Synthesis of linear and cyclic. Medical search. Frequent questions

2021 Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids. (ed.ac.uk)
Peptides can be used to mimic enzyme structures and their secondary interactions and they are easily accessible through solid-phase peptide synthesis. (ed.ac.uk)
Despite this, cyclic peptides remain underexplored as chiral ligands for catalysis due to synthetic complications upon macrocyclization. (ed.ac.uk)
Here, we show that the solid-phase synthesis of peptides containing metal-binding amino acids, bipyridylalanine (1), phenyl pyridylalanine (2) and N,N-dimethylhistidine (3), can be combined with peptide macrocylization using peptide cyclase 1 (PCY1) to yield cyclic peptides under mild conditions. (ed.ac.uk)
High conversions of the linear peptides were observed (approx. (ed.ac.uk)
This study shows that PCY1 can tolerate peptides containing amino acids with classic inorganic and organometallic ligands as side chains, opening the door to the streamlined and efficient development of cyclic peptides as metal ligands. (ed.ac.uk)
LifeTein offers the formation of cyclic peptides via disulfide bridges between cysteine residues within the peptide. (lifetein.com)
LifeTein has gained extensive experience in synthesizing these challenging cyclic peptides. (lifetein.com)
Amphiphilic cyclic peptides containing alternative arginine and tryptophan such as [WR] 5 have been shown to enhance the transport of cargo molecules across the cell membrane. (chapman.edu)
Herein, we report the synthesis and biological evaluation of a novel series of hybrid cyclic-linear peptides containing alternative positive and hydrophobic amino acids on the ring and side-chain [(RW) 5 ]K(RW) X (X=1-5) to compare their molecular transporter efficiency. (chapman.edu)
The peptides were synthesized through Fmoc solid-phase peptide synthesis. (chapman.edu)
These data suggest the potential of this series of hybrid cyclic-linear peptides compared to [WR] 5 as molecular transporters of large molecules, such as a negatively charged phosphopeptide. (chapman.edu)
Turn around times for some labeled peptides, cyclic peptides and peptides carrying post-translational modifications may be longer depending on the nature of the peptide sequence or project. (umich.edu)
Advanced Peptide Synthesis Service ** Deuterated Peptides ** Free HPLC/MS/COA Analysis. (biomodul.de)
We offer a wide range of peptide library designs, including linear peptides, cyclic peptides, and peptide mixtures. (biomodul.de)
Synthesis and Characterization of Biologically Potent Endothelin Classes of Peptides. (tkmcas.ac.in)
PEGylated dendrimer polystyrene support: synthesis, characterisation and evaluation of biologically active peptides. (tkmcas.ac.in)
Synthesis and characterization of linear and cyclic endothelin peptides on PEGylated poly(O-benzyl ether) dendrimeric supports. (tkmcas.ac.in)
Comparative Molecular Transporter Efficiency of Cyclic Peptides Containing Tryptophan and Arginine Residues. (omicsdi.org)
Custom synthesis and commercial manufacturing variety of new and small peptide, specially for Cosmetic Peptides. (honorbiotech.com)
Expertise on Linear, cyclic or modified peptides in solid phase, Liquid phase or hybrid phase, maximizing efficiency and productivity to reduce your timeline and cost. (honorbiotech.com)

Various diepoxides easily react with amines or diamines to form cross-linked, cyclic or linear addition-polymers, which are implemented in construction, electronic, aerospace, medical and dental industries [1,2] . (beilstein-journals.org)
It is hypothesized that these innovative polymers, characterized by unique cyclic architectures and charge densities, can effectively perform in gene delivery applications and antimicrobial roles, potentially surpassing their linear chain counterparts. (stars-natur.cz)
The synthesis will be designed to produce polymers of different charge densities and distributions, thereby allowing the study of structure-activity relationships. (stars-natur.cz)
Both physical and chemical characteristics of the synthesized cyclic polymers will be analyzed. (stars-natur.cz)
The solution properties of these polymers will be compared to their linear analogs to identify the benefits of cyclic architecture. (stars-natur.cz)
The efficacy of these new cyclic polymers for gene delivery will be compared to linear counterparts to evaluate their potential advantages. (stars-natur.cz)
Silicone oils are linear polymers synthesized by ring - opening polymerization. (ukessays.ae)
Synthesis and Evaluation of chloro SPIRO and amino SPIRO Supports: Novel Hydrophilic Cross-linked Polystyrene Polymers for Solid Phase Peptide Synthesis. (tkmcas.ac.in)
The electronic structure of a molecular quantum ring (stacks of 40-unit cyclic porphyrin polymers) is characterised via scanning tunnelling microscopy and scanning tunnelling spectroscopy. (nottingham.ac.uk)
Monosubstituted derivatives of γ-cyclodextrin (γ-CD) are suitable building blocks for supramolecular polymers, and can also serve as precursors for the synthesis of other regioselectively monosubstituted γ-CD derivatives. (beilstein-journals.org)

Synthesis, Characterization, and Evaluation of PS-PPDC Resin: A Novel Flexible Cross-linked Polymeric Support for Solid-Phase Organic Synthesis. (tkmcas.ac.in)
Synthesis, Characterization and Application of Bisphenol A Glycerolate Dimethacrylate Cross-Linked Polystyrene (PS-BGD): A Flexible Support for Gel Phase Peptide Synthesis. (tkmcas.ac.in)

Synthesis of cyclic polyacetylene offers fresh take on classic semiconducting polymer. (acs.org)
The material could be a useful addition to the polymer electronics toolbox, and researchers are keen to understand how its physical and electronic properties compare to those of its linear sibling . (acs.org)
For example, simply wafting acetylene over a vial coated with a solution of the catalyst created a flexible, shiny film of the cyclic polymer in a few seconds. (acs.org)
A method for the production of cyclic polyammonium ions is presented which utilizes a polymer cyclization of azide terminated linear polymer based on the "click" reaction. (caltech.edu)
These results highlight the critical role of purity to the successful formation of cyclic or linear interlocked polymer using a ROMP process. (caltech.edu)
cNDI-1 exhibits an off-pathway aggregate in cyclic hydrocarbon (MCH) but produces a helical supramolecular polymer in linear alkane (decane) by well-defined J-aggregation. (rsc.org)
The chiral seed of cNDI-1 was also successfully employed for the synthesis of a helical supramolecular polymer from the off-pathway aggregate of achiral cNDI-2 . (rsc.org)
A linear polyhydroxyurethane was carefully designed to enable its dissolution in ε-Caprolactone, which under appropriate conditions, facilitated its solvent-free ring-opening polymerization from the pendent hydroxy groups of the polymer. (kth.se)

Two notable examples of this catalysis are the fixation of CO 2 to epoxides for the synthesis of cyclic carbonates and the reduction of CO 2 to CO. Recent examples of COFs for the capture of CO 2 will be discussed followed by COF catalysts which use CO 2 as a feedstock for the production of value-added products. (frontiersin.org)
Two of these value-added products are CO and industrially relevant cyclic carbonates. (frontiersin.org)
Carbon dioxide and its derivatives were explored for the preparation of diverse cyclic carbonates serving as precursors to dynamic polyhydroxyurethane networks and copolymers with complex architecture. (kth.se)

Several synthetic strategies (such as cationic ring-opening polymerizations and subsequent post-polymerization modifications) will be utilized to yield cyclic polycations of different structures and cycle sizes, ensuring high cyclization yields. (stars-natur.cz)

Cyclic di-AMP (also called c-di-AMP and c-di-adenosine monophosphate) is a second messenger used in signal transduction in bacteria and archaea. (wikipedia.org)
It is one of many ubiquitous nucleotide second messengers including cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), guanosine pentaphosphate ((p)ppGpp), and cyclic di-GMP (c-di-GMP). (wikipedia.org)

These scientists discovered that the tiara-like platinum thiolate complexes were suitable as precursors for the synthesis of monodispersed zero-valent platinum clusters with a specific atomicity: a reaction that previous chemical methods could not realize. (nanowerk.com)

Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. (omicsdi.org)

My current research involves the potential optimization of linear peptoids via cyclization in order to better treat against two fungal pathogens, Cryptococcus neoformans and Candida albicans. (mtsu.edu)

Although disulfide bridges are normally formed toward the end of peptide synthesis, it can be advantageous to couple or elongate chains that include a pre-formed disulfide bond. (lifetein.com)
Solid-Phase Peptide Synthesis of Endothelin Receptor Antagonists on Novel Flexible, Styrene-Acryloyloxyhydroxypropyl Methacrylate-Tripropyleneglycol Diacrylate [SAT] Resin. (tkmcas.ac.in)
Poly(ethylene glycol) grafted polystyrene dendrimer resins: Novel class of supports for solid phase peptide synthesis M.A.Siyad and G.S. Vinod Kumar. (tkmcas.ac.in)

Results of these basic reactions suggested that platinum thiolates initially undergo a linear chain growth, followed by entropically favorable formation of smaller cyclic compounds. (nanowerk.com)
But these compounds have been synthesised in nature for millions of years, so Paul ÓMáille and colleagues at the Institute of Food Research decided to investigate the production of cyclic compounds in A. annua, which is also known as sweet wormwood. (chemistryworld.com)
However, ADS produces cyclic compounds whereas BFS makes less complex, linear terpenes. (chemistryworld.com)

The cellular uptake of a number of fluorescent-labeled phosphopeptides, including F'-GpYLPQTV, F'-NEpYTARQ, F'-AEEEIYGEFEAKKKK, F'-PEpYLGLD, F'-pYVNVQN-NH2, and F'-GpYEEI (F' = fluorescein), was evaluated in the presence or absence of a [WR]4, a cyclic peptide containing alternative arginine (R) and tryptophan (W) residues, in human leukemia cells (CCRF-CEM) after 2 h incubation using flow cytometry. (omicsdi.org)

The ring-opening metathesis polymerization of a [2]catenane was investigated, using both a cyclic metathesis catalyst and bulky metathesis catalysts for the formation of cyclic polycatenanes and polyrotaxanes respectively. (caltech.edu)
Linear impurities present in either or both the [2]catenane monomer and the metathesis catalysts are believed to be responsible for the formation of the non-interlocked polyether and free macrocycle. (caltech.edu)
Electrocatalytic activity and stability of these catalysts for oxygen reduction were studied by cyclic voltammetry and linear sweep voltammetry at rotating disk electrode (RDE). (ac.rs)

In chemical synthesis, the folding and disulfide formation of the fully unprotected amino acids in an aqueous solution by a mild oxidization to form the target product with the correct disulfide bonds. (lifetein.com)
Chemical synthesis of the fluorescent, cyclic dinucleotides cthGAMP. (lmu.de)

The peptide is simply synthesized via solid or solution phase synthesis, and the solution is then oxidized at pH 8-9. (lifetein.com)
As these rings are non-trivial to synthesize individually in solution, we propose the presented workflow to identify and characterize feasible molecules for bulk phase synthesis. (nature.com)

The enzymatic steps of glycolysis and the subsequent synthesis of acetyl-CoA involve a linear sequence, whereas the oxidation of acetyl-CoA in the Krebs cycle is a cyclic sequence of reactions in which the starting substrate is subsequently regenerated with each turn of the cycle. (encyclopedia.com)

The title compound, (4S,5S,8R,10Z)-2,2,5,6,8,10- hexamethyl-4-phenyl-l,3-dioxa-6-aza-2-silacycloundec- 10-en-7-one, crystallizes with two virtually identical molecules in the asymmetric unit, each with the same absolute configuration. (caltech.edu)
As synthetic chemists well know, cyclic molecules are extremely useful but rarely straightforward to make. (chemistryworld.com)

Cyclic di-AMP has been identified (along with 2'3'-cGAMP) as a ligand that induces closing of the STING dimer, leading to STING polymerization and pathway activation. (wikipedia.org)
While several different synthesis methods have been developed from multi-nuclear metal complexes or stable ligand-protected "magic number" clusters, the precursors were not scalable and the exact preservation of atomicity was never provided. (nanowerk.com)

Formation of cyclic polycateanes was explored utilizing the mutual recognition between secondary ammonium ions and crown ether macrocyles. (caltech.edu)
The product of the RCM of linear crown ether dienes around cyclic polyammonium ions was investigated using 2D-DOSY. (caltech.edu)

We prepared a set of monosubstituted 2 I - O -, 3 I - O -, and 6 I - O -(3-(naphthalen-2-yl)prop-2-en-1-yl) derivatives of γ-CD using two different methods. (beilstein-journals.org)

It has been shown by 1 H and 13 C NMR spectroscopy that 2-mercaptobenzoyl- hydrazones of aliphatic and aromatic aldehydes exist in solution as tautomeric mixtures of linear and cyclic benzo-1,3,4-thiadiazepine forms. (scirp.org)

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. (thomassci.com)
Converting a linear, organic molecule into a cyclic one typically involves making and breaking several carbon-carbon bonds in the same step while holding all the parts in a specific conformation. (chemistryworld.com)

Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides. (omicsdi.org)

The effect of annealing temperatures and TMC concentrations are also investigated by electrochemical techniques such as cyclic and linear sweep voltammograms. (csircentral.net)

In order to promote the condensation process and lower the condensation temperature, the synthesis should be conducted in a basic environment. (docksci.com)

Cyclic di-AMP is synthesized by a membrane-bound diadenylate cyclase (also called diadenylyl cyclase, CdA, and DAC) enzyme called CdaA (DacA). (wikipedia.org)
Since cyclic di-AMP is a signaling nucleotide, it is presumed to adhere to the same regulation pathways, where environmental changes are sensed by synthesis or degradation enzymes, which modulate enzyme concentration. (wikipedia.org)
We also anticipated that our cyclic cMO strategy could be adapted to accommodate enzyme-mediated activation. (cdc.gov)
11 The 4,5-dimethoxy-2-nitrobenzyl (DMNB)-containing linkers used in our previous study allowed optical MO uncaging, but cyclic cMOs could accommodate enzyme-cleavable linkers as well. (cdc.gov)

Similarly, c-di-AMP levels affect peptidoglycan precursor synthesis, suggesting a strong link between the c-di-AMP and peptidoglycan synthetic pathways. (wikipedia.org)
Cell-free protein synthesis (CFPS) has recently become very popular in the field of synthetic biology due to its numerous advantages. (jove.com)
A concise synthetic route to the tunicamycin antibiotics is described, illustrated by the preparation of (+)-tunicamycin-V (1-V), Key features of the synthesis include (1) the development and application of a silicon-mediated reductive coupling of aldehydes and allylic alcohols to construct the undecose core of the natural product and (2) the development of an efficient procedure for the synthesis of the trehalose glycosidic bond within the antibiotic. (caltech.edu)

Phosphodiesterase (PDE) enzymes degrade cyclic di-AMP to the linear molecule 5'-pApA (phosphadenylyl adenosine). (wikipedia.org)
Strikingly, three enzymes generated cyclic terpenes and shared a single mutation called Y402L. (chemistryworld.com)

The synthesis of organo - silicon materials started in the 1860s. (ukessays.ae)

In bacteria, cyclic di-AMP has been implicated in the control of growth, cell wall homeostasis, bacterial biofilm formation and virulence gene expression, heat and osmotic stress regulation and responses, sporulation, potassium transport, lysis, and antibiotic resistance. (wikipedia.org)
Selected cyclic polycations will be assessed for their antimicrobial properties against antibiotic-resistant bacteria ( e.g . (stars-natur.cz)

In particular I want to know more about the synthesis of RDX from methenamine + HNO3 and the reasons behind all the temperature adjustments during its synthesis or how impurities affect the synthesis (eg NOx concentration, presence of sulfates or other salts, etc). (sciencemadness.org)

At high concentrations, cyclic di-AMP binds to receptor and target proteins to control specific pathways. (wikipedia.org)
The effectiveness of these new structures will be compared to the linear analogs, potentially illuminating new pathways in the fight against antibiotic resistance. (stars-natur.cz)

The first step of the synthesis of silicones is the reduction of SiO 2 into Si. (ukessays.ae)
Herein, we report a facile hydrothermal synthesis of flower-like nanostructured molybdenum sulphide and its incorporation on to graphene as a potential oxygen reduction reaction catalyst in alkaline medium. (csircentral.net)

I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Improving the sustainability of synthesis is a major goal in green chemistry, which has been greatly aided by the development of asymmetric transition metal catalysis. (ed.ac.uk)
Hello, I'm interested in the chemistry behind explosives and their synthesis in general. (sciencemadness.org)

The aim of the thermal and other control methods is to force the reaction towards the formation of the cyclic products and the breakup of the linear byproducts. (sciencemadness.org)
Methods: Herein, we present the synthesis of biodegradable polymeric Poly (D, L-Lactide-co-glycolide) (PLGA) particles loaded with SOR (PS) by emulsion-solvent evaporation process. (bvsalud.org)
The ability of source control devices to block aerosols can be tested by expelling an aerosol through a headform using constant airflows, which are simpler, or cyclic airflows, which are more realistic but require more complex methods. (cdc.gov)

Cyclic di-AMP has been linked to fatty acid synthesis regulation in Mycobacterium smegmatis, the growth of S. aureus in conditions of low potassium, the sensing of DNA integrity in B. subtilis, and cell wall homeostasis in multiple species. (wikipedia.org)
Ethylene brassylate, a fatty acid-derived macrodilactone, was employed for the synthesis of permanent and dynamic polyamide networks, carried out in a single step and under mild temperature, by leveraging the inherent properties of the monomer. (kth.se)

Critical aspects in this endeavor are the use of renewable monomers to decrease the environmental footprint, implementing green syntheses and production processes and the design for increased recyclability as an end-of-life option to diverge from the generation of plastic waste. (kth.se)

There are several strategies that have been proposed to tackle this problem, such as adding nuclease inhibitors or chemical modification of linear DNA ends for protection. (jove.com)
Their ability to function as potent inhibitors of oligosaccharide synthesis in eukaryotic cells has established them as unique biochemical probes of the role of glycosylation on protein structure and function. (caltech.edu)

an ability that is derived from the high acidity of zeolite frameworks ( Zeolite Synthesis, 1989 ). (frontiersin.org)

However, linear DNA templates are rapidly degraded by exonucleases that are naturally present in the cell extracts. (jove.com)
By using cell extracts from exonuclease-deficient knockout cells, linear DNA templates remain intact without requiring any end-modifications. (jove.com)
However, linear DNA is rapidly degraded by exonucleases naturally present in cellular extracts 4 . (jove.com)

Graphitic carbon nitride: synthesis, properties, and applications in catalysis. (docksci.com)

The linear (non cyclic) alkanes have a molecular formula of CnH2n+2. (ukessays.com)

Based on these results, they optimized the synthesis protocol in two steps that resulted in a crude product with platinum tiara-like complexes of various ring sizes. (nanowerk.com)

In general terms the cyclic nitramine formation takes place in a rather thick and complex "primordial soup" of the respective building blocks. (sciencemadness.org)
In the other approach, the reversible nature of olefin metathesis allows for a magic ring synthesis to occur wherein two free macrocycles can be employed as the stationary materials, leading to the formation of the same [2]catenane. (caltech.edu)
The next step is the hydrolysis of the dimethyl - dichloro - silane, which results into the formation of HCl and a mix of cyclic and linear oligomers of polysiloxanes. (ukessays.ae)

The industrial synthesis of BADGE and other commercially available diepoxides proceeds mainly by using epichlorohydrin, whereby usually several side products and oligomers are formed in significant concentrations [10-12] . (beilstein-journals.org)
The collision cross-section of cyclic products and precursors has a linear correlation with ion mass-a relationship that does not hold for acyclic systems. (nature.com)
The tunicamycins are a family of natural products represented generally by structure 1, wherein R indicates one of several long-chain branched, linear, saturated or unsaturated acyl substituents. (caltech.edu)

This comprehensive project holds significant potential to advance our understanding of cyclic polycations, offering a unique perspective on their potential as effective antimicrobial agents and gene delivery systems. (stars-natur.cz)
18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)

This is a fast, easy, and direct approach for expression in cell-free protein synthesis systems using linear DNA templates. (jove.com)
Cell-free protein synthesis (CFPS) systems are increasingly being used as a fast, simple, and efficient method for biosensor engineering, decentralized manufacturing, and prototyping of genetic circuits 1 . (jove.com)
There are solutions that address this problem, such as using the λ-phage GamS protein 5 or DNA containing Chi sites 6 as protective agents, or directly protecting the linear DNA by chemical modification of its ends 2 , 7 , 8 , 9 . (jove.com)

Butane-1,4-diol is formed as an intermediate during the synthesis of THF. (thomassci.com)
The resultant amino polyol is a versatile intermediate for the synthesis of any of the homologous tunicamycin antibiotics. (caltech.edu)

Alkanes that are cyclic (ring structure) are called cycloalkanes. (ukessays.com)

Olefin metathesis has been employed in the efficient syntheses of a [2]catenane with the templation being provided by the recognition between a secondary ammonium ion and a crown ether. (caltech.edu)

For every ring that is present, there are two less hydrogen atoms than the equivalent (in terms of number carbons) linear alkane. (ukessays.com)

1) Patent US2859215A on RDX synthesis gives a temperature range between -10 and +40°C. Some other recipes found in the web employ an ice-salt bath (-30°C). What changes with the temperature? (sciencemadness.org)

Effective solvent-assisted nucleation in linear alkanes due to shape matching with the peripheral alkyl chains of a monomer is responsible for the pathway complexity. (rsc.org)

On-surface synthesis provides a route for the production of 1D and 2D covalently bonded polymeric structures. (nottingham.ac.uk)

Cyclic di-AMP synthesis is inhibited by the GImM I154F mutation in the lactococcus lactis bacterium. (wikipedia.org)

In this project we will focus on polysiloxanes: synthesis and structure - properties relationships. (ukessays.ae)

Metabolisation of the PGA suture within the tissue occurs by the uptake of water, thus reversing the synthesis. (dentalvarehuset.no)

Anatomy19

Organisms11

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes65

Disciplines and Occupations4

Technology, Industry, Agriculture4

Information Science3

Health Care3

Peptides21

Polymers10

Characterization2

Polymer8

Carbonates3

Yield cyclic1

Adenosine monophosphate2

Precursors for the synthesis1

Delivery of cell-impermeable1

Cyclization1

Peptide synthesis3

Compounds3

Alternative arginine1

Catalysts3

Chemical synthesis2

Phase synthesis2

Enzymatic1

Molecules2

Ligand2

Ions2

Derivatives1

Mixtures1

Organic2

Phosphopeptides1

Sweep1

Condensation1

Enzyme4

Synthetic3

Enzymes2

Organo1

Bacteria2

Impurities1

Pathways2

Reduction2

Chemistry3

Methods3

Fatty2

Processes1

Inhibitors2

Frameworks1

Extracts3

Catalysis1

Molecular formula1

Crude1

Formation3

Products3

Gene2

Protein3

Intermediate2

Ring structure1

Efficient1

Alkane1

Temperature1

Complexity1

Production1

Mutation1

Properties1

Uptake1