• M imotopes provides custom peptide synthesis, catalogue peptides, PepSet™ peptide libraries, reagents, antibodies, and an array of other immunology services for the research market. (nridigital.com)
  • Peptides generally don't produce an antigenic response on their own, so conjugation facilitates a way to produce anti-peptide antibodies by coupling to a T-cell carrier protein. (nridigital.com)
  • Mimotopes offers phosphopeptide synthesis for cell research, as well as phosphopeptides to be used as antigens in the production of anti-phosphopeptide antibodies. (nridigital.com)
  • Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β 3 integrin. (illinois.edu)
  • We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β 3 activity (a radiolabeled version, 64 Cu-NOTA-PEG 4 -cRGD 2 , for PET imaging, and a fluorescent version, FITC-PEG 4 -cRGD 2 , for in vitro work). (illinois.edu)
  • We offer a wide range of peptide library designs, including linear peptides, cyclic peptides, and peptide mixtures. (biomodul.de)
  • Expertise in cyclic peptides using tether / spacer, olefin metathesis, RA etc. (tcgls.com)
  • Synthesis of cyclic dinucleotides- Cyclic dinucleotides (CDNs) activate STING, leading to a potent type I IFN response. (tcgls.com)
  • We can synthesise difficult peptides (greater than 100 amino acids) and peptides with a wide and increasing range of amino acid modifications including N-terminal, C-terminal and side-chain modifications, multiple disulphide bridges, fluorescent labels, lipidation, D-amino acid and heavy isotope incorporation, biotinylation, glycosylation, post translational modifications, PEGylation and more. (2bscientific.com)
  • Amino acid analysis can be provided as an additional service to determine peptide composition, and can also be used to determine net peptide if required. (2bscientific.com)
  • Briefly, each peptide is isotopically labeled by incorporating 15N/13C to one amino acid residue, typically Val, Phe, Arg, Ile, or Leu near the C-terminus. (yale.edu)
  • A two-pool OBOC strategy was developed to distribute the fluorine-containing amino acid throughout the peptide sequence during library synthesis. (uwo.ca)
  • With labels and modifications, changes can be made to a peptide without altering the base amino acid sequence. (nridigital.com)
  • In practice, this parameter is defined by the number of amino acid residues shared by neighboring peptides. (proteogenix.science)
  • We provide solid phase peptide synthesis to customers from the biomedical, biotechnology and pharmaceutical industry. (tcgls.com)
  • His research was focused on the following areas: structure elucidation and synthesis of natural products, synthetic potential-dependent ion channels in lipid membranes, 3D-structure and biosynthesis of microbial metabolites, automated multiple parallel synthesis of peptides and organic compounds, structure-activity relationships of peptide hormones, biosensor developments, combinatorial chemistry for lead structure search, peptide libraries, complete B- and T-cell epitope mapping of viral proteins, immunobiochemistry. (wikipedia.org)
  • In 1989, he was awarded the Max-Bergmann Medallion for his scientific work in the field of Lantibiotics, and in 1992 he received the Leonidas Zervas Award of the European Peptide Society for distinguished contributions in the field of peptide chemistry. (wikipedia.org)
  • Combinatorial chemistry : synthesis, analysis, screening. (wikipedia.org)
  • His research group has a special interest in peptide hormone and neurotransmitter chemistry, biology and biophysics, especially the chemical biology of human behaviour and disease states including diabetes, cancer, obesity, pigmentary disorders, sexual function and pain, especially prolonged and neuropathic pain. (hstalks.com)
  • Our DDS segment provides comprehensive services from hit identification to IND, including expertise with diverse chemistry, library design and synthesis, in vitro biology and pharmacology, drug metabolism and pharmacokinetics, as well as natural products. (prnewswire.com)
  • This thesis will document a method of combinatorial chemistry to construct libraries of new potential peptide-based imaging agents for positron emission tomography (PET) imaging. (uwo.ca)
  • Each peptide in the library contains a single fluorine atom incorporated through established SPAAC chemistry. (uwo.ca)
  • This 18 F-azadibenzocyclooctyne (ADIBO-F) was radiolabelled from its toluenesulfonate precursor in 21-35 % radiochemical yields, and subsequently incorporated into two cancer-targeting peptides through SPAAC chemistry. (uwo.ca)
  • from the technical review on the medicinal chemistry and molecular pharmacology of opioid peptides and the opiates which took place on September 4-6, 1984, at Bethesda, Maryland"--Page iv. (epa.gov)
  • Synthesis remains a central, creative and exciting branch of chemistry. (soci.org)
  • Polyclonal antibody-based heterologous immunoassays have shown superior sensitivities to homologous ones, but the synthesis of heterologous haptens may be time-consuming, requiring expertise in synthetic chemistry. (cdc.gov)
  • In this area, we have developed a methodology for the incorporation of protected isocyanates into organic molecules and this chemistry is being applied to the synthesis of a diverse set of biologically important, nitrogen-containing heterocycles. (exeter.ac.uk)
  • My teaching activities cover all aspects of organic chemistry from basic structure and bonding in organic molecules, to complex organic synthesis. (exeter.ac.uk)
  • The majority of peptides are in freeze dried form and will contain counter ions and physically bound water as a result of cleavage from resin, hplc and drying. (2bscientific.com)
  • Peptide and biochemical purity is assessed using an array of techniques including HPLC, NMR, microanalysis, high voltage electrophoresis, TLC, and mass spectrometry as appropriate. (2bscientific.com)
  • Peptides purified by reversed phase HPLC or ion exchange chromatography have their purity given as the area under the curve of the major peak when analysed at a specific wavelength, usually 230nm. (2bscientific.com)
  • After instrument cleavage of the peptide from the resin, crude peptides are purified by reverse phase HPLC and analyzed by MALDI-MS (Applied Biosystems 4800 MALDI-Tof/Tof). (yale.edu)
  • Advanced Peptide Synthesis Service ** Deuterated Peptides ** Free HPLC/MS/COA Analysis. (biomodul.de)
  • All the peptides synthesized are controlled by MS and HPLC. (proteogenix.science)
  • Mimotopes supplies and distributes peptide reagents and chemicals both within and outside of Australia. (nridigital.com)
  • AnaSpec offers 320 reagents for peptide synthesis. (anaspec.com)
  • The proposed objectives were design and synthesis of photo-cross-linking peptide-based probes specific for PTMs and validation of the methodology using purified proteins, cell lysates and representative cancer cell lines. (europa.eu)
  • Following extensive optimisations at the chemical synthesis stages, peptide probe libraries were generated to target key PTMs such as protein arginine methylation and protein lysine side-chain succinylation in histone- and non-histone proteins. (europa.eu)
  • Its utility lies in the capability of heterocyclic compounds to mimic the structure of peptides and to bind reversibly to proteins [ 1 - 4 ]. (ijpsonline.com)
  • Studies using synthetic peptides and whole proteins demonstrate that these diazirine analogues are efficient substrates for prenyltransferases. (bvsalud.org)
  • Photo-cross-linking experiments using peptides incorporating the diazirine-functionalized isoprenoids selectively cross-link to several different proteins. (bvsalud.org)
  • The aim of the project is to investigate protein-protein interactions between the molecular chaperone DNAJB6 and aggregation-prone peptides and proteins which cause severe neurodegenerative protein aggregation diseases. (lu.se)
  • Linear peptides, especially those with long sequences, are particularly unpredictable and susceptible to unintentional folding. (nridigital.com)
  • Antibacterial drugs were originally isolated from natural sources, but as the threat of antibacterial resistance looms, the development of intelligently designed antimicrobial drugs, including small molecules and custom antimicrobial peptides has been fostered. (genscript.com)
  • We provide a range of services for small molecules (including highly potent) and peptides. (almacgroup.com)
  • We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances. (almacgroup.com)
  • With over 25 years of peptide manufacturing experience, AnaSpec is your trusted source of highly complex peptides. (anaspec.com)
  • Our partner has the technology to synthesize 96 complex peptides in parallel and offers various grades of quality controls. (2bscientific.com)
  • According to the patent, such arrays may be used for multiplex detection of chemical and biomolecular species, or may be combined with parallel synthesis of anchor probe libraries to provide a multiplex diagnostic device. (genomeweb.com)
  • A typical custom synthesis peptide run will yield between 5 - 50 mg of the peptide in question, depending upon the number of amino acids and complexity of the product. (2bscientific.com)
  • Chemical Catalogue -- Custom synthesis, synthesis optimization, libraries. (ccl.net)
  • Additionally, labels and modifications can make a standard peptide versatile and adaptable to any purpose. (nridigital.com)
  • Bon Opus Biosciences uses the standard peptide synthesis approach with solid-phase integration and access to our comprehensive library of modifications and amino acids. (bonopusbio.com)
  • Professor Maguire underlined the central importance of organic synthesis to the field of chemical biology and the interfaces with drug development and process development. (soci.org)
  • Dr Nick Gathergood, Dublin City University, added that EuCheMS has belatedly recognised organic synthesis as a strategically important subject and it will henceforth have a much higher profile at European level. (soci.org)
  • I am an organic chemist with research interests that cover a wide range of aspects of synthesis. (exeter.ac.uk)
  • The second major area of my group's research has involved studies into the use of structurally 'unusual' heterocycles as protected, reactive functional groups in organic synthesis. (exeter.ac.uk)
  • Mimotopes supplies custom peptides with fully customisable sequences and modifications, including options for the N and C termini. (nridigital.com)
  • In this work we demonstrate that phage display peptide libraries can be used as a source of phage-borne peptidomimetics to facilitate the development of sensitive heterologous assays. (cdc.gov)
  • Antimicrobial peptides(AMPs) are short peptide ranging from 10 to 50 amino acids and has a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses, as well as cytotoxic activity on cancer cells, anti-inflammatory, and immunomodulatory activities. (genscript.com)
  • The distinct activity of antimicrobial peptides governs their sequence, namely, the incorporation of these peptides into microbial cell membranes. (genscript.com)
  • Due to the negative charge of many microbial membrane components (e.g. phospholipids, lipopolysaccharides and teichonic acids), antimicrobial peptides are often cationic in nature. (genscript.com)
  • Antimicrobial peptides could be the answer to this problem. (lu.se)
  • Histatins, a family of saliva peptides that act as a first line of defence of our innate immune system and possess antimicrobial properties. (lu.se)
  • PepChip Kinase is a family of peptide microarrays containing up to 3,000 kinase substrates (phosphorylation sites) for rapid target identification. (mimotopes.com)
  • Kinase Substrates Library, Group II, biotinylat. (anaspec.com)
  • The use of this Group II of distinct 18 peptide mixtures, in combination with Group I of 180 distinct peptide mixtures (cat# 62017-1), can provide sequence preference information of different kinases. (anaspec.com)
  • The sequence motifs of MHC-bound natural peptide libraries (major histocompatibility complex) has been determined for the first time by Günther Jung's PhD student Stefan Stevanovic in cooperation with the cell-biological group of Hans-Georg Rammensee. (wikipedia.org)
  • After several rounds of extensive labelling validation experiments, a probe derived from peptide sequence of the mitochondrial protein glutamate dehydrogenase (GDH) was found to be one of the best, and has served as a prototype system for the further research developments in the project. (europa.eu)
  • Reputable production labs use custom DNA synthesis services to develop a distinct genetic sequence, which undergoes variable transition phases. (bonopusbio.com)
  • In the second part of this research, circular dichroism, solution and solid-state nuclear magnetic resonance (NMR) methods were used to assess the structure of two SP-B-based peptides, Super-Mini-B and N-terminal insertion sequence (SP-B₁₋₇). (mun.ca)
  • Super-Mini-B is composed of the N-terminal 7-residue insertion sequence and the N-and C-terminal helices of SP-B. Interestingly, it was observed that Super-Mini-B produces greater lipid membrane perturbation than the peptide which lacks the N-terminal insertion sequence (i.e. (mun.ca)
  • Understanding Conformational Evolution of Dynamic Chemical Library by Computational Simulation. (emory.edu)
  • The integrated Explorer autosampler allows sequential chemical synthesis of up to 48 samples per queue. (mcmaster.ca)
  • The dimer abrin, is composed of two protein subunits, A and B. Working as a chemical team, B enables the molecule ingress into the cell, while once inside, the A subunit inhibits the process of protein synthesis. (cdc.gov)
  • anti-peptide antigen with terminal cysteine residue. (biomodul.de)
  • A fluorescent peptide is used in biological experiments to detect a reaction or change. (nridigital.com)
  • N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation. (expasy.org)
  • Among the most potent novel inhibitors, one peptide, RKLLW-NH2, shares the amphiphilic character of the nonamer fragment VMNGLQNRK of the autoinhibitory, substrate-like, but reverse-binding prosegment of human cathepsin L which blocks the active center of the enzyme. (uni-bielefeld.de)
  • Our custom peptide synthesis partner is able to synthesize any kinds of peptides from 2 to 100+ amino acids with a 99% purity rate. (2bscientific.com)
  • Our partner can synthesize peptides from 2 to 120 aa, mg to multi-grams at various purity grade. (2bscientific.com)
  • For each protein to be quantified, we synthesize minimally two tryptic peptides(25 µM small scale fmoc using the Yale WM Keck Small Peptide Synthesis Resource). (yale.edu)
  • To a synthetic chemist, it provides an opportunity to synthesize a library of compounds based on a core scaffold and to screen the derivatives for various biological activities. (ijpsonline.com)
  • We also feature a library of peptides to begin the synthesis process, where we can synthesize up to 98 peptides simultaneously. (bonopusbio.com)
  • Although smaller libraries are much easier and less expensive to synthesize, the likelihood of researchers finding the precise interface residues in complex projects is often limited. (proteogenix.science)
  • The candidate will be trained in mRNA Display, peptide synthesis, protein expression and purification, and biophysical analysis of target-ligand interactions. (gettinghired.com)
  • Consistent with the project proposal, synthesis of peptide probes carrying various synthesised unnatural amino acids, photo cross-linkers and bio-orthogonal moieties were optimised and the probes were successfully applied in protein labelling experiments. (europa.eu)
  • Additional screens identified 1018 as a potent anti-biofilm peptide that prevented biofilm formation and led to the eradication of mature biofilms in both Gram-negative and Gram-positive bacteria. (ubc.ca)
  • Further studies identified even more potent D-enantiomeric anti-biofilm peptides DJK-5 and DJK-6 that also prevented (p)ppGpp accumulation, were highly synergistic with conventional antibiotics and exhibited in vivo activity. (ubc.ca)
  • Providing services for all stages of drug development for small (including highly potent) molecules and peptides. (almacgroup.com)
  • This positional scanning synthetic peptide combinatorial library (PS-SPCL) has been used in rapid identification of serine/threonine kinase phosphorylation motif. (anaspec.com)
  • Suitable for applications such as epitope mapping and screening, a variety of PepSet preset combinatorial library and array styles are available. (nridigital.com)
  • These include overlapping peptides, alanine scanning, combinatorial positional scanning, truncated peptide libraries, and scrambled peptide libraries, as well as combinatorial libraries comprised of more than one different type. (nridigital.com)
  • Following pretreatment acquisitions, animals have been divided into treatment and control buy peptide online groups, and kinase inhibitor library for screening was administered to the mice in the remedy group. (alksignaling.com)
  • The biosynthesis of vancomycin-type and other peptide antibiotics is now a major topic of the research group of Roderich Süßmuth. (wikipedia.org)
  • Further, the peptide was found to be synergistic with different classes of antibiotics to prevent and eradicate bacterial biofilms. (ubc.ca)
  • Genosphere Biotechnologies bietet Ihnen die kostengünstige parallele Peptidsynthese von "custom peptide libraries / arrays / pools" an. (biomodul.de)
  • From affirming new leads with a scrambled library to identifying essential residues, a PepSet peptide library can offer more than the sum of its peptides. (nridigital.com)
  • In contrast, when offset numbers are low and peptides short, the resulting library will have more peptides, making it easier to identify the interface residues but also resulting in more time-consuming experiments. (proteogenix.science)
  • Turnaround time for a peptide synthesis is typically 1-3 weeks but may be longer for peptides over 60 amino acids, those with difficult modifications or if TFA removal, or non-routine analysis is required. (2bscientific.com)
  • Synthesis of Nucleoside derivatives- Nucleosides and their derivatives have found applications in biotechnology, biology and medicine. (tcgls.com)
  • The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. (wiley-vch.de)
  • Sie planen ein Forschungsprojekt und benötigen dafür regelmäßig spezielle Peptide, Proteine, Plasmide und poly- bzw. (biomodul.de)
  • Biotinylation is the addition of a biotin group to the terminus or side chain of a peptide to allow for binding to avidin and streptavidin. (nridigital.com)
  • Conjugation of a peptide to another molecule, such as an immunogenic carrier protein or oligo has broad applications in immunological and molecular research. (nridigital.com)
  • Amanda Eriksson Skogs fund will be used to investigate Histatins, Saliva peptides with important functions for our innate immune system. (lu.se)
  • Topical antibiotic was applied onto the how to dissolve peptide edges of the wound to prevent subsequent dermal infection. (alksignaling.com)
  • We have unrivalled expertise in the synthesis of complex, constrained and other special peptides and our scientists are happy to assist in selecting the most appropriate peptide specification for your application. (2bscientific.com)
  • Expertise in synthesis allows researchers to attack interdisciplinary problems, to grapple with mechanistic problems and hence design superior processes. (soci.org)
  • With 200000+ peptides synthesized and 99+ % success rate, trust our unrivalled expertise. (proteogenix.science)
  • Custom peptides are an invaluable tool in numerous fields of research, including immunology and drug development projects. (nridigital.com)
  • Different strategies for the isolation of these peptides were explored using two metabolites of pyrethroid insecticides. (cdc.gov)
  • He received the Akabori Memorial Award 2000 form the Japanese Peptide Society and the ESCS-Award 2003 of the European Society of Combinatorial Sciences. (wikipedia.org)
  • It was used technique of documentation based on literature available at Scielo (Scientific Electronic Library Online) and MEDLINE between 2000 and 2010. (bvsalud.org)
  • Peptide libraries are powerful tools for bioactive molecule discovery and development. (biomodul.de)
  • Mimotopes offers several optional peptide modifications including carbamylation, glycosylation, methylation and acetylation. (nridigital.com)
  • Over 300 peptide modifications are available within the standard synthesizing process, and the lab will collaborate with you to ensure the correct selection. (bonopusbio.com)
  • The biosynthetic intermediates of ribosomally synthesized and post-translationally modified peptides of several lantibiotics have been analyzed and the corresponding enzymes have been characterized. (wikipedia.org)