Systemic disorder. Medical search. Frequent questions

Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many organs, with musculoskeletal symptoms being the most common. (nih.gov)
We also evaluated health status and SLE disease activity by both the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and serological markers. (nih.gov)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
Systemic lupus erythematosus (SLE) has been the most commonly reported rheumatologic cause of ESRD. (medscape.com)
In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE). (ox.ac.uk)
Systemic lupus erythematosus (SLE) is a complex connective tissue disorder that involves multiple organs. (bmj.com)
The impact of endocrine disorders on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS) is reviewed. (springer.com)
Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis. (uchicago.edu)
Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B and T cells to self-antigens. (nih.gov)

More recently, PTSD has been linked with autoimmune disorders and neurodegenerative diseases. (psychiatrictimes.com)
however, in some patients, hematospermia may be the first indicator of other urologic diseases or systemic disorders (see DDx/Diagnostic Considerations ). (medscape.com)
In the arena of periodontal medicines, the studies of past decades suggest a link between human periodontal afflictions and certain systemic disorders such as cardiovascular diseases, diabetes mellitus, respiratory disorders, preterm birth, autoimmune disorders, and cancer. (encyclopedia.pub)
This review is an attempt to juxtapose the presence of periodontal infection in addition to systemic diseases such as cardiovascular disease, respiratory disorders, preeclampsia, glycemic control diseases, autoimmune disorders, and cancer. (encyclopedia.pub)
Consequently, dermatologic manifestations of renal disease may be divided into 3 general categories including: (1) dermatologic manifestations of diseases associated with the development of ESRD, (2) dermatologic manifestations of uremia, and (3) dermatologic disorders associated with renal transplantation. (medscape.com)
These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)
Rheumatic and autoimmune diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. (clevelandclinic.org)
3 Spondyloarthropathies are a group of various rheumatic diseases of which ankylosing spondylitis (ASp) and psoriatic arthritis (PsA) are the most frequently occurring disorders ( table 1 ). (bmj.com)
Environmental stress is widely recognized as one of the main risk factors for neuropsychiatric diseases, including mood and anxiety disorders. (hindawi.com)
The four major mechanisms leading to increased oral pigmentation are discussed in detail: physiologic pigmentation, systemic diseases (eg, Peutz-Jeghers syndrome [PJS]), oral mucosal insults (eg, amalgam tattoo), and neoplastic processes (eg, melanoma). (medscape.com)
Endocrine diseases are a heterogeneous group of disorders which can affect nearly any body system including the musculoskeletal system. (springer.com)
Rheumatic manifestations of endocrine disorders may present as a definite rheumatic disease (such as pseudogout in hyperparathyroidism), as rheumatic symptoms such as arthralgia and myalgia, as positive immune serology, or may mimic rheumatic diseases (e.g., skeletal abnormalities in hypoparathyroidism can mimic ankylosing spondylitis). (springer.com)
Rheumatic diseases are associated with endocrine disorders which may have an impact on the clinical aspects of those diseases. (springer.com)
Oxcarbazepine may also be used to treat bipolar disorder and nerve pain (neuralgia) and nerve damage (neuropathy) that result from certain neurological diseases. (medicinenet.com)

Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune connective tissue disorder characterized by thickening and fibrosis of the skin and internal organs. (acrabstracts.org)
Systemic sclerosis. (clevelandclinic.org)
Johns Hopkins researchers have greatly increased understanding of the causes of systemic sclerosis, using mice, lab-grown cells and clues from a related disorder. (medindia.net)
Until now we've had little insight and no effective treatment strategies for systemic sclerosis, and many patients die within a year of diagnosis," says Hal Dietz, a professor in the Institute of Genetic Medicine and director of the Smilow Center for Marfan Syndrome Research at Johns Hopkins. (medindia.net)
Patients with systemic sclerosis, also known as systemic scleroderma, experience a sudden hardening, or fibrosis, of the skin. (medindia.net)
A rare connective tissue autoimmune disorder, systemic sclerosis, also known as scleroderma, is difficult to treat. (medindia.net)
Systemic sclerosis rarely runs in families, Dietz says, making the gene for the disease, if it exists, very difficult to find. (medindia.net)
But Dietz's group was struck by the similarities between systemic sclerosis and a less severe, much rarer condition called stiff skin syndrome (SSS), which does run in families, and they suspected that learning more about SSS would also shed light on systemic sclerosis. (medindia.net)
As the team expected, both groups of mice developed patches of stiff skin, along with elevated levels of proteins and cells involved in the immune response much like humans with SSS or systemic sclerosis. (medindia.net)
The team also tested the compounds on lab-grown human skin cells with systemic sclerosis, with the same results. (medindia.net)
This raises the possibility that systemic sclerosis patients could eventually be treated with similar compounds in humans, Dietz says. (medindia.net)
A number of the compounds that proved effective in SSS mice and systemic sclerosis cells are currently being explored by drug companies for the treatment of other conditions, prominently including cancer. (medindia.net)
Progressive systemic sclerosis predominantly affects women (3 to 8 women vs. 1 man). (scirp.org)
The objective of this presentation is to guide any practitioner towards diagnosis of renal crisis in the face of sudden multiple organ failure resulting from progressive systemic sclerosis. (scirp.org)
The etiology mentioned was progressive systemic sclerosis. (scirp.org)

A high prevalence of cutaneous disorders is expected, because most patients with ESRD have an underlying disease process with cutaneous manifestations. (medscape.com)
Rare manifestations of the disorder include inflammation of the pancreas, gastrointestinal tract, and spleen. (wikipedia.org)
Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)

Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (medscape.com)
The Executive Board of the Hellenic Institute for the Study of Sepsis decided to support research activity in HS when data generated from the Out-Patients Department of Immunology of Infections of ATTIKON University General Hospital showed that circulating white blood cells of patients with HS share common functional characteristics with sepsis patients thus making HS a study prototype of systemic inflammation. (sepsis.gr)
Also, chronic systemic inflammation itself is an independent CV risk factor. (bmj.com)
Inflammatory joint disorders (IJD) are characterised by chronic inflammation of the joints and related tissues. (bmj.com)
RA is the archetype of a systemic immune-mediated disease and it is defined as a chronic symmetric inflammation primarily involving the synovial joints ( table 1 ). (bmj.com)
2 Alongside joint involvement, the systemic inflammation distinctive for RA can affect other organs including the bowels, skin, lungs, kidneys, nervous system and also the heart and blood vessels. (bmj.com)
Laboratory findings include increased blood eosinophil and atypical lymphocyte counts, elevated blood markers for systemic inflammation (e.g. erythrocyte sedimentation rate, C-reactive protein), and evidence of internal organ involvement. (wikipedia.org)
Diet is strongly linked to systemic inflammation. (medicalnewstoday.com)

The established treatment includes prompt systemic corticosteroids, steroid-sparing immunosuppressive drugs and biological agents. (bmj.com)
Systemic corticosteroids are commonly used as well but no controlled clinical trials have assessed the efficacy of this treatment. (wikipedia.org)

Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Inflammatory joint disorders (IJD), including rheumatoid arthritis (RA), ankylosing spondylitis (ASp) and psoriatic arthritis (PsA), are prevalent conditions worldwide with a considerable burden on healthcare systems. (bmj.com)
IJD comprise a broad range of related disorders of which rheumatoid arthritis (RA) and spondyloarthropathies are the most common. (bmj.com)
Rheumatoid arthritis is the most common coexisting autoimmune disorder in patients with Grave's disease and Hashimoto thyroiditis. (springer.com)

Several large cohort studies demonstrate a prospective association between PTSD symptoms and cardio-metabolic disorders, such as myocardial infarction, stroke, type 2 diabetes mellitus, and coronary heart disease. (psychiatrictimes.com)
Ocular symptoms are correlated to systemic disease activity and can present as an initial manifestation of SLE. (bmj.com)
In 1845, skin lesions were reported by Hebra and later biopsied in 1872 by Kaposi who also pointed to systemic symptoms. (bmj.com)
2 Ocular involvement may correlate with systemic disease activity and precede other systemic symptoms stressing the important role the ophthalmologist may play. (bmj.com)
The easiest choice is to focus on pharmacologic therapy for target symptoms rather than the personality disorder as a whole. (madinamerica.com)
Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications. (wikipedia.org)
In children, lymphoma may present as one or more painless masses, often in the neck, accompanied by signs and symptoms resulting from local compression, as well as signs and symptoms of systemic disturbances, such as fever and weight loss. (aafp.org)
Oxcarbazepine can cause drug reactions with eosinophilia and systemic symptoms (DRESS), also known as multi-organ hypersensitivity, which can be life-threatening or fatal. (medicinenet.com)

Breathing ethylene glycol vapors may irritate eyes and lungs but is unlikely to cause systemic toxicity. (cdc.gov)
Additionally, a conscious effort is made to propose the various periodonto-therapeutic tools so as to apprise the reader about the availability of appropriate treatment for the disease at the earliest stage without allowing it to progress and cause systemic adverse effects. (encyclopedia.pub)

Periodontitis and Systemic Disorder" Encyclopedia , https://encyclopedia.pub/entry/12939 (accessed December 07, 2023). (encyclopedia.pub)

Mechanism-based insights into the disease pathogenesis and association are highly relevant and shall be useful in avoiding any systemic complications. (encyclopedia.pub)

In a previous experiment , they pinpointed the genetic mutation responsible for SSS in a gene for a protein called fibrillin-1, which plays a role in other connective tissue disorders. (medindia.net)

Translocations and other types of mutations involving the RUNX1 gene have been associated with different types of leukemia and related blood disorders, including acute lymphoblastic leukemia (ALL), chronic myelomonocytic leukemia (CMML), familial platelet disorder with predisposition to acute myeloid leukemia, and myelodysplastic syndromes (MDS). (medlineplus.gov)
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that affects skin areas rich in apocrine glands. (sepsis.gr)
Indeed, while the fast response to stress includes plasticity enhancing effects associated with improved cognition, the long-term adaptive changes induced by stress, in particular following chronic stress, can be deleterious, leading to impaired function, enhanced susceptibility, or triggering of mood and anxiety disorders. (hindawi.com)

PJS is an autosomal dominant disorder characterized by intestinal hamartomatous polyps in association with mucocutaneous melanocytic macules. (medscape.com)
Associations of heritable mucocutaneous disorders with systemic cancers. (mhmedical.com)

There are rare reports of blood disorders that include reduced counts of all types of blood cells. (medicinenet.com)

Our center is recognized for excellence in the diagnosis and management of a variety of inflammatory and autoimmune disorders that affect the joints, muscles, skin, blood vessels, brain, and other vital organs. (clevelandclinic.org)

But when you ask the prescribing psychiatrist why she is giving 5 drugs to this person who she has labeled with the term "borderline personality disorder', she will most likely say that it is because she also has the diagnosis of "major depressive disorder" and/or "bipolar disorder, type II," and/or, in a recent worrisome expansionist trend, "attention deficit disorder" etc., etc. (madinamerica.com)
Borderline Personality Disorder (BPD) is a diagnostic category characterized by fluctuations in mood, self-image, behavior, and relationships. (madinamerica.com)

Systemic ethylene glycol toxicity can occur through ingestion. (cdc.gov)
Ethylene glycol does not absorb well through the skin so systemic toxicity is unlikely. (cdc.gov)
Eye exposure may lead to local adverse health effects but is unlikely to result in systemic toxicity. (cdc.gov)

However, lung involvement in this disorder typically resolves. (wikipedia.org)

Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
Prior to 1996, there were numerous reports on individuals presenting with a medication-induced disorder now recognized as the DRESS syndrome. (wikipedia.org)
The reports often named the disorder based on the medication evoking it, e.g. the anticonvulsant hypersensitivity syndrome, allopurinol hypersensitivity syndrome, and dapsone hypersensitivity syndrome. (wikipedia.org)
In 1996, however, the term DRESS syndrome was coined in a report attempting to simplify the terminology and consolidate these various clearly related syndromes into a single underlying disorder. (wikipedia.org)
Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome (PJS) and Addison disease. (medscape.com)
Telling someone that their personality is disordered is a violent thing to do, implying that the problem is with who they are , rather than a syndrome they have, or an understandable response to horrific life events. (madinamerica.com)
Nail-Patella Syndrome Nail-patella syndrome is a rare hereditary disorder that results in abnormalities of the kidneys, bones, joints, toenails, and fingernails. (msdmanuals.com)

Ocular disorders among stroke patients. (who.int)
Thirty-nine patients (47.0%) were dearth of information on the pattern of ocular between ages of 51 and 60, while 1 (1.2%) was disorders in patients with stroke. (who.int)

Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)

The editorial argued that the problem may be even more widespread than found in the study, and stated, "Clearly, psychiatrists need to receive better education about evidence-based treatments for severe personality disorders. (madinamerica.com)
Why Patients With Severe Personality Disorders Are Overmedicated: (Commentary). (madinamerica.com)

Patients must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure or treatment of a condition or disorder. (rarediseases.org)
Psychiatric disorders such as anxiety and depression are also present in many SLE patients. (nih.gov)
The findings indicate that the challenges and subsequent biases associated with patients with psychiatric conditions and/or substance use disorders end up adversely affecting clinician well-being and, in turn, patient care. (ahrq.gov)
The researchers performed a cross-sectional survey of self-selected psychiatric services, and found that of 2,600 patients with a diagnosis of personality disorder, more than two-thirds (68%) had a diagnosis of emotionally unstable personality disorder (EUPD). (madinamerica.com)
The Use of Psychotropic Medication in Patients With Emotionally Unstable Personality Disorder Under the Care of UK Mental Health Services. (madinamerica.com)
Since then, multiple studies have been performed demonstrating the efficacy of lithium in patients with mood disorders, such as depression, manic depression, and melancholia. (medscape.com)
Anterior and posterior segments, together with neuro-ophthalmic disorders were found among stroke patients in this study. (who.int)

C omplex Post-Traumatic Stress Disorder (C-PTSD) has long been hailed as a beacon of hope in the maze of psychiatric diagnoses, even among those of us who have felt harmed by such labels. (madinamerica.com)
Additionally, she argued that the existing trauma category of Post-Traumatic Stress Disorder (PTSD) only addressed reactions to isolated, one-off traumatic events, like flashbacks. (madinamerica.com)

Although, the disease appears as a locoregional infection, the periodontal pathogens, in addition their metabolic products and systemic mediators, receive access to the bloodstream, thereby contributing to the development of systemic disorders. (encyclopedia.pub)

NORD is not a medical provider or health care facility and thus can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. (rarediseases.org)
In the advanced stages of the disease, the pathogenic bacteria of dental plaque and their metabolic products may enter into the systemic circulation during mastication or mechanical procedures. (encyclopedia.pub)
Nephrology: nephritis, nephritic proteinuria associated with systemic autoimmune disease. (clevelandclinic.org)
Neurologic syndromes, including seizure disorders, can also be a feature of celiac disease (CD) or subclinical CD, sometimes associated with cerebral calcification. (ox.ac.uk)
Transmission an incidence rate of 1.5 cases/1,000 live births and a of T. gondii can occur through food items and the en- burden of disease of 1.2 million disease-adjusted life vironment. (cdc.gov)
The SCARs disorders have similar disease mechanisms. (wikipedia.org)
Over the past decade, advances in the understanding of SLE pathogenesis placed the innate immune system as a key player in perpetuating and amplifying this systemic disease. (nih.gov)

Systemic changes and local interventions are urgently needed to mitigate challenges and improve patient care for people with psychiatric conditions and/or substance abuse disorders, according to an AHRQ-funded study in Annals of Emergency Medicine . (ahrq.gov)
This therapy proved ineffective, but lithium was noted to be a highly effective treatment of psychiatric disorders in the late nineteenth century. (medscape.com)

In addition, uremia and conditions associated with renal replacement therapy are fraught with numerous and, often, relatively unique cutaneous disorders. (medscape.com)

It is now clearer than ever that employers can play a critical role in preventing drug-related deaths and helping workers access treatment and maintain recovery from substance use disorders. (cdc.gov)
The toolkit provides information, tools, and resources to help employers across all industry sectors to effectively prevent and address substance use disorders in the workforce, hire people who are in or seeking recovery, and support recovery in the workplace. (cdc.gov)

2016). For this reason, FASD is now commonly referred to as an 'invisible' disorder - it can exist in the absence of overt physical features (Mather, 2015). (aifs.gov.au)

However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Menstrual Disorders. (drugs.com)
If secondary osteoporosis is present, treatment for the primary disorder should be provided. (medscape.com)
If the nail's appearance does not improve with treatment of the underlying disorder, manicurists may be able to hide deformities and some dystrophies with appropriate trimming and polishes. (msdmanuals.com)

There is a large body of evidence describing the clinical presentation of seizures with MS and SLE, and showing that refractory epilepsy can complicate these already challenging disorders. (ox.ac.uk)

Psychiatrists are giving drugs to most people with emotionally unstable personality disorders outside of the best-practice clinical guidelines, according to a study in the Journal of Clinical Psychiatry . (madinamerica.com)

[ 7 ] The tendency to develop pigmentation appears to be genetically determined, but color intensity might be influenced by smoking, hormones, systemic medications, and physical factors. (medscape.com)

The association between thyroid disorders and encephalopathies, often termed Hashimoto's encephalopathy, is well known but the pathogenic significance of antithyroid antibodies in this condition is still debated. (ox.ac.uk)

Fetal Alcohol Spectrum Disorder (FASD) is a term used to describe the wide variety of lifelong developmental effects associated with prenatal alcohol exposure. (aifs.gov.au)
This paper is a companion paper to Fetal alcohol spectrum disorders: Current issues in awareness, prevention and intervention (McLean & McDougall, 2014), which outlines research on the prevention of FASD and provides implications for practitioners. (aifs.gov.au)
Fetal Alcohol Spectrum Disorder (FASD) is a diagnostic term that is used to describe the diverse and lifelong developmental effects that exposure to alcohol during pregnancy has on the developing fetus (Cook et al. (aifs.gov.au)
Fetal Alcohol Spectrum Disorder (FASD) is a diagnostic term used to describe impacts on the brain and body of individuals prenatally exposed to alcohol. (aifs.gov.au)

This special issue is intended to collect findings highlighting the idea that the understanding of the pathophysiology of stress-related pathologies (especially mood and anxiety disorders) must include an integrated approach, from the molecules to behavior, embracing the plasticity of the ever-changing brain in mammals. (hindawi.com)

The following neonatal characteristics and disorders were registered: blood gases, early and late respiratory dysfunction, pulmonary deterioration, retinopathy of prematurity (ROP), necrotising enterocolitis (NEC) and bronchopulmonary dysplasia (BPD). (bmj.com)

Diseases4

Chemicals and Drugs5

Psychiatry and Psychology15

Information Science1

Health Care1

Lupus Erythematosus10

Diseases14

Sclerosis15

Manifestations3

Inflammation8

Corticosteroids2

Rheumatoid Arthritis4

Symptoms8

Cause systemic2

20231

Complications1

Connective1

Chronic3

Mucocutaneous2

Blood disorders1

Organs1

Borderline personal2

Toxicity3

Involvement1

Syndrome7

Ocular2

Intestinal1

Severe2

Patients7

Post-Traumati2

Infection1

Disease7

Psychiatric2

Renal1

Substance Use Disorders2

Commonly1

Treatment3

Evidence1

Personality1

Medications1

Thyroid1

Fetal4

Findings1

Respiratory1