Rational design and a SAR study of this class of compounds led to a new series of quinazoline derivatives with single-digit nanomolar potency. (northwestern.edu)
The present invention relates to a family of S-substituted quinazoline derivatives that inhibitors of the enzyme phosphodiesterase 7 (PDE7), useful for the treatment or prevention of diseases mediated by said enzyme, especially inflammatory, neurodegenerative, neurological, psychiatric and/or autoimmune diseases. (justia.com)
The present invention relates to a family of S-substituted quinazoline derivatives that have selective or specific inhibitory activity of the enzyme phosphodiesterase 7 (PDE7), without significantly inhibiting other phosphodiesterases such as the enzyme phosphodiesterase 4 (PDE4). (justia.com)
The S-substituted quinazoline derivatives of the present invention are, therefore, useful for the treatment or prevention of diseases mediated by said enzyme PDE7, especially inflammatory, neurodegenerative, neurological, psychiatric and/or autoimmune diseases. (justia.com)
The inventors of the present patent, after extensive and exhaustive research, have surprisingly discovered a family of S-substituted quinazoline derivatives that have selective or specific inhibitory activity of the enzyme phosphodiesterase 7 (PDE7), without significantly inhibiting other phosphodiesterases such as the enzyme phosphodiesterase 4 (PDE4). (justia.com)
Inhibitors2
Here we report a novel class of GCase quinazoline inhibitors, obtained in a high throughput screening, with moderate potency against wild-type GCase. (northwestern.edu)
c) Organic syntheses of heterocyclic compounds including cofactors, substrates, inhibitors and activators of the above enzymes, as well as relevant detergents and related lipids. (edu.au)
Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones, Advances in Organic Synthesis (2022) 16: 63. (eurekaselect.com)
Expedient1
An expedient synthesis of oxazepino and oxazocino quinazolines" (PDF). (wikipedia.org)
Organic1
The invention discloses an afatinib refined product synthetic method, and belongs to the technical field of organic synthesis. (lookchem.com)
Chemistry1
chemistry methods in different research areas, including synthesis. (eurekaselect.com)
Enzymes1
Patent application PCT WO2008/113881 discloses a family of compounds with a quinazoline nucleus that have dual inhibitory activity of enzymes PDE7 and PDE4 and are useful for the treatment of inflammatory or autoimmune diseases. (justia.com)
Class1
4] have shown a synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring. (wikipedia.org)