• it is phosphorylated to form active metabolite 2-fluoro-ara-ATP, which inhibits DNA synthesis. (medscape.com)
  • An anthracycline antineoplastic agent, daunorubicin inhibits DNA and RNA synthesis by intercalating between DNA base pairs. (medscape.com)
  • 16. A drug that inhibits the ergosterol synthesis causing disruption of membrane function and Increase permeability? (medparhlo.com)
  • Biological Activity: Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. (epigenetics-modulation-frontier.com)
  • It is nonenzymatically cleaved to mercaptopurine , a purine analogue that inhibits DNA synthesis. (mdwiki.org)
  • Fludarabine is a purine analogue and is metabolized rapidly to F-Ara-ATP, which inhibits DNA synthesis by inhibition of DNA polymerases and prevents elongation of DNA strands through direct incorporation into the DNA molecule. (pocketdrugguide.com)
  • These RNA oligonucleotides serve as primers, or starting points, for DNA synthesis by bacterial DNA polymerase III (Pol III). (wikipedia.org)
  • DnaG is important in bacterial DNA replication because DNA polymerase cannot initiate the synthesis of a DNA strand, but can only add nucleotides to a preexisting strand. (wikipedia.org)
  • DnaG catalyzes the synthesis of oligonucleotides in five discrete steps: template binding, nucleoside triphosphate (NTP) binding, initiation, extension to form a primer, and primer transfer to DNA polymerase III. (wikipedia.org)
  • This dinucleotide synthesis reaction is the same reaction as any other enzyme that catalyzes the formation of DNA or RNA (DNA Polymerase, RNA Polymerase), therefore DnaG must always synthesize oligonucleotides in the 5' to 3' direction. (wikipedia.org)
  • Once an oligonucleotide of appropriate length has been synthesized from the elongation step of primer synthesis, DnaG transfers the newly synthesized primer to DNA polymerase III for it to synthesize the DNA leading strand or Okazaki fragments for the lagging strand. (wikipedia.org)
  • This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. (guidelinecentral.com)
  • Herpesviruses contain a variety of virus-specific enzymes involved in the control of protein synthesis, gene expression, nucleic acid metabolism, and DNA synthesis (DNA polymerase, helicase-primase, thymidine kinase, transcription factors, protein kinases). (doctor-dr.com)
  • Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine. (scilifelab.se)
  • Fludarabine Phosphate Injection, USP contains fludarabine phosphate, a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-ß-D-arabinofuranosyladenine (ara-A) that is relatively resistant to deamination by adenosine deaminase. (guidelinecentral.com)
  • Among them is a 1971 antiviral drug, Ribavirin capable of disrupting the RNA synthesis of the coronovirus itself, the bug responsible for the biggest health crisis event of the 21st Century. (medialternatives.com)
  • The mechanism for primer synthesis by primases involves two NTP binding sites on the primase protein (DnaG). (wikipedia.org)
  • Once two nucleotides are bound to the primase, DnaG catalyzes the formation of a dinucleotide by forming a phosphodiester bond via dehydration synthesis between the 3' hydroxyl of the nucleotide in the initiation site and the α-phosphate of the nucleotide in the elongation site. (wikipedia.org)
  • 05. Which of the following drugs are protein synthesis inhibitor? (medparhlo.com)
  • The loss of class I expression was restored in the presence of phosphonoacetic acid (30 micrograms/ml), a late herpesviral protein synthesis inhibitor. (curehunter.com)
  • The tegument is made up of enzymes like VP16, which subverts cellular proteins, enzymes involved in viral nucleic acid reproduction, and VHS (Virion Host Shut off), which stops the host cell's cytoplasmic protein synthesis. (doctor-dr.com)
  • Ara-C is intracellularly converted by the canonical dNTP synthesis pathway to ara-CTP, which serves as a substrate but not an allosteric activator of SAMHD1. (scilifelab.se)
  • Systemic absorption is unlikely following ocular administration even when nasolacrimal secretions are swallowed, since vidarabine is rapidly deaminated in the gastrointestinal tract. (pharmacycode.com)
  • The rate limiting step of the primer synthesis occurs after NTP binding but before or during dinucleotide synthesis. (wikipedia.org)
  • DnaG catalyzes the synthesis of oligonucleotides that are 10 to 60 nucleotides (the fundamental unit of DNA and RNA) long, however most of the oligonucleotides synthesized are 11 nucleotides. (wikipedia.org)
  • The virus infected cell may only be attacked during the period of active synthesis of DNA. (pharmacycode.com)
  • After cells divide, they enter a period of growth (G1 phase), followed by DNA synthesis (S phase). (medscape.com)
  • 11. A drug inhibit the human gonadal and adrenal steroids synthesis along with fungistatic property? (medparhlo.com)
  • 8. Vidarabine and 2-deoxycoformycin as antileukemic agents against monocytic leukemia. (nih.gov)
  • 18. The effect of deoxyadenosine plus deoxycoformycin on replicative and repair synthesis of DNA in human lymphoblasts and isolated nuclei. (nih.gov)
  • In a smaller number of patients found to be resistant to topical vidarabine, trifluridine was also effective. (nih.gov)
  • Trifluridine interferes with DNA synthesis in cultured mammalian cells. (nih.gov)
  • In other clinical studies, trifluridine was evaluated in the treatment of herpes simplex virus keratitis in patients who were unresponsive or intolerant to the topical administration of idoxuridine or vidarabine. (nih.gov)
  • The tegument consist of enzymes such as VP16 which is responsible for subverting cellular proteins and enzymes to involve in viral nucleic acid replication and VHS (Virion Host Shut off ) protein which shut off the host cell protein synthesis in the cytoplasm. (microshorts.org)
  • It inhibits protein synthesis by binding to RNA . (nih.gov)
  • It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis. (nih.gov)
  • This article reports the synthesis of 42 novel bis-heterocyclic derivatives and the structure-activity relationship study conducted based on results of biological assays against Trypanosoma cruzi amastigotes. (bvsalud.org)
  • The mechanism for primer synthesis by primases involves two NTP binding sites on the primase protein (DnaG). (wikipedia.org)
  • Our research group has been studying the design and synthesis of analogues of natural lignans aiming to identify compounds with antiparasitic activity. (bvsalud.org)