BiosynthesisLipoproteinsEnergy metabolismEnzymesEnzymePathwaysRole of lipidGluconeogenesisTriacylglycerol synthesisCatabolismAberrant Lipid MetabolismMetabolicBlood lipidCarbohydrate metabolismMembraneCholesterolCarbohydratesRegulatesLipoproteinRegulationProtein.synthesisAccumulationGlucosePathwayHepaticDegradationGlycogenCitric acidImprove lipidLipolysisKetoneAbsorptionSecretionLiverEndoplasmic ReticulumEndocrinologyHumansExogenousStimulating the body'sAlterationsTumorigenesisLong-chainMoleculesAcidDefectsGenesCellularTissuesCell MetabolismMolecular MetabolismBiochemistryDropletModulatesUtilizationAdipose tissueRegulateOccursAdipocytes
Biosynthesis5
- Lipid Biosynthesis 10. (routledge.com)
- Our study implicates promotion of ether lipid biosynthesis as a novel therapeutic target to promote healthy aging. (massgeneral.org)
- starch/sugar metabolism and fermentation for biofuels, storage lipid biosynthesis: regulation and applications. (manchester.ac.uk)
- Similar to SREBP-1a and SREBP-1c, SREBP-2 acts by first binding to sterol regulatory DNA sequences, and subsequently up-regulating the synthesis of enzymes involved in sterol biosynthesis. (novusbio.com)
- [ 8 ] The exact pathogenesis by which this mutation causes the clinical findings in individuals with CHILD syndrome is still under investigation, but contributing factors likely include deficient cholesterol synthesis, buildup of toxic metabolites in the cholesterol biosynthesis pathway, and abnormal sonic hedgehog signaling. (medscape.com)
Lipoproteins7
- Due to the hydrophobic nature of membrane lipids, triglycerides and cholesterols, they require special transport proteins known as lipoproteins. (wikipedia.org)
- Chylomicrons are one sub-group of lipoproteins which carry the digested lipids from small intestine to the rest of the body. (wikipedia.org)
- Blood plasma lipids and the major groups of lipoproteins. (muni.cz)
- Lipids and Lipoproteins in Disease. (mcgill.ca)
- Biochemistry: Structure, function and metabolism of lipids and lipoproteins as they relate to lipid storage diseases, obesity, insulin resistance, diabetes, heart disease, Alzheimers disease and other neurological diseases. (mcgill.ca)
- Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
- All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. (msdmanuals.com)
Energy metabolism4
- The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. (harvard.edu)
- 2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
- These genes increase oxygen availability by inducing erythropoiesis and angiogenesis, and also reduce its demand via regulation of energy metabolism by reducing oxidative phosphorylation and inducing non-oxygen-demanding glycolysis [ 5 , 6 , 7 ]. (springer.com)
- We have taken a major interest in how mitochondria are genetically regulated, given their pivotal role in cellular energy metabolism and control of insulin secretion from beta-cells. (lu.se)
Enzymes6
- Lipid metabolism often begins with hydrolysis, which occurs with the help of various enzymes in the digestive system. (wikipedia.org)
- Digestion is the first step to lipid metabolism, and it is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes. (wikipedia.org)
- 1. Cholecystokinin: releases bile/pancreatic enzymes on gallbladder in presence of lipids. (flashcardmachine.com)
- His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. (harvard.edu)
- Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. (harvard.edu)
- However, as a compensatory response to reduce altered catabolism/ROS production, anabolic enzymes expression levels are also increased, resulting in higher gluconeogenesis and lipid synthesis. (elifesciences.org)
Enzyme8
- Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis. (mpg.de)
- The team also found that increasing ether lipid synthesis alone (by overexpressing a single, key ether lipid biosynthetic enzyme called fard-1 ) was sufficient to extend C. elegans' lifespan, orchestrating a metabolic stress defense response through a factor called SKN-1, which is the worm counterpart to the mammalian protein Nrf. (massgeneral.org)
- long-term regulation of glucose utilisation, enzyme-level control of glycolysis and gluconeogenesis, links to fatty acid metabolism, glycogen turnover, sugar interconversions and the citric acid cycle. (manchester.ac.uk)
- Berberine supplementation activates the enzyme AMPK, which contributes to metabolism regulation. (dallasnews.com)
- We found upregulation of the key fructose transporter and metabolizing enzyme mRNAs, Slc2a2 , Khka , and Khkc , and higher ketohexokinase activity in the Hif-p4h-2 gt/gt small intestine relative to the WT, suggesting enhanced metabolism of fructose in the former. (springer.com)
- We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. (lu.se)
- This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. (sigmaaldrich.com)
- [ 11 ] The NSDHL enzyme is located both within the membranes of the endoplasmic reticulum and on the surface of intracellular lipid storage droplets. (medscape.com)
Pathways6
- However, the role and the pathways of lipid metabolism in the occurrence and development of lung carcinoma have not been fully studied, and the role of blood lipids in the prognosis of lung carcinoma is still unclear [ 5 ]. (hindawi.com)
- Identification of two pathways mediating protein targeting from ER to lipid droplets. (harvard.edu)
- Describe the key features of cellular metabolism, including central catabolic and anabolic pathways. (manchester.ac.uk)
- From aiding in the digestion of lipids to regulating essential metabolic pathways, BAs have garnered significant interest among researchers and healthcare professionals. (randox.com)
- Carboxylic acids and glycerol feed into physiological pathways like the citric acid cycle, sugar synthesis, and lipid synthesis. (europa.eu)
- Adolph (1999) summarized that lipids are not only structural building blocks of cells and tissues but at the same time suppliers of C- atoms for a number of biosynthetic pathways as well as carriers of essential fatty acids and fat-soluble vitamins. (europa.eu)
Role of lipid2
- Since 2007, Dr. Farese's laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD). (harvard.edu)
- Cell ultrastructural events, cytoarchitecture and cell surface changes, and the role of lipid solvent s on DNA, protein and collagen synthesis are studied. (cdc.gov)
Gluconeogenesis1
- FXR also modulates lipid transport and metabolism, as well as hepatic gluconeogenesis. (randox.com)
Triacylglycerol synthesis3
- Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. (harvard.edu)
- In the enrichment analysis, functional terms were revealed including fatty acid synthesis, triacylglycerol synthesis, and lipid and lipoprotein metabolism. (usp.br)
- ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
Catabolism3
- Lipid catabolism is accomplished by a process known as beta oxidation which takes place in the mitochondria and peroxisome cell organelles. (wikipedia.org)
- Catabolism of haemoglobin, bilirubin metabolism. (muni.cz)
- 11. Synthesis and Catabolism of Nucleotide. (saujanyabooks.com)
Aberrant Lipid Metabolism1
- Our central hypothesis is that identifying and targeting metabolic processes connected with aberrant lipid metabolism will result in the alleviation of lipotoxic effects and the mitigation of cardiac dysfunction. (unl.edu)
Metabolic5
- The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body.Upon completion of this course the student should understand: biochemical processes characteristic for individual organs and tissues and principles of their regulation, metabolic interrelationships between metabolism of nutrients under various conditions in organism, principles of maintenance of homeostasis and acid-base equilibrium in the body. (muni.cz)
- Metabolic fate of chylomicrons and VLDL, the metabolism of HDL. (muni.cz)
- You will learn about diseases caused by defects in metabolism, such as diabetes, which will emphasise the importance of metabolic control. (manchester.ac.uk)
- Diseases caused by defects in metabolism will be studied to emphasise the importance of metabolic control. (manchester.ac.uk)
- Using comprehensive metabolomic analysis, we demonstrate unexpected metabolic differences in fatty acid metabolism between mutant IDH1 and IDH2 in patient samples with targetable metabolic interventions. (lu.se)
Blood lipid5
- The tie-in between the level and the prognosis is to determine whether the blood lipid level during the initial treatment of small cell lung carcinoma affects the prognosis and to provide a theoretical basis for the clinical treatment of SCLC patients. (hindawi.com)
- Insulin plays a crucial role in regulating blood lipid metabolism. (biorxiv.org)
- Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
- In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
- Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
Carbohydrate metabolism3
- Overview of carbohydrate metabolism. (unibo.it)
- Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. (diabetesjournals.org)
- Adipose tissue plays a crucial role in the regulation of energy homeostasis, insulin sensitivity, and lipid/carbohydrate metabolism. (diabetesjournals.org)
Membrane10
- Other types of lipids found in the body are fatty acids and membrane lipids. (wikipedia.org)
- An interface coordinating lipid metabolism with proteins that regulate membrane trafficking is necessary to regulate Golgi morphology and dynamics. (tamu.edu)
- Such an interface facilitates the membrane deformations required for vesicularization, forms platforms for protein recruitment and assembly on appropriate sites on a membrane surface and provides lipid co-factors for optimal protein activity in the proper spatio-temporally regulated manner. (tamu.edu)
- Membrane lipids. (mpg.de)
- When lung carcinoma occurs, the proliferation of tumor cells is abnormally active, and the tumor cells continue to proliferate, and in this process, more energy and cell membrane synthesis are required. (hindawi.com)
- More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology. (harvard.edu)
- Lipid compositions, together with specific protein decoration, dictates membrane properties and thus organellar functions. (barthsyndrome.org)
- Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
- Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). (aacrjournals.org)
- The addition of a cloned and purified recombinant PLD to HeLa cells resulted in substantial remodeling of the host membrane architecture, as measured by lipid raft formation. (cdc.gov)
Cholesterol11
- The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol. (wikipedia.org)
- In the cytosol of epithelial cells, triglycerides and cholesterol are packaged into bigger particles called chylomicrons which are amphipathic structures that transport digested lipids. (wikipedia.org)
- derivatives of cholesterol that prevent lipids from coalescing. (flashcardmachine.com)
- The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (nih.gov)
- Sterol regulatory element-binding proteins (SREBPs) compose a family of transcriptional factors that regulate the expression of various genes required for the synthesis of phospholipids, fatty acids, and cholesterol. (novusbio.com)
- Out of the three isoforms present (SREBP-1a, SREBP-1c and SREBP-2), SREBP-2 has been implicated more directly in the synthesis of cholesterol during metabolism. (novusbio.com)
- This interaction prevents the cleavage of SREBP-2, which results in the synthesis of cholesterol and uptake of LDL despite high levels of present sterols. (novusbio.com)
- Cholesterol is necessary for the synthesis of hormones, production of digestive acids, stabilization of cell membranes, and formation of myelin on nerve fibers. (medscape.com)
- As a result, cells are unable to produce cholesterol and there is a buildup of toxin byproducts of the cholesterol synthesis pathway. (medscape.com)
- Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)
- Factors that stimulate hepatic lipoprotein synthesis generally lead to elevated plasma cholesterol and TG levels. (msdmanuals.com)
Carbohydrates4
- Synthesis and Mobilization of Storage and Structural Carbohydrates 8. (routledge.com)
- 9. Metabolism of Carbohydrates. (saujanyabooks.com)
- Structure and metabolism of carbohydrates. (unibo.it)
- Thyroid hormone also controls skeletal growth and differentiation and metabolism of carbohydrates, lipids, and vitamins. (medscape.com)
Regulates6
- Our study revealed that insulin negatively regulates the influx and positively regulates the efflux of lipids, which is consistent with previous findings. (biorxiv.org)
- Numerous studies have investigated how insulin regulates amino acids and lipids in the bloodstream 4 , 18 , 19 . (biorxiv.org)
- In addition, insulin indirectly regulates FFA synthesis from TAG by regulating blood glucose levels 5 . (biorxiv.org)
- Activation of FXR regulates bile acid synthesis, delivery, and clearance, maintaining their levels within a safe range. (randox.com)
- Here, we show that stromal CAVIN1 regulates lipid abundance in the prostate cancer microenvironment and suppresses metastasis. (aacrjournals.org)
- Now, Guo and GarcĂa have revealed that a protein called SIR-2.1, which regulates metabolism in worms, also helps to protect the animals from the effects of aging. (elifesciences.org)
Lipoprotein1
- Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)
Regulation3
- We also observed that the earlier peak time of lipids compared to BCAAs is dependent on insulin's negative regulation of their influx. (biorxiv.org)
- While there has been extensive research on the mathematical modeling of insulin's regulation of blood glucose 8 - 13 , there has been limited investigation of its selective regulation of blood amino acids and lipids 14 - 17 . (biorxiv.org)
- We examined regulation of lipid partioning in beta-cells and its control of insulin secretion. (lu.se)
Protein.synthesis3
- Proline, which can improve protein synthesis. (wishtv.com)
- Insulin reduces blood amino acid concentrations by limiting the release of amino acids into the bloodstream from skeletal muscle 18 , 20 and promoting protein synthesis in the liver and other tissues 3 . (biorxiv.org)
- Our identification of a genetic variant of TFB1M , encoding a protein that controls protein synthesis in mitochondria, which is associated with increased risk of Type 2 Diabetes, has been a strong thrust. (lu.se)
Accumulation3
- Spatial lipidomics revealed an accumulation of highly unsaturated and shortened lipids and reduction of sphingolipids throughout the brains of cPSAP DAT mice. (nature.com)
- 2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
- We show that depletion of CAVIN1 in prostate stromal cells markedly reduces their lipid droplet accumulation and increases inflammation. (aacrjournals.org)
Glucose8
- Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism. (deepdyve.com)
- We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
- Therefore, our current finding indicates an important role of hypothalamic inflammation in PM2.5 exposure-mediated hepatic glucose and lipid metabolism disorder. (deepdyve.com)
- 2010), nonalcoholic steatohepatitis, impaired hepatic glucose metabolism (Zheng et al. (deepdyve.com)
- 2017). Whether central inhibition of IKK2 could reverse the dysfunction of glucose and lipid metabolism remains unknown. (deepdyve.com)
- Insulin plays a crucial role in regulating the metabolism of blood glucose, amino acids, and lipids in humans. (biorxiv.org)
- One of insulin's primary functions is to regulate blood glucose levels, but it also has a role in regulating other blood metabolites such as amino acids and lipids 3 - 6 . (biorxiv.org)
- To address this gap, we utilized mathematical model selection to explore insulin's selective regulatory mechanisms on blood amino acids and lipids, considering their temporal patterns after oral glucose ingestion. (biorxiv.org)
Pathway1
- Collectively, these landmark discoveries provided initial insight into the COX pathway of arachidonate metabolism. (medscape.com)
Hepatic1
- Medium-chain fatty acids (MCFA) are readily absorbed from the small intestine directly into the bloodstream and transported to the liver for hepatic metabolism, while long-chain fatty acids (LCFA) are incorporated into chylomicrons and enter the lymphatic system. (europa.eu)
Degradation1
- Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. (wikipedia.org)
Glycogen1
- Glycogen synthesis and glycogenolysis. (unibo.it)
Citric acid2
- control of protein turnover, nitrogen handling, links to nucleic acid metabolism, amino acid oxidation, integration with citric acid cycle. (manchester.ac.uk)
- Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)
Improve lipid2
- Threonine, to improve lipid metabolism. (wishtv.com)
- This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)
Lipolysis1
- During feeding, insulin inhibits the activity of hormone-sensitive lipases that regulate lipolysis in adipose tissue and also inhibits the synthesis and release of FFA into the blood by degrading TAG 22 . (biorxiv.org)
Ketone1
- Blood lipids consist of free fatty acids and ketone bodies, such as 3-hydroxybutyrate. (biorxiv.org)
Absorption5
- The majority of lipid digestion and absorption, however, occurs once the fats reach the small intestines. (wikipedia.org)
- The second step in lipid metabolism is absorption of fats. (wikipedia.org)
- Digestion and absorption of lipids. (muni.cz)
- These properties allow bile acids to emulsify and solubilize lipids, facilitating their digestion and absorption 1 . (randox.com)
- Bone resorption occurs mainly on the bone surface, by the osteoclasts (OC) on bone metabolism in continuous absorption. (frontiersin.org)
Secretion1
- TSH synthesis and secretion are stimulated by thyrotropin-releasing hormone (TRH), which is synthesized by the hypothalamus and is secreted into the hypophyseal portal vasculature for transport to the anterior pituitary gland. (medscape.com)
Liver4
- HIF-P4H-2 inhibition enhances intestinal fructose metabolism protecting the liver. (springer.com)
- Growth, liver, and muscle fatty acid (FA) content, and transcript expression of lipid metabolism and inflammation-related genes were evaluated. (usda.gov)
- Transcripts related to de novo FA synthesis, acac and acly, were higher in liver of GL salmon fed the FO-free diet compared to all treatments, while fasb was higher in GL salmon fed the FO-free diet compared to both strains fed the FO diet. (usda.gov)
- Lipids are fats that are either absorbed from food or synthesized by the liver. (msdmanuals.com)
Endoplasmic Reticulum1
- Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. (harvard.edu)
Endocrinology1
- He trained in medicine at the University of Colorado School of Medicine, and completed a research fellowship in Endocrinology and Metabolism at the University of California, San Francisco and the Gladstone Institutes. (harvard.edu)
Humans1
- The findings, which are published in eLife , suggest that boosting production of ether lipids in humans may support healthy aging and reduce the impact of aging-related diseases. (massgeneral.org)
Exogenous1
- Fig. 3: Increased SCD activity is required for cancer cells to adapt to exogenous lipid limitation. (nature.com)
Stimulating the body's1
- New research led by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, reveals that metformin promotes longevity by stimulating the body's production of molecules called ether lipids, a major structural component of cell membranes. (massgeneral.org)
Alterations4
- They showed that PSAP loss triggers global lipid alterations and induces ferroptosis selectively in neurons 21 . (nature.com)
- Genetic alterations of CAV1N1 and CAV1 modify lipid metabolism and underpin lipodystrophy syndromes. (aacrjournals.org)
- The working hypothesis is that alterations in pyruvate metabolism will contribute to balancing redox state and alleviating oxidative stress leading to improvement of cardiac function during diabetes. (unl.edu)
- Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
Tumorigenesis2
- Recent developments in technologies, such as lipidomics and machine learning, have underlined the critical effects of altered lipid metabolism in tumorigenesis. (medworm.com)
- Lipids contribute to tumorigenesis by providing fuel to cancer metabolism and supporting growth and signaling. (aacrjournals.org)
Long-chain1
- My PhD studies at Nencki Institute of Experimental Biology PAS in Warszawa, Poland, focused on the role of long-chain fatty acids metabolism in different models of left ventricular hypertrophy, and have borne fruit in several highly cited publications, a considerable amount of conference proceedings, domestic and EU scientific grants and scholarships, and an international patent. (unl.edu)
Molecules1
- Since lipids are hydrophobic molecules, they need to be solubilized before their metabolism can begin. (wikipedia.org)
Acid9
- By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)
- 6. Individual amino Acid Metabolism. (saujanyabooks.com)
- 7. Amino acid Metabolism. (saujanyabooks.com)
- One key receptor associated with bile acid metabolism is the Farnesoid X receptor (FXR). (randox.com)
- The cancer cells show elevated de novo fatty acid synthesis, an in. (medworm.com)
- Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. (frontiersin.org)
- The working hypothesis is that adjusting fatty acid transport, synthesis, and utilization will alleviate lipotoxic effects and inhibit cardiac steatosis and inflammation. (unl.edu)
- Further investigations by Smith concluded that aspirin and indomethacin inhibited synthesis by specifically blocking oxygenation of arachidonic acid. (medscape.com)
- [ 9 ] Additionally, CLA purportedly reduces fatty acid synthesis in adipocytes, suggesting that this supplement decreases fat deposition, directly contributing to an improvement in body composition in adults and children. (medscape.com)
Defects1
- however, it is also caused by autosomal recessive defects in the organification of iodine (thyroid hormone synthesis) and defects in other enzymatic steps in T4 synthesis and release. (medscape.com)
Genes1
- The experiments reveal that genes that Increase production of ether lipids are required to extend lifespan in response to the biguanides. (massgeneral.org)
Cellular3
- To provide students with an understanding of the essential features of cellular metabolism, and the mechanisms through which metabolism is controlled. (manchester.ac.uk)
- Explain how different control mechanisms may be integrated to coordinate cellular metabolism, with reference to specific examples. (manchester.ac.uk)
- It was during my postdoctoral stay in Dallas at Southwestern Medical Center that I really developed my understanding of cellular metabolism. (lu.se)
Tissues2
- Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting. (nature.com)
- As one of the important components of lung tissues, lipids can be synthesized and broken down in the lungs. (hindawi.com)
Cell Metabolism1
- Cell Metabolism, 2020). (barthsyndrome.org)
Molecular Metabolism1
- Robert Farese, Jr., is Chair and Professor of the Department of Molecular Metabolism at the Harvard School of Public Health and Professor of Cell Biology at Harvard Medical School, where he has run a laboratory jointly with Dr. Tobias Walther since 2014. (harvard.edu)
Biochemistry1
- Plant Biochemistry is invaluable to undergraduate students who wish to gain insight into the relevance of plant metabolism in relation to current research questions and world challenges. (routledge.com)
Droplet2
- Structure and function of lipid droplet assembly complexes. (harvard.edu)
- Seipin forms a flexible cage at lipid droplet formation sites. (harvard.edu)
Modulates1
- Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson's disease (PD). (nature.com)
Utilization1
- In: Plant lipids: Biology, utilization and manipulation, S. 123 - 161 (Hg. (mpg.de)
Adipose tissue1
- Lipids are stored in white adipose tissue as triglycerides. (wikipedia.org)
Regulate1
- Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality. (tamu.edu)
Occurs3
- Lipid metabolism also occurs in plants, though the processes differ in some ways when compared to animals. (wikipedia.org)
- FA is mainly synthesized by the new synthesis that occurs in the mammary gland or derived from the ruminal biohydrogenation process. (usp.br)
- Trapping of iodine occurs by 10-12 weeks' gestation, followed by the synthesis of iodothyronines. (medscape.com)
Adipocytes1
- Adipocytes produce a number of hormones that have wide-ranging effects on energy intake, energy expenditure, and carbohydrate and lipid metabolism, including nutrient partitioning and fuel selection. (diabetesjournals.org)