• Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. (springer.com)
  • Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. (springer.com)
  • Cardiovascular disease (CVD) is a world-leading health problem and encompasses a broad spectrum of disorders, including diseases of the blood vessels, the heart muscle, the electrical conduction system, and congenital heart disease. (springer.com)
  • Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
  • Cardiovascular diseases are responsible for 50 % of natural deaths in the EU. (europa.eu)
  • The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated. (elifesciences.org)
  • The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response. (elifesciences.org)
  • Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
  • In this capacity, she has worked across federal and private partners to execute evidence-based strategies to prevent cardiovascular diseases and improve health. (cdc.gov)
  • An often studied liquid biofluid problem is that of blood flow in the human cardiovascular system. (wikipedia.org)
  • Multiple system atrophy (MSA) is a progressive, sporadic and adult-onset neurodegenerative disease characterized by a combination of autonomic failure with parkinsonism, cerebellar ataxia and autonomic dysfunction ( 1 ). (frontiersin.org)
  • Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease. (bmj.com)
  • Subjects Patients aged 30-84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. (bmj.com)
  • Cardiovascular disease is the leading cause of premature death and a major cause of disability in the UK. (bmj.com)
  • 1 National policies now support targeting of interventions to reduce risk of cardiovascular disease among high risk patients. (bmj.com)
  • An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. (mcw.edu)
  • Animal models have many facets that mimic various disease conditions in humans representing the importance for its tremendous use in biomedical research (Mukherjee et al. (springer.com)
  • 2017). Cardiovascular Disease and Diabetes http://www.org/HEARTORG/Conditions/Diabetes/whyDiabetesMatters/Cardiovascular-Disease-Diabetes UCM 313865 Article.jsp. (poltekkes-smg.ac.id)
  • With the increase in aging and cardiovascular risk factors, the morbidity and mortality of atherosclerotic cardiovascular disease (ASCVD), represented by ischemic heart disease and stroke, continue to rise in China. (biomedcentral.com)
  • Atherosclerotic cardiovascular disease (ASCVD), which mostly involves heart attacks and strokes caused by atherosclerosis, is one of the main causes of death worldwide [ 1 ]. (biomedcentral.com)
  • and how various cutting-edge technologies and models are being employed to study heart biology, uncover disease-related processes, and identify therapeutic targets. (cshlpress.com)
  • We found marginal improvement in influenza vaccination during the past hold income less than $50,000, and no health insurance had a decade among adults with cardiovascular disease, lagging far behind the lower prevalence of vaccination. (cdc.gov)
  • Influenza vaccination can reduce the incidence of cardiovascular ally during the past decade but is far behind the targeted national disease (CVD) in the US. (cdc.gov)
  • It constitutes a demographic-epidemiological model, which represents the population between 35 and 95 years of age and uses a logistic regression model based on the Framingham equation to estimate the annual incidence of cardiovascular disease. (bvsalud.org)
  • METHODS: A discrete event simulation of hypertension care processes projected blood pressure, medication-related adverse events, fatal and nonfatal cardiovascular disease events, and noncardiovascular disease death in LABBPS participants. (bvsalud.org)
  • The purposes of this study were to estimate the extent to which the 31% relative increase in PI among 35-64 years old Mexicans between 2006 and 2012 influenced diabetes (T2D) and cardiovascular disease (CVD) incidence and mortality, and to estimate the impact of the World Health Organization recommended 10% and 15% relative decrease in PI on CVD and T2D incidence and mortality by 2025 and 2030, respectively. (bvsalud.org)
  • Implementation of Hospital-to-Home Model for Nutritional Nursing Management of Patients with Chronic Kidney Disease Using Artificial Intelligence Algorithm Combined with CT Internet. (cdc.gov)
  • Cardiovascular-related morbidity and mortality remain the world's number one killer. (healthadvances.com)
  • Machine learning models for diabetes management in acute care using electronic medical records: A systematic review. (cdc.gov)
  • Biomechanics is the study of the structure, function and motion of the mechanical aspects of biological systems, at any level from whole organisms to organs , cells and cell organelles , [1] using the methods of mechanics . (wikipedia.org)
  • Comparative biomechanics is often applied in medicine (with regards to common model organisms such as mice and rats) as well as in biomimetics , which looks to nature for solutions to engineering problems. (wikipedia.org)
  • Computational biomechanics is the application of engineering computational tools, such as the Finite element method to study the mechanics of biological systems. (wikipedia.org)
  • Ladies and gentlemen, thank you for standing by, and welcome to the Cardiovascular Systems Inc. Fiscal 2020 First Quarter Earnings Conference Call. (nasdaq.com)
  • In the cardiovascular system, mercury induces hypertension in humans and animals that has wide-ranging consequences, including alterations in endothelial function. (hindawi.com)
  • The results described in this paper indicate that mercury exposure, even at low doses, affects endothelial and cardiovascular function. (hindawi.com)
  • Cox proportional hazards models in the derivation cohort to derive risk equations accounting for competing risks. (bmj.com)
  • Maths is non-invasive - there's no need to operate - so we can use equations to describe the circulatory system in order to better understand human physiology and why certain pathologies occur. (europa.eu)
  • Under certain mathematical circumstances, blood flow can be modeled by the Navier-Stokes equations . (wikipedia.org)
  • Cardiovascular autonomic failure (AF) is one of the main features which worsens dramatically the quality of life. (frontiersin.org)
  • The cardiovascular AF in MSA is thought to be mainly due to a progressive neurodegeneration of several areas involved in autonomic control of the cardiovascular system such as inter alia , cholinergic neurons in the ventrolateral ambiguous nucleus and dorsal motor nucleus of the vagus nerve ( 5 ). (frontiersin.org)
  • Many studies in MSA patients have already depicted cardiovascular autonomic impairments with a reduction in sympathetic and parasympathetic activities ( 6 - 9 ). (frontiersin.org)
  • The interactions between seizures and the autonomic nervous system (ANS) are very complex. (medscape.com)
  • Probable paths of propagation of the epileptic electrical activity to the limbic system and autonomic nuclei. (medscape.com)
  • Certain autonomic changes, especially cardiovascular, are due to antiseizure medications (ASM). (medscape.com)
  • To understand the effect of epilepsy on the autonomic nervous system (ANS), the autonomic functions in patients with epilepsy can be evaluated both during seizures and in their baseline state, also known as the interictal state. (medscape.com)
  • The autonomic regulation or cardiovascular function plays the most crucial role of the autonomic functions and has been the most evaluated part of the ANS. (medscape.com)
  • Mechanical modeling using finite element analysis has been used to interpret the experimental observation of plant cell growth to understand how they differentiate, for instance. (wikipedia.org)
  • Using data from the Behavioral Risk Factor Surveillance System (2015-2017) for 44 states, the District of Columbia, and Puerto Rico, we classified 109,268 baby boomers as caregivers or noncaregivers and compared their general health (poor or fair vs good, very good, or excellent), chronic health conditions, and frequent mental distress (FMD). (cdc.gov)
  • Presents findings from a test of the Million Hearts model for CMS through a large, randomized trial, including hundreds of thousands of beneficiaries across the United States of the Million Hearts model from 2017 to 2021. (rand.org)
  • Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. (lu.se)
  • The regulatory effect of the sympathetic and parasympathetic nervous system on the end organs can be evaluated and quantified. (medscape.com)
  • Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine-taurine containing beverages. (researchgate.net)
  • Traditional ASCVD prediction models (Framingham and China-PAR models) were constructed in the test set. (biomedcentral.com)
  • Currently, the most commonly used survival analysis method is the Cox proportional hazards model, and most traditional ASCVD prediction models are constructed based on this model. (biomedcentral.com)
  • To develop, evaluate and test an array of prediction models, we created stratified (on the outcome measure) random samples of our study population. (lu.se)
  • Practical means to increase the dialytic clearance of bound solutes are required to perform such studies.METHODS: Artificial plasma was dialyzed using two dialysis systems in series. (stanford.edu)
  • Stress coping models or process models have shown that the strain associated with caregiving can result in psychological distress and interference with the immune system (8) and cardiovascular functions (6,7). (cdc.gov)
  • These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. (hrb.ie)
  • The second difficulty is in modelling the topologies and geometries of the human body, both healthy and damaged. (europa.eu)
  • Finally, for the carotid or coronary arteries, we describe the 3D behaviour of the blood so we use the lower-order models to provide accurate inputs to the more detailed 3D models," the professor continues. (europa.eu)
  • The in vivo neointimal hyperplasia model was established 2 weeks after the carotid artery balloon injury in SHR rats. (hindawi.com)
  • Aims: Estimation of prognosis in pulmonary arterial hypertension (PAH) has been influenced by that various risk stratification models use different numbers of prognostic parameters, as well as the lack of a comprehensive and time-saving risk assessment calculator. (lu.se)
  • Risk scores were calculated using the original Swedish Pulmonary Arterial Hypertension Registry (SPAHR)/Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) three-strata model, the updated SPAHR three-strata model with divided intermediate risk, and the simplified three-parameter COMPERA 2.0 four-strata model. (lu.se)
  • Our findings support the 2022 ESC/ERS pulmonary hypertension guidelines' strategy for risk stratification suggesting the utilization of a three-strata model at baseline and a simplified four-strata model at follow-ups. (lu.se)
  • Our results support the 2022 ESC/ERS pulmonary hypertension guidelines' risk stratification strategy, additionally suggesting the updated SPAHR three-strata model with divided intermediate risk, as a promising complement to the new simplified three-parameter COMPERA 2.0 four-strata strategy, when a more comprehensive overview is needed. (lu.se)
  • Anatomical changes seen in these brains can explain partially the cardiovascular and pulmonary events that would lead to SUDEP. (medscape.com)
  • An impaired HRV was observed at 12 months of age in PLP-α-syn female but not in male mice, indicative of cardiovascular AF. (frontiersin.org)
  • Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
  • Causal impact of a full-gene deletion will be investigated in all organ systems by comparing phenotypic characteristics of KO-mice with wild-type control mice of the same genetic C57BL/6N background (Munoz-Fuentes et al. (springer.com)
  • Professor Alfio Quarteroni of the École Polytechnique Fédérale de Lausanne (EPFL, Switzerland) is leading the Mathcard project in developing mathematical models of the blood flow in our cardiovascular system. (europa.eu)
  • Biotribology is the study of friction , wear and lubrication of biological systems, especially human joints such as hips and knees. (wikipedia.org)
  • The prevalence of patients with an increase in the cardiovascular system is increasing. (poltekkes-smg.ac.id)
  • The main objective of this study was to investigate the prevalence of T. gondii among adults in the United States and its association with cardiovascular health using data from the National Health and Nutrition Examination Survey (NHANES 2009-2010). (mdpi.com)
  • The gap between the care patients should get and what they actually receive likely contributes to thousands of preventable deaths each year, and health care systems worldwide continue to face the challenge of delivering quality care at an affordable cost. (rand.org)
  • The National Health System has an innovation problem. (rand.org)
  • At Health Advances, our experience across sectors helps clients navigate the complex commercial challenges in the cardiovascular market and develop strong value propositions to create competitive advantage. (healthadvances.com)
  • A biotechnology company needed a digital health strategy as they prepared to launch a novel therapeutic in the cardiovascular market. (healthadvances.com)
  • For an early-stage biopharmaceutical company, Health Advances assessed the global opportunity and developed sales forecasts for two cardiovascular indications. (healthadvances.com)
  • A manufacturer with a novel cardiovascular monitoring technology asked Health Advances to map out a market access strategy to support discussions with investors. (healthadvances.com)
  • At baseline, both the original SPAHR/COMPERA and the updated SPAHR models, using up to six parameters, provided the highest accuracy (uAUC = 0.73 for both models) in predicting 1-, 3-, and 5-year mortality. (lu.se)
  • At follow-ups, the updated SPAHR model with divided intermediate risk (7-11 parameters) provided the highest accuracy for 1-, 3-, and 5-year mortality (uAUC = 0.90), followed by the original SPAHR/COMPERA model (7-11 parameters) (uAUC = 0.88) and the COMPERA 2.0 model (uAUC = 0.85). (lu.se)
  • Computational models and simulations are used to predict the relationship between parameters that are otherwise challenging to test experimentally, or used to design more relevant experiments reducing the time and costs of experiments. (wikipedia.org)
  • Towards a safe and efficient clinical implementation of machine learning in radiation oncology by exploring model interpretability, explainability and data-model dependency. (cdc.gov)
  • Indeed, women have been reported to develop initially motor symptoms, with men exhibiting mainly cardiovascular dysfunction ( 13 ). (frontiersin.org)
  • We assessed calibration and discrimination for 4 risk scores: published versions of FRS and PCE and versions obtained by refitting models using a subset of the available EHD. (healthpartners.com)
  • Refitting the published models using EHD did not substantially improve calibration or discrimination. (healthpartners.com)
  • Different models' discrimination and calibration degrees were compared to find the optimal prediction model for this population according to different genders and further analyze the risk factors of ASCVD. (biomedcentral.com)
  • By comparing the discrimination and calibration degrees of each model, the RSF showed the best prediction performance in males and females (male: Area Under Curve (AUC) 0.791 (95%CI 0.767,0.813), C statistic 0.780 (95%CI 0.730,0.829), Brier Score (BS):0.060, female: AUC 0.759 (95%CI 0.734,0.783) C statistic was 0.737 (95%CI 0.702,0.771), BS:0.110). (biomedcentral.com)
  • The final model showed excellent calibration. (lu.se)
  • Introduction computer-assisted telephone interview systems to perform struc- tured scripted interviews. (cdc.gov)
  • We have invented a unique approach," he continues, "building 3D models for vessels where we need to simulate all details and using lower-order models for other parts. (europa.eu)
  • Roy did not arrange specific interventions for each diagnosis based on Roy's Adaptation Model which explained the coping relationships on the regulator and cognator subsystems. (poltekkes-smg.ac.id)
  • This volume is a valuable reference for cardiologists, geneticists, and cell and developmental biologists interested in this complex, vital organ and the future of cardiovascular medicine. (cshlpress.com)
  • Most of the safety concerns have centered on the effect of energy drinks on cardiovascular and central nervous system function. (researchgate.net)
  • The use of back belts may produce temporary strain on the cardiovascular system. (cdc.gov)
  • However, accompanying the exponential growth in energy drink usage have been recent case reports and analyses from the National Poison Data System, raising questions regarding the safety of energy drinks. (researchgate.net)
  • The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)
  • As a former Senior Vice President for Science and Quality at the American College of Cardiology, Dr. Wright oversaw the development of guidelines, performance measures and appropriate use criteria to include the National Cardiovascular Data Registry. (cdc.gov)
  • What matters in a transferable neural network model for relation classification in the biomedical domain? (crossref.org)
  • Our findings furthermore support the utility of the updated SPAHR model with divided intermediate risk, when a more comprehensive assessment is needed at follow-ups, complementing the three-parameter COMPERA 2.0 model. (lu.se)
  • A global life sciences investment fund needed a rapid diligence on a cardiovascular investment opportunity. (healthadvances.com)
  • At the cardiovascular level, they concluded that 'if there are any interactions between caffeine and taurine, taurine might reduce the cardiovascular effects of caffeine. (researchgate.net)
  • 2 Therefore, the purpose of this study was to elucidate the impact of caffeine and taurine on arrhythmogenesis in a sensitive whole-heart model. (researchgate.net)
  • Therefore, purpose of this study was to assess acute electrophysiologic effects of caffeine and taurine, two of the main ingredients of energy drinks, in an experimental whole-heart model. (researchgate.net)
  • The purpose of the study was to discuss the problem of nursing care in patients with cardiovascular system disorders. (poltekkes-smg.ac.id)
  • This study uses a case study design with nursing care given to one patient with a cardiovascular system, age disagreement and does not specify the sex to be used in a case study. (poltekkes-smg.ac.id)
  • Considering the limitation of studies investigating the relationship between T. gondii and cardiovascular biomarkers, this study was focused on assessing the association of T. gondii to nine cardiovascular biomarkers. (mdpi.com)
  • Therefore, this study aims to establish a population ASCVD prediction model in rural areas of Xinjiang using survival analysis. (biomedcentral.com)
  • Development and validation of a deep-learning-based pediatric early warning system: A single-center study. (cdc.gov)
  • GlobalData's proprietary machine learning models consider these events in real time, to produce quantitative changes to the LOA and PTSR along with qualitative reasoning why the likelihood of approval has changed. (globaldata.com)
  • Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as the RING finger protein 10 ( Rfn10 ), F-box protein 38 ( Fbxo38 ), and Dipeptidyl peptidase 8 ( Dpp8 ). (springer.com)
  • We can model the release of the drug, blood flow around the stent and absorption of the drug by the wall," says Prof. Quarteroni. (europa.eu)
  • Nurses are expected to have a contribution in the handling of patients with cardiovascular disorders by implementing and deepening using the Roy Adaptation Model (MAR). The role as care provider was applied to men who were supported 70 years with CAD 3VD EF 52% POST-CABG X3 OFF PUMP. (poltekkes-smg.ac.id)
  • Angiotensin II (AngII), as the major effector of the renin-angiotensin-aldosterone system (RAAS), plays an important role in regulating blood pressure and arterial remodeling [ 5 ]. (hindawi.com)
  • Of the 10% of patients in the validation cohort classified at highest risk with either the lifetime risk model or the 10 year risk model, only 18 385(14.5%) were at high risk on both measures. (bmj.com)
  • Roy's Adaptation Model Theory can be used in providing nursing care to patients with cardiovascular system disorders using a format adapted to the format in the hospital. (poltekkes-smg.ac.id)
  • We therefore evaluated the various European Society of Cardiology (ESC)-/European Respiratory Society (ERS)-based three-and four-strata risk stratification models and established a comprehensive internet-based calculator to facilitate risk assessment. (lu.se)
  • Recently, respiratory systems in insects have been studied for bioinspiration for designing improved microfluidic devices. (wikipedia.org)
  • A Cox regression, Lasso-Cox regression, and random survival forest (RSF) model were established in the training set. (biomedcentral.com)
  • Interpretation: Thirty-day survival and neurological outcome in OHCA can rapidly and reliably be estimated during ongoing cardiopulmonary resuscitation in the emergency room using a machine learning model incorporating widely available variables. (lu.se)
  • Chemical measurements tested the ability of the recirculating system to increase the clearance of selected solutes. (stanford.edu)
  • 1) Do published risk scores applied to EHD yield accurate estimates of cardiovascular risk? (healthpartners.com)
  • and model refitting does not meaningfully improve the accuracy of risk estimates. (healthpartners.com)
  • A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection. (elifesciences.org)
  • For better prevention and intervention, relevant guidelines recommend using predictive models for early detection of ASCVD high-risk groups. (biomedcentral.com)