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NanofibersHydrogelPeptidesTissue ScaffoldsNanostructuresTissue EngineeringBiocompatible MaterialsPolyestersPolyglycolic AcidNanotechnologyPolymersHydrogelsLactic AcidMaterials TestingMicroscopy, Electron, ScanningAmino Acid SequenceEncyclopedias as TopicHistiocytosis, Langerhans-CellEpoxy ResinsForensic BallisticsProdrugsProteasome Endopeptidase ComplexProteasome InhibitorsAntibodiesApolipoproteins EVascular Cell Adhesion Molecule-1Antibody Specificity
Self-healing hExtracellular matrixAmyloid-like PeptidesTissuePolymersConductive hydrogelsVitroElectrospunSynthesisCrosslinked polymerNanoparticlesVivoAntimicrobialStiffnessCollagenousStructuresGelatinPolymericBiomimeticDifferentiationPolyethyleneMembraneMonomersEndotheliumPropertiesProposesStabilityFunctionalNanoCellGrowthMaterialSurfaceDeliveryFormationMethodStructureMethodsDesignResults
Self-healing h3
Extracellular matrix5
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • For this purpose, we developed a fibrous scaffold resembling the bone/bone marrow extracellular matrix (ECM) based on protein without addition of synthetic polymers. (nature.com)
  • Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
  • 8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
  • Synthetic biodegradable nanofibers are filamentary structures that mimic the fibrous extracellular matrix and can function as cellular scaffolds for stem cell transplantation, functining as a support for adhesion, replication and differentiation of these cells. (fapesp.br)
Amyloid-like Peptides1
  • Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations. (acs.org)
Tissue7
  • A more recent approach proposes tissue engineering the electrode interface through the use of encapsulated neurons within hydrogel coatings. (frontiersin.org)
  • Our results highlight the remarkablepotential use of BC-Ppy scaffolds as a cardiac patch in tissue regenerativetherapies. (ibecbarcelona.eu)
  • This important feature is significantly have been widely used in pharmaceutical and medical applications as synthetic material for bone tissue engineering, wound healing and drug delivery. (ijbnb.com)
  • Chitosan or combined with synthetic/ natural polymers based composites have been widely investigated for versatile biomedical use of drug delivery, wound healing, anti-microbial agent, tissue engineering, food preservative and anti-tumor activities. (ijbnb.com)
  • Ebru Demir from Sabanxci University has been investigating the use of peptide-based hydrogels as scaffolds for corneal tissue engineering. (typepad.com)
  • Demir's experiments show that the peptide-based hydrogels are biocompatible, have similar transparency to natural corneal tissue, and are strong enough to support corneal cell and blood vessel regeneration. (typepad.com)
  • These properties make the peptide-based hydrogels a good candidate material for use in corneal tissue scaffolds. (typepad.com)
Polymers2
  • In addition, both natural polymers such as proteins or synthetic polymers with a high affinity for water may be used as starting materials when selecting a hydrogel. (wikipedia.org)
  • Hydrogel polymers present a versatile coating option for electrodes as they can be chemically modified to provide a soft and conductive scaffold. (frontiersin.org)
Conductive hydrogels1
Vitro5
  • Three types (Ø 12, 15 and 19 mm) of cylindrical scaffolds were manufactured from the knit, and the properties of those were studied in vitro for 48 weeks. (researchgate.net)
  • The in vitro and in vivo scaffolds lost their mechanical properties after 1 week. (researchgate.net)
  • Faster degradation was observed with in vitro scaffolds compared to in vivo scaffolds during the one-year follow up. (researchgate.net)
  • Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)
  • A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
Electrospun1
  • Here, we demonstrate a high throughput method based on fast transfer of electrospun nanofiber film from roughed metal foil to a receiving mesh substrate. (acs.org)
Synthesis3
  • A variety of different polymerization methods may be utilized for the synthesis of the polymer chains that make up hydrogels. (wikipedia.org)
  • Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides. (uni-bielefeld.de)
  • RAFT polymerization as a scaffold for the synthesis of SNAP-tag labels. (sun.ac.za)
Crosslinked polymer1
  • A hydrogel is a macromolecular polymer gel constructed of a network of crosslinked polymer chains. (wikipedia.org)
Nanoparticles3
  • The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)
  • In the literature, there have been described as many various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles, which can be used in the treatment of chronic periodontal disease. (encyclopedia.pub)
  • The review shows the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. (encyclopedia.pub)
Vivo2
  • For the Ø 15 mm scaffold type, mechanical properties were also studied in a one-year in vivo experiment. (researchgate.net)
  • The objective of this study is to evaluate the effectiveness of the use of nanofibers as a scaffold for stem cell growth and to evaluate its efficacy in vivo for cell therapy for central nervous system injuries. (fapesp.br)
Antimicrobial1
  • To address this public health challenge, Mohamed Soliman, from De Montfort University and Cairo University, is researching the antimicrobial properties of peptide-based hydrogels. (typepad.com)
Stiffness1
Collagenous2
  • Results: Synthetic heterotrimeric collagenous peptides that contain the collagenase cleavage site of human collagen type I and differ in the thermal stability of the triple-helical fold were used to mimic natural collagen and gelatin, respectively. (uni-bielefeld.de)
  • Conclusions: The results confirm the usefulness of synthetic heterotrimeric collagenous peptides in the folded and unfolded state as mimics of the natural substrates collagen and gelatin, respectively, to gain a better a insight into the proteolytic mechanisms of matrix metalloproteinases. (uni-bielefeld.de)
Structures3
  • We report the observation of intermediate structures in the self-assembly of the peptide KFE8 (FKFEFKFE), designed with alternating polar and nonpolar amino acids. (acs.org)
  • So, we need to predict and calculate the proper distance for every different scaffold of β-sheet structures. (springeropen.com)
  • Chemical structures of the interfaces along with the electrical, mechanical and morphological properties at nanoscale appear equally relevant to drive the interactions between living and synthetic systems. (european-mrs.com)
Gelatin1
  • These hydrogels are gel-like materials containing water, similar to gelatin, and are synthesized from peptide materials, which are made from the same building blocks as proteins. (typepad.com)
Polymeric1
  • Due to the polymeric domains created by crosslinking in the gel microstructure, hydrogels are not homogenous within the selected solvent system. (wikipedia.org)
Biomimetic1
  • Biomimetic Heterodimerization of Tetrapeptides to Generate Liquid Crystalline Hydrogel in A Two-Component System. (acs.org)
Differentiation2
  • Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
Polyethylene1
  • Also, commercially available synthetic grafts made of expanded polytetrafluoroethylene (ePTFE) or polyethylene terephthalate (PET) with diameters ≤ 6 mm frequently fail. (biomedcentral.com)
Membrane2
Monomers1
  • Hydrogels are synthesized from hydrophilic monomers by either chain or step growth, along with a functional crosslinker to promote network formation. (wikipedia.org)
Endothelium1
  • Implantation of synthetic grafts without this endothelium barrier may lead to surface protein adsorption followed by platelet adhesion, activation, and aggregation. (biomedcentral.com)
Properties1
  • As a result, hydrogels, self-healing alike, develop characteristic firm yet elastic mechanical properties. (wikipedia.org)
Proposes1
  • This work proposes a microfibers-hydrogel assembled composite as delivery vehicle able to combine into a single system both burst and prolonged release of lactate. (ibecbarcelona.eu)
Stability2
  • In hydrogels, structure and stability of water molecules are highly affected by the bonds. (wikipedia.org)
  • Positive charge was introduced via cationization that additionally supported the stability of the scaffold in cell culture, and acted as nucleation point for mineralization during osteogenesis. (nature.com)
Functional1
  • The side chains "dangle" across the surface of the hydrogel, allowing it to interact with other functional groups and form new bonds. (wikipedia.org)
Nano1
  • Endothelial coverage after 1, 3, and 7 days of culture on flat samples (2D model) was higher on Nano prostheses as compared with Micro scaffolds. (biomedcentral.com)
Cell2
  • BC-Ppy scaffolds improved cell viability andattachment, promoting a desirable cardiomyoblast morphology. (ibecbarcelona.eu)
  • Endothelial cell attachment to an intravascular stent is promoted by coating the stent with an endothelial cell specific adhesion peptide. (patsnap.com)
Growth1
  • This study serves as a strategic guide for companies and investors looking to capitalize on the major growth opportunities for hydrogels across a diverse set of high-potential markets and applications. (researchandmarkets.com)
Material1
  • We conclude the produced scaffolds meet the material and mechanical requirements for vascular prostheses. (biomedcentral.com)
Surface1
  • The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. (patsnap.com)
Delivery1
  • Drug delivery systems (DDS) are used vehicles to transport therapeutic agents including antibodies, peptides, vaccines, drugs, and enzymes to a target location and safely achieve the desired therapeutic effect. (encyclopedia.pub)
Formation1
  • The structure of the hydrogel along with electrostatic attraction forces drive new bond formation through reconstructive covalent dangling side chain or non-covalent hydrogen bonding. (wikipedia.org)
Method1
  • In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate. (patsnap.com)
Structure1
  • The hydrophobic effects combined with the hydrophilic effects within the hydrogel structure can be balanced through dangling side chains that mediates the hydrogen bonding that occurs between two separate hydrogel pieces or across a ruptured hydrogel. (wikipedia.org)
Methods1
  • The following sections summarize the chemical and physical methods by which hydrogels are crosslinked. (wikipedia.org)
Design1
  • These hydrophobic effects can be exploited to design physically crosslinked hydrogels that exhibit self healing abilities. (wikipedia.org)
Results1
  • In a study performed by the University of California San Diego to compare healing ability, hydrogels of varying side chain lengths with similar crosslinking contents were compared and the results showed that healing ability of the hydrogels depends nonmonotonically on the side chain length. (wikipedia.org)