• Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disorder, with a heterogeneous presentation. (lww.com)
  • The disorder was recognized as early as the Middle Ages, with the 12th-century physician Rogerius being the first to apply the term lupus to the classic malar rash, and in 1872, Moric Kaposi first recognized the systemic nature of the disease. (lww.com)
  • The prevalence of systemic lupus erythematosus (SLE) ranges from 7.4 to 159.4 per 100,000 of population, with the highest rates among United Kingdom residents of Afro-Caribbean descent, and non-White populations elsewhere. (lww.com)
  • 4 , 5 Genetic factors are implicated in pathogenesis with a concordance rate for lupus of 24%-60% among monozygotic twins and 2%-5% among dizygotic twins. (lww.com)
  • Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disorder associated with a wide range of symptoms and physical findings. (medscape.com)
  • Indeed, in some cases, HLA genes are more highly related to lupus-associated autoantibodies than to the disease itself. (medscape.com)
  • Intriguingly, many of these polymorphisms are shared with other rheumatic diseases, such as systemic lupus erythematosus. (hindawi.com)
  • Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger. (cdc.gov)
  • One thing that makes a huge difference in living with lupus is the person's role in controlling the disease. (lupuscanada.org)
  • Some of these non-MHC loci have also been implicated in other autoimmune diseases, such as systemic lupus erythematosus, suggesting that immune dysregulation is a very important factor in systemic sclerosis development. (statpearls.com)
  • The CTDs associated with silica exposure include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis and overlap syndromes. (dermatoljournal.com)
  • There is now convincing evidence that several CTDs, including scleroderma (SSc), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) are associated with exposure to crystalline free silica (CFS), and evidence regarding other CTDs is evolving. (dermatoljournal.com)
  • Identify the contribution, risk, and mechanisms of systemic vs. non-systemic ASNHL, to include studies of the role of low-level autoimmunity in long-standing diseases, e.g., rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). (nih.gov)
  • Drug-induced lupus is a lupus-like disease caused by certain prescription drugs. (passmed.uk)
  • The members of the Systemic Lupus Erythematosus Genetics Consortium who participated are listed at the end of the article. (cdc.gov)
  • Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. (cdc.gov)
  • A portrait of Alcott raises the possibility that she had systemic lupus erythematosus (SLE). (cdc.gov)
  • who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
  • A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
  • Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
  • Finally, unanswered questions and potentially informative future research directions are highlighted to speed delivery of etiology-based strategies to reduce autoimmune disease. (frontiersin.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • Animal models of autoimmune diseases have shown that infections can induce autoimmune disease. (cdc.gov)
  • The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. (cdc.gov)
  • We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. (cdc.gov)
  • In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) ( 3 ). (cdc.gov)
  • Infections occur before the onset of symptoms of autoimmune disease, making links to specific causative agents difficult. (cdc.gov)
  • Autoimmune diseases tend to cluster in families and in individuals (a person with one autoimmune disease is more likely to get another), which indicates that common mechanisms are involved in disease susceptibility. (cdc.gov)
  • Studies of the prevalence of autoimmune disease in monozygotic twins show that genetic as well as environmental factors (such as infection) are necessary for the disease to develop ( 6 ). (cdc.gov)
  • More often, many different microorganisms have been associated with a single autoimmune disease, which indicates that more than one infectious agent can induce the same disease through similar mechanisms ( Table ) ( 9 ). (cdc.gov)
  • Since infections generally occur well before the onset of symptoms of autoimmune disease, clinically linking a specific causative agent to a particular autoimmune disease is difficult ( Figure 2 ). (cdc.gov)
  • Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease of multifactorial origin. (bmj.com)
  • For the purposes of this workshop, immune mediated ear disease was defined to include both primary autoimmune sensorineural hearing loss (ASNHL) originating in the inner ear and secondary immune mediated ear disease/hearing loss (IMED) from systemic immune/autoimmune disease originating outside the inner ear. (nih.gov)
  • Investigations of hearing loss associated with the presence of systemic autoimmune disease, e.g. (nih.gov)
  • OMIM 152700) is a complex autoimmune disease that can affect multiple organ systems. (cdc.gov)
  • Genetics participation in pathogenesis appears to be relatively weak, since only a 4.7% concordance between twins has been observed [ 14 ] and family studies revealed only 1.6% frequency among first-degree relatives [ 8 , 15 ]. (hindawi.com)
  • The workshop panel consisted of 10 basic scientists and clinician-scientists with expertise in the areas of autoimmunity, immunology, otolaryngology, genetics, and infectious disease. (nih.gov)
  • Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. (nature.com)
  • By integrating data on the immune profiles of healthy monozygotic and dizygotic twin pairs, we estimated the variance in CD25 expression by helper T cells displaying a naive phenotype to be largely driven by genetic and shared early environmental influences. (nature.com)
  • Conversely, a registry-based study investigated the familial recurrence rate of MS and revealed that monozygotic twin pairs displayed the highest familial risk (17% age-adjusted risk for the unaffected twin) of developing MS, indicating a strong heritable effect 8 . (nature.com)
  • Here we conducted an in-depth pairwise analysis of the systemic immune compartment of 61 monozygotic twin pairs discordant for MS, in which both siblings carry the same genetic and early-life environmental risk for the disease, yet only one is affected by MS. This approach thus eliminated the majority of bias attributed to variable genetic and early environmental influences in a heterogenous population 17 , 18 . (nature.com)
  • Balanitis xerotica obliterans (BXO) has occurred in monozygotic twins, which suggests a genetic basis for the disease in some cases. (medscape.com)
  • Twin studies have demonstrated a 59% concordance for hand osteoarthritis, and familial predispositions to osteoarthritis have long been recognized. (orthopaedia.com)
  • on the other hand, in a twin study, the concordance for systemic sclerosis was found to be relatively low. (statpearls.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • In the U.S., about one in 13 Black or African American children is born with the sickle cell trait , according to the Centers for Disease Control and Prevention. (sideeffectspublicmedia.org)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The term includes a variety of diseases, from localized scleroderma (LS) to systemic sclerosis. (hindawi.com)
  • Based on these findings LS ought to be differentiated from systemic sclerosis by the absence of sclerodactylya, Raynaud's phenomenon, and capillaroscopic abnormalities [ 1 ]. (hindawi.com)
  • Skin pathogenesis seems to be similar between LScs, LS, and systemic sclerosis, although not fully understood [ 1 , 6 - 8 ]. (hindawi.com)
  • The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) ( 2 , 3 ), type 1 diabetes (T1D) ( 4 ), and other autoimmune diseases. (frontiersin.org)
  • Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
  • However, a body of circumstantial evidence links diabetes, multiple sclerosis, myocarditis, and many other autoimmune diseases with preceding infections ( Table ) ( 7 , 8 ). (cdc.gov)
  • Systemic sclerosis is a rare, complex, and chronic multisystem disease. (statpearls.com)
  • Skin involvement is one of the features of systemic sclerosis (SSc). (statpearls.com)
  • The hallmark features of systemic sclerosis include immune dysregulation with inflammation, vascular injury with an anatomic and functional abnormality, and systemic interstitial fibrosis of organs and skin, leading to multisystem organ damage. (statpearls.com)
  • [1] Cardiac involvement is well recognized in systemic sclerosis, which can affect the pericardium, the myocardium, and the conduction system. (statpearls.com)
  • Primary cardiac disease is reported in both diffuse and limited systemic sclerosis. (statpearls.com)
  • However, it was found to be more prevalent and more severe in diffuse systemic sclerosis. (statpearls.com)
  • The etiology of systemic sclerosis and the exact contributing genetic susceptibility is not fully understood. (statpearls.com)
  • [4] [5] As with other autoimmune diseases, the major histocompatibility complex (MHC) has been implicated in systemic sclerosis development. (statpearls.com)
  • Multiple and unique human leukocyte antigens (HLA) class II alleles are associated with systemic sclerosis and specific antibodies profile. (statpearls.com)
  • For example, HLA DQB1*0301, DRB1*1104, and DQA1*0501 haplotypes were found to be strongly associated with systemic sclerosis. (statpearls.com)
  • [6] Also, multiple non-MHC loci have been identified to be associated with systemic sclerosis. (statpearls.com)
  • [12] Epigenetic factors, most notably involving post-translational modification processes, have been described in systemic sclerosis. (statpearls.com)
  • Silica-related systemic sclerosis (Si-SSc) is associated with a specific antibody profile and more severe disease. (dermatoljournal.com)
  • Nonetheless, the expanding helper T cells of twins with MS, which were also elevated in non-twin patients with MS, emerged independent of the individual genetic makeup. (nature.com)
  • Hence, investigating how genetic predisposition and environmental triggers shape the interactions of individual immune cells is vital to understand the pathophysiology of autoimmune diseases including MS. (nature.com)
  • Advancements in genetic technologies and genomics have reshaped healthcare, defining the transition from a 'one size fits all' approach to personalised medicine focused on preventing and treating various diseases utilising a patient's clinical and genetic characteristics. (bmj.com)
  • Historically, systemic genetic studies began in high-income countries (HICs). (bmj.com)
  • Although osteoarthritis is considered a disease of wear and tear, clearly genetic factors are involved. (orthopaedia.com)
  • These studies, however, generally do not identify the actual genetic polymorphism that actually imparts the increased risk of disease. (medscape.com)
  • ALSTROM HALLGREN SYNDROME WITH CLASSICAL FINDINGS: A RARE CASE REPORT OF MONOGENIC CILIOPATHY CO-OCCURRENCE IN TWINS.Clinical Message: With the prevalence of 1 in million cases Alstorm Hallgren syndrome is one of the rare genetic disorder with poor prognosis. (authorea.com)
  • Some postulated that excess catecholamine released during stress can induce an exaggerated sympathetic response precipitating severe, reversible LV dysfunction in patients without coronary disease.2 Whether there is a genetic component is not well understood. (jefferson.edu)
  • Our aim was to discover genetic loci within the MHC region that are associated with specific clinical and/or immunological manifestations within SLE cases and hence to find evidence of genetic variants that may drive specific forms of the disease. (cdc.gov)
  • Covert racism, just like its twin overt racism, is neither innocent nor harmless. (york.ac.uk)
  • The scars of covert racism, often seen in terms of increased levels of disease, negative sanctions, inadequate information, and lost opportunities - serve to continually victimise racial non-elites. (york.ac.uk)
  • Sickle cell researchers, physicians and patients believe these disparities exist - and persist - because of systemic racism. (sideeffectspublicmedia.org)
  • In a series of key recommendations to the Biden Administration, ASN pledged its support to address the twin public health crises of COVID-19 and systemic racism. (kidneynews.org)
  • In an article published by Boston University, Andrew Thurston sheds light on a groundbreaking study that establishes a strong correlation between experiencing racism and an increased risk of heart disease among Black women. (stanford.edu)
  • To determine the association between racial discrimination and heart disease, the research team employed a detailed questionnaire that assessed participants' experiences of racism in various contexts, such as work, housing, and public spaces. (stanford.edu)
  • After examining the self-reported data alongside medical records, the researchers found that perceived racism in employment, housing, and interactions with the police was associated with a 26 percent higher risk of coronary heart disease for Black women. (stanford.edu)
  • A genomic atlas of systemic interindividual epigenetic variation in humans. (merckmanuals.com)
  • Scleroderma is a rare disease of unknown etiology, characterized by thickening and hardening of skin resulting from increased collagen production. (hindawi.com)
  • A deep understanding of disease mechanisms will be needed to deliver etiology-based strategies to reverse this vexing trend. (frontiersin.org)
  • Indeed, "functional and mechanistic work on the molecular etiology of disease remains one of the major challenges in modern biology" ( 5 ). (frontiersin.org)
  • The etiology of geminated teeth remains unknown but nutritional deficiency, endocrine inf luences, infectious/inf lammatory processes, excessive ingestion of medicines, hereditary or congenital diseases, local trauma and ionizing radiation are considered as causative factors 62 . (bvsalud.org)
  • 1 2 Tissue-specific inflammation of exocrine glands, primarily salivary and lacrimal glands, is a hallmark of the disease and results in dryness of the mouth and eyes. (bmj.com)
  • In point of fact, however, abnormalities of the cartilage surfaces, kinematics and soft tissue forces, as well as inflammation and hormonal influences can all cause or promote the disease. (orthopaedia.com)
  • 13 Socioeconomic factors have been associated with poorer outcomes and higher disease activity, 14 although it remains unclear whether it plays a role in disease susceptibility or subsequent progression. (lww.com)
  • 1 Discovering genomic and environmental determinants of health and disease and their interplay is essential for predicting personal susceptibility to various pathologies and individualised risk assessment, early disease detection, personalised treatment for better patient outcomes, and customising disease prevention strategies. (bmj.com)
  • Using complementary multimodal high-throughput and high-dimensional single-cell technologies in conjunction with data-driven computational tools, we identified an inflammatory shift in a monocyte cluster of twins with MS, coupled with the emergence of a population of IL-2 hyper-responsive transitional naive helper T cells as MS-related immune alterations. (nature.com)
  • Investigation of systemic inflammatory processes and identification of biomarkers. (nih.gov)
  • However, even identical twins with SLE are concordant for disease in only 25% of cases and are therefore discordant (ie, one twin has SLE and one does not) in about 75% of cases. (medscape.com)
  • The first describes the findings of a study involving a group of resilient older people aged 90 or more, while the second examines a case of severe Covid-19 in identical twins, only one of whom had long-term symptoms of the disease. (indiatimes.com)
  • Twin reversed arterial perfusion (TRAP) sequence occurs in monochorionic (identical) gestations, usually twins or or triplets, that have a direct artery-to-artery connection between them. (connecticutchildrens.org)
  • TRAP sequence is diagnosed by ultrasound demonstrating identical twins with one twin lacking a heart and multiple anomalies combined with an artery-to-artery connection between the twins. (connecticutchildrens.org)
  • Osteosarcoma in identical twins: A case report. (understandinginterventions.org)
  • Adult Still's disease in only one of identical twins. (mcmaster.ca)
  • from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
  • Localized scleroderma is a rare disease, characterized by sclerotic lesions. (hindawi.com)
  • In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. (hindawi.com)
  • Linear scleroderma en coup de sabre (LCsc) is a rare subset of LS. (hindawi.com)
  • Dry eye disease (DED) represents a heterogeneous and multifactorial group of disorders that affects the tears and ocular surface and results in discomfort and unpleasant visual phenomena, and in some cases, damage to the ocular surface. (bmj.com)
  • These twin consequences heighten our exposure to an especially perilous species of risk-"systemic" risk. (porchlightbooks.com)
  • Rationale and design of the Baylor Infant Twin Study-A study assessing obesity‐related risk factors from infancy. (merckmanuals.com)
  • For best results apply Headway Maxx as a preventative application when conditions become favourable for disease infection - use www.greencast.co.za to forecast disease risk. (syngentaturf.co.za)
  • Background Cigarette smoking is a well-established risk factor for several autoimmune diseases, but its role in primary Sjögren's syndrome (pSS) remains unclear. (bmj.com)
  • Given that the hand is not (typically) a weight-bearing structure, this risk suggests a possible systemic effect of an elevated BMI. (orthopaedia.com)
  • The best indicator of this risk is the size of the acardiac twin. (connecticutchildrens.org)
  • We use of ratio of the estimated fetal weight of the acardiac twin to the estimated fetal weight of the pump twin to identify pregnancies at risk. (connecticutchildrens.org)
  • Cutaneous manifestations may occur before systemic disease and can enable early risk stratification into subtypes, which affect prognosis. (dermatoljournal.com)
  • Patients with complete transposition of the great arteries (TGA) treated by the Senning procedure have a higher risk of developing heart failure due to: a) additional work load of the systemic (morphologic right) ventricle (sRV), b) arrhythmias, mainly caused by surgical implications at the atria as well as c) worsening of systemic tricuspid regurgitation. (techscience.com)
  • However, one major complication is the risk of intraventricular thrombus formation and systemic embolization. (jefferson.edu)
  • The disease tends to occur in families. (medscape.com)
  • The neurodegenerative process is believed to occur sub-clinically before the disease is typically diagnosed in the third decade of life. (frontiersin.org)
  • Three autoantibodies are most frequently creased metabolic demand appears to be the principle modinvolved with autoimmune thyroid disease. (ehd.org)
  • During times of crisis, such as Covid-19 and the public murder of George Floyd in America, systemic inequalities tend to become more apparent to a greater number of people. (york.ac.uk)
  • Dutch elm disease is the most destructive disease of elms in North America. (cityofeagan.com)
  • 1 The disease is clinically heterogeneous, and affected individuals only need 4 out of 11 of the American College of Rheumatology (ACR) criteria to be classified as having SLE. (cdc.gov)
  • Cardiac manifestations of the disease can be a result of the primary disease or secondary to the involvement of another organ. (statpearls.com)
  • Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
  • The data can be interpreted as smoking conferring protective effects, or reflecting early symptoms of pSS that affect smoking habits, emphasising the slow, progressive development of the disease. (bmj.com)
  • With limited test kits and slow results turnaround, we are trying to find out if information from wearable devices can help detect Infectious Disease or COVID-19 before symptoms emerge. (stanford.edu)
  • Conclusions Consistent with a chronic overlapping pain condition, patients with DE disease with more severe NOP symptoms report more frequent and severe non-ocular functional comorbid pain disorders. (bmj.com)
  • The discrepancy between symptoms and signs of disease may be partially explained by another, less-well-studied, component of DE, namely the presence of neuropathic ocular pain (NOP). (bmj.com)
  • Here, we present a case of twin siblings with signs and symptoms consistent with AS and associated with two AMLS1 variants.2. (authorea.com)
  • Soon after autoimmune diseases were first recognized more than a century ago, researchers began to associate them with viral and bacterial infections. (cdc.gov)
  • Since 2020, researchers in several countries, including Brazil, have been looking for genes that confer protection against the novel coronavirus, either preventing infection or avoiding progression to severe disease, in the hope that this knowledge will make a vital contribution to the development of vaccines and treatments for viral diseases. (indiatimes.com)
  • However, as with other viral diseases, reexposure to natural rubella occasionally leads to reinfection without clinical illness or detectable viremia. (cdc.gov)
  • Systemic imaging should also be considered in unilateral cases as a significant proportion of these patients will also have extra-ophthalmic disease. (bmj.com)
  • Collection of large (several thousand strong) cohorts of SLE patients and their family members has allowed genome-wide association studies to proceed in this disease. (medscape.com)
  • His work is focused on filling the social and economic needs of sickle cell disease patients and their families. (sideeffectspublicmedia.org)
  • The disease receives far less research funding compared to other illnesses, which slows progress in the development of new treatments and medical guidelines that help ensure patients get proper medical care. (sideeffectspublicmedia.org)
  • In the wake of the Coronavirus Disease-2019 (COVID-19) Pandemic, the Medicare program is expanding telehealth coverage enabling clinicians to provide a wider range of health care services to their patients without those patients having to travel to a health care facility thereby reducing exposure. (kidneynews.org)
  • Results Despite similar ocular surface findings, patients in the high NOP group had very different systemic (non-ocular) profiles with higher overall pain intensity ratings, higher frequency of comorbid chronic centralised pain conditions, lower quality-of-life indices and more abnormal mental health scores than those in the low NOP group. (bmj.com)
  • If you are a referring physician and have a MTC Localized disease All patients with Billig cheap Prednisone La thyroid cancer plan events accordingly. (gospelitmusic.es)
  • There are a few methylation sites that have been determined as a cause of environmental influences from age, lifestyle, or certain diseases. (wikipedia.org)
  • Identification of disease associations with antigens/antibodies that have positive predictive (diagnostic) value. (nih.gov)
  • We drew mainly on MS and T1D research because intensive investigation has generated detailed insights into vitamin D mechanisms in these diseases and provided valuable guidance for research on other autoimmune diseases. (frontiersin.org)
  • A recent chapter ( 6 ) and a review ( 7 ) have summarized vitamin D mechanisms in autoimmune diseases more generally. (frontiersin.org)
  • Surgical replacement of systemic tricuspid valve (sTV) and cardiac resynchronization device (CRT) implantation after nodal ablation resulted in recovering of the systolic function and a positive remodeling of the sRV. (techscience.com)
  • Researching the Longitudinal Systemic Effects of Dietary Fiber Supplementation. (stanford.edu)
  • Researching COVID-19 disease prediction with Pac-12 student athletes and Fitbit wearable devices. (stanford.edu)
  • needed in soon atopic disease The Recognition and Management of Early and Researching with for, BRIDGE OF CLAY is switch Zusak. (runkwitz.com)
  • detecting reversibility potential of myocardial systolic dysfunction in a severe valvular lesion combined with continuous systemic afterload settings and permanent tachyarrhythmia, and 2. (techscience.com)
  • A Dutch elm disease control program will be successful only if organized on a community-wide basis with the involvement and cooperation of property owners. (cityofeagan.com)
  • Direct involvement can manifest as conduction system abnormalities, myocardial, and pericardial disease. (statpearls.com)
  • It is particularly effective when the disease is less severe and there is no organ involvement. (passmed.uk)
  • Mono-zygotic twin studies reveal 8-29% of changes between the twins' teeth is from the environment. (wikipedia.org)
  • Gemination also described as double teeth, double formations, joined teeth, fused teeth or dental twinning is commonly seen in the maxillary anterior region 17,62 . (bvsalud.org)
  • Two recent editorials in the Clinical Journal of the American Society of Nephrology discuss the benefits and drawbacks of telehealth in the context of treating chronic kidney disease now and in the future. (kidneynews.org)
  • More than 37,000,000 Americans are affected by kidney diseases, and inequities and disparities have long plagued the care for many of those affected. (kidneynews.org)
  • 7 Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (nih.gov)
  • 32 the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA. (nih.gov)
  • prevention of subsequently iatrogenic worsening of systemic ventricular function due to permanent pacing. (techscience.com)
  • Both local and systemic diseases are increasingly treatable using modern therapeutic approaches 2 . (dermatoljournal.com)
  • As gene therapy pioneers begin to tackle systemic diseases and those with a large patient cohort, their focus must increasingly be set on the twin goals of exceptional AAV yields and quality, while constantly scanning the horizon for future technologies to help improve targeted delivery, improve process robustness and decrease cost of goods. (insights.bio)
  • A micro emulsion concentrate fungicide for the preventive, broad spectrum control of various diseases in lawn and turf grasses, sports fields and recreational areas. (syngentaturf.co.za)
  • In women with high pre-gestational BMI and twin pregnancy, our aims were to explore the biochemical and hematological parameters and to study the rate of obstetric adverse outcomes. (mdpi.com)
  • Once the ratio of the acardiac-to-pump twin weight exceeds 0.5, it identifies a pregnancy with a 50% chance of adverse outcome indicating the need for closer monitoring. (connecticutchildrens.org)
  • Once the ratio of the acardiac-to-pump twin weight exceeds 0.7, it identifies a pregnancy with a 90% chance of adverse pregnancy outcome without fetal intervention. (connecticutchildrens.org)
  • We present a unique case of a female patient who developed all these complications, who was successfully treated and was able to carry out a twin pregnancy. (techscience.com)
  • Hydroxychloroquine is used in the management of SLE as it prevents disease progression and has relatively mild side effects, for instance headache, nausea etc. (passmed.uk)
  • Clinical and radiology data were reviewed for laterality of IgG4-ROD and presence of extra-ophthalmic disease. (bmj.com)
  • Systemic imaging was performed in 20 (50%) cases due to clinical suspicion of extra-ophthalmic disease. (bmj.com)
  • Brenda Williams was part of a clinical trial in the 1980s for the first-ever drug to help manage sickle cell disease. (sideeffectspublicmedia.org)
  • These anomalies have clinical significance concerning esthetics, malocclusion and more importantly predisposing the development of dental caries and periodontal diseases. (bvsalud.org)
  • Twin reversed arterial perfusion (TRAP) sequence, also known as acardia, is a rare anomaly unique to multiple gestations in which one twin has an absent, rudimentary, or nonfunctioning heart. (connecticutchildrens.org)
  • There are more and more obese mothers with twin gestations. (mdpi.com)
  • Berger W, Kloeckener-Gruissem B, Neidhardt J. The molecular basis of human retinal and vitreoretinal diseases . (arizona.edu)
  • World Health Organization (WHO) has classified "the diseases of oral cavity, salivary glands and jaws" in WHO-International Classification of Disease -10 (WHO-ICD-10) (K00-K14) 23 . (bvsalud.org)
  • This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
  • In this perspective, as a result of advances diseases considerably contributed to the morbidity- in public policies and medical practice in care mortality situation. (bvsalud.org)
  • To address the question of whether autoimmune diseases can be induced by infections, first autoimmunity needs to be defined. (cdc.gov)
  • Local as well as systemic factors may be responsible for these developmental disturbances. (bvsalud.org)
  • One woman was 114 at the time of the study and was considered the oldest patient to have recovered from the disease in Brazil. (indiatimes.com)
  • In this case study, we present OXGENE's work with Innervate Therapeutics, who are developing gene therapies for Parkinson's and Motor Neuron Disease, that will be delivered directly to the brain via convection-enhanced delivery (CED). (insights.bio)