Synthesis in mammalian cells. Medical search. Frequent questions

We use RT-PCR reverse transcription system and the expand high fidelity PCR system to detect spliced XBP1 mRNA, and fraction cells to determine the location of the unconventional splicing of XBP1 mRNA. (mdpi.com)

The technique, written into an algorithm, is developed through initial application to a structured model for mammalian cells. (imperial.ac.uk)

Poly(ADP-ribose) synthesis and degradation in mammalian nuclei. (oregonstate.edu)
The mechanism, which is based on the synthesis and degradation of three ''master regulator'' proteins (CtrA, GcrA, and DnaA), is converted into a quantitative model, in order to study the temporal dynamics of these and other cell cycle proteins. (ebi.ac.uk)
We introduced autocatalytic transcription of E2F, E2F regulated transcription of cyclin B, Cdc20/Cdh1 mediated E2F degradation, enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis. (ebi.ac.uk)
Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1α (PP1α) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation. (jci.org)
Progression of the mammalian cell cycle is primarily regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. (bdbiosciences.com)
Glycogen accumulation can result as a consequence of impaired degradation or excess synthesis. (medscape.com)

Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)
The research group has now succeeded in synthesizing PCB in animal cells directly by introducing four genes encoding cyanobacterial enzymes related to PCB synthesis. (nibb.ac.jp)
The research group succeeded in synthesizing PCBs in animal cells by introducing these four enzyme genes. (nibb.ac.jp)
It stimulates the expression of immediate early genes (c-fos, c-jun, and c-myc), of the tumor suppressor gene p53, and of genes coding for the syntheses of protective molecules, including metallothioneins, glutathione, and stress (heat shock) proteins. (nih.gov)
In fact, amplification of genes by over replication of certain regions of DNA is one of the primary mechanisms by which cancer cells become resistant to drug therapy. (nih.gov)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
This serum-free and grain-derived-nutrient-free medium promoted the proliferation of bovine myoblasts, the main cell source for cultured beef. (nature.com)
One synthetic pathway produced valine at a sufficient level for cell viability and proliferation. (elifesciences.org)
About 1 microM cadmium stimulates DNA synthesis and cell proliferation in various cell lines, whereas more elevated concentrations are inhibitory. (nih.gov)
Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)

This approach enabled the researchers to induce genetic mosaicism in NPCs, allowing NPCs to carry different fluorescent proteins, and to track cell fate during the developmental continuum. (phys.org)
The 'Optogenetic' method of controlling the position of proteins in cells using light is becoming widely employed as an important method to understand intracellular signal transduction. (nibb.ac.jp)
Golgi apparatus is the site where proteins produced by the ribosomes on rough endoplasmic reticulum further packaged and modified before releasing out of the cell through exocytosis. (markedbyteachers.com)
Animal cell technology is an area of rapid expansion and one that produces a wide range of high-value products, including vaccines, recombinant proteins, drugs for cardiovascular, respiratory and immune diseases, and monoclonal antibodies. (imperial.ac.uk)
Cells need ribosomes in order to create proteins. (europa.eu)
This remarkable book tells a story that parallels his career, dealing at the beginning with the prehistory of research on RNA, DNA, and proteins and then shifting into high gear with a detailed look at the history of bacterial messenger RNA and the author s own specialty, the RNA of eukaryotic cells. (cshlpress.com)
Since many of the proteins involved in regulating the cell cycle of C. crescentus are conserved among many genera of a-proteobacteria, the proposed mechanism may be applicable to other species of importance in agriculture and medicine. (ebi.ac.uk)
Insulin produces the dephosphorylation of only a small subset of proteins at discrete locations, whereas PP1 is ubiquitously expressed and is found in virtually all cellular compartments, suggesting that mechanisms exist for the targeted regulation of PP1 in insulin-responsive cells that selectively permit activation of the enzyme only at these sites. (jci.org)
One clue to this dilemma has emerged from the identification of "targeting" subunits that allow for the compartmentalized activation of the phosphatase, resulting in the specific dephosphorylation of discrete pools of proteins within the cell. (jci.org)

In contrast to the Rough Endoplasmic Reticulum, the Smooth Endoplasmic Reticulum (Smooth ER) that does not have any ribosomes attached to is responsible for lipid and carbohydrate synthesis. (markedbyteachers.com)
These data suggest that PTG plays a critical role in glycogen synthesis and is necessary to maintain the appropriate metabolic balance for the partitioning of fuel substrates between glycogen and lipid. (jci.org)
How does lipid transport between organelles in the cell take place and how is it regulated? (centenary.org.au)
Cholesterol is an essential lipid species of mammalian cells. (bvsalud.org)

Cultured meat is produced by culturing/proliferating animal muscle cells in vitro. (nature.com)
Effect of syphilitic rabbit sera taken at different periods after infection on treponemal motility, treponemal attachment to mammalian cells in vitro, and treponemal infection in rabbits. (bmj.com)
E. coli, P. pastoris , Mammalian cells, Plant cells and in vitro by cell free synthesis. (lu.se)

These pathways were de novo synthesized in 3 kilobase chunks, assembled in yeasto and genomically integrated into a Chinese hamster ovary (CHO) cell line. (elifesciences.org)
This work demonstrates that mammalian metabolism is amenable to restoration of ancient core pathways, paving a path for genome-scale efforts to synthetically restore metabolic functions to the metazoan lineage. (elifesciences.org)
In this report, the authors devised synthetic genomic strategies to introduce essential amino-acid biosynthetic pathways into mammalian cells. (elifesciences.org)
Altogether, this work was found to be of substantial interest as it provides pioneering evidence that mammalian systems may be permissive to the restoration of essential amino acid biosynthetic pathways and is thus anticipated to have a broad impact in the fields of synthetic biology, biotechnology and beyond. (elifesciences.org)
Effects of the carcinogenic metal cadmium on the regulation of mammalian gene expression are reviewed and discussed in the light of observations on interference with cellular signal transduction pathways. (nih.gov)
High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Bursting transcription, as opposed to simple probabilistic models of transcription, reflects multiple states of gene activity, with fluctuations between states separated by irregular intervals, generating uneven protein expression between cells. (wikipedia.org)
Noise in gene expression can have tremendous consequences on cell behaviour, and must be mitigated or integrated. (wikipedia.org)
Variability in gene expression may also contribute to resistance of sub-populations of cancer cells to chemotherapy and appears to be a barrier to curing HIV. (wikipedia.org)
By applying the random forests algorithm, a supervised machine learning approach, we show how a multi-gene signature that classifies individual cells into their correct cell cycle phase and cell size can be generated. (frontiersin.org)
In addition, the group succeeded in increasing the amount of PCB synthesis through disruption of the gene that encodes an enzyme called biliverdin reductase A, which is involved in the metabolism of PCB. (nibb.ac.jp)
The mechanisms underlying the modulation of gene activity by cadmium are discussed in terms of interference with cellular signalling at the levels of cell surface receptors, cellular calcium and zinc homeostases, protein phosphorylation, and modification of transcription factors. (nih.gov)
Before joining the UICCOM Class of 2023, Melanie continued her undergraduate research focused on using RNA spatial patterning in high cell density constructs for therapeutic controlled gene expression. (uic.edu)
Diesel exhaust particulate matter dispersed in a phospholipid surfactant induces chromosomal aberrations and micronuclei but not 6-thioguanine-resistant gene mutation in V79 cells. (cdc.gov)
Diesel exhaust particulate material (DPM) was assayed for induction of chromosomal aberrations (CA), micronucleus (MN) formation, and 6-thioguanine-resistant (TG r) gene mutation in V79 cells as a dispersion in dipalmitoyl phosphatidylcholine (DPPC) in physiological saline, a simulated pulmonary surfactant. (cdc.gov)
The forward gene mutation assay did not show a positive response when cells were treated with up to 136 ug DPM/ml for 24 h, as dispersion in DPPC in saline. (cdc.gov)
Some comparison assays were run on direct dispersions of the DPM into dimethyl sulfoxide, with results equivalent to those seen with a DPPC-saline preparation: DPM in dimethyl sulfoxide (DMSO) was positive for MN induction but was negative for forward gene mutation in V79 cells. (cdc.gov)
The forward gene mutation negative results are consistent with studies of that assay applied to V79 cells challenged with DPM solvent extract. (cdc.gov)
In contrast to individuals with classic Tarui disease, who express only the L4 type isozyme in red blood cells, individuals with late-onset Tarui disease showed the presence of a few hybrid isozymes of M+L with the predominant L4 species, suggesting a "leaky" mutation of the gene coding the M subunit. (medscape.com)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

Mammalian red blood cells lack a nucleus and, thus, contain no genetic material of their own. (conservapedia.com)
In cell division, a cell makes a copy of its DNA and then separates itself into two identical cells - each with its own copy of DNA enveloped inside a nucleus. (visionlearning.com)
The term mitosis refers specifically to the process whereby the nucleus of the parent cell splits into two identical nuclei prior to cell division. (visionlearning.com)
advanced organisms-including animals, plants, fungi, and protists-whose cells have a nucleus and other membrane-bound organelles. (visionlearning.com)
mostly one-celled organisms, bacteria for example, whose cells do not have a nucleus or other membrane-bound organelles. (visionlearning.com)
He began a series of live observations under the microscope using dyed samples of animal tissues and found that a particular mass of material inside the nucleus of cells absorbed the dye quite well. (visionlearning.com)
Eukaryotic cells (from the Greek meaning truly nuclear) can be easily distinguished through a membrane-bound nucleus. (markedbyteachers.com)
Mammalian cells are one of the two types of eukaryotic cells, in which contains many internal membrane bounded structures called organelles, they are separated into different groups in order to increase their efficiency at bringing out particular function, and this is called compartmentalization, however there is processes that requires different organelles working together in order to take place, such as respiration (involves the cytoplasm and mitochondria) and Protein Synthesis (Nucleus, Ribosomes). (markedbyteachers.com)
it contains the DNA information (chromosomes) of the cell and is the site where DNA replication and RNA transcription take place, while the nucleolus is located in the centre of the nucleus containing ribosomes in various stages of synthesis, the nucleolus is also responsible for the manufacture of the ribosomes. (markedbyteachers.com)
We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)

Ribosomes exist within the cell as free ribosomes that free floats within the cytoplasm or fixed ribosomes that are attached to the rough endoplasmic reticulum. (markedbyteachers.com)
In eukaryotic cells, the endoplasmic reticulum (ER) is the main center for the synthesis of diverse types of lipids. (centenary.org.au)
Cells acquire it through synthesis in the endoplasmic reticulum (ER) and uptake from lipoprotein particles. (bvsalud.org)

Using this method, we examined the genomic positions of 6mA in bacteria ( E. coli ), green algae ( C. reinhardtii ), and mammalian cells (HEK239T, Huh7, and HeLa cells). (nature.com)
In contrast to bacteria and green algae, human cells possess a very limited number of 6mA sites which are sporadically distributed across the genome of different cell types. (nature.com)

In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)

The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. (ebi.ac.uk)
He did his postdoctoral research in the Department of Biochemistry & Cell Biology at the National Institute of Infectious Diseases, Japan for 10 years after which he became the Chief in Laboratory of Cell Function. (centenary.org.au)
In 2006, he became the Director of Department of Biochemistry & Cell Biology. (centenary.org.au)

We demonstrated that DNA synthesis occurs discontinuously only on one arm of replication forks (the arm where the direction of synthesis is opposite to the direction of fork movement) through the repeated initiation, synthesis and joining of Okazaki fragments (transient nascent DNA chains of 40 to 300 nucleotides). (nih.gov)
It is induced by INTERFERON-GAMMA and blocks the release of enveloped mammalian viruses by directly tethering nascent VIRAL PARTICLES to the membranes of infected cells. (bvsalud.org)

Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)

This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
Two fundamentals aspects of cell behaviour any model must include are metabolism and the cell cycle. (imperial.ac.uk)
The population balance framework is used to capture cell cycle effects while a single-cell model takes account of some features of intracellular metabolism. (imperial.ac.uk)
Riboflavin supports cell growth and metabolism, aiding researchers in R&D. In cell culture, it is often found as a key ingredient in media formulations. (sigmaaldrich.com)

Cholesterol is an essential component of mammalian cell membranes as well as a precursor of bile acids, vitamin D and steroid hormones. (genome.jp)
Lipids are the major constituents of all cell membranes and play dynamic roles in organelle structure and function. (centenary.org.au)

We have adopted an interdisciplinary approach to disease research, from cell biology to protein expression and chemical synthesis. (edu.au)

Cholesterol homeostasis in humans is regulated by well-balanced mechanisms of intestinal uptake, endogenous synthesis, transport in lipoprotein particles, and biliary excretion. (genome.jp)

The identification of endogenous cell competition among NPCs provides a fundamental basis for comprehending the developmental origin of neuronal vulnerability as well as improving brain health. (phys.org)

The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. (ebi.ac.uk)

Recently, a book chapter with protocols for the Baculovirus Expression Vector System in insect cells was published by LP3. (lu.se)
Lund Protein Production Platform (LP3) has recently published its standard operating procedures for recombinant protein expression using the Baculovirus Expression Vector System (BEVS) in insect cells. (lu.se)

The initial objective of this study was to determine whether a co-regulation of the three Pols for synthesis of ribosomal components could be demonstrated in human cells. (europa.eu)
Firstly, we discovered a major difference between the regulation of Pol I in yeast and mammalian cells. (europa.eu)
From the very beginning of his first lab at MIT, Darnell, his students and postdocs have studied RNA, its synthesis, processing, and transcriptional regulation. (cshlpress.com)
A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation. (ebi.ac.uk)
To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. (ebi.ac.uk)

De novo synthesis begins with the conversion of tryptophan to quinolate, which is converted to NaMN. (wikipathways.org)

Scheme of mammalian tryptophan catabolism. (wikipathways.org)

Most plant and animal cells replicate by splitting into two identical daughter cells. (visionlearning.com)
Mammalian cells are different to Plant cells (which are also eukaryotic), they do not have a cellulose cell wall, and they are bounded by only plasma membrane, so they are sensitive to Osmotic lysis (the bursting or rupturing of the plasma membrane due to osmotic movement of water into the cell when the cell is in a hypotonic environment. (markedbyteachers.com)

To approach this, I attempted to deregulate Pol I transcription in human cells in the same manner as had been done in yeast. (europa.eu)
However, in collaboration with Drs Ingrid Grummt and Holger Bierhoff from the German Cancer Research Center , Heidelberg, Germany, I found that the mechanism by which Pol I synthesised ribosomal RNA in human cells was different enough from the mechanism used in yeast cells, therefore I could not use the previously exploited approach to deregulate Pol I activity in yeast. (europa.eu)
This second project involved the protein Maf1, which inhibited Pol III activity in yeast and mammalian cells. (europa.eu)

In a study published in Developmental Cell , a group led by Prof. Wu Qingfeng from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences demonstrated the presence of cell competition between neural progenitor cells (NPCs) during neurodevelopment. (phys.org)
In-depth models can be utilised as tools in predictive cell biology. (imperial.ac.uk)
It is clear that the biological behaviour of cells is of such complexity that any model, to be robustly predictive, must be sufficiently structured and detailed in terms of the captured biology. (imperial.ac.uk)
My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
He is the coauthor, with S.E. Luria, of General Virology (Wiley) and the founding author with Harvey Lodish and David Baltimore of Molecular Cell Biology (cshlpress.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Kovalenko OV, Plug AW, Haaf T. Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. (bdbiosciences.com)
Aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine, and certain trace amines and is present in a variety of organs including the brain and spinal cord. (lu.se)
It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)

Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)

Assay for MN induction also gave a positive response: Above 50 µg/ml, the frequencies of micronucleated cells (MNC) were about 2 times higher than those in the control group. (cdc.gov)

Population balance models capture the heterogeneity but little structure with which to differentiate the cells due to the computationally intense nature of their solution while single-cell models are good at describing structure but cannot describe heterogeneity. (imperial.ac.uk)
The scope of this review is to describe synthesis of xylopyranosyl donors, as well as protective group chemistry, modifications, and conformational analysis of xylose. (lu.se)

CANCIDAS is an echinocandin antifungal that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. (rxlist.com)

Maf1 phosphorylation was triggered by signals coming from outside the cell, for example nutrient availability, and transferred to Maf1 through a cascade of events which were still poorly understood. (europa.eu)

Wu and his team systematically investigated the potential regulators, spatial properties, molecular features, mechanism and physiological role of cell competition between NPCs. (phys.org)
This work elucidates the drivers, properties, molecular features and physiological function of cell competition in the context of neural stem/progenitor cells during early neurodevelopment. (phys.org)
This work also highlights the physiological role of cell competition in regulating mammalian organ size. (phys.org)
Studies performed at single-cell resolution have demonstrated the physiological significance of cell-to-cell variability. (mdpi.com)
These results indicate that AADC cells are heterogeneously distributed in the rat spinal cord and they may exert different functions in different physiological and pathological situations. (lu.se)

Enhancing subependymal nodules, including a probable giant cell astrocytoma in the region of the foramen of Monro. (medscape.com)

This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
Models of animal cell culture systems have a wide range of potential applications, such as analysis and prediction of experimental results, optimisation of culture conditions for prolonged viability, and perhaps most importantly, the investigation of fundamental metabolic processes and their subsequent elucidation. (imperial.ac.uk)
Current understanding of mammalian cell cultures lies in the association of their metabolic behaviour to their antibody production output. (imperial.ac.uk)

A proposed source of transcriptional noise is transcriptional bursting although other sources of heterogeneity, such as unequal separation of cell contents at mitosis are also likely to contribute considerably. (wikipedia.org)

Amitrole does not induce unscheduled DNA synthesis in hepatocytes of rats exposed in vivo . (inchem.org)

Red blood cells, like all blood cells , are produced in the bone marrow. (conservapedia.com)

The results show a trend towards favoring vascular endothelial growth factor-targeted therapy for PFS and overall survival compared with mammalian target of rapamycin inhibitors, although statistical significance was not reached. (lu.se)
The Eis inhibitors generally did not exhibit cytotoxicity against mammalian cells. (cdc.gov)

Increasing the dosage of downstream ilvD boosted pathway performance and allowed for long-term propagation of second-generation cells in valine-free medium at 3.2 days per doubling. (elifesciences.org)
In a second quantitatively important pathway (driven by IDO in most cell types and by TDO more specifically in liver cells), it is the starting point of the kynurenine pathway. (wikipathways.org)
It is likely that this pathway utilized a flap endonuclease to process the single-stranded DNA that occurs during repair synthesis. (jefferson.edu)
It appears that the cell-free lysate from P. falciparum possesses a complete pathway for the repair of uracil damage and AP sites. (jefferson.edu)

Besides, opening up new avenues for promoting neuronal fitness and brain health , this research may also establish an important experimental paradigm for interrogating cell competition during neurodevelopmental processes and in neurodegenerative diseases. (phys.org)
The effect was that different parts of a cell would absorb more dye, in effect "highlighting" them, as in Figure 3, to reveal structures and processes that were invisible before. (visionlearning.com)
In this essay I would like to talk about the compartmentalisation of the cell and some important processes happen within the cell that requires the corporation of different organelles. (markedbyteachers.com)
The integration of these three research tools represents a unique, novel, and interdisciplinary approach to addressing the complicated research and industrial problem of model-based control and optimisation of mammalian cell culture processes. (imperial.ac.uk)

Our results imply that rare 6mA in the mammalian genome is introduced by RNA m 6 A machinery via a non-targeted mechanism. (nature.com)
Similarly, in multicellular organisms, competitive interactions also occur between cells, creating a cell selection mechanism that eliminates less fit cells within the local tissue environment. (phys.org)
The main objective of the project is to study the effects of hyperosmotic pressure on the antibody production process in the GS-NS0 cell line, with particular attention to the antibody production mechanism. (imperial.ac.uk)
Collectively, our results thus reveal a mechanism for parallel processing of sensory information in the MOB via differential TC vs. MC synchrony, and further contrast mechanisms driving fast network oscillations in the MOB from those driving the sparse synchronization of irregularly-firing principal cells throughout cortex. (elifesciences.org)
From published experimental evidence, we propose a molecular mechanism for control of the cell division cycle in Caulobacter crescentus. (ebi.ac.uk)

Cell competition between sister neural stem/progenitor cells in mosaic environment. (phys.org)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)

We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

The time course of antibody synthesis during syphilis was studied in experimentally infected rabbits. (bmj.com)
Antibody inhibition of treponemal attachment to baby rabbit genital organ (BRGO) cells in culture occurred with immune sera taken 30 days after infection but not earlier. (bmj.com)

Cell-type differences in synchrony could also not be traced to any difference in the synchronization of synaptic inhibition. (elifesciences.org)
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine. (oregonstate.edu)
Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. (lu.se)

As a graduate student with Julius Adler, I identified the basal body of the bacterial flagellum, develop methods for its purification, and elucidate its fine structure and specific attachments to the bacterial cell envelope. (nih.gov)

To determine whether cell competition naturally occurs in the developing brain , the researchers collected more than 1,000 mouse brains with clonal labeling of NPCs and studied their fate using short- and long-term lineage tracing. (phys.org)

CANCIDAS is the first of a new class of antifungal drugs (echinocandins) that inhibit the synthesis of (beta) (1,3)-D-glucan, an integral component of the fungal cell wall. (theodora.com)

Red blood cells (or erythrocytes ) are the major cellular component of the blood that transport oxygen to other areas of the body. (conservapedia.com)

There are two prominent approaches to modelling cells. (imperial.ac.uk)

Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)

Evidence synthesis The literature search identified 812 potential titles and abstracts. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Their findings showed that this manipulation caused a significant enlargement of brain size and a remarkable rise in the number of neurons, indicating the survival of otherwise unfit stem cells during development. (phys.org)

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. (crossref.org)

Thirteen of the compounds were toxic even in the absence of KAN to Mtb and other mycobacteria, but not to non-mycobacteria or to mammalian cells. (cdc.gov)

1995) and subsequently in primary cells (Heyworth et al. (lu.se)

First, rat liver epithelial RL34 cells were cultured by adding Chlorella vulgaris extract (CVE) to inorganic salt solution. (nature.com)
Dead and dying RBCs are broken down and disposed of in the spleen and the liver where the released iron is conserved for reuse in the synthesis of new red blood cells. (conservapedia.com)
These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glycogen synthase activity and glycogen synthesis rate. (jci.org)
There are three subunit isozymes of PFK in mammalian cells: muscle (M), liver (L), and platelet (P or C). Active PFK exists as a tetramer, and the composition of subunits differs according to the tissue type. (medscape.com)

Did you know that every organ and tissue in your body was formed as the result of individual cells making copies of their DNA and separating themselves into two identical cells? (visionlearning.com)

The cytochalasans are a class of fungal metabolites which produce unusual effects on mammalian cells. (soton.ac.uk)

Xue-Lian Sun et al, Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development, Developmental Cell (2023). (phys.org)
This appearance correlated well with the development of antibodies which blocked attachment of T pallidum to host cells. (bmj.com)
2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)

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