• The PA1-029 immunogen is a synthetic peptide corresponding to amino acid residues 23-38 and 226-240 from human NPM. (thermofisher.com)
  • PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • Earlier clinical studies reported a high sensitivity of pretargeted immunoscintigraphy using murine or chimeric anticarcinoembryonic antigen (CEA) bispecific antibody (BsMAb) and peptides labeled with 111 In or 131 I in medullary thyroid carcinoma (MTC). (snmjournals.org)
  • Monoclonal antibody is produced by immunizing animals with a recombinant Protein A-PCNA fusion protein, or with a synthetic peptide corresponding to residues surrounding Cys60 of human Survivin. (cellsignal.com)
  • This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Also, 124 individual EUAs have been issued, which includes 106 molecular tests, 17 antibody tests and 1 antigen test. (biospace.com)
  • This antigen of this antibody was synthetic peptide within human ephrin b aa 47-96 / 333. (novoprolabs.com)
  • Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. (abcam.com)
  • Antibodies are purified by protein A and peptide affinity chromatography. (cellsignal.com)
  • Purity Description Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. (biosensis.com)
  • Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser10 of human histone H3, or with a synthetic peptide surrounding amino-terminal residues adjacent to Asp175 of human caspase-3. (cellsignal.com)
  • Isotype or positive controls by peptides, antibodies and deactivated samples.Peptides short amino acid chains or epitopes or blocking antagonists. (conzort.com)
  • Dr. Eren's research focuses on understanding the structural and mechanistic aspects of Rev-host protein interactions and finding target regions to inhibit Rev activity using antibodies, synthetic peptides, and aptamers. (nih.gov)
  • Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy. (nih.gov)
  • Positive tests for antinuclear antibodies (ANAs) and anti-smooth-muscle antibodies (ASMAs): Tests for antibodies to liver-kidney microsome type 1 (anti-LKM-1), soluble liver antigen (anti-SLA), and liver cytosol type 1 (anti-LC1) may be helpful if ANA and ASMA test results are negative. (medscape.com)
  • See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. (lsbio.com)
  • ELISA protocols for anti-MAA antibodies included five antigens (human serum albumin in three formulations, fibrinogen, and a synthetic peptide) and assays for the IgG, IgM, and IgA isotypes. (bvsalud.org)
  • Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). (cellsignal.com)
  • Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (6). (cellsignal.com)
  • Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. (thermofisher.com)
  • My research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells. (upenn.edu)
  • The class-I and class-II proteins of the Major Histocompatibility Complex play an essential role in immune surveillance, by displaying epitopic peptides derived from the processing of aberrant proteins on the cell surface, where they can be recognized through interactions with specialized receptors on T cells and Natural Killer cells. (upenn.edu)
  • In recent work, our team found that the dynamic plasticity of MHC-I proteins, occurring over a range of timescales from microseconds to milliseconds, plays an essential role in their peptide selector function though the sampling of minor, "excited-state" conformations. (upenn.edu)
  • Our detailed biophysical characterization of the molecular chaperone TAPBPR provided us with a high-resolution view of peptide exchange on MHC-I proteins and led to the development a high-throughput methodology for generating barcoded MHC tetramer libraries encompassing hundreds of unique antigen specificities. (upenn.edu)
  • Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR). (receptors.org)
  • Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (ningbobio.com)
  • Immunohistochemistry: LS-B2013 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. (lsbio.com)
  • Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. (lsbio.com)
  • Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. (neuromics.com)
  • Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase in eukaryotic cells. (abbkine.com)
  • PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (abbkine.com)
  • GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. (mc1-r.com)
  • Application Details Peptide ELISA (1:16000), Western Blot (0.1-1 µg/mL), Immunocytochemistry (10 µg/mL), Flow Cytometry (10 µg/mL). (biosensis.com)
  • Synthetic peptide corresponding to residues 23-38 and 226-240 of human NPM. (thermofisher.com)
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human GAS. (glucagon-receptor.com)
  • Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • Synthetic peptide corresponding to aa 70-85 of human and mouse Ki autoantigen/PA28γ. (enzolifesciences.com)
  • Synthetic peptide surrounding Thr216 of human RORA. (covalab.com)
  • Synthetic peptide from human ALAS1. (lsbio.com)
  • NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. (thermofisher.com)
  • Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue inflammation. (bvsalud.org)
  • NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. (conzort.com)
  • Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
  • The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. (genetex.com)
  • Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
  • PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
  • Preclinical studies showed that new-generation humanized recombinant anti-CEA × antihistamine-succinyl-glycine (HSG) trivalent BsMAb TF2 and radiolabeled HSG peptide (IMP288) present good features for PET. (snmjournals.org)
  • Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (bvsalud.org)
  • Recently the research findings from the laboratory and in experimental animals are translated to an early clinical study in which cancer patients are injected with and experimental tumor-specific peptide-conjugate vaccine. (universiteitleiden.nl)
  • The recognition of antigens by immune cells is a crucial step in tumor-specific killing, and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells, making them an attractive therapeutic target. (techscience.com)
  • Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. (upenn.edu)
  • NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. (conzort.com)
  • It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. (enzolifesciences.com)
  • The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (now referred to as PA28γ). (enzolifesciences.com)
  • SiO2 Materials Science signed a $143 million deal with the DoD's Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND) in partnership with BARDA to accelerate production scale-up of the company's primary packaging platform for storing COVID-19 vaccines and therapeutics. (biospace.com)
  • Currently, neoantigens find utility in various domains, primarily in the realm of neoantigen vaccines such as DC vaccines, nucleic acid vaccines, and synthetic long peptide vaccines. (techscience.com)
  • They are generated by immunizing an animal with an antigen to elicit an immune response. (cellsignal.jp)
  • Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
  • High tumor uptake and contrast can be obtained with pretargeted anti-CEA immuno-PET in relapsed MTC patients, especially using optimized pretargeting parameters: a BsMAb-to-peptide mole ratio of 20 and 30 h pretargeting delay. (snmjournals.org)
  • With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)
  • Outer mitochondrial membrane, nuclear membrane, endoplasmic reticulum membrane. (biolegend.com)
  • This clinical trial studies gallium-68 (68Ga)-prostate specific membrane antigen (PSMA) (gallium Ga 68-labeled PSMA ligand Glu-urea-Lys[Ahx]) positron emission tomography (PET)/computed tomography (CT) or PET/magnetic resonance imaging (MRI) in identifying prostate cancer that may have returned after a period of improvement (biochemical recurrence). (stanford.edu)
  • The ARM is a highly specific sequence which contains a nuclear localization signal. (nih.gov)
  • To gain an atomic-detail description of these processes and to characterize novel therapeutic targets, we integrate cutting-edge structural biology methods from Nuclear Magnetic Resonance Spectroscopy, complementary biophysical and biochemical techniques, computational modeling and functional immunoassays. (upenn.edu)
  • These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. (conzort.com)
  • In this aspect, many mechanisms have been described such as dysregulation and acceleration of cell-death pathways, an aberrant clearance and overload of immunogenic acid-nucleic-containing debris and IC, and the involvement of antigen-presenting cells and other innate immune cells in the induction of this adaptive immune response. (bvsalud.org)
  • Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. (ximbio.com)
  • Description: Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. (glucagon-receptor.com)
  • 2012). It contains a clean synthetic urine that is biocide free and completely undetectable. (sportandradio.com)
  • 2016 ) In Nuclear Instruments & Methods in Physics Research. (lu.se)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • This product was made using synthetic libraries and phage display technology . (abcam.com)
  • A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export. (nih.gov)
  • Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers. (smw.ch)
  • In C4, the TF2-to-peptide mole ratio was increased to 40 (delay 30 h), resulting in high T-SUV max but with higher MBP than in C2. (snmjournals.org)
  • Pharmacokinetics demonstrated a fast TF2 clearance and a clear relationship between blood activity clearance and the ratio between the molar amount of injected peptide to the molar amount of circulating TF2 at the time of peptide injection. (snmjournals.org)
  • Prolongation of the international normalized ratio (INR) and hypoalbuminemia: These markers of severe hepatic synthetic dysfunction may be observed in patients with acute severe autoimmune hepatitis or decompensated cirrhosis. (medscape.com)
  • A) Nuclear staining of scattered cells in the interfollicular area. (neuromics.com)
  • Dr. Weeks' Comment: Lunasin is an anti-cancer peptide derived from soy which has solid science behind it. (weeksmd.com)
  • Capsids of hepatitis B virus e antigen with authentic C termini are stabilized by electrostatic interactions. (nih.gov)