AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Vasculitis, Leukocytoclastic, CutaneousVasculitisSystemic VasculitisPurpura, Schoenlein-HenochSkin Diseases, VascularPolyarteritis NodosaAntibodies, Antineutrophil CytoplasmicChurg-Strauss SyndromeCryoglobulinsWegener GranulomatosisSkin DiseasesRetinal VasculitisMyeloblastinAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisArteritisMucocutaneous Lymph Node SyndromeMicroscopic PolyangiitisBiopsySkinCogan SyndromeCryoglobulinemiaGiant Cell ArteritisPolychondritis, RelapsingEar CartilageEar Deformities, AcquiredTracheobronchomalaciaEar, InnerSweet Syndrome
AngiitisLupusVesselPolyarteritis nodosaRheumatoidBiopsyManifestationsLesionsSymptomsVesselsCorticosteroidsUrticarial vasculitisDisorderGranulomatousDiagnosis of cutaneousInvolvementMicroscopicFindingsANCAPatientsClinicalDiseaseAutoimmuneNecrosisDermalSeverePrimary systemicSyndromeInfectionsOrgansNodulesPurpuraAcuteRenalNecrotizingChapel Hill Consensus ConferenceUncommonVenulesHypersensitivity vasculitis
Angiitis1
  • CNS vasculitis has been reported under a variety of descriptive terms including isolated CNS angiitis, idiopathic angiitis of the CNS, and primary angiitis or vasculitis of the CNS. (fortuneonline.org)
Lupus16
  • In patients with suspected systemic lupus erythematosus or urticarial vasculitis, complement levels should be obtained, including total hemolytic complement (CH100 or CH50), C3 levels, and C4 levels. (medscape.com)
  • Patients with hypocomplementemic urticarial vasculitis syndrome, and less commonly in those with systemic lupus erythematosus, often have circulating anti-C1q antibodies with concomitant low levels of C1q. (medscape.com)
  • SS can occur as a primary disease (primary SS (pSS)) or be associated with another autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis, or systemic sclerosis (SSc) [ 1 ]. (ersjournals.com)
  • Systemic lupus erythematosus (SLE) has been the most commonly reported rheumatologic cause of ESRD. (medscape.com)
  • Specifically, patients with VEXAS syndrome can meet diagnostic or classification criteria for one or more diseases, including relapsing polychondritis, polyarteritis nodosa, giant-cell arteritis, Sweet's syndrome, ANCA-associated vasculitis, systemic lupus erythematosus, and adult-onset Still's disease. (nejm.org)
  • This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. (lookformedical.com)
  • Systemic vasculitis complicating lupus will often present with severe skin rashes which may be necrotic leading to gangrene . (symptoma.com)
  • Neonatal lupus syndromes (NLS) occurs in infants born to mother with rheumatic conditions including systemic lupus erythematous (SLE), Sjögren's disease, mixed connective tissue disease, leukocytoclastic vasculitis, various forms of arthritis, immune-mediated thrombocytopenia, thyroiditis, autoimmune hepatitis, and undifferentiated autoimmune syndromes. (heraldopenaccess.us)
  • Female infants have two to three times' higher incidence for developing cardiac and cutaneous neonatal lupus erythematosus compared to male infants. (heraldopenaccess.us)
  • Introduction: Systemic lupus is a disseminated inflammation of the conjunctive tissue. (hspioa.org)
  • Objective: Describe cardiac manifestations during the follow up of patients diagnosed with systemic lupus. (hspioa.org)
  • All patients diagnosed with systemic lupus according to the American College of Rheumatology criteria, and having done an EKG, a Holter EKG, or a transthoracic echocardiography, were included in the study. (hspioa.org)
  • Results: Cardiovascular lesions were prevalent in 7 cases (43.75%) out of 16 patients diagnosed with systemic lupus. (hspioa.org)
  • Conclusions: Cardiovascular manifestations are frequent during the course of systemic lupus, and occur after few years of disease progression. (hspioa.org)
  • Intraepidermal injections of autologous epidermal cell suspension can be a new and very promising treatment for many other cutaneous disorders as non-scarring alopecia (Alopecia Areata, Androgenic Alopecia) or scarring alopecia (Lichern Plano Pilaris alopecia, Discoid Lupus Erithematosus alopecia), anti-aging therapies. (hspioa.org)
  • Other events with a possible relation to TNF-α-blocking therapy included vasculitis, psoriasis, drug-induced systemic lupus erythematosus, dermatomyositis, and a lymphomatoid-papulosis-like eruption. (biomedcentral.com)
Vessel28
  • Granulomatosis with polyangiitis (Wegener granulomatosis , GPA), MPA, and eosinophilic granulomatosis with polyangiitis ( Churg-Strauss syndrome , EGPA) comprise a category of small vessel vasculitis related to antineutrophil cytoplasmic antibodies (ANCAs) and are characterized by a paucity of immune deposits. (medscape.com)
  • In 1994, a group of experts held an international consensus conference in Chapel Hill, North Carolina, to attempt to redefine the classification of small-vessel vasculitides. (medscape.com)
  • The classification criteria should be applied after a diagnosis of small- or medium-vessel vasculitis has been made, and alternative disorders mimicking vasculitis have been excluded. (medscape.com)
  • Vasculitis is inflammation of the vessel walls. (medscape.com)
  • MPA is characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of granulomatous inflammation. (medscape.com)
  • Based on current understanding of the inflammatory response, cytokine-mediated changes in the expression and function of adhesion molecules coupled with inappropriate activation of leukocytes and endothelial cells are postulated to be the primary factors influencing the degree and location of vessel damage in the vasculitis syndromes. (medscape.com)
  • At least three out of five criteria yields sensitivity and specificity of 95 and 91%: Age at onset ≥ 50 years New onset headache with localized tenderness Temporal artery tenderness or decreased pulsation Elevated ESR ≥ 50 mm/hour Westergren Temporal artery biopsy showing vasculitis with mononuclear cell infiltrate or granulomatous inflammation, usually with multinucleated giant cells These conditions are sometimes considered together with the small vessel vasculitides. (wikipedia.org)
  • 1.4 What happens to the blood vessel in vasculitis? (printo.it)
  • Vasculitis classification in children is based on the size of the blood vessel involved. (printo.it)
  • Large vessel vasculitis, like Takayasu arteritis, affects the aorta and its major branches. (printo.it)
  • Medium vessel vasculitis typically affects arteries supplying the kidneys, bowels, brain or heart (e.g. polyarteritis nodosa, Kawasaki disease). (printo.it)
  • Cutaneous small-vessel vasculitis. (medscape.com)
  • Piette WW, Stone MS. A cutaneous sign of IgA-associated small dermal vessel leukocytoclastic vasculitis in adults (Henoch-Schonlein purpura). (medscape.com)
  • CSVV sometimes refers to small-vessel vasculitis of unknown cause (also called idiopathic cutaneous small-vessel vasculitis). (msdmanuals.com)
  • Cutaneous small-vessel vasculitis is often idiopathic , but all patients should be evaluated for potential underlying causes, including infections (e.g. (amboss.com)
  • The pathological mechanism that causes cutaneous small-vessel vasculitis can also cause vasculitides in organs other than the skin , which are categorized as distinct diseases. (amboss.com)
  • Vasculitis is a rare, inflammatory condition of the blood vessels whereby excess leukocytes within the vessel leads to a loss of structural integrity, and possible destruction. (faoj.org)
  • We present a case of small and medium-vessel vasculitis on the lower extremity with cutaneous manifestations, without an identifiable cause. (faoj.org)
  • Vasculitis varies and may be classified based on the size of the blood vessel involved. (faoj.org)
  • Fever and cutaneous manifestations that reflect neutrophilic dermatosis, leukocytoclastic vasculitis, or medium-vessel vasculitis are common in patients with VEXAS syndrome. (nejm.org)
  • Skin biopsy revealed small and intermediate vessel vasculitis. (scielo.org.za)
  • [6] Takayasu's arteritis is an example of a large-vessel vasculitis in childhood, whereas Kawasaki disease and polyarteritis nodosa are examples of medium-vessel vasculitis disorders. (scielo.org.za)
  • Some forms of vasculitis are characterized by giant cells in the vessel wall. (merckmanuals.com)
  • Granulomatosis with Polyangiitis (GPA) Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent. (merckmanuals.com)
  • the vessel inflammation (true vasculitis) is only part of the pathophysiology and there is predominant parenchymal inflammation in a characteristic pattern that involves specific organs. (merckmanuals.com)
  • Leukocytoclastic vasculitis is a histopathologic term used to describe findings in small-vessel vasculitis. (merckmanuals.com)
  • Here we identified three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation. (nature.com)
  • all presented with systemic inflammation and recurrent neutrophilic small vessel vasculitis. (nature.com)
Polyarteritis nodosa3
Rheumatoid6
  • A skin biopsy from the lesion demonstrated a neutrophilic vasculitis and blood investigations significantly showed a pANCA (Peripheral Anti-Neutrophilic Cytoplasmic Antibody) and rheumatoid factor positivity. (edoj.org.eg)
  • The other differentials considered included rheumatoid neutrophilic dermatosis , rheumatoid vasculitis, non-specific ANCA positive vasculitis and atypical pyoderma gangrenosum. (edoj.org.eg)
  • Rheumatoid arthritis was considered as the primary systemic diagnosis (The diagnosis of EED mainly being based on the nature and distribution of the lesions, and the known association of EED with rheumatoid arthritis and vasculitis). (edoj.org.eg)
  • There are many new and emerging treatments for rheumatoid arthritis including biological treatments , Janus kinase inhibitors, rituximab , tocilizumab with their associated cutaneous side effects. (arthritisdaily.net)
  • Many cutaneous side effects have been reported with their use in rheumatoid arthritis including psoriasis , dermatitis , leukocytoclastic vasculitis, lichenoid drug eruptions , and non-infectious cutaneous granulomatous reactions, such as disseminated granuloma annulare , sarcoidosis-like lesions, and interstitial granulomatous dermatitis. (arthritisdaily.net)
  • Detection of cytomegalovirus antigens in phagocytosed serum complexes from a patient with rheumatoid arthritis, vasculitis, peripheral neuropathy, cutaneous ulceration, and digital gangrene . (symptoma.com)
Biopsy7
  • Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. (wikipedia.org)
  • A skin biopsy of a relatively new lesion should be performed in most adult patients with suspected leukocytoclastic vasculitis (LCV). (medscape.com)
  • In confirming Henoch-Schönlein purpura by cutaneous biopsy, a kidney biopsy may be avoided in some patients. (medscape.com)
  • A skin biopsy demonstrated a prominent neutrophilic vasculitis with subepidermal clefting in the specimen taken from the vesicular area [Fig4 and Fig5] . (edoj.org.eg)
  • Vasculitis was reported as the cause of death on postmortem biopsy. (scielo.org.za)
  • Histological examination from the left medial thigh punch biopsy revealed predominantly lobular neutrophilic panniculitis without dermal infiltrate, papillary dermal edema, or vasculitis. (juniperpublishers.com)
  • The presence of chronic urticaria, abdominal pain, hypocomplementemia, and leukocytoclastic vasculitis on skin biopsy confirmed the diagnosis of HUVS. (hspioa.org)
Manifestations8
  • Patients frequently present with renal manifestations, but systemic manifestations, arthritis, mononeuritis multiplex, and other signs and symptoms are also common. (medscape.com)
  • Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. (ersjournals.com)
  • Sometimes, the disease course can be also complicated by systemic manifestations that can represent the first signs of the disease, also preceding SS by many years [ 11 ]. (ersjournals.com)
  • A high prevalence of cutaneous disorders is expected, because most patients with ESRD have an underlying disease process with cutaneous manifestations. (medscape.com)
  • These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)
  • Cutaneous vasculitis may present with varying clinical manifestations and may be caused by systemic disease or secondarily due to an underlying disorder, drug reaction, or infection [1-2]. (faoj.org)
  • We report a rare case of neonatal vasculitis presenting with skin manifestations similar to infection-based cellulitis. (scielo.org.za)
  • Issues related to the approach to and management of systemic vasculitides, as well as the pathogenesis, clinical manifestations, diagnosis, therapy, and outcomes in GPA and MPA are discussed separately. (medilib.ir)
Lesions6
  • Vasculitis affecting the small vessels of the skin (eg, arterioles, capillaries, postcapillary venules) tends to cause lesions such as purpura, petechiae, and possibly shallow ulcers. (msdmanuals.com)
  • Many diseases present with cutaneous annular lesions, making distinction by physical appearance alone challenging. (aafp.org)
  • A clinical diagnosis of cutaneous vasculitis was considered, the primary differential for the cutaneous lesions being erythema elevatum diutinum. (edoj.org.eg)
  • The following data were analysed: age of onset of disease, sex, duration of disease at diagnosis and during follow-up, topography and description of cutaneous lesions, treatment regimen and response, and duration of follow-up. (medicaljournals.se)
  • It is characterized by chronic and recurrent episodes of lesions which show characteristic of leukocytoclastic vasculitis which is limited to skin and on various organs such as renal, pulmonary, ocular system. (naturalayurvedictreatment.com)
  • [11] Cutaneous lesions are tender to touch but rarely pruritic with an asymmetrical distribution that favors the upper extremities. (eyewiki.org)
Symptoms6
  • Widespread (systemic) vasculitis is usually accompanied by extensive release of inflammatory molecules, causing general symptoms like fever, malaise, as well as abnormal laboratory tests detecting inflammation: erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP). (printo.it)
  • If skin involvement is secondary to a systemic vasculitis, symptoms may also include fever, arthralgias, other organ involvement, or a combination. (msdmanuals.com)
  • and (5) absence of systemic symptoms and signs (1). (aad.org)
  • arteritis risk if you don't treat temporal (giant cell) arteritis granulomatous vasculitis that involves aortic arch at branch points age group of takayasu arteritis younger than 50 - Asian females symptoms of takayasu arteritis 1. (symptoma.com)
  • iii ) No other causes, such as bona fide vasculitis, primary anti-phospholidpids antibody syndrome or drugs, were accounted for clinical symptoms. (medicaljournals.se)
  • 18 years of age were enrolled this study with diagnosis of cPACNS if they had: a clinical symptoms compatible with primary CNS vasculitis, and MRA findings demonstrating arterial stenosis and or aneurism that are not attributable to other disease and background. (fortuneonline.org)
Vessels18
  • Microscopic polyangiitis (MPA) is a vasculitis of small vessels. (medscape.com)
  • Chronic vasculitis of both large and medium vessels, primarily affecting cranial branches of the arteries arising from the aortic arch. (wikipedia.org)
  • There are several vasculitides that affect small vessels. (wikipedia.org)
  • The classification of vasculitides depends mainly on the size and type of blood vessels involved. (printo.it)
  • Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (msdmanuals.com)
  • Overview of Vasculitis Vasculitis is inflammation of blood vessels, often with ischemia, necrosis, and organ inflammation. (msdmanuals.com)
  • Vasculitis can affect the small- or medium-sized vessels of the skin. (msdmanuals.com)
  • Livedo reticularis, nodules, and deep ulcers are usually caused by vasculitis of deeper, medium or large vessels. (msdmanuals.com)
  • A rare cutaneous thrombotic disease due to occlusion of dermal vessels. (bvsalud.org)
  • In a large number of cases cutaneous vasculitis may present as an idiopathic condition and affect both small and medium sized vessels. (faoj.org)
  • Vasculitis is an uncommon condition characterized by inflammation and necrosis of blood vessels and impaired blood flow. (cohencenters.com)
  • Another theory is that deposition of immune complexes within dermal vessels leads to vasculitis, a type III (Arthus type) hypersensitivity reaction. (clinicaladvisor.com)
  • Vasculitis is defined as inflammation of the wall of blood vessels. (scielo.org.za)
  • Vasculitis is a heterogeneous group of blood vessels disorders which characterized by inflammation, necrosis and the obstruction of the inflamed vessels [1]. (fortuneonline.org)
  • In a range of inflammatory vascular process, vasculitis may affect the CNS vessels. (fortuneonline.org)
  • Vasculitis can affect small blood vessels (capillaries), medium size blood vessels and large blood vessels (aorta). (naturalayurvedictreatment.com)
  • Urticarial vasculitis is the rare disease of the inflammation of the blood vessels, which can restrict the flow of blood which damages the organs and various tissues. (naturalayurvedictreatment.com)
  • Microscopic polyangiitis (MPA) is a necrotizing vasculitis without granulomatous inflammation that predominantly affects small vessels (ie, capillaries, venules, or arterioles) and can present with pulmonary capillaritis or in the context of interstitial lung disease [ 3 ]. (medilib.ir)
Corticosteroids7
  • Two events of massive upper gastrointestinal bleeding occurred during treatment with systemic corticosteroids. (bgu.ac.il)
  • Mild cases of RP are usually treated with non-steroidal anti-inflammatory drugs (NSAIDs) or low doses of systemic corticosteroids. (medscape.com)
  • Severe RP may require high-dose systemic corticosteroids, perhaps along with disease-modifying antirheumatic drugs (DMARDs) as steroid-sparing agents or for more severe disease. (medscape.com)
  • In patients with acute immunoglobulin A vasculitis, the administration of systemic corticosteroids reduces joint and abdominal pain but does not reduce the risk of nephritis. (aafp.org)
  • Systemic corticosteroids are the first-line of treatment in most cases. (actasdermo.org)
  • Systemic corticosteroids are the mainstay of therapy in patients with frequent relapses. (juniperpublishers.com)
  • Treatment with systemic corticosteroids along with systemic chemotherapy for the underlying leukemia resulted in rapid clinical response with no relapse at last follow-up. (juniperpublishers.com)
Urticarial vasculitis8
Disorder6
  • Cutaneous vasculitis may be limited to the skin, or may be a component of a systemic primary or secondary vasculitic disorder. (msdmanuals.com)
  • Vasculitis may be due to primary disease or secondary due to an underlying disorder, drug reaction, or infection. (faoj.org)
  • Vasculitis is a rare disorder during the neonatal period. (scielo.org.za)
  • Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. (medicaljournals.se)
  • Secondary vasculitis may be triggered by an infection, a drug, or a toxin or may occur as part of another inflammatory disorder or cancer. (merckmanuals.com)
  • Central nervous system (CNS) vasculitis of childhood is a novel recognized autoimmune brain disorder with significant diagnostic and therapeutic challenges [2,3]. (fortuneonline.org)
Granulomatous1
  • INTRODUCTION - "Classic" granulomatosis with polyangiitis (GPA) is a form of systemic vasculitis (polyangiitis) with necrotizing granulomatous inflammation of the upper and lower respiratory tracts, systemic necrotizing vasculitis, and necrotizing glomerulonephritis [ 1,2 ]. (medilib.ir)
Diagnosis of cutaneous1
  • Accordingly, diagnosis of cutaneous vasculitis, identification of etiological factors, follow-up for systemic involvement and treatment are important. (bgu.ac.il)
Involvement5
  • Cutaneous vasculitis may precede severe systemic involvement, and may end in death. (bgu.ac.il)
  • Livedo reticularis with systemic involvement and stroke is SNEDDON SYNDROME. (bvsalud.org)
  • These may include tests to check for inflammation, organ involvement, immune complex formation and deposition, and ANCA-related vasculitis. (cohencenters.com)
  • CNS vasculitis can cause brain damage with reversible and or irreversible neurologic involvement, including acute ischemic attack, progressive cognitive decline and seizures often with intractable pattern. (fortuneonline.org)
  • Many patients with disease limited to upper respiratory tract or lungs subsequently develop systemic involvement [ 9 ]. (medilib.ir)
Microscopic1
Findings6
  • The clinical and histological findings were consistent with cutaneous necrotizing leukocytoclastic vasculitis. (bgu.ac.il)
  • The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
  • findings include leukocytoclastic vasculitis . (amboss.com)
  • The findings were reviewed by a pathologist at the University of Iowa Hospitals and Clinics and were found to be suggestive of leukocytoclastic vasculitis. (eyerounds.org)
  • 2,9 However, biopsies of affected skin generally do not demonstrate findings of vasculitis. (clinicaladvisor.com)
  • Others postulate that the skin findings are the result of cutaneous trauma caused by repeated, improperly performed injections, or that heparin may be poorly absorbed due to decreased vasculature in adipose tissue. (clinicaladvisor.com)
ANCA2
  • Cutaneous vasculopathy associated with levamisole-adulterated (contaminated) cocaine is an emerging syndrome characterised by a retiform purpura around the ears, the presence of anti- neutrophil cytoplasmic autoantibody ( ANCA ), and leukopenia [3,4]. (dermnetnz.org)
  • Both MPA and GPA are considered ANCA-associated vasculitides, although ANCA testing may be negative in some patients. (medilib.ir)
Patients12
  • Immunofixation electrophoresis is useful to identify subtle paraproteinemia that has been reported in some patients with leukocytoclastic vasculitis. (medscape.com)
  • Retrospective analysis of adult patients with cutaneous leukocytoclastic vasculitis. (medscape.com)
  • Martinez-Taboada VM, Blanco R, Garcia-Fuentes M, Rodriguez-Valverde V. Clinical features and outcome of 95 patients with hypersensitivity vasculitis. (medscape.com)
  • Cutaneous examination of patients with ESRD has shown that 50-100% of patients have at least 1 dermatologic condition. (medscape.com)
  • Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
  • Primary systemic vasculitis is uncommon, accounting for only four percent of cases in patients with cutaneous vasculitis. (faoj.org)
  • Skin eruptions may be a symptom of systemic disorders other than infections, and may be prominent in patients with vasculitis disorders. (scielo.org.za)
  • They may have had other BD or vasculitis patients who have tried it, and may suggest or prescribe treatments in advance to prevent (or lower) any possible reactions you might have. (blogspot.com)
  • BackgroundPatients suffering from systemic autoimmune rheumatic disease (SARD) display poor antibody development after two doses of mRNA vaccinations leaving these patients with only limited humoral protection against severe SARS-CoV-2 disease courses. (bvsalud.org)
  • Of key interest is the effect of conventional synthetic (csDMARD) and biological/ targeted drugs (b/tsDMARDs) disease modifying antirheumatic drugs on the time of protection.ObjectivesTo compare antibody titer development in patients with vasculitis and connective tissue disease (CTD) with healthy controls 6 months after two mRNA vaccinations and after third immunization. (bvsalud.org)
  • Differences between two groups were calculated with Wilcoxon signed-rank test.ResultsA total of 53 patients with SARD (42 patients suffering from connective tissue disease and 11 with vasculitis respectively) and 73 HC were analysed. (bvsalud.org)
  • A: Antibody titers measured 6 months after two doses of mRNA vaccination in patients with connective tissue disease, vasculitis and healthy controls. (bvsalud.org)
Clinical5
  • The spectrum of paraneoplastic cutaneous vasculitis in a defined population: incidence and clinical features. (medscape.com)
  • Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-Schonlein purpura in adults. (medscape.com)
  • Clinical, histopathologic, and laboratory evaluation are imperative to appropriately diagnose cutaneous vasculitis. (faoj.org)
  • Other clinical entities that can present similarly to heparin-induced skin necrosis include calciphylaxis, pyoderma gangrenosum, disseminated intravascular coagulation (DIC), leukocytoclastic vasculitis, and other bullous disorders. (clinicaladvisor.com)
  • The clinical spectrum of primary renal vasculitis. (medscape.com)
Disease9
  • The first is determining the presence of systemic disease. (medscape.com)
  • A cutaneous expression of immune complex disease. (medscape.com)
  • Its pathophysiology is normally alveolar microcirculation damage, and the reason may Cefsulodin sodium be generalized (such as systemic vasculitis) or lung-specific disease [as in diffuse alveolar harm (Father) or an infection] [17, 18]. (angiogenesis-blog.com)
  • An exhaustive search ought to be performed for signals of systemic disease such as for example sinusitis, cutaneous leukocytoclastic vasculitis, iridocyclitis, synovitis, and glomerulonephritis [9]. (angiogenesis-blog.com)
  • CSVV may develop in association with a wide variety of factors, including drugs, infections, systemic disease, or malignancy. (loveinwoori.com)
  • Beyond that, typical treatment plans are aimed at addressing the primary underlying disease associated with vasculitis. (cohencenters.com)
  • In addition to systemic inflammatory disease, progressive bone marrow failure is a defining feature of VEXAS syndrome. (nejm.org)
  • Kawasaki Disease Kawasaki disease is a vasculitis, sometimes involving the coronary arteries, that tends to occur in infants and children between the ages of 1 year and 8 years. (merckmanuals.com)
  • We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
Autoimmune1
  • Any primary or secondary vasculitis can affect the skin, including that due to serum sickness, infections (eg, hepatitis C), cancers, rheumatologic or other autoimmune disorders, and hypersensitivity to drugs. (msdmanuals.com)
Necrosis1
  • Necrotizing vasculitis, also called systemic necrotizing vasculitus, is a category of vasculitis, comprising vasculitides that present with necrosis. (wikipedia.org)
Dermal1
  • however, some cases have also shown extravasated erythrocytes, neutrophils, and eosinophils with mild dermal edema and slight spongiosis Rarely, the pathology can mimic acute generalized pustular dermatosis, bullous drug eruptions (such as erythema multiforme and fixed drug eruption), lichenoid dermatitis, leukocytoclastic vasculitis, or neutrophilic dermatoses (1). (aad.org)
Severe1
Primary systemic1
  • When using the influential classification known as the "Chapel Hill Consensus Conference", the terms "systemic vasculitis" or "primary systemic vasculitides" are commonly used. (wikipedia.org)
Syndrome5
  • Vasculitis as a paraneoplastic syndrome. (medscape.com)
  • Baboon syndrome was initially described as a form of systemic contact dermatitis following non-drug or topical medication sensitization followed by either topical or systemic challenge with the offending agent. (aad.org)
  • Subsequently, a cutaneous adverse drug reaction with a similar morphologic presentation, but without prior sensitization by the causative agent, was also classified as baboon syndrome. (aad.org)
  • We herein report a case of acute myeloid leukemia related subcutaneous sweet syndrome that responded to systemic steroids. (juniperpublishers.com)
  • Sweet syndrome manifests with extra-cutaneous features in up to 50% of cases. (eyewiki.org)
Infections2
  • In secondary skin infections, haematogenous spread of microorganisms to the skin occurs during systemic infection, i.e. neonatal sepsis. (scielo.org.za)
  • Known causes of vasculitis include the following: infections (hepatitis B and Streptococcus spp. (scielo.org.za)
Organs1
Nodules1
  • Cutaneous: Livedo reticularis, skin ulcers, tender erythematous nodules, bullous or vesicular eruptions, infarction and gangrene of fingers or toes, or a combination may occur. (symptoma.com)
Purpura1
Acute2
  • Some of the acute primary vasculitides are quite common paediatric diseases (e.g. (printo.it)
  • Cutaneous necrotizing vasculitis is usually induced by an acute infection or exposure to a drug. (bgu.ac.il)
Renal1
  • In addition, uremia and conditions associated with renal replacement therapy are fraught with numerous and, often, relatively unique cutaneous disorders. (medscape.com)
Necrotizing1
Chapel Hill Consensus Conference1
  • 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. (medscape.com)
Uncommon1
Venules1
Hypersensitivity vasculitis2