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Histiocytosis, Langerhans-CellHistiocytosisDendritic CellsTumor Necrosis Factor-alphaEosinophilic GranulomaHistiocytosis, SinusErdheim-Chester DiseaseHistiocytesHistiocytic SarcomaXanthogranuloma, JuvenileHistiocytosis, Non-Langerhans-CellLangerhans CellsBone DiseasesAntigens, CD1Vulvar DiseasesOrbital DiseasesLymphatic DiseasesDiabetes InsipidusPolydipsiaSea-Blue Histiocyte SyndromeSkin DiseasesVinblastinePenile DiseasesForeheadFatal OutcomeHypoaldosteronismTomography, X-Ray ComputedRemission, SpontaneousOrbital NeoplasmsMannose-Binding LectinsCladribinePrednisoneBiopsySpinal DiseasesAntigens, CDS100 ProteinsLung Diseases, InterstitialMice, Inbred C57BLImmunohistochemistryMagnetic Resonance ImagingDendritic Cells, FollicularSkinLymph NodesLungLung DiseasesAntigen PresentationHistiocytic Disorders, MalignantTreatment OutcomeMice, Inbred BALB CCell DifferentiationCells, CulturedT-Lymphocytes
Langerhans Cell HistiocyMonocytesLymphoidCutaneousReactiveSarcomaHistiocyticMalignant histiocytosisLesionsInfiltrationLymphomaPrognosisEosinophilicSyndromesMonocyte-derivedMononuclearClinicalDermalMonoclonalBenignBiopsyCytokinesPeripheralMastocytosisBoneLymphocytesHistiocytesAggressiveChemotherapyS100MyeloidPhagocytosisPathologicTranslocationMaturationDiseasesInfiltrateNucleiHistiocyte SocietyLungDifferentiationTherapeuticApoptosisNeoplasticLesion
Langerhans Cell Histiocy45
Monocytes4
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)
  • Methods We stimulated purified monocytes and whole peripheral blood mononuclear cells (PBMCs) from patients with GPA, patients with MPA or healthy controls with PR3 or MPO and visualised MGC and granuloma-like structure formation using light, confocal and electron microscopy, as well as measuring the cell cytokine production. (bmj.com)
  • Host recognition of microbes happens through pattern reputation receptors, including Toll-like receptors (TLRs)2 that are indicated on many cells, including macrophages, monocytes (1), and keratinocytes (2). (cancer-ecosystem.com)
Lymphoid8
  • Using a more sensitive technique for detection of mutant BRAF alleles (droplet digital PCR) [ 9 ], BRAF V600E was not detected in DNA extracted from myeloid or lymphoid cells isolated by flowcytometric sorting from a peripheral blood sample collected at the time of the fourth bone sample. (biomedcentral.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
Cutaneous3
  • More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
  • TERT promoter hypermethylation) alterations of TERT (Telomerase Reverse Transcriptase) in rare cutaneous melanocytic tumors, including spitzoid and blue nevus-like melanomas to gain insights into these challenging melanocytic lesions. (mdanderson.org)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
Reactive2
  • Hemophagocytic lymphohistiocytosis (HLH) is an uncommon syndrome characterized by a reactive, systemic proliferation of benign histiocytes throughout the reticuloendothelial system ( 1 ) . (cdc.gov)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
Sarcoma6
  • Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
  • Biopsy of the lesion is necessary to confirm the diagnosis as other orbital lesions in children, such as neuroblastoma, Ewing sarcoma and Wilms tumor, and other bony tumors may also present similarly on clinical exam and radiographic imaging. (reviewofophthalmology.com)
  • What is Ewing's Sarcoma Family of Tumors? (sarcomahelp.org)
  • The tumor which bears his name is generally referred to as Ewing's sarcoma when spoken and either Ewing's sarcoma or Ewing sarcoma when written. (sarcomahelp.org)
  • Pathologists have long known that Ewing sarcoma looks very similar to an even rarer soft tissue tumor called primitive neuroectodermal tumor ( PNET ). (sarcomahelp.org)
  • Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
Histiocytic4
  • Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. (wikipedia.org)
  • In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
  • Histiocytic tumors are derived from the mononuclear-phagocytic and histiocyte system[ 1 - 3 ]. (oncotarget.com)
  • The skin biopsy showed a proliferation of histiocytic cells expressing Langerin, CD1a and S100 and the molecular study was positive for the BRAF p.V600E mutation. (bvsalud.org)
Malignant histiocytosis2
  • Patients with infection-associated HLH usually have persistent unexplained fever, cytopenia, lymphadenopathy, and, frequently, hepatosplenomegaly and coagulopathy, causing diagnostic difficulties with malignant histiocytosis or T-cell lymphoma ( 2 ) . (cdc.gov)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
Lesions3
  • The clinical manifestations of the currently recognized disease entities are highly variable and range from benign localized lesions to highly aggressive systemic diseases[ 4 ]. (oncotarget.com)
  • Excision and intra-lesional steroid injections can spare children from the adverse effects of chemotherapy, with systemic chemotherapy and systemic steroid therapy reserved for recurrent lesions or lesions that fail to respond to initial excision. (reviewofophthalmology.com)
  • RDD shows some variability in the involvement of the entire neuraxis, and because its ability to mimic meningeal and primary brain tumors, it is essential to be aware of this entity and consider RDD in the differential diagnosis of various lesions of the CNS. (surgicalneurologyint.com)
Infiltration6
  • Spontaneous regression is common in these tumors, and it is mediated by infiltration of CD8-expressing T cells followed by expression of Type 1 T helper cell cytokines (such as Interferon-gamma) and recruitment of antitumour effector cells. (wikipedia.org)
  • They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
  • The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • The infiltration of leukemia cells into the skin, known as leukemia cutis, is a rare presentation of this disease and accounts for a diagnostic challenge. (bvsalud.org)
  • Invasive carcinoma eliminates the regular architecture and can include lympho-vascular space invasion, neurotropism, and infiltration of other tissue components such as muscle or cartilage, demonstrating aggressive behavior of the tumor. (entokey.com)
Lymphoma8
  • Neumann MP, Frizzera G. The coexistence of Langerhans' cell granulomatosis and malignant lymphoma may take different forms: report of seven cases with a review of the literature. (medscape.com)
  • Our aim is to deeply characterise paediatric B-cell non-Hodgkin lymphoma to provide a comprehensive understanding of disease initiation and evolution in response to therapy. (ncl.ac.uk)
  • I am also currently revising chapters on childhood lymphoma and tumour lysis syndrome for the second edition of the Oxford University Handbook of Paediatric Haematology and Oncology. (ncl.ac.uk)
  • Lymphoma b cell. (lookformedical.com)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
Prognosis1
  • RUNX1 mutations are also associated with an unfavorable prognosis chronic myelomonocytic leukemia and systemic mastocytosis. (cornell.edu)
Eosinophilic3
  • A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
  • In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
  • It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
Syndromes2
Monocyte-derived2
  • Kiertscher SM, Luo J, Dubinett SM, Roth MD. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. (medscape.com)
  • Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
Mononuclear1
  • [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
Clinical1
  • The histiocytoses: clinical presentation and differential diagnosis. (medscape.com)
Dermal1
  • Histogenesis is still controversial- dermal dendritical cells? (eurocytology.eu)
Monoclonal3
  • Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. (policylab.us)
  • Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. (policylab.us)
  • The antibody is a new monoclonal antibody against a C-type lectin found on the surface of Langerhans cells. (homeremedylifestyle.com)
Benign1
Biopsy4
  • Definitive diagnosis, if necessary, can be made by identification of Langerhans cell granulomas in lung biopsy samples acquired by video-assisted thoracoscopy. (medscape.com)
  • Once the diagnosis is established by tissue biopsy, systemic evaluation is necessary for proper staging of the disease. (reviewofophthalmology.com)
  • The usual treatment strategies for LCH include observation, biopsy with either subtotal or total curettage, intra-lesional steroid injections, systemic steroid therapy or chemotherapy. (reviewofophthalmology.com)
  • A skin and lung biopsy both revealed histiocytosis of the L (Langerhans) group. (bvsalud.org)
Cytokines1
  • Deregulated manifestation of the cytokines continues to be implicated in tumor, autoimmunity, and hyper-inflammatory areas (7C9). (cancer-ecosystem.com)
Peripheral1
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
Mastocytosis1
  • RUNX1 mutations have been reported in approximately 10% of myelodysplastic cases, 5-15% of acute myeloid leukemia, 8-37% of chronic myelomonocytic leukemia, 10% of T cell acute lymphoblastic leukemia, 3% of systemic mastocytosis, 2% of essential thrombocythemia and 2% of polycythemia vera. (cornell.edu)
Bone2
Lymphocytes3
  • CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. (thermofisher.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
Histiocytes2
Aggressive2
  • Genotyping identified a 45 year-old woman with an aggressive and treatment-refractory, ultrastructurally confirmed systemic BRAF -mutant LCH. (oncotarget.com)
  • Identification of genomic alterations that drive the clinically aggressive serous and clear cell tumors of the endometrium. (researchgate.net)
Chemotherapy1
S1003
  • Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)
  • En la biopsia cutánea se evidenció proliferación de células histiocitarias con positividad inmunohistoquímica para Langerina, CD1a, S100, resultando el estudio molecular de la misma positivo para la mutación BRAF p.V600E. (bvsalud.org)
  • En la biopsia pulmonar se evidenció una proliferación de células histiocitarias con positividad inmunohistoquímica para CD68 y para S100 y negatividad para Langerina y CD1a, detectándose en la misma mutaciones en NRAS c.38G>A en el exón 2 (p.G13D). (bvsalud.org)
Myeloid2
  • These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)
  • RUNX1 mutations are independently associated with unfavorable outcomes and shorter survival after hematopoietic stem cell transplantation in patients with myelodysplastic syndrome and myelodysplastic syndrome/acute myeloid leukemia. (cornell.edu)
Phagocytosis1
  • Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)
Pathologic3
  • As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
  • In ideal cases, the differences between normal cells and pathologic Langerhans cells (PLCs) should be used to guide treatment of the disease. (medscape.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Translocation1
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Maturation1
  • Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. (medscape.com)
Diseases1
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Infiltrate1
Nuclei1
  • Cytology reveals cells with clear to lightly basophilic cytoplasm and round or indented nuclei with fine chromatin and indistinct nucleoli. (wikipedia.org)
Histiocyte Society1
  • The information on this page has been written and reviewed by the Histiocytosis Association Board of Trustees Scientific Committee and a member of the Histiocyte Society , and subsequently audited by patients and families to ensure enough information was captured. (histio.org)
Lung1
  • It is believed that cigarette smoke attracts specific immune cells in the lungs (Langerhans cells) which leads to a cascade of inflammation and injury to the air passages and lung tissue over time. (histio.org)
Differentiation1
  • In mammalian cells, the miRNAs give a key degree of natural rules in developmental and differentiation pathways (18). (cancer-ecosystem.com)
Therapeutic1
  • For a growing number of tumors the BRAF V600E mutation carries therapeutic relevance. (oncotarget.com)
Apoptosis1
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Neoplastic1
Lesion1