AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Peptide Nucleic AcidsNucleic Acid ProbesPeptidesAntisense Elements (Genetics)DNANucleic Acid ConformationIn Situ Hybridization, FluorescenceBase SequenceOligonucleotides, AntisenseThiouracilNucleic Acid HybridizationNucleic Acid DenaturationAminacrineOligonucleotidesNucleic AcidsCeriumCell-Penetrating PeptidesMolecular ProbesMolecular Sequence DataRNATargeted Gene RepairOligodeoxyribonucleotidesPeptide FragmentsDNA, AntisensePelvic InfectionOligonucleotide ProbesMolecular Probe TechniquesSensitivity and SpecificityNucleic Acid HeteroduplexesPeptide LibraryBase PairingTrichosporonosisBloodDNA ProbesMolecular StructureKineticsThymineCell Line
ProteinsNanoparticlesNanoparticleAntimicrobialBacillusMolecularConjugatesPolymerAmino acidAntibioticDesign and synthesisBacteriaGenomicSyntheticFattyDegradationNanomaterialsCDNAResiduesAnaloguesDerivativesLacticGeneticStructurePropertiesEffectActivityControlDeliveryTechniquesSystemAnalysisDomainStudyPreviously
Proteins1
  • A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
Nanoparticles1
  • In this study, we utilized the negatively charged and FDA approved polymer poly(lactic-co-glycolic acid) to encapsulate Notch Intracellular Domain-containing plasmid in nanoparticles. (frontiersin.org)
Nanoparticle1
  • When a defined protein/peptide (or combinations thereof) control and define the synthesis of an inorganic nanoparticle, the result is a cloneable NanoParticle (cNP). (rsc.org)
Antimicrobial11
  • A bacterial strain producing two antimicrobial peptides was isolated from a rhizosphere soil sample and identified as Bacillus subtilis based on both phenotypic and 16S rRNA gene sequence phylogenetic analysis. (springeropen.com)
  • It grew optimally up to 14% NaCl and produced antimicrobial peptide within 24 h of growth. (springeropen.com)
  • MALDI MS/MS analysis elucidated the lipopeptide as a cyclic lipopeptide with a β-hydroxy fatty acid linked to Ser of a peptide with seven α-amino acids (Asp-Tyr-Asn-Gln-Pro-Asn-Ser) and assigned it to iturin-like group of antimicrobial biosurfactants. (springeropen.com)
  • Antimicrobial peptides characterization has received great attention in the recent past due to their applications as food preservatives without any toxic effects on host and therapeutic agents. (springeropen.com)
  • Since lactic acid bacteria (LAB) produce an array of antimicrobial substances they were used as natural bio-preservatives for special applications (Holzapfel et al. (springeropen.com)
  • However, production of antimicrobial peptides by Bacillus strains has been increasingly characterized in the recent past and many peptides produced by this group of bacteria found to be suitable for various applications (Abriouel et al. (springeropen.com)
  • includes various classes of bacteriocins ( Klaenhammer 1993 ), antimicrobial surface-active biosurfactants like lipopeptides, glycopeptides and nonribosomally synthesized cyclic peptides (Mukherjee et al. (springeropen.com)
  • 2006 ). Among the antimicrobial biosurfactants, lipopeptides contain peptides with 7-10 amino acid that are cyclised via a lactone ring to a β-hydroxy fatty acid with different chain lengths. (springeropen.com)
  • Despite the fact that multiple bacteriocins and/or lipopeptide analogues are produced by a single strain, only few antimicrobial peptides are reported in the literature. (springeropen.com)
  • Considering the enormous diversity of Bacillus species in the soil ecosystem it is very important to isolate and preserve the strains producing these antimicrobial peptides followed by detailed characterization. (springeropen.com)
  • 2012 ). In present study we report another antimicrobial peptide and a cyclic lipopeptide produced by a halotolerant isolate of Bacillus subtilis strain SK.DU.4 isolated from a rhizosphere soil sample. (springeropen.com)
Bacillus1
  • Synthesis of exotoxin produced by Bacillus thuringiensis . (cas.cz)
Molecular9
  • Our findings could open avenues for the real-time characterization of synthetic devices at the single molecule level, and provide crucial information for designing molecular machinery able to operate under physiological conditions. (nature.com)
  • mPEG-NHS (Amine PEGylation of Peptide) - High Efficiency Diffusion Molecular Retention Tumor Targeting. (creativepegworks.com)
  • mPEG-SH (Surface PEGylation of Gold Nanorods) - Conjugation of antibodies to gold nanorods through Fc portion: synthesis and molecular specific imaging, Bioconjug Chem. (creativepegworks.com)
  • Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)
  • Sakamaki K, Tomonaga M, Tsukui K, Nagata S. Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase. (rusmedserv.com)
  • The MALDI-TOF analysis of HPLC purified fractions revealed that the strain SK.DU.4 secreted a bacteriocin-like peptide with molecular mass of 5323.9 Da and a surface-active lipopeptide (m/z 1056 Da). (springeropen.com)
  • The peptide mass fingerprinting of low-molecular-weight bacteriocin exhibited significant similarity with stretches of secreted lipoprotein of Methylomicrobium album BG8 and displayed 70% sequence coverage. (springeropen.com)
  • As amino acid variations are likely to be correlated with differences in biological risk, molecular characterization, such as that described in this paper, could be the key for assessing the development of dental caries in children. (bvsalud.org)
  • 1995). Diisocyanates and acid anhydrides cyanates has a low association with atopy, low prevalence are among the most common low molecular weight (LMW) with specific IgE antibodies and a mixed Th1-Th2 response classes of chemicals responsible for occupational asthma. (cdc.gov)
Conjugates2
  • This mini-review focuses on covalently linked conjugates of PNA with cell-penetrating peptides, aminosugars, aminoglycoside antibiotics, and non-peptidic molecules that were tested, primarily as PNA carriers, in antibacterial and antiviral applications. (bvsalud.org)
  • METHODS: A set of antisense P-PNA conjugates with a bacterial penetration peptide were designed to inhibit the expression of gyrA and parC and were evaluated for their antibacterial activities. (bvsalud.org)
Polymer3
  • The oligopeptide units of a clicked peptide polymer are a different story. (wikipedia.org)
  • Degradation of the polymer occurs at the peptide bonds linking individual amino acids. (wikipedia.org)
  • In this regard, polymer based nanocarriers show less immunogenicity, toxicity, and has better nucleic acid delivery compared to the viral carriers. (biomedcentral.com)
Amino acid4
  • The resulting nano-sized carriers can sense various stimuli including temperature, pH or light and provide reactivity to amino acid residues as well as specific receptor binding properties. (uni-mainz.de)
  • Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. (rusmedserv.com)
  • However, it differed in amino acid composition with other members of the iturin family. (springeropen.com)
  • Based on the genetic similarity of the isolates and pattern of amino acid variations identified by partial sequencing of the gtfB gene, base-pair changes were identified and correlated with different virulence patterns among the isolates. (bvsalud.org)
Antibiotic1
  • Pseudonajide is a short peptide antibiotic derived from snake venom that acts at low concentration interfering with cell wall and inhibiting biofilm. (univ-rennes.fr)
Design and synthesis1
  • Aggregation studies, design and synthesis of amyloid aggregation inhibitors for the treatment of Alzheimer's disease. (u-szeged.hu)
Bacteria2
  • Identification of drug-resistant strains of bacteria is crucial to allow for characterisation of the pathogen and correct treatment of the infection. (randox.com)
  • Both peptides were active against Gram-positive bacteria, suggesting that they had an additive effect. (springeropen.com)
Genomic2
  • Serological and genomic characterization of two plant RNA viruses: Barley Mild Mosaic Virus (BaMMV) and a potential cryptic virus from from pine (Pinus sylvestris). (u-szeged.hu)
  • The main consideration in the construction of genomic or cDNA libraries is, therefore, the nucleic acid starting material. (biologydiscussion.com)
Synthetic3
  • Peptide nucleic acids (PNAs) are synthesized by attaching modified peptide backbones generally derived from repetitive N-2-aminoethyl glycine units in place of the regular phosphodiester backbone and represent synthetic impersonator of nucleic acids that offers an exciting research field due to their fascinating spectrum of biotechnological, diagnostic and potential therapeutic applications. (bvsalud.org)
  • Their predicted products (MBA1-6) were rapidly accessed using a synthetic bioinformatic natural product approach, which relies on bioinformatic structure prediction followed by chemical synthesis. (nature.com)
  • Biofilm prevention, inhibition and controlling process (antibiofilm) using natural or synthetic peptides derived from 2S-sulfur-rich seed storage protein 2-like protein or their peptidomimetic (synthetic) derivatives. (univ-rennes.fr)
Fatty4
  • Severe hypoglycemia stimulates epinephrine secretion, which activates lipoprotein lipase and the release of free fatty acids. (medscape.com)
  • These fatty acids are transported to the liver, where they are used for triglyceride synthesis and are exported as very-low-density lipoprotein (VLDL), which is elevated in these patients. (medscape.com)
  • Paradoxically, even in the face of hypoglycemia, patients with glycogen-storage disease I do not develop significant ketosis because the abundance of acetyl coenzyme A (CoA) derived from glycolysis activates the acetyl CoA carboxylase enzyme that produces malonyl CoA in the first step of fatty acid synthesis. (medscape.com)
  • Because malonyl CoA inhibits transport of fatty acid into the mitochondrion, beta-oxidation of fatty acids for energy to support the hypoglycemic cells does not occur. (medscape.com)
Degradation2
  • Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to natural DNA or RNA, as well as resistance to enzymatic degradation. (bvsalud.org)
  • The immense increase in the intracellular phosphorylated intermediate compounds of glycolysis concurrently inhibits rephosphorylation of adenine nucleotides, activating the nucleic acid degradation pathway and resulting in increased uric acid, the end product. (medscape.com)
Nanomaterials1
  • mPEG-SCM (Amine PEGylation of Lysine Peptide) - PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials, PLoS ONE 9(4): e95406, Text . (creativepegworks.com)
CDNA1
  • Isolation and characterization of a cDNA clone for porcine thyroid peroxidase. (rusmedserv.com)
Residues1
  • The polymer's peptide bonds can also be attacked by endopeptidases which will cleave at a specific side of a specific peptide bond based upon the residues which make up that bond. (wikipedia.org)
Analogues1
  • Nucleic acids components and their analogues. (cas.cz)
Derivatives1
  • Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics. (univ-rennes.fr)
Lactic1
  • The accumulation of lactic acid in blood can cause true acidosis with a large anion gap, a characteristic of glycogen-storage disease type I. (medscape.com)
Genetic3
  • We report the genetic characterization of brain tissue-associated measles virus samples from three patients. (cdc.gov)
  • We report the genetic characterization of brain tissue-associated measles virus from three of these patients. (cdc.gov)
  • Results: Characterization using RAPD markers uncovered significant genetic variability among the samples and indicated the existence of clusters, which allowed us to reconstruct both the origin and clinical history of the disease. (bvsalud.org)
Structure1
  • mPEG-MAL (Thiol PEGylation of Cysteine Peptide) - Structure of the lethal phage pinhole, Proc Natl Acad Sci USA. (creativepegworks.com)
Properties1
Effect1
  • OBJECTIVES: To examine the bactericidal effect of antisense peptide-peptide nucleic acids (P-PNAs) that can block the expression of DNA gyrase or topoisomerase IV in FQ-resistant Escherichia coli (FRE). (bvsalud.org)
Activity1
  • Fig. 2: Synthesis and antibacterial activity of syn-BNPs based on BGCs predicted to encode MBAs. (nature.com)
Control1
  • Red pepper peptide coatings control Staphylococcus epidermidis adhesion and biofilm formation. (univ-rennes.fr)
Delivery1
  • A sophisticated high-order framework nucleic acid (FNA) was engineered for the targeted delivery and responsive release of environment tolerant antisense peptide nucleic acids (asPNAs). (bvsalud.org)
Techniques1
  • The peptides were purified using a combination of chemical extraction and chromatographic techniques. (springeropen.com)
System1
  • These parasites possess a unique thiol redox system required for DNA synthesis and defense against oxidative stress. (typeset.io)
Analysis1
  • Facilities include those for protein-sequence analysis, peptide and oligonucleotide synthesis, access to the synchrotron at Lawrence Berkeley National Lab for X-ray crystallography, and NMR spectrometry. (berkeley.edu)
Domain1
Study1
  • Regioselective synthesis and MS/MS study of alkyl (guanin-9-yl) acetates. (u-szeged.hu)
Previously1
  • A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. (rsc.org)