Nucleoside analogs as anticancer, antimicrobial, antiviral and cardioprotective agents. (presby.edu)
Acyclovir7
Zovirax ( acyclovir ) Cream, 5% is a herpes simplex virus (HSV) nucleoside analogue DNA polymerase inhibitor used to treat recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older. (rxlist.com)
ZOVIRAX is the brand name for acyclovir , a synthetic nucleoside analogue active against herpes viruses . (rxlist.com)
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). (drugs.com)
Acyclovir is a synthetic nucleoside analogue active against herpesviruses. (drugcite.com)
Acyclovir - SVS is a synthetic analog of a purine nucleoside - a dezoksiguanidina. (rxeli.com)
34.5 and 35.1 the purpose of removing waste products forced by high plex formulation of saquinavir was approved acyclovir synthetic purine nucleoside analogue that is released over a period classification of sexual vigor and sexual well-being but wiihtsn been unequivocally proven in the excitement phase. (thehasse.org)
Synthesis5
Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. (cas.cz)
RNA-dependent RNA polymerase (RdRp), also known as nsp12, is a key component in the synthesis of viral ribonucleic acid (RNA) and is considered the primary target of nucleoside analog (NA) inhibitors. (nature.com)
3) Favipiravir, a purine nucleic acid analog, could mimics the purines G and A to form non-canonical base pairs and has also been found to act against coronaviruses via other mechanisms, including non-obligate chain termination and slowing of RNA synthesis. (nature.com)
Gumina, G. Synthesis, stereochemical characterization, and antimicrobial evaluation of a potentially non-nephrotoxic 3'-C-acethydrazide puromycin analog. (presby.edu)
Also in progress is a new versatile and convergent approach to the synthesis of nucleoside analogues. (weebly.com)
This review focuses on the most recent and significant examples of nanotechnology-based approaches for the delivery of antiretroviral agents belonging to the classes of nucleoside-analog reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). (unime.it)
Pyrimidine nucleoside3
Gemcitabine is a synthetic pyrimidine nucleoside and cytarabine analogue which is metabolised intracellularly to active diphosphate and triphosphate nucleosides. (medicscientist.com)
Quite possibly the most encouraging new cytotoxic specialist is Gemcitabine ip 1000mg Injection, a pyrimidine nucleoside antimetabolite. (rizochem.com)
Gemcitabine is a synthetic pyrimidine nucleoside prodrug, which is a nucleoside analog in which the hydrogen atoms on deoxycytidine's 2′ carbon have been replaced with fluorine atoms. (rizochem.com)
Acyclic2
and tenofovir disoproxil, which is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate. (formularywatch.com)
Directed by Professor Yvan Guindon, this laboratory is working on development of new synthetic methodologies for the elaboration of new stereogenic centers on acyclic substrates, which are considered to be among the most difficult chemical entities to modify diastereoselectively due to the lack of rigidity in their structure. (weebly.com)
Inhibitor5
The active pharmaceutical ingredient (API) of Lamivudine Oral Solution is the nucleoside reverse transcriptase inhibitor (NRTI) lamivudine, a well established and documented product for the treatment of HIV/AIDS in combination with other products. (who.int)
Lamivudine is a nucleoside analog reverse transcription inhibitor of HIV and hepatitis B virus that acts as a synthetic cytidine analog. (cdc.gov)
EMTRIVA, a nucleoside analog HIV-1 reverse transcriptase inhibitor, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (drugs.com)
EPIVIR-HBV is a nucleoside analogue reverse transcriptase inhibitor indicated for the treatment of chronic hepatitis B virus (HBV) infection associated with evidence of hepatitis B viral replication and active liver inflammation. (guidelinecentral.com)
Among individuals receiving nucleoside invert transcriptase inhibitor (NRTI)Conly ISBT, no individuals (0%, 0/32) in the dolutegravir group skilled PDVF weighed against 22% (7/32) individuals in the raltegravir group (worth, treatment difference, and 95% self-confidence interval. (researchensemble.com)
Cytidine2
Purse Lab Ph.D. student Ben Turner has published a new paper showing that fluorescent tricyclic cytidine analogues are substrates for the reverse transcriptases (RTs) of three retroviruses: avian myeloblastosis virus (AMV), Moloney murine leukemia virus (M‐MLV), and human immunodeficiency virus 1 (HIV‐1). (sdsu.edu)
The Purse Lab has invented a new cytidine analogue that becomes vastly more fluorescent upon incorporation into double-stranded DNA. (sdsu.edu)
Triphosphate1
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). (millionpharma.net)
Gemcitabine and other nucleoside analogs, LY2334737 and sofosbuvir inhibition of EV-A71 infection were disclosed using molecular and proteomic quantification, and in vitro and in vivo efficacy evaluation. (nature.com)
Since gemcitabine is known to metabolize rapidly in vivo , other nucleoside analogs, LY2334737 and sofosbuvir conferred protection in mice against lethal EV-A71 challenge by potentially reducing the death rate, viral titers as well on virus-induced pathology in the limb muscle tissue of mice. (nature.com)
A preliminary assay of the cytotoxic activity of symmetrical 1,1'-disulfides was performed on two human tumor cell lines, and a noteworthy activity was recorded for a range of these synthetic compounds. (cnr.it)
Viral1
Specifically, the drugs are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain. (millionpharma.net)
Antifungal1
Fluconazole is a synthetic triazole with antifungal activity. (granulesindia.com)
Graduate1
The Purse Group at SDSU is a diverse team of graduate and undergraduate researchers using the tools of synthetic and physical organic chemistry to create new nucleoside analogues for applications in biophysical studies and chemical biology and to create and study self-assembling molecular systems. (sdsu.edu)
Tablets1
This combination drug containing two important tablets are nucleoside analogues which are synthetic in nature. (hebrs.com)
Metabolite1
Cetirizine Hydrochloride is a synthetic phenylmethyl-piperazinyl derivative, antihistaminic Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist. (granulesindia.com)
Enzyme1
Ph.D. student George Samaan of the Purse Lab has designed, synthesized, and tested new 8-oxoguanosine analogues to inhibit GTP cyclohydrolase IB, an enzyme essential for the growth and survival of some pathogenic bacteria including N. gonorrhoeae . (sdsu.edu)
Route1
The new synthetic route is much shorter and has a seven-fold higher overall yield than the originally used route. (chemistryviews.org)
Bases1
The resulting molecules isoxazole-1,2,4-oxadiazole analogs were synthesized using mild bases in ethanol under microwave irradiation. (bvsalud.org)
Ani Shalamberidze, a Ph.D. student member of our team, has published a JACS paper in collaboration with the Kleiner Lab at Princeton shows that a combination of judiciously selected fluorescent nucleoside analogues with genetic upregulation of nucleoside kinase activity enables metabolic labeling and live-cell imaging of RNA biology. (sdsu.edu)
Atazanavir is an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease. (granulesindia.com)
Synthesize1
These RTs use the fluorescent substrate analogues to synthesize a fluorescently labeled double-stranded DNA from an RNA template, with possible future applications in studying retroviral replication. (sdsu.edu)
Biological1
Various indole analogues are also attracted the attention of researchers because of the diverse biological activities. (chemistryjournals.net)
Pharmaceutical1
Due to its wider applications the indole analogues, they will replace many existing heterocyclic based pharmaceutical products. (chemistryjournals.net)
Drug1
Nanocarriers such as natural and synthetic polymeric nanoparticles, dendrimers, liposomes, and various drug conjugates have been discussed. (unime.it)
Natural2
Diazepine allosteric modulatory sites, have no open 24.8.5.2 description re, they are sta- the leaving group when the following monoclonal antibodies natural and synthetic lion of membrane filters (see fig. 1997. (thehasse.org)
Indole nucleus is present in many natural as well as synthetic products. (chemistryjournals.net)
Combination1
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including zidovudine and other antiretrovirals. (nih.gov)
Studies1
Feske, B. D. Synthetic studies toward 3′-C-puromycin analogs. (presby.edu)
Acts1
2) Remdesivir acts as a nucleoside analog and could be incorporated into the growing RNA strand by the RdRp. (nature.com)
Treat1
It is a nucleoside analog originally developed to treat influenza. (chemistryviews.org)