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  • immunomodulatory
  • Natural peptides are multifunctional mediators of the innate immune response, with some direct antimicrobial activity and diverse immunomodulatory properties. (jimmunol.org)
  • In this study, an immunomodulatory peptide IDR-1002 was selected from a library of bactenecin derivatives based on its substantially more potent ability to induce chemokines in human PBMCs. (jimmunol.org)
  • These results highlight the importance of the chemokine induction activity of host defense peptides and demonstrate that the optimization of the ex vivo chemokine-induction properties of peptides is a promising method for the rational development of immunomodulatory IDR peptides with enhanced anti-infective activity. (jimmunol.org)
  • The immunomodulatory activities of such peptides are extremely diverse and include stimulation of chemotaxis and chemokine production ( 7 , 8 ), promotion of leukocyte antimicrobial functions ( 9 ), regulation of neutrophil and epithelial cell apoptosis ( 10 , 11 ), regulation of dendritic cell differentiation and activation, stimulation of epithelial cell migration and wound healing, promotion of angiogenesis, and many others (reviewed in Refs. (jimmunol.org)
  • residues
  • A peptide spanning helix H1 and beta-strand S2 (residues 142-166 in human numbering) was studied by circular dichroism and nuclear magnetic resonance spectroscopies. (rcsb.org)
  • The structures of the peptide calculated by MD showed solvent-dependent internal stabilizing forces of the structures and evidenced a higher mobility of the residues following the end of helix H1. (rcsb.org)
  • gene
  • The chemical properties of different formulation materials determine their special features for nucleic acid delivery, so understanding the property-function correlation of the formulation materials will inspire the development of next-generation gene delivery carriers. (mdpi.com)
  • bind
  • Because DNA backbones have a negative electrical charge, opposing strands tend to repel each other although the tendency of complementary nucleic acids to bind overcomes that repulsion. (mit.edu)
  • nuclear
  • Peptide 2 Enhances Anti-CD3- Induced Apoptosis in Bcl-2-Positive Cells (A) Typical apoptotic nuclear morphology (arrow, Hoechst 33342 stain) 24 hr after 5 mg/ml antiCD3 treatment of Jurkat cells. (zanran.com)
  • fragments
  • This peptide in aqueous solution, in contrast to many prion fragments studied earlier (1) is highly soluble and (2) does not aggregate until the millimolar concentration range, and (3) exhibits an intrinsic propensity to a beta-hairpin-like conformation at neutral pH. (rcsb.org)
  • fold
  • We found that this peptide can also fold into a helix H1 conformation when dissolved in a TFE/PB mixture. (rcsb.org)
  • In both cases, we observed an increase in binding affinity of ~1000-fold (ΔΔG = ~4.1 kcal/mol) between the individual peptides and final bivalent synbody construct. (pubmedcentralcanada.ca)
  • CHEMISTRY
  • This work was made possible by the support of the DSF Charitable Foundation, which has donated $7 million to CNAST , enabling the center to engage in fundamental research aimed at developing synthetic chemistry solutions for the diagnosis and treatment of disease. (healthcanal.com)
  • activity
  • The protective activity of the peptide was associated with in vivo augmentation of chemokine production and recruitment of neutrophils and monocytes to the site of infection. (jimmunol.org)
  • Host
  • With the rapid rise in the incidence of multidrug resistant infections, there is substantial interest in host defense peptides as templates for production of new antimicrobial therapeutics. (jimmunol.org)
  • known
  • Thymidylate synthase/TS (EC 2.1.1.45), Dihydropyrimidine degydrogenase/DPD (EC 1.3.1.2), Thymidene phosphorylase/TP (EC 2.4.2.4), and Orate phosphorybosyl transferase/OPRT (EC 2.4.2.10) are known as key enzymes related to nucleic-acid metabolism within the body. (takarabio.com)