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  • mannose receptor
  • It is now clear that there are several distinct mannose recognition molecules expressed by mature macrophages and selected endothelia, including the classic multilectin mannose receptor (MR), DC-SIGN and DC-SIGN-related molecules, and Langerin. (asmscience.org)
  • tumor
  • The identification of the most efficient strategy for tumor antigen loading of dendritic cells (DCs) remains a challenge in cancer immunotherapy protocols. (edu.au)
  • Autologous dead tumor cells have been demonstrated to constitute an acceptable source of multiple tumor-associated antigens (TAA) to pulse DCs. (edu.au)
  • Bone marrow-derived DCs demonstrated comparable uptake of primary apoptotic, necrotic, or fused dead tumor cells. (edu.au)
  • The current study therefore provides further informations on the use of dead whole tumor cells as antigen sources for effective active anti-cancer immunotherapy. (edu.au)
  • Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. (semanticscholar.org)
  • Linnebacher M, Wienck A, Boeck I, Klar E: Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO). (exbio.cz)
  • Results: With administration of a toll-like receptor agonist agonist (CpG) alone or CpG combined with same-site ablation, we found dramatic differences between the local and distant tumor environments, where the directly treated tumors were skewed to high expression of F4/80, Cd11b and Tnf and the distant tumors to enhanced Cd11c, Cd3 and Ifng. (adaptivebiotech.com)
  • First, while ablation alone enhanced intratumoral antigen cross-presentation (up to ~8% of CD45+ cells), systemic cross-presentation of tumor antigen remained low. (adaptivebiotech.com)
  • Second, type I interferon (IFN) release from tumor cells increased with the ablation-immunotherapy treatment as compared with ablation or immunotherapy alone. (adaptivebiotech.com)
  • Our understanding of this process has been greatly enhanced by the discovery of several dozen tumor-associated antigens expressed by human melanoma, which can be recognized by tumor-reactive T cells. (cancer.gov)
  • A unique advantage in targeting tumor-associated carbohydrate antigens (TACAs) is that multiple proteins and lipids on cancer cells can be modified with the same carbohydrate structure which might be shared with bacterial antigens ( 2 ). (frontiersin.org)
  • Monoclonal
  • 3 , 4 ] As assays have become more sensitive for detecting monoclonal B-CLL-like cells in peripheral blood, researchers have detected a monoclonal B-cell lymphocytosis in 3% of adults older than 40 years and 6% in adults older than 60 years. (cancer.gov)
  • Thymic
  • A loss of function at the AIRE locus is widely known to induce autoimmune activation against host tissues due to lack of central tolerance during thymic T cell development. (jyi.org)
  • Positive selection in the thymic cortex is able to expand T cell clones with receptors that bind major histocompatibility complex (MHC)/self-peptide complexes with at least moderate affinity (De Martino et al. (jyi.org)
  • In order to eliminate these autoreactive T cells from escaping from the thymus into the periphery, T cell clones positively selected for in the thymic cortex undergo negative selection in the thymic medulla. (jyi.org)
  • The deletion of autoreactive T cell clones through thymic-expressed TSAs is known as central tolerance. (jyi.org)
  • Vaccination
  • In this review we highlight new insights gained into the immunogenetics of allorecognition, with particular emphasis on how viral infection and vaccination may specifically activate allo-HLA reactive T cells. (springer.com)
  • Reactivity
  • 1999 ). Mature naïve T cells exhibit a high frequency (10%) of cross-reactivity against mismatched allogeneic HLA molecules from one individual to which they have not been previously exposed (Zerrahn et al. (springer.com)
  • hypothesis
  • This hypothesis can partially explain how autoreactive T cells survive positive selection in the cortex but fail to pass negative selection in the medulla (Marrack, McCormack, & Kappler, 1989). (jyi.org)
  • immune response
  • In vivo studies so far suggest only a limited role for endogenous NK cells in augmenting a humoral immune response, by demonstrating their ability to selectively stimulate trinitrophenyl (TNP)-specific IgG2a in response to the soluble TI antigen TNP-LPS. (asmscience.org)
  • tolerance
  • Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. (springer.com)
  • Therefore, even APECED patients with similar mutations at the AIRE locus may have dissimilar symptoms due to variation in specific self-antigen tolerance (De Martino et al. (jyi.org)
  • Peripheral T cell deletion, anergy and regulation are mechanisms of tolerance induction in these models. (fitness-vip.com)
  • Another mechanism of immune tolerance is derived from regulatory T cells (Treg). (fitness-vip.com)
  • immunotherapy
  • Combining same-site ablation with CpG amplified cross-presentation in the draining lymph node (~16% of CD45+ cells) compared to the ablation-only (~0.1% of CD45+ cells) and immunotherapy-only cohorts (~10% of CD45+ cells). (adaptivebiotech.com)
  • Expression of genes associated with T-cell activation and stimulation (Eomes, Prf1 and Icos) was 27, 56 and 89-fold higher with ablation-immunotherapy treatment as compared to the no-treatment controls (and 12, 32 and 60-fold higher for immunotherapy-only treatment as compared to the no-treatment controls). (adaptivebiotech.com)
  • Immunotherapy fights cancer by supercharging the immune system's natural defenses (include T-cells) or contributing additional immune elements that can help the body kill cancer cells. (utexas.edu)
  • mechanisms
  • In this chapter, we focus on the mechanism of γδ T cell-mediated recognition of antigens, and delineate the mechanisms, by which tea product can activate γδ T cells to facilitate cancer prevention activities. (springer.com)
  • locus
  • Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V H 12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other V H region transgenes (V H B1-8 and V H glD42) leads to the almost exclusive generation of conventional, or B-2, cells. (rupress.org)
  • lymphocyte
  • Estefan a E, Flores R, G mez-Lozano N, Aguilar H, L pez-Botet M, Vilches C: Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. (exbio.cz)
  • Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C: Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. (exbio.cz)
  • Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. (utexas.edu)
  • 2 ] In this disorder, lymphocyte counts in the blood are usually greater than or equal to 5,000/mm 3 with a characteristic immunophenotype (CD5- and CD23-positive B cells). (cancer.gov)
  • expression
  • If indeed signals transmitted through a BCR of a certain specificity lead to the generation of B-1 cells, then interference with the cell surface expression of that specific BCR may alter the differentiation process of these cells. (rupress.org)
  • Here, we generated IgH double (V H 12 and V H B1-8 or V H 12 and V H glD42) insertion mice to test whether the expression of a second H chain in V H 12-expressing B cells may act in a dominant negative manner to perturb the generation of B-1 cells. (rupress.org)
  • Type I IFN release is synergistic with toll-like receptor activation in enhancing cytokine and chemokine expression. (adaptivebiotech.com)
  • CD28
  • Signal 2 (S2) is derived from ACP's co-stimulation in response to the interaction of CD80 (B7-1) and CD86 (B7.2) with the engagement of CD28 on the surface of T cell. (fitness-vip.com)
  • Signal 2 is derived from APC's costimula-tion in response to the interaction of CD80 (B7-1) and CD86 (B7-2) on the surface of dendritic cells (DC), with the engagement of CD28 on the surface of T cells. (fitness-vip.com)
  • lymphoid
  • Immune correlates of response were identified, demonstrating higher lymphoid infiltrates in responders to both therapies and a more clonal and diverse T cell infiltrate in responders to nivolumab monotherapy. (adaptivebiotech.com)
  • cytotoxicity
  • Castriconi R, Dondero A, Negri F, Bellora F, Nozza P, Carnemolla B, Raso A, Moretta L, Moretta A, Bottino C (2007) Both CD133(+) and CD133(−) medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity. (springer.com)
  • immunoglobulin
  • CLL B cells express relatively low levels of surface-membrane immunoglobulin (compared with normal peripheral blood B cells) and a single light chain (kappa or lambda). (cancer.gov)
  • Treg
  • The desired cells can be recovered using a Treg marker such as CD25, GITR, CTLA4, CD137, latent TGF-beta (LAP), GARP (LRRC32) or CD121a/b. (patents.com)
  • The Treg cells having a demethylated Foxp3 TSDR region can be used, for example for preparation of pharmaceutical compositions for use in treatment. (patents.com)
  • Allorecognition
  • This situation closely resembles the case of allogeneic hematopoietic stem cell transplantation (HSCT), wherein allorecognition causes both the graft-versus-leukemia (GVL) effect and graft-versus-host disease (GVHD). (jcancer.org)
  • regulatory T cel
  • This disclosure provides a method of identifying or separating activated regulatory T cells that have a demethylated Foxp3 TSDR region from a mixture of activated T cells. (patents.com)
  • and (4) detecting cells in the mixture that have not bound with the first molecule but have bound the second molecule, thereby identifying activated regulatory T cells in the cell mixture that have a demethylated Foxp3 TSDR region. (patents.com)
  • In previous work, we and others have exploited this natural regulatory system using TCR peptides to amplify regulatory T cells that potentially can treat human autoimmune diseases such as multiple sclerosis (MS) and arthritis. (begellhouse.com)
  • thymus
  • T cells that have survived positive and negative selection leave the thymus and enter the circulation as mature naïve T cells. (springer.com)
  • chains
  • In mice coexpressing V H 12, V H B1-8 and a transgenic κ chain able to pair with both H chains, double H chain-expressing B-2 cells, and B-1 cells that have lost V H B1-8 are generated, whereas V H B1-8 single producers are undetectable. (rupress.org)
  • response
  • Failure to delete autoreactive T cell clones allows their release into the periphery, where they may proliferate and initiate an autoimmune response. (jyi.org)