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  • oligonucleotide
  • The global oligonucleotide synthesis market is poised to reach USD 2.20 billion by 2021 from USD 1.33 billion in 2016, growing at a CAGR of 10.6% from 2016 to 2021. (gii.co.jp)
  • Major factors contributing to the growth of the global oligonucleotide synthesis market include increasing R&D expenses in the pharmaceutical and biotechnology companies, the rising demand for synthesized oligonucleotides due to the growing field of molecular diagnostics, increasing government investments to develop genomic technologies, rising venture capital investments, and increasing demand for synthetic genes. (gii.co.jp)
  • North America commands the largest share of the global oligonucleotide synthesis market in 2016 and is expected to grow at a second-highest growth rate from 2016-2021. (gii.co.jp)
  • Considering the potential of oligonucleotides (therapeutic oligonucleotides) in the treatment of chronic diseases, the oligonucleotide synthesis market is expected to flourish in the coming years, provided these drugs get rapid market approvals. (gii.co.jp)
  • viral
  • To further analyze the consequences of the genomic 3′ noncoding region deletion, we examined viral RNA replication in a neuroblastoma cell line, SK-N-SH cells. (asm.org)
  • While the mutations in the Sabin 5′ noncoding regions (NCRs) have been shown to affect translation efficiency of the viral genomes ( 48 - 50 ) with the resulting loss of translation efficiency proposed to contribute to the mechanism of attenuation ( 55 ), all elements contributing to cell-specific attenuation have yet to be fully elucidated. (asm.org)
  • Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized b. (nih.gov)
  • Using high resolution electron microscopic autoradiography and immunocytochemistry with monoclonal antibodies against poliovirus proteins of the P2 genomic region, the location of these proteins in respect to the virus-induced vesicle formation and the viral RNA synthesis was followed during the viral replication cycle. (nih.gov)
  • These results suggest a role for nsP3 or nsP3-containing polyproteins in the synthesis of viral minus-strand and subgenomic RNAs. (asm.org)
  • sequence
  • The movement and expansion of indigenous mtDNA lineages, studied through coding-region and control-region variants obtained from complete sequence data, suggest that the prehistory of the region has to be rethought. (readabstracts.com)
  • nsP3 is a phosphoprotein comprising two regions: an N-terminal portion which is highly conserved among alphaviruses and a C-terminal portion which is not conserved, varying both in sequence and in length. (asm.org)
  • synapses
  • Furthermore, we are able to show input-specific LTD within the CA1 region, with expression shown only by those synapses specifically stimulated by a low-frequency protocol. (noneto.com)
  • Approach
  • Chawla A., Sharma A., Sharma A. K., Review: A Convenient Approach for the Synthesis of Imidazole Derivatives Using Mcrowaves , Der Pharma Chemica, 4 (1):116-140 (2012). (ac.ir)
  • A pyrosequencing-based approach showed that the cps region of Kp13 ( cps Kp13 ) is 26.4 kbp in length and contains genes common, although not universal, to other strains, such as the rml BADC operon that codes for L-rhamnose synthesis. (biomedcentral.com)
  • mutants
  • We have constructed a library of random linker insertion mutations in the nsP3-coding region and characterized selected viable mutants. (asm.org)
  • Initially, 126 mutants containing insertions in the conserved region and 23 with insertions in the nonconserved region were screened for temperature-sensitive (ts) plaque formation or for significant differences in plaque morphology. (asm.org)
  • All nonconserved-region mutants were similar to the parental virus, whereas 13 of those in the conserved region were either ts or exhibited altered plaque phenotypes. (asm.org)
  • CR3.39 was able to complement ts mutants from Sindbis virus complementation groups A, B, F, and G. Another mutant isolated from the library, CR3.34, while not ts for plaque formation or RNA synthesis, formed smaller plaques and was defective in subgenomic RNA synthesis at all temperatures examined. (asm.org)
  • Operator
  • This also supports our earlier suggestion regarding the possible complexity of the internal operator region situated between argE and C . (springer.com)
  • When the operator captures a subject using the master camera, the region reproduced by the integral 3-D display is regulated in real space according to the subject's position and view angle of the master camera. (spiedigitallibrary.org)
  • mutations
  • Although numerous studies have investigated the effect of mutations in nsP1-, nsP2-, and nsP4-coding regions on Sindbis virus-specific RNA synthesis, relatively little is known about the function of the region encoding nsP3. (asm.org)
  • systems
  • For systems exhibiting this behavior, process synthesis principles are developed to illustrate the evolution of a process flowsheet for the separation of a mixture into its pure components. (wiley.com)
  • large
  • The two-tier population history of Island Southeast Asia (ISEA) is refuted by demonstrating that mitochondrial DNA diversity in the region is extremely high and includes a large number of indigenous clades. (readabstracts.com)
  • sites
  • Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. (google.com)
  • SOURCE
  • No. 5,143,854 and PCT WO 92/10092 or others, can be detected by exposing marked regions of sample to radiation from a source and detecting the emission therefrom, and repeating. (google.com)
  • present
  • In this paper we present an unsupervised algorithm to select the most adequate grouping of regions in an image using a hierarchical clustering scheme. (springer.com)
  • separate
  • In conjunction with using the sensitizers and protecting groups described above, a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support is provided. (google.com)
  • together
  • The Synthesis of Operations Evaluations for the Latin America and Caribbean Region brings together the findings of seven operations evaluations, conducted from mid-2013 to mid-2017. (wfp.org)
  • evidence
  • Genetic analysis of the nsP3 region of Sindbis virus: evidence for roles in minus-strand and subgenomic RNA synthesis. (asm.org)
  • This provides direct evidence for the occurrence of differential transcription effectiveness in a regulon exhibiting a correlative but not strictly coordinated pattern of enzyme synthesis. (springer.com)
  • image
  • Pauwels, E.J., Frederix, G.: Finding salient regions in images: Non-parametric clustering for image segmentation and grouping. (springer.com)
  • Using the cooperative control function, the reference cameras can capture images at the narrowest view angle that does not lose any part of the object region, thereby maximizing the resolution of the image. (spiedigitallibrary.org)