Nucleotide synthesisMetabolism and inhibitsPyrimidinesBiosynthesisInhibitsNucleotidesNucleoside phosphorylaseNucleic acid synthesisProtein SynthesisDeficiencyUric acidEnzymeNovo synthesisPrecursorNitrogenEnzymesInhibitors of guanosineAnalogsNucleosidesGuanosineProteinsOrganicMoleculesInhibitionSalvageOverproductionPathwaysMitochondrialBasesFolateAnalogueSubstratesPathwayCompoundsSynthetaseOxygenCellMedicineEssentialDecreaseDrugsTreatmentEffectsPotentialWorkLarge
Nucleotide synthesis1
- What is the function of the NDPK enzyme in nucleotide synthesis? (lecturio.de)
Metabolism and inhibits1
- Antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. (medscape.com)
Pyrimidines3
- Hitchings, who would later become a member of the National Academy of Sciences, "talked about purines and pyrimidines, which I must confess I'd never even heard of up to that point, and it was really to attack a whole variety of diseases by interfering with DNA synthesis. (cuny.edu)
- Amino acids, purines, and pyrimidines should also be available. (cliffsnotes.com)
- Emphasis is placed on the properties of 2-thioalkyl pyrimidines as intermediates because they provide the basis for a traceless solid-state synthesis of purines, pteridines, and their analogues. (strath.ac.uk)
Biosynthesis3
- Purine synthesis may either refer to: in vivo purine synthesis: Purine metabolism#Biosynthesis laboratory purine synthesis: Purine#Laboratory synthesis This disambiguation page lists articles associated with the title Purine synthesis. (wikipedia.org)
- In the first reaction unique to purine nucleotide biosynthesis, PPAT catalyzes the displacement of PRPP's pyrophosphate group (PP i ) by Gln's amide nitrogen. (citizendium.org)
- MZB inhibits the de novo purine biosynthesis of purines, but unlike azathioprine (AZT), it is not incorporated into nucleic acids in the cell. (hindawi.com)
Inhibits5
- Inhibits purine synthesis and proliferation of human lymphocytes. (medscape.com)
- Competitively binds to estrogen receptor, producing nuclear complex that decreases DNA synthesis and inhibits estrogen effects. (medscape.com)
- it inhibits the enzyme dihydrofolate reductase, which is essential for purine and pyrimidine synthesis. (medscape.com)
- It is an analogue of purine nucleoside which inhibits the synthesis and repair of DNA. (e-lactancia.org)
- MZB has a very specific mechanism of action on the lymphocytes that inhibits their proliferation without interfering with purine synthesis in other cell types. (hindawi.com)
Nucleotides3
- The de novo synthesis of purine nucleotides by which these precursors are incorporated into the purine ring, proceeds by a 10 step pathway to the branch point intermediate IMP, the nucleotide of the base hypoxanthine . (citizendium.org)
- This reaction is also shared with the pathways for the synthesis of the pyrimidine nucleotides, Trp , and His . (citizendium.org)
- This enzyme performs two steps in the process that produces (synthesizes) purine nucleotides. (medlineplus.gov)
Nucleoside phosphorylase3
- Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. (frontiersin.org)
- Purine nucleoside phosphorylase (PNP) deficiency (OMIM 613179) is a rare autosomal recessive metabolic disease leading to combined immunodeficiency and neurological abnormalities, which may include developmental delay, hypotonia, and spasticity ( 1 , 2 ). (frontiersin.org)
- Purine nucleoside phosphorylase is a ubiquitously expressed enzyme of the purine salvage pathway as is adenosine deaminase, deficiency of which also causes immunodeficiency. (frontiersin.org)
Nucleic acid synthesis2
- These agents bind to estrogen receptors, preventing stimulating effects of estrogen on nucleic acid synthesis. (medscape.com)
- Phosphorus is an essential element for nucleic acid synthesis and for the construction of phospholipids. (cliffsnotes.com)
Protein Synthesis4
- BBA Section Nucleic Acids And Protein Synthesis , 521 (1), 45-54. (tau.ac.il)
- Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
- Quinine, an alkaloid found in the bark of the cinchona tree, has been traditionally used as a natural remedy for malaria by interfering with the parasite's protein synthesis. (selfgrowth.com)
- 10-formylTHF serves as a formyl donor for MET-tRNA in mitochondrial protein synthesis, and as a precursor of purines. (alzforum.org)
Deficiency3
- The results suggest that the intensive activity of the pathway of purine synthesis de novo in the chick liver is mediated by the high PP-rib-P concentration, which may be due at least in part to the relative partial deficiency of HGPRT. (tau.ac.il)
- Lesch-Nyhan syndrome (LNS) is the most severe form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency (see this term), a hereditary disorder of purine metabolism, and is associated with uric acid overproduction (UAO), neurological troubles, and behavioral problems. (orpha.net)
- Vitamin B 6 deficiency may impair hemoglobin synthesis and lead to microcytic anemia (3) . (oregonstate.edu)
Uric acid1
- The end product of complete catabolism of purines is uric acid. (msdmanuals.com)
Enzyme2
- This enzyme is inhibited by the products of purine synthesis, AMP, IMP, and GMP as a part of negative feedback. (picmonic.com)
- An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. (bvsalud.org)
Novo synthesis1
- In the de-novo synthesis of Purines, Inositol Mono-phosphate is formed from a 10-step reaction. (picmonic.com)
Precursor1
- Furthermore, Gln serves as a precursor for the synthesis of arginine, which is indispensable for the optimal growth of neonatal piglets 14 and plays important roles in essential metabolic pathways 15 . (nature.com)
Nitrogen2
- It serves as an intermediate of a complicated 9 step process that involves the addition of carbon and nitrogen moieties to Inositol's cytoskeleton for Purine synthesis. (picmonic.com)
- Nitrogen is used for the synthesis of proteins, amino acids, DNA, and RNA. (cliffsnotes.com)
Enzymes3
- Six enzymes take part in IMP synthesis. (citizendium.org)
- Adenylosuccinate lyase and other enzymes involved in purine synthesis form a group of proteins (a protein complex) called the purinosome. (medlineplus.gov)
- These elements often are used for the synthesis of enzymes. (cliffsnotes.com)
Inhibitors of guanosine1
- There are already safe and effective inhibitors of guanosine synthesis used in patients for other diseases besides cancer. (sciencedaily.com)
Analogs2
- From her first publication in 1939 to her last in 1998, Trudy was involved in the investigation of purines and purine analogs as chemotherapeutic agents. (cuny.edu)
- Nidetzky, B. Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs. (beilstein-journals.org)
Nucleosides3
- Purine bases and nucleosides bearing functionalized C-substituents in position 6. (cas.cz)
- Rusinov, V. L. Approaches to the synthesis of heterocyclic C-nucleosides. (beilstein-journals.org)
- Banerjee, S. Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity. (beilstein-journals.org)
Guanosine1
- MYC-expressing cells had a particular need for a specific type of purine called guanosine. (sciencedaily.com)
Proteins1
- it suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction. (medscape.com)
Organic1
- We reviewed a few plausibly organic syntheses of phospholipids under prebiotic conditions with special attention paid to the starting materials as pro-chiral dihydroxyacetone and dihydroxyacetone phosphate (DHAP), which are the key molecules to break symmetry in phospholipids. (mdpi.com)
Molecules2
- The study, published in Cell Metabolism , found that MYC stimulated synthesis of purine molecules. (sciencedaily.com)
- Antibiosis, which is defined by detrimental interactions between at least two species, usually involves the synthesis of antimicrobial molecules that inhibit growth or kill other bacterial species [ 18 ]. (biomedcentral.com)
Inhibition2
- The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. (hindawi.com)
- Cellular studies with O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino) purine demonstrated inhibition of MCF-7 cell growth and target protein phosphorylation, consistent with CDK1 and CDK2 inhibition. (rcsb.org)
Salvage2
- Purines may be synthesized de novo or recycled by a salvage pathway from normal catabolism. (msdmanuals.com)
- PNP, with adenosine deaminase (ADA), is part of the purine salvage pathway. (frontiersin.org)
Overproduction1
- disorder causes purine overproduction. (msdmanuals.com)
Pathways2
- She elucidated some alterations in metabolic pathways that led to resistance to the purine antagonists. (cuny.edu)
- Specific responses in S. aureus included increased expression of de novo and salvation pathways for purine and pyrimidine synthesis, a switch to glucose fermentation, and decreased expression of major virulence factors and global regulators. (biomedcentral.com)
Mitochondrial1
- A ) Schematic of the mitochondrial fatty acid synthesis pathway and downstream lipoic acid synthesis. (elifesciences.org)
Bases2
- Thus purine moieties are initially formed as part of the ribonucleotides rather than as free bases . (citizendium.org)
- UAO is due to deficient recycling and enhanced synthesis of purine bases. (orpha.net)
Folate2
- Folate, in the form of 5,10 Methyl Tetrahydrofolate is required for the synthesis of the Inosine skeleton. (picmonic.com)
- Thus, folate serves as a substrate in purine synthesis. (picmonic.com)
Analogue1
- Tenofovir disoproxil is a diester pro-drug of the purine based nucleotide analogue, tenofovir. (who.int)
Substrates1
- We report RNA-catalysed RNA synthesis on structured templates when using trinucleotide triphosphates (triplets) as substrates, catalysed by a general and accurate triplet polymerase ribozyme that emerged from in vitro evolution as a mutualistic RNA heterodimer. (elifesciences.org)
Pathway1
- MtFAS is an essential pathway in mammalian skeletal myoblasts but does not contribute to synthesis of major cellular lipids. (elifesciences.org)
Compounds1
- Methods are described for the synthesis of 7-deazaguanines substituted at positions 2, 6 and 9 (purine numbering) such that a wide diversity of compounds can be prepared. (strath.ac.uk)
Synthetase2
- Phosphoribosylpyrophosphate synthetase superactivity treatment is with allopurinol and a low-purine diet. (msdmanuals.com)
- Chick liver, in comparison with rat liver, was found to contain a high activity of purine synthesis de novo, a high content and availability of 5-phosphoribosyl 1-pyrophosphate (PP-rib-P), comparable activity of PP-rib-P synthetase, and low activity of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and of adenine phosphoribosyltransferase (APRT). (tau.ac.il)
Oxygen1
- To make the successful 6MP, Trudy replaced an oxygen atom on the purine ring with a sulfur atom. (cuny.edu)
Cell3
- This complex comes together when there is a shortage of purines or when a large amount of purines is needed, such as during cell division. (medlineplus.gov)
- Both organisms also induced lysogenic mechanisms related to prophage induction ( S. aureus ) and R- and F- pyocin synthesis ( P. aeruginosa ), possibly as a response to stress resulting from nutrient limitation or cell damage. (biomedcentral.com)
- Berberine works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane. (selfgrowth.com)
Medicine1
- As a result, alkaloids find applications in various industries, including medicine, agriculture, and even the synthesis of fine chemicals. (selfgrowth.com)
Essential1
- Purines are essential for cells to produce RNA and DNA, both of which are required for growth and division. (sciencedaily.com)
Decrease1
- Some agents function as antimetabolites to decrease DNA and RNA synthesis and are used to treat a number of autoimmune conditions. (medscape.com)
Drugs2
- Our findings suggested that mice with MYC-expressing SCLC might benefit from treatment with drugs that inhibit purine synthesis," said Dr. Fang Huang, a visiting scholar at CRI and first author on the paper. (sciencedaily.com)
- Rauter, A. P. Nucleoside analogues: N-glycosylation methodologies, synthesis of antiviral and antitumor drugs and potential against drug-resistant bacteria and Alzheimer's disease. (beilstein-journals.org)
Treatment1
- The 6-mercaptopurine (6MP) became the first purine antagonist to be useful in the treatment of acute lymphoblastic leukemia in children. (cuny.edu)
Effects1
- Her 1954 paper that quantified the synergistic effects of purine antagonists with pyrimidine and folic acid antagonists has become a classic in the field. (cuny.edu)
Potential1
- Methylthioinosin (MTI), a metabolite of the purine synthesis, was identified as a potential ligand for TLR2. (tum.de)
Work3
- in recognition of the extraordinary services he has rendered by his work on sugar and purine syntheses. (wikidata.org)
- These methods supplement our previous work that established routes for the synthesis of 7- and 8-substituted 7-deazaguanines. (strath.ac.uk)
- The work represents the first successful iterative synthesis of a potent CDK inhibitor based on the structure of fully activated CDK2-cyclin A. Furthermore, the potency of O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino)purine was both predicted and fully rationalized on the basis of protein-ligand interactions. (rcsb.org)