AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
LamininReceptors, LamininBasement MembraneMolecular Sequence DataPolymerase Chain ReactionAmino Acid SequenceProtein BiosynthesisRNA, MessengerCells, CulturedBase SequenceKineticsFibronectinsCell LineCell AdhesionCollagenExtracellular MatrixDNAMolecular StructureIntegrinsMutationProtein Synthesis InhibitorsStereoisomerismIntegrin alpha6beta1Escherichia coliImmunoglobulin Light ChainsImmunoglobulin Heavy ChainsMolecular WeightDystroglycansElectrophoresis, Polyacrylamide GelProtein BindingReverse Transcriptase Polymerase Chain ReactionCycloheximideTranscription, GeneticExtracellular Matrix ProteinsLiverRNATime FactorsDNA ReplicationBinding SitesTritiumCyclizationCloning, MolecularIntegrin alpha6LeucineMyosin Heavy ChainsCell DivisionAmino AcidsPeptide FragmentsRecombinant ProteinsBacterial ProteinsTumor Cells, CulturedIntegrin alpha3beta1Fluorescent Antibody TechniqueMicroscopy, ElectronCarbon IsotopesMagnetic Resonance SpectroscopyGene Expression RegulationLutheran Blood-Group SystemMacromolecular SubstancesModels, MolecularImmunohistochemistryGlycoproteinsCell-Free SystemGene ExpressionRabbitsDNA PrimersFibroblastsPeptidesCattleMyosin Light ChainsDactinomycinBlotting, WesternSignal TransductionProteoglycansAntigens, CD29Chemistry Techniques, SyntheticPuromycinSequence Homology, Amino AcidPeptide BiosynthesisTemperatureAntibodies, MonoclonalThymidineMembrane ProteinsCell DifferentiationCollagen Type IVCulture MediaProtein ConformationCatalysisProtein Structure, TertiaryBlotting, NorthernDose-Response Relationship, DrugStructure-Activity RelationshipCell MovementProteinsRats, Inbred StrainsPhosphorylationTransfectionMethionineChick EmbryoSubstrate Specificity
FibronectinProteinsExtracellularGlycoproteinHeparan sulfateEntactinReceptorFibrillar collagenPeptideGeneLigandsMembranesBasal laminaBasement membraneIncreasesMimicPolypeptideStimulateReverse transcriTissueContrastHomologyReductionPeptidesCellularBoundBovineConsistsOrganizationGenesSkinEffectsDomainHumanResultsExpressionFoundMouseSubsequentDomainsStudyContentTypeCellsLevels
Fibronectin4
Proteins6
  • We make use of a highly flexible multi-step cloning strategy in order to allow for the rapid synthesis of new recombinant proteins that can introduce many different biofunctionalities. (frontiersin.org)
  • Although HS chains are not required for correct folding and secretion of the protein, lack of HS or decreased sulfation can decrease perlecan's ability to interact with matrix proteins. (wikipedia.org)
  • These short chains act as a decoy by making the skin understand that certain proteins and major components of the cutaneous matrix of the dermis and the dermal-epidermal junction have been modified. (cinqmondes.com)
  • Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
  • Laminin proteins are integral components of structural scaffolding in animal tissues. (sigmaaldrich.com)
  • Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)
Extracellular3
  • Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. (sigmaaldrich.com)
  • This study aims to investigate the effects of oral administration of sodium nitrite on expression of laminin α5 in extracellular matrix of mice testicular interestitium using an Immunohistochemical (IHC) assessment. (biomedres.info)
  • An intracellular domain that interacts with actin filaments of the cytoskeleton (sometimes with intermediate filaments), an extracellular domain that binds collagen, fibronectins and laminins, and an intramembrane domain containing hydrophobic amino acid sequences inserted among the lipid fatty acid chains. (uvigo.es)
Glycoprotein2
Heparan sulfate7
  • Perlecan consists of a core protein of molecular weight 469 kDa to which three long chains (each approximately 70-100 kDa) of glycosaminoglycans (often heparan sulfate, HS, but can be chondroitin sulfate, CS) are attached. (wikipedia.org)
  • Perlecan isolated from developing growth plates has been shown to bind to FGF-2 via its heparan sulfate side chains, and to FGF-18 via domain III of its core protein and mediates their action on FGF receptors. (wikipedia.org)
  • Modifications of the heparan sulfate chains on C- and N-terminal domains are the best-studied differences in the secretory pathway of perlecan. (wikipedia.org)
  • Chondroitin sulfate can be substituted for heparan sulfate, and sulfate incorporation or the sugar composition of the chains can change. (wikipedia.org)
  • Differential heparan sulfate chain modification can occur through a number of regulatory signals. (wikipedia.org)
  • Although initially the glycosaminoglycan (GAG) chains of perlecan were thought to be exclusively heparan sulfate, chondroitin sulfate chains can be substituted and this may be dependent upon the cell type. (wikipedia.org)
  • BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
Entactin1
  • Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (cusabio.com)
Receptor3
  • The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the β1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)
  • His main research concerns Biochemistry, 67 kDa Laminin Receptor, Apoptosis, Optoelectronics and Cancer research. (research.com)
  • It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
Fibrillar collagen1
  • A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
Peptide13
  • Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
  • In this study, we identified a novel function of the YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts. (peptide.com)
  • To elucidate this novel function regarding collagen synthesis, we treated human dermal fibroblasts with YIGSR peptide in both a time- and dose-dependent manner. (peptide.com)
  • According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. (peptide.com)
  • This YIGSR peptide-mediated collagen type 1 synthesis was modulated by FAK inhibitor and MEK inhibitor. (peptide.com)
  • This study clearly reveals that YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate peptide for the treatment of skin aging and wrinkles. (peptide.com)
  • By expressing a recombinant form of the N-terminal domain I of the protein and demonstrating that digestion of the peptide with either heparanase or chondroitinase did not lead to complete loss of the peptide's activity, it was shown that chondroitin sulfate chains can be added to human perlecan. (wikipedia.org)
  • This peptide comprises short chains of amino acids that act as cellular messengers. (cinqmondes.com)
  • The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage. (lookformedical.com)
  • Eicosanoids, followed, metabolic renal monomers, are invasive and essential splicing chains that are solar repeats generating download The Dark Art Of Death 1979, failure, protein, N-hydroxylation length myosin, arachidonic distribution degradation and peptide, and the fibroblast of postsynaptic book. (familie-vos.de)
  • Expression cells, which may be ovarian or ciliary, control circled to the particle peptide through building with membranes and rely bound or lagging chains or non-processive Groups in the covalent periods of the kinase tumor. (familie-vos.de)
  • Heptapeptide-8 is a powerful peptide (active chain of amino acids) used in skin care for its anti-aging properties. (pauldanielsydney.com)
  • Progeline (Trifluoroacetyl Tripeptide-2) is an advanced peptide (active chain of amino acids) that protects the matrix of the skin and increases skin elasticity and the production of collagen, and reduces the appearance of wrinkles and sagging. (pauldanielsydney.com)
Gene3
  • The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. (beds.ac.uk)
  • Viruses are known to affect intracellular events such as gene transcription, and protein synthesis and targeting. (grantome.com)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Ligands1
  • The Ca2+ ligands form a classic pentagonal bipyramid with six ligands contributed by one polypeptide chain and the seventh supplied by a neighboring EGF-like domain. (embl.de)
Membranes1
Basal lamina1
  • In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
Basement membrane2
  • The C-terminal Domain V, which has homology to the G domain of the long arm of laminin, is responsible for self-assembly and may be important for basement membrane formation in vivo. (wikipedia.org)
  • Our hypothesis is that this abnormality, associated with damage to the basement membrane, is due to a virally-induced increase in laminin expression, which could account for the cellular infiltration and destruction. (grantome.com)
Increases1
  • Sodium Hyaluronate increases hydration, promotes collagen synthesis, reduces the appearance of wrinkles and discolouration, improves complexion and gives a more youthful fullness to the skin. (pauldanielsydney.com)
Mimic1
  • It tones and retextures the skin and is known to mimic the action of laminin-5, an important molecule which is necessary for the health and appearance of the skin, and helps regenerate and renew the skin on a cellular level. (pauldanielsydney.com)
Polypeptide1
  • A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)
Stimulate2
  • Peptids® - Patented active ingredients - helps repair skin damage and stimulate collagen synthesis. (cinqmondes.com)
  • Another study has demonstrated that both serum and synovial fluid from rheumatoid arthritis (RA) could not stimulate chondrocyte proteoglycan synthesis once the IGF-1 function was blocked by a primary antibody [ 6 ]. (biomedcentral.com)
Reverse transcri2
  • The mRNA expression of MMP-2 and MMP-9 was determined by reverse transcription-polymerase chain reaction, and the protein expression of MMP-2 and MMP-9 by gelatin zymography analysis and qualified by the gel electrophoresis image analysis in different HA concentrations. (molvis.org)
  • We investigated the effects of different level of HA concentrations on mRNA and protein expressions of MMP-2 and MMP-9 in cultured trabecular meshwork cells using reverse transcription-polymerase chain reaction (RT-PCR) method and gelatin zymography analysis. (molvis.org)
Tissue3
  • TissueFab ® - Low endotoxin GelMA-UV Laminin kit enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine. (sigmaaldrich.com)
  • The IHC tests showed that the ECM of the mice testicular interstitial tissue showed reaction to anti-laminin-α5 antibody. (biomedres.info)
  • High concentration of sodium nitrate did not change the laminin α5 expression in the ECM of the testicular interstitial tissue. (biomedres.info)
Contrast1
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Homology1
Reduction2
  • A reduction of laminin content will cause a separation of the two skin compartments followed by a slack and wrinkled superficial appearance. (basf.com)
  • The reduction in the amount of laminin in treatment II group was significant compared to the control group (P=0.003). (biomedres.info)
Peptides1
  • Made in Australia to the highest standards, Paul Daniel Ageless Eye Serum is an advanced cosmeceutical formulation rich in peptides (active chains of amino acids), biologically active botanical compounds, vitamins and antioxidants that promotes collagen and elastin and provides lift around the eyes to give a firmer and smoother eye contour. (pauldanielsydney.com)
Cellular1
  • As a consequence, we detected a higher density of replication forks traveling simultaneously on DNA fibers, which relies on limiting cellular dNTP pools to support processive DNA synthesis. (bvsalud.org)
Bound2
  • Endogenous laminin α5 and bound Lu-Fc were detected with anti-laminin α5 domain LEb/L4b and anti-human IgG, as indicated. (bio-rad-antibodies.com)
  • Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Bovine2
  • This was in agreement with previous data showing chondroitin sulfate GAG chains attached to bovine perlecan produced by chondrocytes and that recombinant human domain I protein was glycosylated with both heparan and chondroitin sulfate chains when expressed in Chinese Hamster Ovary cells. (wikipedia.org)
  • An ex vivo study showed that IGF-1 in fetal bovine serum was responsible for maintaining articular cartilage proteoglycan synthesis. (biomedcentral.com)
Consists2
  • It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains. (lookformedical.com)
  • It consists of three identical alpha1(II) chains. (lookformedical.com)
Organization2
Genes1
Skin4
  • By specifically stimulating laminin synthesis, BasalineTM effectively smoothes out creases at the skin surface. (basf.com)
  • By specifically stimulating laminin synthesis, Basaline TM effectively smoothes out creases at the skin surface. (basf.com)
  • Basaline TM , a relief smoother and activator of laminin, reactivates the synthesis of laminin in an intelligent manner because it stimulates only those systems with a laminin deficit, a condition unique to mature skin. (basf.com)
  • Basaline TM acts on laminin to cause a smoothing of the skin surface in mature subjects (in vivo data). (basf.com)
Effects2
Domain2
  • The N-terminal domain I (aa ~1-195) contains attachment sites for HS chains. (wikipedia.org)
  • Domain V also has attachment sites for HS/CS chains. (wikipedia.org)
Human2
Results1
  • Finally, a synthesis was made of the results of the survey, focus group discussions and face-to-face interviews. (helsinki.fi)
Expression2
  • Kruskal Wallis test showed no significant difference in laminin α5 expression in the ECM of the interstitial spaces of seminiferous tubules between the groups. (biomedres.info)
  • To reduce the degree-loss experiment, it is found that the sum of Centella asiatica (L.) Urban can help improve the expression of the mid-layer adhesion protein-5 in the hair follicle cells, while the laminin is a vital effect of the signaling process in the hair development of hair. (zhenyibio.com)
Found1
  • We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
Mouse2
Subsequent2
  • Gel)ma Laminin -UV/365 nm, low endotoxin features a ready-to-use bioink that is formulated for high cell viability, and printability and is designed for extrusion-based 3D bioprinting and subsequent 365 nm light crosslinking and a solution of Laminin to enhance the bioink. (sigmaaldrich.com)
  • subsequent specific chain bicarbonate( PPAR-alpha) regulates the odorant one-particle of spontaneous molecular enzyme in the transfer. (evakoch.com)
Domains1
Study1
  • His study focuses on the intersection of Biochemistry and fields such as Histamine with connections in the field of Alpha chain and Basophil activation. (research.com)
Content1
  • One-way ANOVA showed a significant difference in the laminin α5 content between the control and treatment II group. (biomedres.info)
Type3
  • An atomic download durability design of concrete structures rilem in available knowing is the type of PIP2 and IP3 with the unsustainable chain. (familie-vos.de)
  • In infants, III collagen synthesis is more synthesis, why is this also a lot The reason why the baby will not leave scars after the healing of the baby is healing, that is, because of the more secretion of Type III collagen. (zhenyibio.com)
  • For example, cells can change the type and amount of adhesion molecules in the plasma membrane by synthesis, degradation, or hidden them temporarily in internal compartments by endocytosis and exocytosis. (uvigo.es)
Cells2
  • All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
  • The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
Levels1
  • Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)