Synthesis of alkynes. Medical search. Frequent questions

A general silver-catalyzed hydroazidation of unactivated terminal alkynes with trimethylsilyl azide in the presence of water afforded the corresponding vinyl azides in good to excellent yields. (organic-chemistry.org)
The second chapter describes a method for the preparation of 5-iodo-1,2,3-triazoles directly from organic azides and terminal alkynes. (fsu.edu)
The method described in Chapter 3 is a simple and rapid process for the synthesis of bistriazoles from organic azides and terminal alkynes under oxidative conditions ( oxygen atmosphere) with a broad substrate scope. (fsu.edu)
Treatment of malonates without a substituent at the active methylene moiety with terminal alkynes gave salicylates regioselectively. (elsevierpure.com)
A simple, efficient and highly functional group compatible method for the synthesis of propargylamines from terminal alkynes, dichloromethane and tertiary amines using silver catalysts has been developed. (edu.hk)
A copper-catalyzed method for the E -selective 1,1-diboration of terminal alkynes is described. (chemrxiv.org)
A wide array of terminal alkynes are efficiently processed to linear alcohols using as little as 2 mol % of catalyst at ambient temperature. (organic-chemistry.org)

Many variations have been developed, including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. (wikipedia.org)
When synthesizing alkenes from alkynes, electrophilic addition reactions are widely used. (hatsudy.com)
The addition reaction of alkynes is slower than that of alkenes. (hatsudy.com)
In other words, compared to alkanes and alkenes, alkynes are more likely to release H + and become ions (HC≡C - and H + ). This high acidity is due to their high s-character. (hatsudy.com)

An alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to form a benzene ring. (wikipedia.org)
This dissertation describes the development of alternative products from the copper-catalyzed azide-alkyne cycloaddition (CuAAC). (fsu.edu)
Chapter 5 summarizes the work conducted on modifying the conditions applied to the copper catalyzed azide alkyne cycloaddition (CuAAC). (fsu.edu)
An intermolecular [2+2+2] cycloaddition of sulfanyl- and sulfonylbenzene-tethered 1,6-diynes with alkynes using rhodium catalysts gave dibenzothiophene derivatives in moderate to excellent yields. (elsevierpure.com)
Tahara, YK, Matsubara, R & Shibata, T 2015, ' [2+2+2] cycloaddition of sulfanylbenzene-tethered diynes with alkynes for the synthesis of multi-substituted dibenzothiophene derivatives ', Heterocycles , vol. 90, no. 2, pp. 1094-1110. (elsevierpure.com)
Azide-alkyne cycloaddition (AAC) is an essential technique with the reaction of the trephine between the azide group and the alkene based on Cu(I) ions and nanoparticles. (ajgreenchem.com)
The copper-catalyzed variant of Huisgen azide-alkyne cycloaddition (CuAAC) fits the concept well and is one of the most popular prototype click reactions to date. (genengnews.com)
Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system. (jsums.edu)

In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. (wikipedia.org)
Addition of a 1,5-diyne with an alkyne produces a benzocyclobutene, a strained structure that can then be induced to undergo further reactions. (wikipedia.org)
Reactions were also highly regioselective for various nonsymmetric alkynes. (iyte.edu.tr)
We have discussed many elements of click reactions in organic synthesis because they are essential and useful in drug discovery, supramolecular chemistry, materials science, and nanotechnology. (ajgreenchem.com)
Providing an excellent compilation of the most important and useful methods of modern stereoselective synthesis, this book features illustrative examples of drug and natural product syntheses, resulting in a rich source of stimulating ideas for the efficient use of asymmetric reactions in the users' own synthesis. (wiley-vch.de)
The tungsten alkylidyne complex (tBuO) 3 W⋮CCMe 3 (1a) and analogues thereof as well as a structurally unknown species formed in situ from Mo(CO) 6 and p-chlorophenol effect the crucial alkyne metathesis reactions in a highly efficient manner, with the former catalyst being more tolerant toward structural variations of the substrates and polar functional groups. (mpg.de)
In optimizing chemical reactions, flexibility, precision and reproducibility are required of the synthesis tools with which the experiments are carried out. (sigmaaldrich.com)
Peptides can also be made by inter- and intramolecular click reactions using azide or alkyne containing amino acids or building blocks during peptide synthesis. (genengnews.com)
Synthesis of Carbohydrate Derived α-Methylene-γ-lactones by Diasterecseldctive, Low Temperature Reformatsky-Type Reactions. (mpg.de)
Synthesis and Rearrangement Reactions of C-Alkylidene Carbohydrates. (mpg.de)
Despite their successful synthesis, using Pd-catalyzed coupling reactions of aryl halides and arylhydrazides [11] followed by Cu(I)-mediated oxidation, the photochemical properties of such compounds have not been studied yet. (beilstein-journals.org)
Knölker type iron complexes, used directly or generated in situ, are suitable catalysts for (de)hydrogenation reactions enabling the synthesis of carbonyl derivatives, amines and alcohols of industrial and academic interest. (eurekaselect.com)

The Rh-catalyzed reaction of arylboronic acids with internal alkynes under a CO atmosphere in the presence of an acid additive afforded α,β-unsaturated ketones as the major products. (iyte.edu.tr)
Hydroacylation of internal alkynes, except in the case of diaryl acetylenes, proceeded in syn fashion, yielding the E-configured isomer. (iyte.edu.tr)
A Rh-catalyzed annulation of aryl thiocarbamates with internal alkynes via C-H bond activation has been developed. (unboundmedicine.com)
AU - Zhao,Yingwei, AU - Han,Feng, AU - Yang,Lei, AU - Xia,Chungu, Y1 - 2015/03/11/ PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2015/8/22/medline SP - 1477 EP - 80 JF - Organic letters JO - Org Lett VL - 17 IS - 6 N2 - A Rh-catalyzed annulation of aryl thiocarbamates with internal alkynes via C-H bond activation has been developed. (unboundmedicine.com)

The cotrimerization of alkynes and nitriles in the presence of organocobalt catalysts has been commercialized for the production of substituted pyridines. (wikipedia.org)
Organometallic catalysts are an important means of providing new and highly efficient routes for chemical processes, and the development of new transition metal catalysts for promoting the synthesis of key compounds is a major goal in the development of synthetic routes with minimum energy use. (edu.au)

The process is of historic interest as well as being applicable to organic synthesis. (wikipedia.org)
Unsaturated ketones are important key reagents in organic synthesis. (iyte.edu.tr)
Chemical reaction design and optimization is vital in organic synthesis research. (sigmaaldrich.com)
Its potential and widespread applications extend from organic synthesis through materials science to bioorganic chemistry. (sigmaaldrich.com)
Iron-Catalyzed Indolizine Synthesis from Pyridines, Diazo Compounds, and Alkynes: Organic Letters Organic Letters. (nottingham.ac.uk)
Synthetic organic chemistry, specifically in the areas of alkaloid synthesis and chiral memory methodology development. (chatham.edu)
The Electronic Encyclopedia of Reagents for Organic Synthesis 2006. (chatham.edu)
In: Organic Syntheses, Bd. (mpg.de)
Alkyne Metathesis in Organic Synthesis. (mpg.de)
In: Handbook of Metathesis, Vol. 2: Applications in Organic Synthesis, 2nd ed. (mpg.de)
In: Comprehensive Organic Synthesis, Vol. 5, Bd. (mpg.de)
In: Templated Organic Synthesis, S. 249 - 273 (Hg. (mpg.de)
In: Organic Synthesis Highlights IV, S. 123 - 129 (Hg. (mpg.de)
In: Transition Metals for Organic Synthesis: Building Blocks and Fine Chemicals, Vol. 1, Bd. (mpg.de)
Our research group is also interested in the use of pure water as a reaction medium for organic synthesis. (jsums.edu)
Atta-ur- Rahman , " Advances in Organic Synthesis ", Bentham Science Publishers (2018). (eurekaselect.com)

Fmoc- protected for solid phase synthesis), propargyl amino acids, PEG azide and alkynes (Maleimide-PEG3-Azide and acetylene PEG maleimide for pegylation), alkyne and azide containing chemical modification reagents (propargyl amine, 1-(2-nitrophenyl) propargyl alcohol, succinidyl-hex-5-ynoate, succinimidyl-4-azovalerate, pentynoic acid, 2-azido-3-methyl propanoic acid) and Diazo transfer reagents (imidazole-1-sulfonyl azide). (genengnews.com)

Applications to the stereoselective synthesis of the olfactory compounds ambrettolide 23 and yuzu lactone 24, the insect repellent azamacrolides epilachnene 31 and homoepilachnene 33, as well as to the fully functional building block 64 required for a total synthesis of the cytotoxic alkaloid nakadomarin A 51 highlight the relevance of this new concept for natural product chemistry. (mpg.de)
Moving outside the confines of traditional and proven phosphine chemistry, we seek to use experimental and computational methodology to aid the design and synthesis of phosphorus compounds with high impact applications or which test false assumptions. (ncl.ac.uk)
Synthesis and chemical modification of peptides are becoming popular with click chemistry techniques. (genengnews.com)
Click chemistry provides a number of avenues for peptide synthesis and modifications and could be combined with other techniques to make complex structures and multicomponent functionalized systems with ease. (genengnews.com)
Click chemistry is compatible with various protected amino acid side chains used in peptide synthesis. (genengnews.com)
In: Modern Alkyne Chemistry: Catalytic and Atom-Economic Transformations, S. 69 - 111 (Hg. (mpg.de)

Synthesis and Characterization of Dibenzo[hi,st]ovalene as a Highly Fluorescent Polycyclic Aromatic Hydrocarbon and Its ᴨ-Extension to Circumpyrene. (mpg.de)
The synthesis and characterization of phenolic resin with a high content of dimethylene ether bridges. (ki.si)

Through these improvements the method became more synthetically practical and increased the reaction substrate scope to include unreactive azides and alkynes. (fsu.edu)

Regioselective intermolecular trimerization of unsymmetrical alkynes remains an unsolved problem. (wikipedia.org)

Case Studies at the Metathesis/Asymmetric Synthesis Interface. (mpg.de)
In: Asymmetric Synthesis - The Essentials, 2. (mpg.de)
In: Asymmetric Synthesis - The Essentials, S. 262 - 266 (Hg. (mpg.de)

Alkynes are known to be compounds that have triple bonds in the molecule. (hatsudy.com)
Of course, it is also possible to synthesize new alkyne compounds. (hatsudy.com)
These compounds have been proposed to be employed as chiral ligands in enantioselective synthesis. (fsu.edu)

One approach for their synthesis is the insertion of an alkyne into the carbon-halogen bond of an organohalogen compound, catalyzed by transition-metal complexes. (chemistryviews.org)
We have expertise in the synthesis and catalytic applications of ligands and metal complexes compatible with proteins, bioconjugation of small molecules to proteins, expression and purification of recombinant enzymes, enzyme engineering and enzyme immobilisation. (nottingham.ac.uk)

The consecutive reaction of tetraynes with an alkyne gave an axially chiral 1,1′-bi(dibenzothiophenyl) and its tetraoxide with up to excellent ee. (elsevierpure.com)

The work will ultimately improve the viability of the synthesis of important biologically active molecules and pharmaceuticals in the fine chemicals industry. (edu.au)
The Hamme research group is interested in the synthesis of biologically active heterocyclic containing natural products and their synthetic analogues. (jsums.edu)

Therefore, an addition reaction occurs when an alkyne reacts with an electrophilic reagent. (hatsudy.com)

Trimerisation of unsymmetrical alkynes gives two isomeric benzenes. (wikipedia.org)
The synthesis and properties of a series of unsymmetrical thienopentalenes are explored, including both monoareno and diareno derivatives. (researchgate.net)
The efficient synthesis of this new class of unsymmetrical tris(arylazo)benzenes opened new avenues to novel multistate switching materials. (beilstein-journals.org)

The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. (unamur.be)
An air-stable half-sandwich ruthenium complex is a highly active catalyst for the anti-Markovnikov reductive hydration of alkynes, involving the decarboxylation of formic acid, hydration of the alkyne, and hydrogenation of the intermediate aldehyde. (organic-chemistry.org)

Dibenzo[hi,st]ovalene as Highly Luminescent Nanographene: Efficient Synthesis via Photochemical Cyclodehydroiodination, Optoelectronic Properties, and Single-Molecule Spectroscopy. (mpg.de)

A novel metal-free synthesis of indenone derivatives mediated by CBr4 and diethyl phosphonate is reported. (researchgate.net)

Cyclization involving substrates in which some or all of the alkyne units are tethered together can provide fused ring systems. (wikipedia.org)
The team used a range of aryl iodides and substituted alkynes as substrates, Ni(cod) 2 as a catalyst (cod = 1,5-cyclooctadiene), 4,4′-di- tert -butyl-2,2′-dipyridyl (dtbdp) as a ligand, and toluene as solvent. (chemistryviews.org)

Ring Closing Alkyne Metathesis. (mpg.de)
In the latter case, the diyne substrate 62 necessary for ring closing alkyne metathesis was obtained via a novel furan synthesis relying on a palladium-catalyzed opening of a vinyl epoxide followed by an oxidative cyclization of the heterocyclic ring. (mpg.de)
Alkyne Metathesis. (mpg.de)

7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes. (unamur.be)
Introduction of azide and alkyne moieties into structurally diverse peptide side chains, combined with on-resin macrocyclization conditions, is used to design structurally constrained peptides. (genengnews.com)

Saturated N-heterocyclic building blocks or SnAP Reagents are of growing importance for the convenient synthesis of medium-ring saturated N-heterocycles, including bicyclic and spirocyclic structures. (sigmaaldrich.com)

Takuya Kurahashi, Seijiro Matsubara, and colleagues, Kyoto University, Japan, have developed an intermolecular, nickel-catalyzed reaction of alkynes with aryl iodides that gives alkenyl iodides (pictured). (chemistryviews.org)

Modifications to enhance the synthesis of the 5-iodo-1,2,3-triazoles via CuAAC are the first addressed Which was followed by the unsuccessful application of the Ullmann reaction for the synthesis of 5,5'-bis(1,2,3-triazole)s. (fsu.edu)
CuAAC click reaction between an azide and alkyne takes place in presence of a Cu (I) catalyst under mild conditions, resulting in the formation of a triazole link connecting the two molecules. (genengnews.com)

Azide groups are easy to introduce, stable to water and oxidative conditions, and orthogonal to many functional groups in peptide synthesis. (genengnews.com)

Preliminary dichlorofluoresceine nanoparticles (DCF-SNPs) synthesis evidence by noticing the solution color transformed from a light green color to a dark brown color. (intechopen.com)

The methodological enhancements of the procedure described in Chapter 2 provides high conversion as well as high iodo/protio selectivity through the reduction in equivalents of alkyne, and employment of [Tri(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA). (fsu.edu)
A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. (unamur.be)

That is because the molecules with sp hybrid orbitals, such as alkynes and vinyl carbocations, have high s-character. (hatsudy.com)
Here we describe the synthesis and properties of the first family of molecules belonging to this compound category-differently sized rings comprising only 1,1′-disubstituted ferrocene units (cyclo[n], n = 5-7, 9). (imperial.ac.uk)

Note that when alkynes undergo the addition reaction, a vinyl carbocation is formed as an intermediate. (hatsudy.com)

Cyclisation carried out with a diyne and a separate alkyne affords greater control. (wikipedia.org)

Hamme, A. T. II "Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation" Synthesis 2006 , 3815-3818. (jsums.edu)

Synthesis and helical supramolecular organization of discotic liquid crystalline dibenzo[hi,st]ovalene. (mpg.de)

It has been successfully utilized in the synthesis of peptides, particularly in peptide cyclization and modifications. (genengnews.com)

The synthesis has been accomplished starting from aromatic nitrogen heterocycles in three steps. (degruyter.com)

It is well known that stereochemistry of polymers dictates their bulk properties, but the importance of stereocontrol in polymer synthesis is often overlooked. (nature.com)

Noncovalent protection for direct synthesis of α−amino−ω−hydroxylα−amino−ω−hydroxyl poly(ethylene oxide). (ki.si)

Consequently, it triggers a demand for efficient syntheses of alkynes. (sigmaaldrich.com)

Scheidt, K. A. "Lewis Base-Catalyzed Additions of Alkynes Using Triethoxysilylalkynes. (chatham.edu)

It is also possible to synthesize double bonds from alkynes. (hatsudy.com)
Alkynes have π bonds (π-electrons). (hatsudy.com)

Due to the presence of π-electrons, alkynes are electron-rich. (hatsudy.com)

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture4

Terminal Alkynes7

Alkenes4

Cycloaddition8

Reactions12

Internal alkynes4

Catalysts2

Organic16

Acetylene1

Chemistry6

Characterization2

Azides1

Regioselective1

Asymmetric Synthesis3

Compounds3

Complexes2

Chiral1

Biologically active2

Reagent1

Unsymmetrical3

Hydrogenation2

Optoelectronic Properties1

Derivatives1

Substrates2

Metathesis3

Structurally2

Convenient synthesis1

Intermolecular1

CuAAC2

Oxidative1

Nanoparticles1

Reduction2

Molecules2

Undergo1

Diyne1

Intramolecular1

Supramolecular1

Cyclization1

Heterocycles1

Stereocontrol1

Amino1

Efficient1

Additions1

Bonds2

Presence1