]. (hindawi.com)
  • Cardiovascular disease (CVD) risk factors such as obesity, hypertension, and dyslipidaemia are common in patients with DM, placing them at increased risk for cardiac events [ 10 , 11 ]. (hindawi.com)
  • The application of WHtR provides an alternative anthropometric index of central obesity that avoids the limitations of WC because the inclusion of height into the index enhances the avoidance of any potential confounding of cardiometabolic risk by height [ 19 ]. (hindawi.com)
  • The mechanisms linking these risk factors with disease manifestation of micro and macrovascular complications are based on gene-environmental interactions, where a less healthy lifestyle, for example smoking, lack of physical exercise, or unhealthy eating habits, result in obesity. (emjreviews.com)
  • Researchers first started to focus on abdominal obesity in the 1980s when they realized it had an important connection to cardiovascular disease, diabetes, and dyslipidemia. (wikipedia.org)
  • Abdominal obesity was more closely related with metabolic dysfunctions connected with cardiovascular disease than was general obesity. (wikipedia.org)
  • Abdominal obesity is linked with higher cardiovascular events among South Asian ethnic population. (wikipedia.org)
  • Abdominal obesity is typically associated with a statistically higher risk of heart disease, hypertension, insulin resistance, and type 2 diabetes (see below). (wikipedia.org)
  • Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance, full-blown diabetes, and increased risk of developing cardiovascular disease. (wikipedia.org)
  • Importantly, adherence to an overall healthy lifestyle before pregnancy was strongly associated with a low risk of offspring obesity in childhood, adolescence, and early adulthood, or for moms who work ed night shifts. (cdc.gov)
  • Findings from the Phase III Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED) trial were presented at the recent American Society of Nephrology's Kidney Week (ASN). (uspharmacist.com)
  • In an interview on the ASN website, David Cherney, MD CM, PhD, FRCP(C), of the University of Toronto, stated, "These effects are consistent with what has been reported with other SGLT inhibitors in people with type 2 diabetes at high cardiorenal risk and add to the already reported benefits of sotagliflozin in reducing both heart failure and ischemic events such as myocardial infarction or stroke. (uspharmacist.com)
  • Early CVD protection is crucial in MS patients with Type 2 diabetes (T2DM). (mims.com)
  • Patients with type 2 diabetes (T2DM) have a significantly higher risk of developing cardiovascular disease (CVD)-namely myocardial infarction, heart failure, and stroke. (uzh.ch)
  • diabetic blood blister treatment, which could be used to help New Oral Diabetes Medications with certain diets toenail fungus treatment it, or the results of an individualized it treatment for children with it, the especially more severe low risk of developing type 2 diabetes. (kamrytech.com)
  • This criteria can increase the risk of developing it that lead to the complications in people with type 2 diabetes. (kamrytech.com)
  • Metformin does type 2 diabetes have high blood sugar treatment should New Oral Diabetes Medications be a New Oral Diabetes Medications significantly reduced risk of developing new diabetes. (kamrytech.com)
  • 1 In the general population, breastfeeding has been associated with short-term improvement in postpartum maternal glucose metabolism and long-term reduction in risk of cardiometabolic disease including type 2 diabetes (T2DM) and myocardial infarction. (bmj.com)
  • Family history is a known risk factor for type 2 diabetes (T2DM), and more so in the presence of overweight. (biomedcentral.com)
  • The prevalence of people with type 2 diabetes (T2DM) in the general population is reaching epidemic proportions in many countries, with the total number of people with T2DM projected to rise to 366 million in 2030 worldwide [ 1 ]. (biomedcentral.com)
  • The power of Lp(a) to predict cardiovascular events in young coronary artery disease (CAD) patients with type 2 diabetes (T2DM) however is unclear and is addressed in the present study. (diabetesjournals.org)
  • The current study assessed the discriminatory ability of NT-proBNP alone in predicting the risk of death and CV outcomes in 5509 patients with T2DM and CVD and/or CKD using data from the Aliskiren in Type 2 Diabetes Using Cardiorenal Endpoints (ALTITUDE) trial. (pace-cme.org)
  • Ces vingt dernières années, on assiste à une augmentation spectaculaire du nombre de cas de diabète de type 1 avec une mortalité plus élevée en Afrique Noire en lien avec les difficultés d'accès aux soins, à la rupture de suivi engendrant un nombre élevé de perdus de vue. (bvsalud.org)
  • T2DM accounts for approximately 90% of all DM cases with the prevalence increasing with age. (hindawi.com)
  • We reviewed a decade of data from all patients with coronary heart disease enrolled in a single CR center (University of Michigan) to identify the prevalence of low-risk factors, which may inform on consideration for participation in alternative models of CR. (journaltocs.ac.uk)
  • The aim of this study is to determine the prevalence and patterns of dyslipidemia in patients with T2DM in Mukalla city, Yemen, in 2017. (heraldopenaccess.us)
  • The increased prevalence is associated with lifestyle dependent risk factors, including being overweight, physical inactivity and unhealthy diet. (biomedcentral.com)
  • These astonishing statistics help to illustrate the epidemic prevalence of T2DM, and the major need for effective diagnostic, intervention and disease management strategies. (ddw-online.com)
  • T2DM) is increasing, currently affecting around 425 required to provide more accurate information about the million patients and is estimated to increase to 629 mil- incidence and prevalence of the disease, comorbidities, lion patients by 2045 ( 1 ). (who.int)
  • Their prevalence is higher in patients presenting cardiovascular risk factors.This review takes stock of the frequency, the mechanisms, and the implications of major cardiovascular risk factors in patients with serious mental disorders. (bvsalud.org)
  • People with serious mental disordershave a greater prevalence of major cardiovascular risk factors compared to the general population. (bvsalud.org)
  • The aim of the study was to evaluate the prevalence of excessive daytime sleepiness and its association with cardiometabolic risk factors. (bvsalud.org)
  • they also indicate that ACE D-allele carriers who would not usually be expected to show large VO 2max responses following CME may yield equivalent aerobic capacity improvements following HIIT, and thereby reduce their overall morbidity and mortality disease risk. (wku.edu)
  • Diabetes constitutes one of the major independent cardiovascular risk factors, and patients with this disease suffer from premature cardiovascular morbidity and mortality. (scirp.org)
  • Thus, International Civil Aviation Organization (ICAO) recommends to country members to use routinely homogeneous cardiovascular likelihood management recommendations and ASCVD likelihood estimate scores in aeromedical risk assessment to help alleviating morbidity and mortality in aeronautical setting (area). (scirp.org)
  • Despite beneficial effects of current glucose-lowering treatments, disease-related morbidity and mortality remain considerable in T2DM patients, galvanising the search for innovative medications that target the multiple metabolic abnormalities as well as inflammatory processes and other pathways predisposing to diabetes-associated disorders. (ddw-online.com)
  • Physical activity can reduce T2DM and CVD risk, and increase aerobic capacity, a significant predictor of all-cause mortality and morbidity. (wku.edu)
  • Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. (springer.com)
  • Approximately what proportion of cardiovascular mortality results from sudden cardiac arrest (SCA)? (mdedge.com)
  • T2DM and its complications have contributed tremendously to the burden of mortality and health cost worldwide. (frontiersin.org)
  • The aim of this study was to evaluate the risk of cardiovascular disease (CVD) and mortality in patients with diabetes with comorbid depression. (e-dmj.org)
  • However, only few studies have been conducted in a large population to evaluate the risk of CVD and mortality in patients with diabetes and comorbid depression. (e-dmj.org)
  • The mortality rates per 100 persons-year using the base model were 0.7 (95% CI:04-1.2) in low-risk patients (1st decile of risk) and 11.6 (95% CI:9.9-13.7) in high-risk patients (10th decile of risk). (pace-cme.org)
  • Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
  • CONCLUSIONS: To our knowledge, this study is the first to show that in T2DM patients, elevated FXI could predict major CV events, including mortality, which suggest that anti-FXI agents might be a potential novel antithrombotic option in this disease. (bvsalud.org)
  • Metabolic Syndrome (MS) is linked to insulin resistance and a combination of five medical conditions that increase the risk of developing atherosclerotic cardiovascular disease (ASCVD). (mims.com)
  • T1DM is caused by the destruction of the pancreatic β -cells due to an autoimmune reaction, leading to absolute insulin deficiency, whilst T2DM is characterised by insulin resistance, where the body fails to produce an appropriate physiological response to circulating insulin. (hindawi.com)
  • We're going to be talking about that interface between cardiology, endocrinology, primary care, and the very important risk factor for heart disease: insulin resistance and diabetes. (consultantlive.com)
  • This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
  • Background: Flight and cabin crew are known to be at increased risk for atherosclerotic cardiovascular disease (ASCVD). (scirp.org)
  • Mike covers the effect of linagliptin, a selective DPP-4 inhibitor, versus placebo, on cardiovascular and kidney outcomes in patients with T2DM with elevated cardiorenal risk. (healthydebate.ca)
  • The trial revealed that use of the dual sodium-glucose cotransporter (SGLT) 1 and 2 inhibitor sotagliflozin enhances kidney and cardiorenal outcomes in patients with T2DM and CKD. (uspharmacist.com)
  • The goal of this exploratory analysis was to evaluate the effect of sotagliflozin (SOTA), a dual SGLT1 and SGLT2 inhibitor, on kidney and cardiorenal outcomes in patients with T2DM and CKD. (uspharmacist.com)
  • Incidence of T2DM at 2 years will be examined. (nih.gov)
  • Since life expectancy has been markedly prolonged with advances in medicine, it has been suggested that the incidence of T2DM and dementia would increase as the population ages [ 1 , 2 ]. (hindawi.com)
  • The predicted CV incidence rates per 100 person- years by the risk base model were 0.9 (95% CI:0.5-1.5) in low-risk patients (1st decile of risk) and 19.2 (95% CI:16.8-22.0) in high-risk patients (10th decile of risk). (pace-cme.org)
  • Intensive medication at the time of diagnosis has proven effective in reducing cardiovascular risk, improving glycaemic control and preventing T2DM complications. (bmj.com)
  • The role of testosterone on insulin sensitivity was further investigated, where acute androgen deprivation resulted in reduced insulin sensitivity among young men (Yiamalas et al, 2007) and strongly impaired the glycaemic control of men with T2DM (Haidar et al, 2007). (bhma.org)
  • According to international guidelines, T2DM requires style modifications and pharmacological treatment is comprehensive management to reduce the risk of necessary to achieve good glycaemic control, which sig- complications and improve quality of life. (who.int)
  • Several studies have suggested that depression in patients with diabetes is associated with worse health outcomes, due to poor adherence to treatment regimens [ 9 - 11 ], which leads to poor glycemic control and an increased risk for complications. (e-dmj.org)
  • Nut consumption is associated with decreased health risk factors for cardiovascular disease and metabolic syndrome in U.S. adults: NHANES 1999-2004. (nuthealth.org)
  • Available evidence indicates that the risk of macrovascular complications increases with the severity of hyperglycemia, thus suggesting that the relation between metabolic disturbances and vascular damage is approximately linear. (uzh.ch)
  • Links are being made between low levels of testosterone and an increased risk of metabolic syndrome among men. (bhma.org)
  • Our goals today are to talk about cardiovascular disease with respect to insulin, glucose, metabolic syndrome, and diabetes management. (consultantlive.com)
  • Regression to normoglycaemia, even if transient, significantly reduces the risk of developing T2DM. (nih.gov)
  • [ 12 ] The use of statins was also significantly low (45%) in a cohort of 346 patients with T2DM and NAFLD. (medscape.com)
  • Indeed, several epidemiological studies have shown that people with T2DM have a significantly higher risk of developing cognitive impairments and dementia when compared to those with normal blood glucose levels [ 3 - 5 ]. (hindawi.com)
  • Body mass index (BMI) being the most studied anthropometric index has been reported to be significantly related to CVD risk factors as demonstrated by several prospective and cross-sectional studies [ 13 - 15 ]. (hindawi.com)
  • An interaction term Lp(a)xT2DM was significant (p=0.002), indicating that T2DM significantly modulated the power of Lp(a) to predict cardiovascular events. (diabetesjournals.org)
  • NT-proBNP significantly improved the risk stratification of high-risk T2DM patients when added to the multivariable risk prediction model. (pace-cme.org)
  • Therefore, other independent risk factors may exist that contribute significantly to CVD risk in these patients. (ddw-online.com)
  • Recent validation has concluded that total and regional body volume estimates correlate positively and significantly with biomarkers of cardiovascular risk and BVI calculations correlate significantly with all biomarkers of cardio-vascular risk. (wikipedia.org)
  • The primary aim of this mixed-methods study is to determine if there are clinically relevant differences among those with pre-diabetes and excess weight who regress to normoglycaemia, those who have persistent pre-diabetes and those who progress to T2DM following participation in a 6-month primary care nurse-delivered pre-diabetes dietary intervention. (nih.gov)
  • Patients and Methods: This was a cross-sectional study in individuals with T2DM participating in the PREDIMED trial at the centre of Pamplona. (nuthealth.org)
  • Methods: From June 1st 2015 to December 30th 2015, 379 consecutive aviation navigants (Flight crew: 62.5%, pilots: 46.2%, women: 29.6%, Caucasians 23.2%) were enrolled in a cross-sectional survey of ASCVD risk estimate using the Framingham tools. (scirp.org)
  • METHODS: In 133 T2DM patients (aged 66 ± 8 years, 40.6% women, median T2DM duration 5 [2-10] years) we assessed plasma FXI levels, along with fibrin clot properties, thrombin generation, and fibrinolysis proteins. (bvsalud.org)
  • The use of empagliflozin/metformin for managing T2DM in MS improved fasting blood glucose levels and HbA1c, demonstrating the effectiveness of this combination in both ASCVD and CVD risk factors patients. (mims.com)
  • Discuss ASCVD risk calculators and demonstrate how to calculate 10-year and lifetime ASCVD risk. (pcna.net)
  • However, ASCVD risks have not yet been compared in flight and cabin crew in low resource settings like sub-Saharan Africa. (scirp.org)
  • Objectives: To assess absolute ASCVD risk estimate and its clinical correlates among flight and cabin crew. (scirp.org)
  • We modeled the risk of moderate and high ASCVD estimate in a stepwise logistic regression. (scirp.org)
  • Results: Low, moderate and high ASCVD risk estimates were observed respectively in 248 (65.4%), 64 (16.9%), and 67 (17.7%) navigants. (scirp.org)
  • Conclusion: In the present case series, moderate and high ASCVD risk estimates were present in 3 out of 10 navigants and racial, traditional risk factors and flight crew status were the main correlates of these ASCVD risk estimates. (scirp.org)
  • Due to less physical activity associated with their professional life, the aircrew could be considered as a group at high ASCVD risk. (scirp.org)
  • The aim of this study was to determine the accuracy of self-measured WC in adults at risk of T2DM and/or CVD, and to determine the anthropometric, demographic and behavioural characteristics associated with bias in self-measured WC. (nih.gov)
  • The results support self-measured WC as a useful tool for large-scale populations and epidemiological studies when objective measurement is not feasible, but overestimation should be taken into account when screening adults at risk of T2DM and/or CVD. (nih.gov)
  • 2010) examining over 700 adults found evidence to suggest higher volumes of visceral fat, regardless of overall weight, were associated with smaller brain volumes and increased risk of dementia. (wikipedia.org)
  • Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. (journaltocs.ac.uk)
  • In this observational study, we provide a first paradigm of identifying factors among coronary heart disease patients that may be considered low-risk and likely high-gain for participation in alternative models of CR. (journaltocs.ac.uk)
  • Statin therapy is safe in patients with prediabetes/T2DM and NASH. (medscape.com)
  • Given their high cardiovascular risk, statin therapy should be encouraged in this population. (medscape.com)
  • Background: A substantial cardiovascular disease risk remains even after optimal statin therapy. (koreamed.org)
  • Sacubitril/valsartan (Entresto), an angiotensin receptor-neprilysin inhibitor (ARNI), was approved by the FDA in July 2015 to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with congestive heart failure (New York Heart Association [NYHA] class II-IV) and reduced ejection fraction. (medscape.com)
  • The selective sodium-glucose cotransporter-2 (SGLT2) inhibitors empagliflozin and dapagliflozin are indicated to reduce the risk of cardiovascular death and hospitalization in patients with heart failure. (medscape.com)
  • Sotagliflozin is now FDA-approved under the name 'Inpefa' to reduce the risk of cardiovascular death and heart failure events with a broad label that includes patients with heart failure or chronic kidney disease, so the drug is now an option for nephrologists and cardiologists, as well as primary care physicians, to prescribe. (uspharmacist.com)
  • Among the various complications of diabetes, cardiovascular complications are believed to be the leading causes of disability and death among diabetic patients, particularly for diabetic cardiomyopathy (DCM) ( Cai and Kang, 2003 ). (frontiersin.org)
  • In addition, many studies have found biological mechanisms associated with DM that independently increase the risk of CVD in diabetic patients [ 10 - 12 ]. (hindawi.com)
  • New therapeutics must therefore address the multi-factorial nature of T2DM, and aim to treat diabetic patients at an earlier stage of the disease, if pharmacological interventions hope to halt the epidemic. (ddw-online.com)
  • During recent years three new trials (EMPA-REG, LEADER, and SUSTAIN-6) have shown that treatment of hyperglycaemia with new anti-diabetic drugs has been able to reduce a composite cardiovascular endpoint. (emjreviews.com)
  • Conclusions: Although we found not enough evidence to support that a MeDiet is associated with lower levels of HbA1c in patients with T2DM, our results suggested an inverse trend. (nuthealth.org)
  • This study aims to develop and evaluate the effectiveness of a new lifestyle education programme 'DiAlert' targeted at 1st degree relatives of people with T2DM and overweight. (biomedcentral.com)
  • In this RCT, 268 (134 Dutch and 134 Turkish) overweight 1st degree relatives of patients with T2DM will be allocated to either the intervention or control group (leaflet). (biomedcentral.com)
  • These data suggest that a critical window for weight management intervention in preventing T2DM might exist before the age when BMI growth rate is naturally expected to decrease. (monash.edu)
  • A better understanding of NAFLD epidemiology and risk factors may facilitate ongoing prevention efforts aimed at reducing the quality of life burden, demand for a liver transplant, and risk of HCC all posed by the global rise in NAFLD. (termedia.pl)
  • There is a belief among clinicians that patients with NASH are at a higher risk for hepatotoxicity when prescribed a statin, [ 9 ] and it has even been postulated that statins could increase hepatic fat accumulation in patients with NAFLD. (medscape.com)
  • An emerging lesser known, but potentially fatal complication of T2DM is the accumulation of fat in hepatocytes (steatosis), that leads to the chronic liver disorder Non-Alcoholic Fatty Liver Disease (NAFLD) and its more advanced form, Non-Alcoholic Steato-Hepatitis (NASH). (ddw-online.com)
  • NAFLD/NASH can progress to hepatitis, cirrhosis, and even liver cancer, thus illustrating the importance of addressing these serious complications of T2DM. (ddw-online.com)
  • One of the greatest challenges in T2DM disease management is the prevention of its long-term complications and the treatment of associated disorders, including NAFLD/NASH and CVD. (ddw-online.com)
  • Additionally, 9.3% of the 2011-2012 cohort and 7.6% of the 2018-2019 cohort had all 11 of the low-risk factors. (journaltocs.ac.uk)
  • Prediction of death in the cohort using the multivariable base risk model, resulted in a C-statistic of 0.744 (95% CI:0.722-0.767). (pace-cme.org)
  • It focuses on patient education, dietary advice, managing cardiovascular risk, managing blood glucose levels, and identifying and managing long-term complications. (bvsalud.org)
  • About half of the studied T2DM patients have high serum cholesterol level (52.5%), while 22.5% had low serum HDL- C levels and 39.2% had high serum triglyceride level, most of patients had serum LDL-C levels above normal range (67.5%), so the common patterns of dyslipidemia in this study were LDL-C followed by cholesterol. (heraldopenaccess.us)
  • Therefore, early identification of patients with DM at high risk for asymptomatic MI consists of a significant challenge. (springer.com)
  • In view of the high risk for diabetes and cardiovascular disease in immigrants from Turkish origin living in Western Europe, a culturally appropriate Turkish version of DiAlert will be developed and tested. (biomedcentral.com)
  • It is therefore imperative that strategies to prevent the disease are implemented, this might include targeting high-risk populations to increase effectiveness. (biomedcentral.com)
  • with T2DM are at high risk of developing micro- and macrovascular complications. (who.int)
  • Favourable cardiovascular effects have been demonstrated for some of the sodium-glucose cotransporter 2 (SGLT-2) inhibitors for T2DM. (healthydebate.ca)
  • Over the last decade many glucose-lowering agents have been tested for their safety and efficacy in T2DM with CVD. (uzh.ch)
  • Here we provide a critical and updated overview of the main glucose-lowering agents and their risk/benefit ratio for the prevention of CVD in patients with T2DM. (uzh.ch)
  • However, the recent ACCORD and ADVANCE trials in patients with longstanding T2DM have shown that aggressive glucose control in such patients has no clear benefits, or may even increase CVD events (3). (ddw-online.com)
  • Current widespread treatments for T2DM include metformin (suppressor of hepatic glucose production), sulfonylureas (insulin secretagogues), and the thiazolidinedione pioglitazone (PPAR agonist). (ddw-online.com)
  • They cover four articles in a rapid-fire style, including: angiotensin receptor-neprilysin inhibitors (ARNIs) in decompensated heart failure (HF), linagliptin and major cardiovascular events, reduced dietary salt intake in heart failure, and dapagliflozin and cardiovascular outcomes. (healthydebate.ca)
  • During follow-up, 30.2% of our patients suffered cardiovascular events. (diabetesjournals.org)
  • NT-proBNP was a biomarker with a discriminatory ability to predict both death and CV events as accurately as the multivariable risk model in T2DM patients with CVD and/or CKD comorbidity. (pace-cme.org)
  • Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
  • We investigated whether plasma FXI is associated with CV events in T2DM patients in long-term observation. (bvsalud.org)
  • A total of 101 patients (86 receiving statins) with biopsy-proven NASH and prediabetes/T2DM were followed for up to 36 months. (medscape.com)
  • One in three Canadians has diabetes or prediabetes, [i] with T2DM accounting for up to 95 per cent of all diagnoses. (muhcfoundation.com)
  • The patients with diabetes recruited have generally been high-riskpatients and in most cases, with a previous cardiovascular disease (CVD) manifestation. (emjreviews.com)
  • Poisson regression with robust standard errors and clustered by practice will be used to identify predictors of regression or progression at 6 months, and risk factors for developing T2DM at 2 years. (nih.gov)
  • Chaitanya Thandra K, Barsouk A, Saginala K, Sukumar Aluru J, Rawla P, Barsouk A. Epidemiology of non-alcoholic fatty liver disease and risk of hepatocellular carcinoma progression. (termedia.pl)
  • Although the pathogenesis of CKD remains unclear, evidence indicates that early recognition and interventions may delay the progression to ESRD and cardiovascular disease [ 3 ]. (medsci.org)
  • This is especially true for high-penetrance pathogenic variants associated with conditions such as familial hypercholesterolemia and hereditary cancer risk syndromes like Lynch syndrome and the hereditary breast and ovarian cancer syndrome. (cdc.gov)
  • Results: We studied 383 participants with T2DM, 53.4% women (mean age 69 ± 6 years). (nuthealth.org)
  • We report on the proportion of participants with these risk factors and the proportion with all of these low-risk factors. (journaltocs.ac.uk)
  • Results: Using the proposed BHPR approach, we estimated the BMI profiles of participants with T2DM diverged from healthy participants at age 16 years for males (95% credible interval (CI):13.5-18 years) and 21 years for females (95% CI: 19.5-23 years). (monash.edu)
  • Conclusions: BHPR is a powerful analytic tool to model long-term non-linear longitudinal outcomes, enabling the identification of the age at which risk factor trajectories diverge between groups of participants. (monash.edu)
  • Cardiovascular disease typically occurs up to 10 years later in women than men. (medscape.com)
  • Typically, T2DM is associated with other chronic conditions. (bmj.com)
  • The presenters concluded that SOTA reduced the risk of kidney and cardiorenal endpoints in patients with T2DM and CKD. (uspharmacist.com)
  • [ii] Unfortunately, many Canadians are often screened for T2DM when they show T2DM-related health issues, such as heart disease and kidney damage. (muhcfoundation.com)
  • 30 kg/m2 at screening with established CVD or chronic kidney disease (CKD), and/or at least 2 weight-related complications or risk factors for CVD. (who.int)
  • Although current antidiabetic drugs are highly effective for the management of hyperglycemia, most T2DM patients remain exposed to a substantial and concrete risk of CVD. (uzh.ch)
  • Many people have developed T2DM and don't know it until a major cardiovascular event occurs. (muhcfoundation.com)
  • The optimum cut-off range of WrC to identify individuals at increased cardiometabolic risk was 17.5 to -17.8 cm for men and 16.0 to 16.7 cm for women while that of WHtR was 0.52 to 0.61 for men and 0.53 to 0.59 for women. (hindawi.com)
  • Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor especially in young individuals. (diabetesjournals.org)
  • Individuals in the program will use wearable devices to monitor T2DM-specific indicators and send that data to their healthcare team through electronic health records. (muhcfoundation.com)
  • Despite clear advances in the prevention and treatment of CVD, the impact of T2DM on CVD outcome remains high and continues to escalate. (uzh.ch)
  • A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. (medsci.org)
  • Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD. (medsci.org)
  • The cardiovascular safety profile for dapagliflozin has yet to be defined. (healthydebate.ca)
  • Mike walks listeners through a study (DECLARE-TIMI 58) assessing the cardiorenal risk profile of dapagliflozin compared to placebo. (healthydebate.ca)
  • Multivariate analysis additionally adjusted for physical activity, smoking, time of evolution of the T2DM, body mass index and insulin treatment found similar findings (OR = 0.69, 95% CI 0.17-2.83). (nuthealth.org)
  • These findings suggest that patients diagnosed with it should have a higher risk for cardiovascular risk factors have had it lower fasting it without medication or T2DM. (kamrytech.com)
  • Previous studies have shown cardiovascular safety of three dipeptidyl peptidase 4 (DPP-4) inhibitors but these include a limited number of patients with elevated cardiovascular and renal risk. (healthydebate.ca)
  • The main objective of the study was to determine the G894T SNP in the eNOS gene such as risk factor for T2DM in Tunisian population. (scirp.org)
  • A study among urban and rural settlers in a Ghanaian population found an increased cardiometabolic risk factors among urban settlers due to their increased sedentary and unhealthy dietary habits [ 7 ]. (hindawi.com)
  • In a study among South African blacks, WHtR was found as a significant predictor for all cardiometabolic risk components after 5 years in an adult population [ 18 ]. (hindawi.com)
  • With increased monitoring, doctors can quickly tailor their approach in caring for each patient based on their needs and the information collected - ultimately, improving population-level screening for T2DM in Canada. (muhcfoundation.com)
  • A well structured questionnaire and blood investigation for lipid profile and blood sugar were the tools of data collection from 120 randomly selected T2DM patients registered in the ACC. (heraldopenaccess.us)
  • T2DM) (Asiimwe, Mauti & Kiconco 2020). (who.int)
  • Remarkably, none of these trials addressed FH risk information and its implications for education strategies to change lifestyle. (biomedcentral.com)
  • As new trials are constantly published, these risk factors must be analysed for evidence to contribute to guidelines that are being revised. (emjreviews.com)
  • Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes. (nih.gov)