Systemic mice nude. Medical search. Frequent questions

GL-ONC1 (CAS Registry Number (CAS RN): 1473430-36-2) is a triple modified and attenuated vaccinia virus (Lister strain) that causes regression and elimination of a wide range of solid tumors in preclinical mouse models. (wikipedia.org)
Systemic administration of GL-ONC1 via intravenous injection was under investigation in multiple clinical trials: In one study, GL-ONC1 was administered to patients with advanced solid organ tumors as a monotherapy. (wikipedia.org)
Systemic improvements were noted, with CLG limiting liver metastasis, reducing pro-inflammatory cytokines IL-6 and IL-10 in liver tissues, decreasing MMP-2 in blood and MMP-2 and MMP-9 in tumors, and inhibiting TGF-ß1 expression in liver tissues. (bvsalud.org)
In vivo, both local and systemic administration of CIGB-300 elicited significant antitumor effects in murine syngeneic cancers and human tumors xenografted in nude mice [ 21 ]. (oncotarget.com)
In vivo, Interferon alfa-2a, recombinant has been shown to inhibit the growth of several human tumors growing in immunocompromised (nude) mice. (drugs.com)
We have evaluated the antitumor effect of HSVtk/ganciclovir gene therapy under Tet-On regulation by means of adeno-associated virus-2 (AAV-2)-mediated HSVtk gene transfer with direct intratumoral injections in mice bearing breast cancer tumors. (biomedcentral.com)
In ex vivo experiments, tumor growth of BALB/C nude mice breast cancer was retarded after rAAV-2/HSVtk/Tet-On was injected into the tumors under the Dox induction. (biomedcentral.com)
The expression of HSVtk gene in MCF-7 cells and BALB/C nude mice tumors was up-regulated by Tet-On under Dox induction with reverse transcription-PCR (RT-PCR) analysis. (biomedcentral.com)
For studies of the role of NK cells in vivo, we will examine primary mouse and human tumors and metastases from the same individual for susceptibility to NK cells in both beige mice and nude mice immunosuppressed for NK activity and will characterize mechanism of resistance to the growth tumors and metastases by adoptive transfers with defined lymphocyte subpopulations. (grantome.com)
All the xenotransplanted mice were measured for size of the tumors, picture of the gross tumors and biopsies H&E staining and ApoTag for Apoptosis review. (aphios.com)

To perform this study, we used human tumor xenografts in immunodeficient mice. (springer.com)
Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
The Chinese medicine formula Chanling Gao (CLG) exhibits significant tumor inhibitory effects in colorectal cancer (CRC) nude mice. (bvsalud.org)
Posttreatment, tissues and blood were analyzed for indicators of tumor inhibition and systemic effects. (bvsalud.org)
CLG inhibited tumor growth, improved overall health metrics, and ameliorated abnormal blood cell counts in CRC nude mice. (bvsalud.org)
As for CTP4-DTA pDNA delivery the overall tumor load of the liver was reduced without any significant systemic toxicity, indicating specific DTA expression in tumor tissue. (uni-muenchen.de)
The tumor-specific expression of DTA pDNA could also be confirmed in vitro and was further investigated in an orthotopic liver dissemination model in NMRI nude mice. (uni-muenchen.de)
In vivo distribution of ACNVs was detected in healthy and tumor-bearing mice after scavenger receptors (SRs) blockade. (dovepress.com)
However, such antitumor activity has been repeatedly demonstrated with, for example, mouse interferon-alfa in transplantable mouse tumor systems. (drugs.com)
Balb/c nude mice were inoculated with IGROV-1 cells, and the resulting tumor was imaged by MRI using these in vivo Gd-liposomes formulated with low charge and a poly(ethylene glycol) (PEG) calyx for long systemic circulation. (westminster.ac.uk)
Given its enhanced tumor selectivity, improved safety profile, and substantial oncolytic effects following systemic delivery in murine models, it should also serve as a useful vector for tumor-directed gene therapy. (elsevierpure.com)
Antagonizing TGF-beta activity has been shown to inhibit tumor invasion in vitro and tumorigenicity, but a systemic inhibition or lack of TGF-beta signaling results in acute inflammation and disruption of immune system homeostasis. (dbcls.jp)

In conclusion, no toxicity was observed in mice 6 months after administration of PEGylated gold nanoshells and the distribution kinetics progressed from intravascular flow at 30 min to intratumoral cells 24 h later. (springer.com)
Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. (spandidos-publications.com)
In the present study, we evaluated toxicity and anti-cancer activities of BD in an animal model of breast-to-lung cancer metastasis with triple-negative highly invasive humane breast cancer cells MDA-MB-231 implanted in the mammary pad of nude mice. (spandidos-publications.com)
Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. (dogcancerblog.com)
The lack of systemic toxicity such as loss in body weight and inflammation of major organs, suggest the safety of the lipid excipients towards the biological system. (um.edu.my)
A topical formulation of an antineoplastic drug that is effective against visual and subcutaneous Kaposi's sarcoma will reduce the systemic use of these drugs, minimizing blood toxicity levels and improving a patient's quality of life. (aphios.com)

Furthermore, the ACA-NLC formulations have exhibited significant anti-tumour efficacy in nude athymic (Nu/Nu) mice models. (um.edu.my)
Immunization of type VII collagen in athymic nude SJL mice did not induce an autoimmune response, whereas the repletion of T cells from type VII collagen-immunized wild-type mice to the thymic mice showed autoantibody production and resulted in a blistering disease phenotype, supporting the role of T cells in the induction of epidermolysis bullosa acquisita. (medscape.com)

To test this, we used systemic VEGF monoclonal antibody (VEGF-MAb) to treat PTC xenografts in nude mice. (uthscsa.edu)
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)
Rats bearing the Dunning R-3327H rat prostate cancer and nude mice bearing LNCaP or PC-3 human prostate cancer xenografts were used as model systems. (aacrjournals.org)
0.05) inhibits growth of LNCaP human prostate cancer xenografts in intact male nude mice, but this inhibition is not as great as that by equimolar oral dosing with dutasteride. (aacrjournals.org)
In contrast, no response was induced by dutasteride in nude mice bearing androgen-independent PC-3 human prostatic cancer xenografts. (aacrjournals.org)

In the in vivo experiments, systemic delivery of siRNA against β-catenin, sticky siRNA targeting PAR-1 and plasmid DNA encoding for CTP4 controlled DTA were evaluated in a disseminated liver metastasis model of LS174T colorectal cancer. (uni-muenchen.de)
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. (dogcancerblog.com)

In accordance, CIGB-300 decreases the viability and proliferation of CLL cell lines, promotes apoptosis of primary leukemia cells and displays antitumor efficacy in a xenograft mouse model of human CLL. (oncotarget.com)

In particular, chemoradiotherapy is associated with systemic toxicities that often reduce compliance and prevent timely completion of therapy. (medscape.com)

In conclusion, systemic VEGF-MAb significantly reduced the growth of PTC, suggesting that VEGF-MAb might be useful for treatment of resistant PTC. (uthscsa.edu)

The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. (shengsci.com)
Systemic delivery of HTL-001 resulted in improved control of subcutaneous murine and human xenograft tumours and improved survival in a murine orthotopic model. (biomedcentral.com)

U373 inoculated subcutaneous in nude mice (2 mg/kg and 9 mg/kg) as well as paclitaxel (8 mg/kg), but on the contrary of paclitaxel, only ZK 219477 demonstrated antitumour activity against U373 implanted in nude mice (9 mg/kg): 8 complete response out 9 treated mice. (knowcancer.com)

Alpha-interferons are totally filtered through the glomeruli and undergo rapid proteolytic degradation during tubular reabsorption, rendering a negligible reappearance of intact alfa interferon in the systemic circulation. (drugs.com)
Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic enzymes of androgen metabolism, particularly 5α-reductases (i.e. (aacrjournals.org)

For example, extracts or purified compounds from Scutellaria barbata, Astragalus membranaceus and Curcuma longa suppressed growth, induced oxidative stress and apoptosis, inhibited breast cancer cell invasiveness and prevented breast cancer metastases in mice ( 11 - 14 ). (spandidos-publications.com)
The topical treatment of Dermos™ has proven to be quite effective in vivo against xenotransplanted KS Y-1 cells in nude mice and was shown to cause apoptosis in vitro in KS Y-1 cells by 3D epifluorescence confocal microscopy. (aphios.com)

In this study, the cloning and expression of mouse IL-33 gene in Escherichia coli (E. coli ), purification of recombinant protein, and generation of polyclonal antibody against IL-33 are described. (hindawi.com)
Initial studies demonstrated that rabbit antimouse type VII collagen antibodies, as well as rabbit antibodies raised against human recombinant protein type VII collagen, were able to induce blisters in mice. (medscape.com)

1946. Systemic pharmacology and pathology of sulfur and nitrogen mustards. (cdc.gov)

In addition, gold nanoshells did not induce any tissue damage, such as necrosis, inflammatory infiltrate or fibrosis in mouse liver, spleen, kidney or bone marrow after 6 months. (springer.com)
Significant expression of IL-33 was seen in mouse liver and lung tissues determined with the anti-IL-33. (hindawi.com)

In a preclinical model of mouse xenografted with human renal cancer, we analysed the bio-distribution of a single dose (160 μg/kg) intravenously injected of poly-ethylene glycol (PEG)ylated gold nanoshells (~150 nm), in blood, normal and tumoral tissues. (springer.com)
In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. (spandidos-publications.com)
Perillyl alcohol (POH) is a monoterpene that has been used orally for the treatment of systemic cancer. (cns.org)
Paclitaxel, a unique anti-mitotic agent, has been approved by the FDA for systemic application in metastatic cases of breast cancer and refractory cases of ovarian cancer, and AIDS-KS. (aphios.com)

Luciferase- positive U251 TMZ-resistant glioma cells were stereotactically implanted into the right frontal lobe of nude mice. (cns.org)

In a model of viral pathogenesis, mice treated with vSP survived substantially longer when compared with mice treated with the wild-type virus. (elsevierpure.com)
Induction of an active model of autoimmunity against type VII collagen in a hairless mouse strain (SKH1) revealed that regulatory T cells, which have been identified for their ability to inhibit the development of autoimmune diseases, do not inhibit the development of autoantibodies against the self-protein mouse-type VII collagen. (medscape.com)

F10 does not penetrate the BBB in healthy mice (data not shown), thus intra-cranial (i.c.) administration of F10 results in high local concentrations that may be therapeutically beneficial. (alzet.com)
Administration of IL-33 to mice induces production of Th2 cytokines and severe pathological changes in mucosal organs [ 2 ]. (hindawi.com)

[ 5 , 6 ] More recently, affinity-purified antitype VII collagen autoantibodies from epidermolysis bullosa acquisita patients have induced blisters in an adult hairless mouse strain (SKH1), further supporting a pathogenic role of antitype collagen VII autoantibodies. (medscape.com)

Possible defects in the functioning of the IFN-NK system in patients with putative persistent viral diseases, multiple sclerosis and systemic lupus erythematosus will be pursued. (grantome.com)

Systemic corticosteroids (ie, prednisone) are not an agent of choice for alopecia areata because of the adverse effects associated with both short- and long-term treatment. (medscape.com)

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. (dogcancerblog.com)

1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)

Liposomal formulations of daunorubicin and doxorubicin have been approved by the FDA for first-line and second-line systemic treatment of AIDS-KS. (aphios.com)
Nude mice were treated with PBS as controls, low and high doses of "topical" treatment: 0.05 - 0.1 mg/daily for 7 days. (aphios.com)
Treatment can be topical or systemic. (medscape.com)

In a preclinical PK study, similar concentrations of ZK 219477 were detected in plasma (1.2 μg/ml) and brain (0.9 μg/g) after 10 min after i.v. application in scid mice. (knowcancer.com)

Intranasal delivery of POH was conducted in nude mice. (cns.org)

In this double blind clinical trial, 80 patients with chronic moderate periodontitis and a healthy systemic status were chosen, and divided into two 40-subject groups. (bvsalud.org)

CRC in situ nude mouse models were treated with CLG. (bvsalud.org)

The human IL-33 gene is located on chromosome 9p24.1, while its mouse counterpart can be found on the syntenic chromosome 19qC1 region [ 2 ]. (hindawi.com)

We performed a sequential analysis of uptake and distribution of large-sized PEGylated gold nanoshells and focussed the study on their intracellular distribution in the xenografted human cancers, as well as on their long-term tolerance in normal mouse organs. (springer.com)

Dose-finding studies in nude mice demonstrate that F10 administered i.c. using an Alzet osmotic mini-pump at doses up to 200 mg/kg administered over 7 days are well-tolerated and do not cause damage to normal brain (Fig. 2b). (alzet.com)

animal info (nu/nu mice). (alzet.com)

MATERIALS AND METHODS: Male C57BL/6 N mice suffered from ischemia stroke by mechanical detachment of carotid artery thrombi with the stimulation of ferric chloride. (bvsalud.org)