Synthetic nucleoside. Medical search. Frequent questions

Rauter, A. P. Nucleoside analogues: N-glycosylation methodologies, synthesis of antiviral and antitumor drugs and potential against drug-resistant bacteria and Alzheimer's disease. (beilstein-journals.org)
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including RETROVIR. (drugs.com)
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. (medlineplus.gov)
I spent several tears years working with students on using new chemistry to design potential antiviral nucleoside analogues. (davidson.edu)
Ribavirin is a chemically derived pharmaceutical and belongs to a class of drugs called nucleoside analogues. (pharmaceutical-business-review.com)
The importance of nucleoside analogues in a number of areas of drug discovery and chemical biology continues to act as a spur to develop practical and efficient synthetic methods for accessing these compounds. (thieme.de)
Nucleoside analogues (nukes) can cause fat accumulation in some people, possibly because they contribute to insulin resistance, which is associated with an increase in gut fat. (mevio.com)

Rusinov, V. L. Approaches to the synthesis of heterocyclic C-nucleosides. (beilstein-journals.org)
Nidetzky, B. Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs. (beilstein-journals.org)
Banerjee, S. Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity. (beilstein-journals.org)
This very feature makes nucleoside phosphoramidites useful intermediates in oligonucleotide synthesis. (wikipedia.org)
Phosphoramidites are modified nucleosides used in the chemical synthesis of oligonucleotides. (usp.org)
Abstract: In the present work, a new and eco-friendly approach for the synthesis of 5-selenyl-uracils via a simple, regioselective and metal-free protocol was developed, which provides a greener character to the preparation of this class of compounds synthetic- and biologically relevant. (ufsc.br)
The biocatalytic production of C-nucleosides is therefore a very strong, elegant alternative to classical chemical synthesis and even superior to it in terms of efficiency,' says Bernd Nidetzky. (tugraz.at)
The biocatalytic synthesis of further relevant C-nucleosides. (tugraz.at)
Paolo Quadrelli presents the synthesis of N,O-nucleosides from (nitrosocarbonyl)mesitylene. (thieme.de)
The Synthetic Organic Chemistry Core (SOCC) at UTMB was established in 1998 to study and develop new methods and protocols for the synthesis of modified nucleosides representing known DNA damage, and for conversion of these nucleosides into phosphoramidites that can be conveniently and site-specifically incorporated into synthetic DNA sequences. (utmb.edu)
The synthetic organic services provided have also been adapted and expanded over the past 18 years to accommodate the growing need for synthesis and purification of other small molecules and bioconjugates that are of interest to biomedical and environmental health researchers at UTMB and elsewhere. (utmb.edu)
The SOCC specifically has expertise in the synthesis of modified nucleosides representing known site-specific DNA damage and also development of methods and protocols for purifying and analyzing these defined products. (utmb.edu)
Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. (cas.cz)
In recognition of his innovations and scholarship in the field of organic synthesis, Professor Trost has received the ACS Award in Pure Chemistry, ACS Award for Creative Work in Synthetic Organic Chemistry, Arthur C. Cope Scholar Award, and the Presidential Green Chemistry Challenge Award, among many others. (stanford.edu)
We previously described the synthesis of 1-O-octadecyl-2-O-benzyl-glycero-3-phospho-RVn (V2043), an orally bioavailable lipid prodrug of remdesivir nucleoside (RVn, GS-441524) with broad spectrum antiviral activity against viruses with pandemic potential. (cdc.gov)

We offer an unparalleled selection of natural and synthetic nucleosides, nucleotides, oligonucleotides, and their analogs to support your scientific breakthroughs in cell biology and drug discovery. (sigmaaldrich.com)
Poster session presented at RSC Symposium on Nucleosides and Nucleotides: synthetic and biological chemistry, London, United Kingdom. (qub.ac.uk)

Nucleoside phosphoramidites are derivatives of natural or synthetic nucleosides. (wikipedia.org)
Still, the same protocol was applied to obtain selenium nucleosides derivatives. (ufsc.br)

Clevudine is a synthetic pyrimidine nucleoside analog antiviral agent with activity against hepatitis B virus (HBV) and Epstein-Barr virus (EBV). (prosci-inc.com)
This is the first systematic structure-activity study of pyrimidine nucleoside‐based diarylethenes photoswitches. (chemistryviews.org)

Nucleoside phosphoramidites were first introduced in 1981 by Beaucage and Caruthers. (wikipedia.org)
There are three main methods for the preparation of nucleoside phosphoramidites. (wikipedia.org)
Although some bisamidites were reported as thermally unstable compounds, 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite, the amidite used to prepare commercial nucleoside phosphoramidites is relatively stable. (wikipedia.org)
Nucleoside phosphoramidites are purified by column chromatography on silica gel. (wikipedia.org)
Nucleoside phosphoramidites are relatively stable compounds with a prolonged shelf-life when stored as powders under anhydrous conditions in the absence of air at temperatures below 4 °C. The amidites withstand mild basic conditions. (wikipedia.org)

Lamivudine is a nucleoside analog reverse transcription inhibitor of HIV and hepatitis B virus that acts as a synthetic cytidine analog. (cdc.gov)

Synthetic oligonucleotides are short nucleic acid chains that can control gene expression in a sequence-specific manner. (usp.org)
As a new class of therapeutics, synthetic oligonucleotides have shown great promise in the treatment of neurological disorders, metabolic diseases, cancers, and other diseases. (usp.org)
Synthetic oligonucleotides often contain low levels of multiple classes of impurities which can ultimately influence their efficacy and toxicity. (usp.org)

FUZS-5 is a thymidine nucleoside analogue. (guidetopharmacology.org)
ZOVIRAX® Ointment Glaxo Wellcome Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, an acyclic nucleoside analog, is a substrate specific for herpesvirus-specified thymidine kinase. (rxmed.com)
Bromodeoxyuridine (BrdU) is a synthetic nucleoside that is an analogue of thymidine (the "T" in the A+T & C+G DNA base pairings. (rechargebiomedical.com)

To avoid undesired side reactions, reactive hydroxy and exocyclic amino groups present in natural or synthetic nucleosides are appropriately protected. (wikipedia.org)
Once the nucleosides were appropriately protected, they were phosphorylated with a synthesized phosphoramidate reagent. (uwo.ca)

In medicinal chemistry, the molecular family of carbon (C)-nucleosides is particularly in demand. (tugraz.at)

Lamivudine and zidovudine tablets, a combination of 2 nucleoside analogue reverse transcriptase inibitors, are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)
Therapy should involve combinations of drugs-two nucleoside-analogue reverse-transcriptase inhibitors combined with either a protease inhibitor (PI) or a non-nucleoside-analogue reverse-transcriptase inhibitor. (medscape.com)

Thus, we present the SPAgE-AgAP as a potent tool applicable in simple, fast, and sensitive electrochemical detection of reducible or catalytically active species, with prospective applications in hot research areas including chemical and synthetic biology. (researchgate.net)
According to the researchers, this reversible control of DNA structure and function by light offers promising applications in synthetic biology, bionanotechnology, and next-generation computing. (chemistryviews.org)

As long as a nucleoside analog contains at least one hydroxy group, the use of the appropriate protecting strategy allows one to convert that to the respective phosphoramidite and to incorporate the latter into synthetic nucleic acids. (wikipedia.org)
To be incorporated in the middle of an oligonucleotide chain using phosphoramidite strategy, the nucleoside analog must possess two hydroxy groups or, less often, a hydroxy group and another nucleophilic group (amino or mercapto). (wikipedia.org)

Aldrich, C. C. 1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides. (beilstein-journals.org)
The C-nucleoside based drug Remdesivir has these necessary antiviral properties and is effective against a number of RNA viruses, including corona and ebola viruses. (tugraz.at)

SRI Biosciences Chief Strategy Officer Nathan Collins, Ph.D., will present an overview of SynFini, the company's fully automated, end-to-end synthetic-chemistry system, at the Society for Laboratory Automation & Screening (SLAS) 2020 Conference. (sri.com)
The synthetic route utilized 5-ethynylpyrimidines and azidoribofuranoses as CuI 'click' chemistry substrates. (uwo.ca)
Then the modified nucleobases were attached to the ribofuranose using a synthetic technique called copper 'click' chemistry. (uwo.ca)

Abacavir tablet, a nucleoside analogue human immunodeficiency virus (HIV-1) reverse transcriptase inhibitor, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)

These differ from the naturally more frequently occurring nitrogen (N)-nucleosides - the classical building blocks of RNA - in the way the sugar is linked to the so-called nucleic base. (tugraz.at)

Status: Approved by EMA Ribavirin is a chemically-derived synthetic analogue of guanosine that has a broad spectrum anti-viral effect by inhibiting RNA polymerase of various RNA viruses. (pharmaceutical-business-review.com)

Thomas Carell, an organic chemist at Ludwig Maximilian University of Munich in Germany, and his colleagues created synthetic RNA molecules that could produce peptides up to 15 amino acids long. (the-scientist.com)
The fact that RNAs containing a couple of these nucleosides were able to bind amino acids and string them together to build peptides "is a very exciting finding," Martin tells Nature , "not only because it maps out a new route to RNA-based peptide formation, but because it also uncovers new evolutionary significance to the naturally occurring modified bases of RNA. (the-scientist.com)

The biocatalytic production of C-nucleosides could provide further impetus for this new hope as well as RNA vaccines based on C-nucleosides. (tugraz.at)

Nucleosides are naturally occurring biological molecules, which are fundamental building blocks of DNA and RNA. (sru.edu)

In the second method, the protected nucleoside is treated with the phosphorochloridite in the presence of an organic base, most commonly N-ethyl-N,N-diisopropylamine (Hunig's base). (wikipedia.org)
In the third method, the protected nucleoside is first treated with chloro N,N,N',N'-tetraisopropyl phosphorodiamidite in the presence of an organic base, most commonly N-ethyl-N,N-diisopropylamine (Hunig's base) to form a protected nucleoside diamidite. (wikipedia.org)

My research program at Davidson started with an emphasis on synthetic methodology in nitrogen heterocycles. (davidson.edu)
Instead of a carbon-nitrogen bond, C-nucleosides have a carbon-carbon bond. (tugraz.at)

Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. (mdpi.com)

The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. (mdpi.com)

Due to the COVID 19 pandemic and the associated intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is experiencing an enormous increase in interest. (tugraz.at)

The researchers engineered the RNA molecules to include two modified nucleosides that are found in ribosomes , enzymes made up of RNAs and proteins that synthesize proteins from RNA transcripts. (the-scientist.com)

For the first time, two researchers from Graz University of Technology and the acib competence centre (Austrian Centre of Industrial Biotechnology) have now succeeded in biocatalytically producing C-nucleosides with the help of enzymes. (tugraz.at)

Nucleoside reverse transcriptase inhibitors inhibit the enzyme that allows for reproduction of the virus. (medscape.com)

I have experience with Raman, Infrared and UV-vis spectroscopies, chemical imaging and multivariate data analysis (a.k.a. data mining or chemometrics) for solving several issues in questioned document examinations (ink and paper discrimination, dating of inks, determining the order of ink crossings, indented writing) as well as the identification of new synthetic drugs and gunshot residues (GSR). (sru.edu)

Moreover, these artificial nucleosides were easily detectable in the excess of natural nucleosides down to molar ratio 1:12000. (researchgate.net)
Natural and synthetic nucleosides have an antiviral effect and can act as building blocks of ribonucleic acids (RNA). (tugraz.at)

Nucleoside-modified messenger RNA (modRNA) is a modified form of mRNA that encodes the spike (S) glycoprotein of the SARS-CoV-2 virus, the virus that causes COVID-19. (republicbroadcasting.org)

Une étude SAR a permis la synthèse d'une librairie de plus de 60 ANs en incorporant différentes bases azotées, des phosphoramidates en position C3' et/ou C5', mais également des lipoates sur l'amine de la base azotée. (umontreal.ca)

More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular and environmental stress. (boku.ac.at)

Andres Jäschke, Heidelberg University, Germany, and colleagues have developed pyrimidine nucleosides with the structural features of diarylethenes. (chemistryviews.org)

Palladium and ruthenium catalysts represent a major part of the lab's efforts, in order to invent new synthetic processes together with new opportunities for selectivity complementary to that obtained using other metal complexes. (stanford.edu)

The study of TNA and other artificially-produced genetic polymers is part of a rapidly emerging discipline known as synthetic genetics. (nanowerk.com)

Nucleoside-Derived Low-Molecular-Weight Gelators as a Synthetic Microenvironment for 3D Cell Culture. (nih.gov)

Bernd Nidetzky, Head of the Institute of Biotechnology and Bioprocess Engineering at TU Graz and at the same time Scientific Director of the Austrian Centre of Industrial Biotechnology (acib), and Martin Pfeiffer from acib discovered and characterized in a study the enzyme 'YeiN', which can link the two nucleoside building blocks ribose-5-phosphates and uracil by means of a specific carbon bond. (tugraz.at)

Testosterone Propionate was the first commercially accessible testosterone product, despite the fact that it was not the first synthetic testosterone preparation. (mevio.com)

Mass-spectrometry-based methods have been at the forefront of identifying and quantifying modified nucleosides. (boku.ac.at)

Dans la littérature, il n'y a aucun précédent pour la création de centres stéréogéniques en utilisant une approche radicale faisant usage des NHC-boranes. (umontreal.ca)

Advantageously, differential pulse voltammetry at SPAgE-AgAP allowed highly sensitive detection of artificial nucleosides dTPT3 and d5SICS (developed to expand genetic alphabet in semi-synthetic organisms) using their catalytic hydrogen evolution signals, with limits of detection of 0.4 pmol l⁻¹. (researchgate.net)

Organisms1

Chemicals and Drugs49

Phenomena and Processes8

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Analogues7

Synthesis15

Nucleotides2

Derivatives2

Pyrimidine nucleoside2

Phosphoramidites5

Hepatitis B vir1

Oligonucleotides3

Thymidine3

Appropriately protected2

Medicinal chemistry1

Analogue reverse2

Biology2

Analog2

Remdesivir2

Chemistry3

Abacavir1

Nucleic1

Broad-spectrum1

Amino2

Biocatalytic1

Biological1

Organic2

Nitrogen2

Vaccine1

Lipid1

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Enzymes1

Reverse1

Drugs1

Natural2

MRNA1

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Rapidly1

Molecular1

Study1

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