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Models, CardiovascularBlood PressurePressureCardiac OutputSystoleMyocytes, CardiacBlood Pressure DeterminationHeartHemodynamicsHypertensionHeart RateVentricular PressureHypertension, PulmonaryHydrostatic PressureMyocardial ContractionHeart VentriclesVentricular Function, LeftCardiac CatheterizationDiastoleMyocardiumTime FactorsArrhythmias, CardiacBlood Pressure Monitoring, AmbulatoryPulmonary ArteryPulseDogsHypertrophy, Right VentricularEchocardiographyCardiac Surgical ProceduresArterial PressureCardiomegalyPulmonary Wedge PressureVentricular Function, RightVascular ResistanceDeath, Sudden, CardiacAntihypertensive AgentsCardiac Pacing, ArtificialHeart FailureTransducers, PressureElectrocardiographyIntracranial PressureIntraocular PressureVentricular FunctionEchocardiography, DopplerHeart DiseasesProspective StudiesMonocrotalineStroke VolumeCardiac VolumeCoronary CirculationCentral Venous PressureHypertrophy, Left VentricularRats, Sprague-DawleyAtmospheric PressureTreatment OutcomeAir PressureTricuspid Valve InsufficiencyVenous PressureVentricular RemodelingDisease Models, AnimalFollow-Up StudiesAortaAnoxiaRats, WistarCardiac TamponadeVentricular Dysfunction, LeftVentricular Dysfunction, RightHypotensionAnalysis of VarianceCardiomyopathiesRegional Blood FlowPulmonary Valve StenosisMyocardial InfarctionBlood Flow VelocityCardiac Output, LowComplianceBaroreflexOrgan SizeReproducibility of ResultsReference ValuesCardiotonic AgentsPressoreceptorsPredictive Value of TestsArteriesBody WeightHeart ArrestBrachial ArteryDose-Response Relationship, DrugOxygen ConsumptionRetrospective StudiesMyocardial IschemiaHeart Function TestsManometryPerfusionMonitoring, PhysiologicOxygenAutonomic Nervous SystemRegression AnalysisExercise TestPulsatile Flow
ArterialVascularOutcomesPredictComputationalAimsResponseResultsResearchSystemStudyDynamicExtensiveUniversityTimeHeartVentricularContractilityComputational modelsRespiratoryDynamicsRealisticSimulationSystemicMyocyteFlowNumericalCharacteristicsHighTransientBloodMajorAnalysisOutputDataHeartExperimentalLong-termSourceCurrent
Arterial6
  • 2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
  • Autoregulatory adaptation of the cardiac output and downstream arterial resistance was modeled in response to intervention‐induced hemodynamic perturbations. (nsf.gov)
  • This study describes a multidimensional 3D/lumped parameter (LP) model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. (sharif.edu)
  • A new extensive LP model of the entire arterial network (48 arteries) was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. (sharif.edu)
  • The currently most accepted theory of pathogenesis of syringomyelia is that obstruction to CSF flow in the subarachnoid space results in a mismatch in timing between the arterial pulse peak pressure and CSF pulse peak pressure. (marysfamilymedicine.org)
  • Earlier arrival of peak CSF pressure compared to peak spinal arterial pressure encourages flow of CSF into the perivascular space. (marysfamilymedicine.org)
Vascular5
  • One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
  • 3) Cardiovascular actions of relaxin and its therapeutic potential in the context of three pathologies: (i) relaxin-induced maternal vascular remodeling and associated functional benefits in preeclampsia, (ii) relaxin-induced left atrial remodeling and suppression of atrial fibrillation, and (iii) relaxin-induced left ventricular remodeling and associated functional benefits in the setting of diastolic dysfunction. (pitt.edu)
  • Abstract We propose svMorph, a framework for interactive virtual sculpting of patient-specific vascular anatomic models. (nsf.gov)
  • They are also compatible with popular vascular modeling software, such as SimVascular. (nsf.gov)
  • Proximal and extensive treatment achieved median reductions of 14% and 40% in main PA systolic pressure, 27% and 56% in pulmonary vascular resistance, and 10% and 45% in right ventricular stroke work, respectively. (nsf.gov)
Outcomes2
  • Our study aims to model, assess, and predict hemodynamic outcomes of transcatheter interventions in these patients. (nsf.gov)
  • No benefit was observed for type 2 diabetes, cardiovascular or cognitive outcomes. (elifesciences.org)
Predict1
  • It utilizes noninvasive blood flow and pressure seed data and temporal cardiac muscle regional activity to predict the operation of the heart under normal and congestive heart failure conditions. (sharif.edu)
Computational2
  • To illustrate our tools, we morph several image-based, patient-specific models to create a range of shape changes and simulate the resulting hemodynamics via three-dimensional, computational fluid dynamics. (nsf.gov)
  • Our computational methods accurately predicted postinterventional PA pressures, the primary indicators of success for treatment of peripheral PA stenosis. (nsf.gov)
Aims1
  • This paper aims at giving an insight into these modelling decisions by comparing Fiber and Lumped Plasticity Finite Element Models in static and dynamic non-linear analysis in a RC frame. (scielo.org)
Response1
  • Abstract Researchers must decide on how they will model the non-linear material response in a Finite Element simulation to assess seismic vulnerability. (scielo.org)
Results1
  • Methods and Results Isolated proximal and "extensive" interventions (stenting and/or balloon angioplasty of proximal and lobar vessels) were performed in silico on 6 patient‐specific PA models. (nsf.gov)
Research1
  • Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
System3
Study1
  • In the Fall 2019 Quarter, he taught a special study course (BioE 297: Physics-Based Modeling and In Silico Clinical Trials). (ucsf.edu)
Dynamic1
  • A two-dimensional, seven link, nine degrees of freedom biped model was developed to investigate the dynamic characteristics of normal and transfemoral amputee locomotion during the entire gait cycle. (sharif.edu)
Extensive1
  • Conclusions In patients with Williams and Alagille syndromes, extensive transcatheter intervention is required to sufficiently reduce PA pressures and right ventricular stroke work. (nsf.gov)
University1
  • Working with a faculty steering committee, Dr. Hay led the redesign of the entire university budget away for historical budgeting to an RCM model. (arizona.edu)
Time2
  • A computer aided-design (CAD) algorithm was proposed to efficiently handle the coupling of two or more 3D models with the LP model, and substantially lessen the coupling processing time. (sharif.edu)
  • If at that time peak CSF pressure is high then the perivascular space could act as a 'leaky' one-way valve (8, 24-27). (marysfamilymedicine.org)
Heart1
  • Therefore when the heart beats and there is increase in volume of intracranial blood, CSF is displaced from the cranial to the spinal subarachnoid space through the foramen magnum thus avoiding a deleterious increase in intracranial pressure. (marysfamilymedicine.org)
Ventricular11
  • The Modified Luo-Rudy Dynamic Model of the Mammalian Ventricular Myocyte. (nih.gov)
  • A dynamic model of the cardiac ventricular action potential. (nih.gov)
  • Originating as a guinea pig ventricular myocyte model it has taken on more generality. (nih.gov)
  • Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte. (nih.gov)
  • This model simulates the action potential for a human ventricular myocyte accounting for Na, K and Ca transport and dynamics. (nih.gov)
  • From ten Tusscher KHWJ, Noble D, Noble PJ and Panfilov AV. A model for human ventricular tissue, Am J Physiol 286:H1573-H1589, 2004. (nih.gov)
  • Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block. (virtualrat.org)
  • Ventricular washout was simulated and showed an increase as cardiac output increased, with a maximum value of 89% after four cycles at 120 bpm 25 mm. (nature.com)
  • Next, a systematic review was conducted to compile blood pressure, cardiac output, and ventricular volume data for groups of healthy subjects. (clemson.edu)
  • Regression algorithms used this aggregate data to formulate predictive models for the outputs - systolic and diastolic blood pressure, ventricular volumes, cardiac output, and heart rate - against the characteristics - age, height, weight, and exercise intensity. (clemson.edu)
  • Background Arterial stiffening and peripheral wave reflections have been considered the major determinants of raised pulse pressure (PP) and isolated systolic hypertension, but the importance of cardiac contractility and ventricular ejection dynamics is also recognised. (researchgate.net)
Contractility1
  • Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. (nih.gov)
Computational models2
  • Lumped Parameter Networks (LPN) are computational models that can capture the systemic responses of the cardiovascular system. (clemson.edu)
  • Hæmodynamical simulations using one-dimensional (1D) computational models exhibit many of the features of the systemic circulation under normal and diseased conditions. (researchgate.net)
Respiratory3
  • 5.Batzel, J.J., L. Ellwein, and M.S. Olufsen, Modeling cardio-respiratory system response to inhaled CO2 in patients with congestive heart failure. (virtualrat.org)
  • Patient-specific modeling of cardiovascular and respiratory dynamics during hypercapnia. (virtualrat.org)
  • They develop novel models for simulating pulse wave signals and biomedical signal processing techniques to assess the functions of the cardiovascular, respiratory and autonomic nervous systems. (researchgate.net)
Dynamics1
  • Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice. (virtualrat.org)
Realistic1
  • Many researchers have already introduced behavior-aware protocols for a better understanding of architecture and realistic modeling of behavioral characteristics, similarities, and aggregation of mobile users. (unib.org)
Simulation1
  • A simulation-based procedure generated data of virtual subjects to confirm whether these regression models built based on aggregate data can perform well for individual-level predictions. (clemson.edu)
Systemic1
  • An LPN describes the systemic behavior by providing outputs such as the blood pressure, flowrate, and heart chamber volume at the points defined in the network. (clemson.edu)
Myocyte1
  • A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. (virtualrat.org)
Flow7
  • The transient outflow volume flow rate and pressure results were compared against in vitro experiments using a hybrid cardiovascular simulator and showed good agreement, with maximum root mean square errors of 15% and 5% for the flow rates and pressures respectively. (nature.com)
  • These contain a single rotating impeller giving kinetic energy to the blood which is converted to pressure head by either stator blades (in an axial flow pump) or a volute (in a centrifugal flow pump). (nature.com)
  • The parameters of the angle between beam scanning and flow directions, the angular velocity of the galvanometer, and the offset of incident light were introduced, and a formula for calculating the range was derived. (preprints.org)
  • In this paper, an analytical model for calculating critical ventilation flow rate was proposed through the quantification and constraint solution of ventilation effect and ventilation cost. (preprints.org)
  • The study demonstrates that the critical ventilation flow rate can be increased significantly at higher stagnation pressures and larger nozzle diameters. (preprints.org)
  • And the discrepancy of critical ventilation flow rates under different nozzle diameters will be enhanced with the increase of stagnation pressure. (preprints.org)
  • For the stagnation pressure of 0.4MPa, the critical ventilation flow rate under 4mm nozzle even increases by 52% relative to the 2mm nozzle. (preprints.org)
Numerical1
  • Recent interest in verifying 1D numerical schemes has led to the development of alternative experimental setups and the use of three-dimensional numerical models to acquire data not. (researchgate.net)
Characteristics1
  • The direction of trends between model outputs and the input subject characteristics reported in this study agree with the results in current literature. (clemson.edu)
High1
  • The high prediction errors (20% - 50%) can be attributed to the best models being linear. (clemson.edu)
Transient1
  • Models the influence of voltage-dependent calcium (Ca2+)-independent transient current (Ito1) on the action potential duration (APD) in normal vs failing canine and human cardiac myocytes. (nih.gov)
Blood2
Major1
  • Therefore, early detection of peripheral artery disease (PAD) and aneurysmal disease is fundamental to reduce the risk of major adverse cardiovascular and limb events. (preprints.org)
Analysis1
  • Abierto Inglés The fast expansion of ICT (information and communications technology) has provided rich sources of data for the analysis, modeling, and interpretation of human mobility patterns. (unib.org)
Output2
  • Shear stress distribution over time was also measured, showing that no more than \(4.5\times 10^{-4}\) % of the total volume exceeded 150 Pa at a cardiac output of 7 L/min. (nature.com)
  • Future studies involving the LPN can use the output values predicted by these regression models as targets to model the cardiovascular system of a population cohort or an individual described using age, height, weight, and exercise intensity. (clemson.edu)
Data2
  • Although the multivariable regression models use aggregate data, the expected error for individual predictions is provided. (clemson.edu)
  • The experimental data are used to verify the analytical model by calculating the effective ventilation time. (preprints.org)
Heart5
  • Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model. (nih.gov)
  • This model was reproduced in collaboration with the author prior to publication, courtesy of the Am Heart Assoc. (nih.gov)
  • We have also translated these technologies to the clinic by developing patient-specific models of cardiac electromechanics [12-14] that have shown exciting potential to improve prediction of therapeutic outcomes in patients with dyssynchronous heart failure. (virtualrat.org)
  • 8.Ottesen, J.T., J. Mehlsen, and M.S. Olufsen, Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation. (virtualrat.org)
  • Patient-specific modeling of dyssynchronous heart failure: a case study. (virtualrat.org)
Experimental1
  • The experimental method was used to investigate the effects of nozzle diameter and stagnation pressure on diffusion and ventilation for horizontal hydrogen leakage in a cuboid chamber. (preprints.org)
Long-term1
Source2
  • Open source code) Quantitative model of time- and voltage-dependent transmembrane currents for Na+, K+, and a leak current, Ileak. (nih.gov)
  • Model # 0128 (Open source code. (nih.gov)
Current1
  • We are now realizing the utility of all of this foundational work by applying integrated models in current and proposed studies. (virtualrat.org)