• However, the efficacy of traditional treatments is hindered by systemic toxicity, limited therapeutic effects, and drug resistance. (doaj.org)
  • However, traditional treatments may have limitations, such as systemic toxicity, poor bioavailability, and lack of specificity, which can lead to undesirable side effects and reduced efficacy. (alliedacademies.org)
  • Therefore, researchers have been exploring new strategies to enhance the delivery of anticancer drugs directly to the tumor site while minimizing toxicity to healthy tissues. (alliedacademies.org)
  • These systems involve the use of drug carriers or scaffolds that can be implanted directly into the bone to deliver high concentrations of anticancer drugs to the tumor site while minimizing systemic exposure and toxicity. (alliedacademies.org)
  • These systems can be designed to release drugs over a prolonged period, which can improve drug efficacy and reduce toxicity [ 2 ]. (alliedacademies.org)
  • These systems can deliver high concentrations of drugs directly to the tumor site, which can improve drug efficacy and reduce toxicity. (alliedacademies.org)
  • Systemic chemotherapy generally combines several cytotoxic drugs that have synergistic mechanisms of action and nonoverlapping toxicity. (mhmedical.com)
  • The current case study demonstrates that GcMAF and SDT can be used in combination with conventional therapies in patients with metastatic cancer, especially where treatment options are limited due to factors such as toxicity. (iiarjournals.org)
  • Immunotherapy has become an attractive new strategy in the treatment of cancer, due in part to minimal toxicity and an excellent safety profile when compared to conventional therapies such as chemotherapy and radiation. (iiarjournals.org)
  • Additionally, these treatment options often involve invasive procedures, drug resistance, and systemic toxicity [ 1 ]. (ntno.org)
  • However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)
  • More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)
  • High toxicity, mainly manifested as nausea, intestinal obstruction, leukopenia and thrombocytopenia , tachycardia, urinary closure or oliguria, so use must be cautious, when the above reaction is found, the drug should be stopped immediately. (cancerfax.com)
  • Although FAP has limited expression in normal adult tissues, it is highly expressed in the tumor microenvironment of many solid cancers - a characteristic that makes it an ideal target for anticancer therapy. (doaj.org)
  • Hence, it represents an important target for anticancer therapy. (nature.com)
  • In addition to its standalone treatments, Privo is planning to combine its products with immunotherapy to improve immunotherapy's outcome as 70% to 85% of patients taking immunotherapy drugs fail to respond to the treatment. (afcr.org)
  • GcMAF-based immunotherapy can be combined with many other therapies. (iiarjournals.org)
  • This case study also suggests a new concept of cancer treatment using local destruction of cancer tissue, in this case conducted with SDT, to be used in combination with GcMAF immunotherapy as a systemic treatment. (iiarjournals.org)
  • Immunotherapy includes systemic administration of cytokines, adaptive transfer of activated T cells, NK cells, dendritic cells and macrophages. (healthcaremarts.com)
  • Therefore, a combination of immunotherapy with conventional chemo- and radiation therapy is commonly used for the treatment of cancer. (healthcaremarts.com)
  • But systemic administration of cytokines, such as interferons and interleukins, commonly used for immunotherapy, have their own toxic side effects that can be life threatening to many patients. (healthcaremarts.com)
  • Systemic therapy is any treatment directed at destroying cancer cells throughout the body and may include chemotherapy, immunotherapy or newer precision cancer medicines. (hoapb.com)
  • Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial. (cdc.gov)
  • Subjects must have received no more than 2 lines of prior systemic therapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the locally advanced or metastatic setting. (mayo.edu)
  • Patients with stage III prostate cancer are curable and have a number of treatment options, including external beam radiation therapy (EBRT) with or without hormone therapy, surgical removal of the cancer with radical prostatectomy, or active surveillance without immediate treatment. (texasoncology.com)
  • Another form of treatment, usually hormone therapy, radiation therapy or participation in a clinical study is generally recommended. (texasoncology.com)
  • Chemotherapy, hormone therapy, and targeted therapy are systemic therapies. (nhcs.com.sg)
  • Age, menopausal status, the use of certain drugs (including menopausal hormone therapy), pregnancy, and genetics can affect breast density. (febohealth.com)
  • The two main types of hormone therapy include combined hormone therapy and estrogen replacement therapy. (febohealth.com)
  • The standard of care therapy for GBM consists in surgical resection of the tumor, followed by radiotherapy and adjuvant plus concomitant chemotherapy with Temozolomide (TMZ) (Stupp protocol) ( 3 ). (frontiersin.org)
  • Multimodal therapy with debulking surgery, combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. (biomedcentral.com)
  • Multimodal therapy incorporating surgery, radiotherapy, and chemotherapy is thus expected to improve survival in patients with RPS. (biomedcentral.com)
  • Preoperative radiotherapy was not administered because a large treatment volume could otherwise lead to late radiation-related damage of critical organs, such as the kidneys, liver and small bowel and because the patient required a therapeutic strategy that would produce more rapid relief of symptoms. (biomedcentral.com)
  • Radiation therapy, or radiotherapy, uses high-energy rays to damage or kill cancer cells by preventing them from growing and dividing. (kahlertregionalcancer.org)
  • In cancer treatment, MMWT has been used as monotherapy or in combination with chemo- and radiotherapy to increase immunity, and to reduce the toxic side effects of the above therapies [3,7,20]. (healthcaremarts.com)
  • Local therapy includes surgery and radiotherapy. (nhcs.com.sg)
  • If stomach cancer does not respond to drugs used in earlier treatments or if it comes back, different drugs or combinations may be used. (cancer.ca)
  • Treatments like chemotherapy, radiation and invasive surgery can wreak havoc on your body. (marijuanadoctors.com)
  • Hormone replacement therapy (HRT) can give you a higher risk of breast cancer if you have received such treatments with estrogen for several years or more at a time. (tourmyindia.com)
  • Radiation treatments as a young child or adult to treat other cancers of the chest can increase the risk of developing breast cancer. (tourmyindia.com)
  • The development of local drug delivery systems for bone cancer treatment has several advantages over traditional treatments. (alliedacademies.org)
  • Chemotherapy may be used as the primary treatment for your cancer, or it may be used to prepare you for other treatments such as radiation therapy or surgery. (healthline.com)
  • Standard of care surgical/radiation treatments for OC can severely damage a patient's ability to speak, chew, and swallow. (afcr.org)
  • Surgery combined with radiation is one of the most common treatments for malignant tumors in the head and neck. (bvsalud.org)
  • It is necessary to develop effective systemic treatments that can find and destroy cancer cells anywhere in the body in order to reduce the risk of cancer recurrence. (kahlertregionalcancer.org)
  • In addition to potentially shrinking the cancer so that it can be removed, neoadjuvant therapy allows patients to avoid the difficulty of undergoing treatments after surgery, which is a time when they may be experiencing side effects. (kahlertregionalcancer.org)
  • Our prostate cancer treatments include external beam radiation therapy (EBRT), where radiation is delivered from outside the body and aims a laser-like x-ray beam from multiple angles directly toward the treatment site. (genesiscare.com)
  • Going through treatments that require radiation exposure to the chest area may also increase your risk (specially if the exposure occurred at a younger age). (febohealth.com)
  • Second-line and subsequent therapy may involve single agents (eg, taxanes) or molecular therapy, such as ramucirumab to target vascular endothelial growth factor (VEGF) receptor or trastuzumab for metastatic adenocarcinoma that overexpresses HER2. (medscape.com)
  • Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. (wjgnet.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • The Graduate School of Biomedical Engineering at Tohoku University has created a lymphatic drug delivery system (LDDS) that allows anticancer medications to be administered directly into metastatic LNs. (justcarehealth.com)
  • Despite the prostate cancer being treated locally with radiation or surgery, over half of patients will experience recurrence of their cancer. (texasoncology.com)
  • An effective treatment is needed to cleanse the body of micrometastases in individuals at high risk of recurrence after local therapy. (texasoncology.com)
  • Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
  • Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. (frontiersin.org)
  • Our focus is translational research that advances the understanding of cancer treatment resistance mechanisms through the development of novel targeted therapies in order to improve patient survival. (massgeneral.org)
  • Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
  • With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
  • Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
  • Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
  • Furthermore, our studies have shown that the combined millimeter wave- and chemotherapy can reduce the tumor metastasis, and tumor resistance to chemotherapeutic drugs. (healthcaremarts.com)
  • Resistance to cancer drugs is common. (msdmanuals.com)
  • For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
  • Attempts to alter MDR1 function and prevent drug resistance have been unsuccessful. (msdmanuals.com)
  • Side effects of chemotherapy will depend mainly on the type of drug or combination, the dose, how it's given, if radiation therapy is given at the same time and your overall health. (cancer.ca)
  • By combining ADT with a higher dose of EBRT delivered with 3D-CRT or IMRT radiation therapy the outcomes of stage III patients have been improved. (texasoncology.com)
  • The established cornerstones of successful treatment with chemotherapy and radiation are (1) combination therapy, (2) dose intensity, and (3) adjuvant and neoadjuvant therapy. (mhmedical.com)
  • Most cytotoxic drugs have a steep dose-response curve, and small increments in dose can significantly influence a drug's therapeutic efficacy. (mhmedical.com)
  • TBI provides a uniform dose of radiation to the entire body, penetrating areas in traditional chemotherapy cannot reach. (justcarehealth.com)
  • They used irradiation gamma rays (a one-time dose of 1.0 GY) and anticancer drug CDDP adjusted with a solvent to have an osmotic pressure of 1987 kPa and a viscosity of 11.3 mPas. (justcarehealth.com)
  • Radiation is usually given in the form of high-energy beams that deposit the radiation dose into the body where cancer cells are located. (hoapb.com)
  • Successful, non-invasive delivery of biodegradable and non-toxic combination therapies that can target existing cancerous cells and prevent the development of new tumors all in one dose is ideal for clinical treatment. (ntno.org)
  • In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
  • The applied rigorous thermodynamical considerations show the proper terminology and dose concept of hyperthermia, which is based on the energy‑absorption (such as in the case of ionizing radiation) instead of the temperature‑based ideas. (spandidos-publications.com)
  • On the whole, according to the present study, the appropriate dose in oncological hyperthermia must use an energy‑based concept, as it is well‑known in all the ionizing radiation therapies. (spandidos-publications.com)
  • Despite recent advances in imaging, surgery, radiation, and systemic therapies, overall survival (OS) has improved only 5% in the last decade. (afcr.org)
  • Clinical trials are ongoing to evaluate neoadjuvant chemotherapy administered alone or in combination with adjuvant therapy, and the results of some small studies suggest that neoadjuvant therapy may improve survival. (kahlertregionalcancer.org)
  • The combination of concurrent fluorouracil (5-FU)and ionizing radiation therapy for patients with unresectable disease hasresulted in a twofold increase in median survival: approximately 10 months vs 5months. (cancernetwork.com)
  • In an attempt to improve systemic disease control, which could possiblyimpact overall survival, investigators at several centers are testingneoadjuvant chemotherapy strategies. (cancernetwork.com)
  • Perioperative therapy is common practice, with chemoradiotherapy after surgery showing a clear survival benefit. (medscape.com)
  • Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
  • In some cases, participation in a clinical trial utilizing new, innovative therapies may provide the most promising treatment. (radiationoncologyassociates.co)
  • These vesicles can encapsulate anticancer drugs and target them to the tumor site while minimizing exposure to healthy tissues. (alliedacademies.org)
  • This approach can enhance drug accumulation at the tumor site and reduce exposure to healthy tissues. (alliedacademies.org)
  • When designing these technologies, it is important to focus on adequate circulation time, specific delivery to cancerous tissue only, evasion of normal tissues and accumulation in the organs, lack of an immune response, and concomitant treatment and noninvasive monitoring in order for successful drug delivery to occur. (ntno.org)
  • Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)
  • Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
  • Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
  • X-rays or other types of ionizing in much higher dosage, are used to and there is excess risk of B-cel radiation, immunosuppression is maintain the functional and anatom- non-Hodgkin lymphoma (NHL) when most pronounced if the entire body, ical integrity of foreign tissues graft- immunosuppression is accompanied rather than a limited area, is irra- ed onto another individual, such as by continuing immune stimulation diated. (who.int)
  • Anticancer drugs that inhibit the molecular signaling pathways in malignant cells and drugs that overcome cancer's ability to evade immune response may provide a new foundation to improve outcome for children and adolescents with cancer. (mhmedical.com)
  • Weakened immune system: The risk of developing lymphoma may be increased by having a weakened immune system (such as from an inherited condition or certain drugs used after an organ transplant). (rxwiki.com)
  • We knew a combination of treatment that enhances systemic tumor immune effects would be an important therapeutic strategy," said graduate student Shota Sora, who was part of the research team headed by Professor Tetsuya Kodama. (justcarehealth.com)
  • After the therapy, the expression of immune-response related genes (CD4, CD8, and IL-12b) increased in the spleen, indicating an activated immune response. (justcarehealth.com)
  • In this article, we have reviewed the current knowledge of the effects of millimeter wave therapy (MMWT) on the immune system. (healthcaremarts.com)
  • As an adjunct therapy, they are widely used to protect the immune system from the toxic effects of chemo- and radiation therapy in the treatment of cancer [3,7]. (healthcaremarts.com)
  • This study will investigate the safety and effectiveness of the drug Leflunomide to treat uveitis-an inflammation of the eye caused by an immune system abnormality. (drugpatentwatch.com)
  • Modern immune checkpoint therapy demonstrates that cancer can be defeated. (mdpi.com)
  • from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
  • When combined with total-body irradiation (TBI), the new LDDS has a superior antitumor effect than conventional chemotherapy on early-stage LN metastasis. (justcarehealth.com)
  • Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)
  • The chemotherapy drugs help make the cancer cells more sensitive to radiation therapy. (cancer.ca)
  • One 2017 study showed that the FDA approved at least 150 chemotherapy drugs to treat cancer. (healthline.com)
  • Chemotherapy drugs are broadly classified based on their mode of action. (healthline.com)
  • Most chemotherapy drugs cannot tell the difference between a cancer cell and a healthy cell. (hoapb.com)
  • The eventual goal of these therapies is to provide targeted, individualized treatment options that allow health professionals to monitor the cancer tissue, trigger release of therapeutics, and monitor the response to the release. (ntno.org)
  • In this study, we constructed a nano-drug delivery system (NPF@DOX) targeting FAP to increase the therapeutic efficiency of synergistic chemo-photothermal therapy against OSCC.Methods: We utilized PEGylated nano-graphene oxide (NGO) to link doxorubicin (DOX) and fluorescently-labeled, FAP-targeted peptide chains via hydrogen bonding and π-π bonding to enhance the targeting capability of NPF@DOX. (doaj.org)
  • Importantly, FAP-targeted NPF@DOX in combination with PTT showed better tumor suppression performance in vivo and in vitro than did either therapy individually.Conclusion: NPF@DOX can precisely target OSCC, and combined treatment with chemical and photothermal therapy can improve the therapeutic outcomes of OSCC. (doaj.org)
  • Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
  • Secondly, the central nervous system (CNS) has a unique microenvironment and is protected by the blood-brain barrier (BBB), which limits the access of systemically delivered drugs to the brain reducing the therapeutic options available for GBM. (frontiersin.org)
  • Additionally, GBM is characterized by high inter-tumor and intra-tumor heterogeneity at a cellular, molecular, histological, and clinical level leading to very different responses to therapeutic agents and failure of targeted therapies ( 9 , 10 ). (frontiersin.org)
  • Lab principal investigator James C. Cusack, MD , is co-inventor of the patent "Use of NF-kappaB inhibition in combination therapy for cancer," (United States patent 6,831,057), which describes the therapeutic strategy noted above and is now licensed to two pharmaceutical companies for novel drug development. (massgeneral.org)
  • Sonodynamic therapy (SDT) using low-intensity ultrasound is a novel therapeutic modality. (iiarjournals.org)
  • The current standard treatment for stage III prostate cancer is external beam radiation therapy (EBRT) in conjunction with long-term androgen deprivation therapy (ADT). (texasoncology.com)
  • For chemotherapy, two-drug cytotoxic regimens that include a platinum agent are generally preferred for first-line therapy. (medscape.com)
  • Multidrug regimens typically are given as repetitive cycles of a fixed combination of drugs. (msdmanuals.com)
  • Perioperative regimens may combine benefits of both to improve long-term outcome. (cdc.gov)
  • It is particularly effective as an adjuvant therapy (therapy given in addition to the primary treatment) to surgery by helping to eliminate any microscopic cancer cells leftover after surgery. (kahlertregionalcancer.org)
  • Clinical studies that have evaluated adjuvant radiation therapy have yielded conflicting results and there currently remains no consensus whether radiation should be used as adjuvant therapy or combined with chemotherapy for the treatment of pancreatic cancer although it is offered to many patients. (kahlertregionalcancer.org)
  • Chemotherapy, targeted and hormonal therapy may be used before surgery (neoadjuvant therapy), or after surgery (adjuvant therapy). (nhcs.com.sg)
  • It is now known that Capecitabine can be combined with other active drugs such as Irinotecan and Oxaliplatin. (wjgnet.com)
  • Early clinical studies combining irinotecan (CPT-11, Camptosar) and gemcitabine (Gemzar) have yielded encouraging results. (cancernetwork.com)
  • This multi-institution phase II trial of induction irinotecan/gemcitabine followed by twice-weekly gemcitabine and upper abdominal radiation has been initiated to determine the activity of this regimen in patients with unresectable pancreatic cancer. (cancernetwork.com)
  • The multi-modality approach to treatment for osteosarcoma requires that patients be treated by a multi-disciplinary team consisting of the primary care physician, an orthopedic surgeon experienced in bone tumors, a pathologist, radiation oncologists, pediatric oncologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others. (radiationoncologyassociates.co)
  • Therefore, it is essential for patients with Hodgkin lymphoma to be treated at medical centers where medical oncologists, radiation oncologists and surgeons work together. (hoapb.com)
  • There are several types of local drug delivery systems for bone cancer treatment, including: Polymeric drug delivery systems: Polymeric drug delivery systems involve the use of biocompatible and biodegradable polymers that can encapsulate and release anticancer drugs in a controlled manner. (alliedacademies.org)
  • Combined radiofrequency ablation and PEI for the treatment of HCC. (aetna.com)
  • Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. (frontiersin.org)
  • Similar to surgery, radiation therapy is a local treatment used to eliminate or eradicate visible cancers. (kahlertregionalcancer.org)
  • Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)
  • who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
  • Treatment with surgery or radiation is referred to as local therapy because they treat prostate cancer in or near the prostate only. (texasoncology.com)
  • One approach that has gained significant attention in recent years is the development of local drug delivery systems for bone cancer treatment. (alliedacademies.org)
  • Systemic chemotherapy can be administered prior to or following local control of solid tumors and may be administered concurrently or sequentially with radiation therapy in children or adolescents with leukemia or solid tumors. (mhmedical.com)
  • Effective treatment of localized osteosarcoma requires both local and systemic therapy. (radiationoncologyassociates.co)
  • Local therapy consists of surgery and is directed at removing the primary osteosarcoma. (radiationoncologyassociates.co)
  • The delivery of systemic therapy in addition to local treatment is necessary to maximize a patient's chance of cure. (radiationoncologyassociates.co)
  • Hypothesis: Combining SBRT and nivolumab or nivolumab and ipilimumab will have similar (or better) local control rates as observed in SBRT only series. (mycancergenome.org)
  • Radiation therapy, unlike chemotherapy, is considered a local treatment. (hoapb.com)
  • However, local treatment of tumours with radiation therapy or surgery may be recommended when symptoms need to be alleviated. (nhcs.com.sg)
  • The major modalities of therapy are Surgery (for local and local-regional disease) Radiation. (msdmanuals.com)
  • Method: Local anesthesia, then electrocautery, this therapy is suitable for a small number and small area of ​​genital warts. (cancerfax.com)
  • Using a microwave surgical treatment machine and lidocaine for local anesthesia, insert the tip of the rod-shaped radiation probe into the sharp wetness and reach the base of the wart body. (cancerfax.com)
  • Treatment includes radiation therapy, medical therapy (local and systemic), and surgery, alone or in combination. (medscape.com)
  • The purpse of this study is to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for Telisotuzumab Vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate effectiveness in the selected population(s) (Stage 2). (mayo.edu)
  • Magnetic drug delivery systems: Magnetic drug delivery systems involve the use of magnetic nanoparticles that can be loaded with anticancer drugs and targeted to the tumor site using an external magnetic field. (alliedacademies.org)
  • In this review, we report and discuss recent advances in nanoparticle-mediated plasmonic photothermal therapy for GBM treatment and discuss the preclinical challenges commonly faced by researchers to develop and test such systems. (frontiersin.org)
  • Despite great advances in molecular understanding, identification of predictive factors and technological advances for patient's treatment and care, only a few drugs are currently approved for GBM and we are still far from reaching a cure ( 1 , 2 ). (frontiersin.org)
  • This leads to very poor and unchanged prognosis despite drug delivery advances. (frontiersin.org)
  • Risk-stratified, multimodality therapy is based on a variety of factors including patient age and gender, site of disease, extent of disease (localized or disseminated, or extent of extramedullary involvement), histology, molecular characteristics of the cancer cells, and response to therapy. (mhmedical.com)
  • Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
  • Background: The mainstay of therapy for newly diagnosed multiple myeloma patients remains systemic chemotherapy. (drugpatentwatch.com)
  • Systemic therapy is treatment directed at eliminating cancer cells throughout the body, and usually consists of chemotherapy. (radiationoncologyassociates.co)
  • The usual treatment regimen consists of daily applications of low power MMW radiation for 15 to 30 minutes for 5 to 15 days. (healthcaremarts.com)
  • Treatment of patients with stage II, III, IV or recurrent Hodgkin lymphoma typically consists of systemic therapy. (hoapb.com)
  • For many children and adolescents with solid tumors, complete surgical resection is a critical component of therapy. (mhmedical.com)
  • Understanding the principles of therapy and the inherent acute and long-term toxicities of cancer therapy is important for pediatricians and all healthcare providers who are caring for increasing numbers of childhood cancer survivors. (mhmedical.com)
  • End-organ function should be assessed before giving drugs with organ-specific toxicities. (msdmanuals.com)
  • The fundamental principle of curative therapy for children and adolescents with cancer is eradication of malignant cells and their precursors by tailoring treatment plans to incorporate surgery, radiation, and systemic chemotherapy, as required for specific cancer types and subtypes. (mhmedical.com)
  • Treatment with radiation is based on the principle of cytotoxicity against malignant cells and is more effective during cell mitosis and nonspecific to all cells exposed to radiation. (bvsalud.org)
  • When taken orally, P. leucotomos provides some degree of protection against the harmful effects of ultraviolet radiation,[3,4] thereby helping to minimize the photoaging effects of sunlight, including hyperpigmentation and textural changes. (jcadonline.com)
  • It is important for patients to obtain as much information as possible about the results of each treatment modality and to obtain more than one opinion on the matter, especially when deciding on surgery versus radiation therapy. (texasoncology.com)
  • Because a high percentage of these cancer patients are diagnosed in advanced stages, the treatment is increasingly invasive, including surgery, radiation therapy, or chemotherapy applied in isolation or in association with other treatment, depending on the tumor's site, histological degree, clinical stage, and the patient's physical condition 1 . (bvsalud.org)
  • Approximately 60% of the patients receive radiation therapy to treat head and neck cancer and most receive the combined therapy so that the development of a series of changes is expected to affect the oral cavity 5 . (bvsalud.org)
  • 4 Patients should clearly understand the risks and benefits of being treated with radiation and discuss them with their physician. (kahlertregionalcancer.org)
  • Approximately 25% to 33% of patients are unable to receive chemotherapy or radiation treatment following surgery. (kahlertregionalcancer.org)
  • Rapid therapy is essential because lymph node (LN) metastases in cancer patients is an indication that things are becoming worse. (justcarehealth.com)
  • With the results showing that both TBI and LDDS improve the efficacy of LB metastasis and distant metastases therapy, this novel approach is a promising way to treat cancer patients," added Sora. (justcarehealth.com)
  • Based upon some estimates, there are more than 1000 medical facilities in Russia alone where MMW therapy is being used, and the number of patients undergoing medical treatment exceeds 250 thousand per year [1]. (healthcaremarts.com)
  • In spite of the large numbers of patients treated with MMW therapy (MMWT) in the former Soviet Union, this treatment modality is virtually unknown to Western physicians and scientists. (healthcaremarts.com)
  • Following the induction therapy, patients without disease progression received twice-weekly gemcitabine at 40 mg/m² and radiation. (cancernetwork.com)
  • It has also improved symptoms in patients with rheumatoid arthritis, and the Food and Drug Administration has approved it for treating patients with this disease. (drugpatentwatch.com)
  • Radiation therapy is an important treatment modality for patients with Hodgkin lymphoma. (hoapb.com)
  • In 2002, Funkhouser coined the term "theranostics" to represent a new class of treatment options that are capable of providing both therapy and diagnostics to patients [ 13 ]. (ntno.org)
  • Therapy continues in responders or patients with stable disease. (msdmanuals.com)
  • This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
  • Sora and his colleagues investigated the dual therapy of LDDS and TBI on metastasis model mice for LN and distant metastases. (justcarehealth.com)
  • Capecitabine (Xeloda ® ) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specific conversion to the active drug. (wjgnet.com)
  • Radiation therapy is not typically useful in eradicating cancer cells that have already spread to other parts of the body. (kahlertregionalcancer.org)
  • Chemotherapy alone or combined modality treatment with chemotherapy and radiation therapy is typically utilized even for early stage lymphoma. (hoapb.com)
  • An in vivo bioluminescence imaging system, a high frequency ultrasound system, and histology showed the new therapy was more effective than employing LDDS or TBI alone. (justcarehealth.com)
  • In an effort to increase the chance that a cancer may be surgically removed, some cancer centers use radiation therapy and chemotherapy before surgery to shrink the cancer. (kahlertregionalcancer.org)
  • Hypothesis: Combining radiation and nivolumab or nivolumab and ipilimumab will improve the best overall response rate compared to historical controls with SBRT or nivolumab alone. (mycancergenome.org)
  • Furthermore, NPF@DOX exhibited a high photothermal conversion efficiency (52.48%) under near-infrared radiation. (doaj.org)
  • As a consequence, non-neoplastic cells exposed to radiation are subjected to destruction, a fact that limits the dosage to be used in cancer therapy 6 . (bvsalud.org)
  • Chemotherapy uses anticancer (cytotoxic) drugs to destroy cancer cells. (cancer.ca)
  • This means that the drugs travel through the blood to reach and destroy cancer cells all over the body, including those that may have broken away from the primary tumour in the stomach. (cancer.ca)
  • Chemotherapy is a chemical drug therapy that's often used to destroy cancer cells in your body. (healthline.com)
  • These medicines are currently used mainly in the treatment of advanced disease alone or in combination with other therapies. (hoapb.com)