• Evidence synthesis is a vital part of evidence-informed decision-making, but high growth in the volume of research evidence over recent decades has made efficient evidence synthesis increasingly challenging. (biomedcentral.com)
  • As the appreciation and need for timely and rigorous evidence synthesis continue to grow, so too will the need for tools and frameworks to conduct reviews of expanding evidence bases in an efficient and time-sensitive manner. (biomedcentral.com)
  • Efforts to future-proof evidence synthesis through the development of new evidence synthesis technology (ESTech) have so far been isolated across interested individuals or groups, with no concerted effort to collaborate or build communities of practice in technology production. (biomedcentral.com)
  • In order to future-proof evidence synthesis against the evidence avalanche, we must support community enthusiasm for ESTech, reduce redundancy in tool design, collaborate and share capacity in tool production, and reduce inequalities in software accessibility. (biomedcentral.com)
  • Tom works on novel methodologies for comparative effectiveness research, with emphasis on the steps of evidence synthesis (by means of systematic review and meta-analysis), and evidence contextualization (by means of decision and economic analysis). (brown.edu)
  • He joined the Brown faculty in 2012 as a professor of biostatistics and founding member and Co-Director of the Center for Evidence Synthesis in Health in the Brown School of Public Health. (brown.edu)
  • How Can Evidence Synthesis be Conducted at the Speed of a Pandemic? (cdc.gov)
  • Azide groups are easy to introduce, stable to water and oxidative conditions, and orthogonal to many functional groups in peptide synthesis. (genengnews.com)
  • Click chemistry provides a number of avenues for peptide synthesis and modifications and could be combined with other techniques to make complex structures and multicomponent functionalized systems with ease. (genengnews.com)
  • Peptides can also be made by inter- and intramolecular click reactions using azide or alkyne containing amino acids or building blocks during peptide synthesis. (genengnews.com)
  • Click chemistry is compatible with various protected amino acid side chains used in peptide synthesis. (genengnews.com)
  • Somerset, New Jersey (PRWEB) March 28, 2016 -- LifeTein is unveiling an expedited peptide synthesis program, promising to place peptides in its customers' hands within 3-5 business days. (prweb.com)
  • The RushPep™ peptide synthesis service was designed to circumvent the existing limitations of conventional solid-phase peptide synthesis (SPPS), which involves a long coupling time and low yield. (prweb.com)
  • When designing the RushPep™ methodology , our focus was to not only to produce peptides of high quality and purity but also to offer a streamlined solution that would increase the efficiency of researchers' protein discovery workflows," stated Dr. Ya Chen, Head of LifeTein's Rush Peptide Synthesis Group. (prweb.com)
  • Chen continued, "The reliability of RushPep™ rush peptide synthesis ensures that the peptides are finished in 3-5 business days with high-batch-to-batch reproducibility. (prweb.com)
  • LifeTein is a global contract research organization (CRO) specializing in peptide synthesis services , including various modifications such as multiple phosphorylations, biotin, FITC, D-amino acids, stapled peptides and cell penetrating peptides. (prweb.com)
  • Fmoc- protected for solid phase synthesis), propargyl amino acids, PEG azide and alkynes (Maleimide-PEG3-Azide and acetylene PEG maleimide for pegylation), alkyne and azide containing chemical modification reagents (propargyl amine, 1-(2-nitrophenyl) propargyl alcohol, succinidyl-hex-5-ynoate, succinimidyl-4-azovalerate, pentynoic acid, 2-azido-3-methyl propanoic acid) and Diazo transfer reagents (imidazole-1-sulfonyl azide). (genengnews.com)
  • The synthesis of the AOMKs has always been challenging and current methodologies involve both solution and solid-phase synthesis. (thieme-connect.com)
  • The Synthesis Report (SYR) is the last of the Sixth Assessment Report products, finalized in March 2023, in time to inform the 2023 Global Stocktake by the United Nations Framework Convention on Climate Change as mandated by Decision 1/CP.21 . (ipcc.ch)
  • 2023 is when countries will review progress towards the Paris Agreement goals, including the goal of keeping global warming to well below 2°C while pursuing efforts to limit it to 1.5°C. The Synthesis Report of the Sixth Assessment Report (AR6) provides an overview of the state of knowledge on the science of climate change, emphasizing new results since the Fifth Assessment Report (AR5) in 2014. (ipcc.ch)
  • In this review, first various methods used to prepare metal nanoparticles are highlighted and further tannic acid mediated synthesis of metal nanoparticles is emphasized. (hindawi.com)
  • This developed increased interest of scientific community in the synthesis of metal nanoparticles of defined morphology. (hindawi.com)
  • Various procedures have been developed for the synthesis of metal nanoparticles and nanomaterials including physical, chemical, and biological methods. (hindawi.com)
  • Continuous gas-phase synthesis of core-shell nanoparticles via surface segregation. (lu.se)
  • Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. (wiley-vch.de)
  • Overcoming ammonia synthesis scaling relations with plasma-enabled catalysis. (nature.com)
  • The Centre for Analysis and Synthesis is working with research questions that are fundamental in their nature and can contribute to a more sustainable future. (lu.se)
  • Fritz Haber filed a German patent in 1908 for the synthesis of ammonia for which he won a Nobel Prize in Chemistry in 1918. (wipo.int)
  • With this process the ammonia final concentration reached 82.5 vol%, which is higher than state-of-the-art ammonia synthesis under high temperature and pressure (25 vol%, 450 °C, 200 bar). (nature.com)
  • Fig. 1: Schematic illustration of the ammonia synthesis process. (nature.com)
  • Marnellos, G. & Stoukides, M. Ammonia synthesis at atmospheric pressure. (nature.com)
  • Breaking scaling relations to achieve low-temperature ammonia synthesis through LiH-mediated nitrogen transfer and hydrogenation. (nature.com)
  • Ammonia synthesis by N 2 and steam electrolysis in molten hydroxide suspensions of nanoscale Fe 2 O 3 . (nature.com)
  • Ammonia synthesis using a stable electride as an electron donor and reversible hydrogen store. (nature.com)
  • The Brønsted-Evans-Polanyi relation and the volcano plot for ammonia synthesis over transition metal catalysts. (nature.com)
  • But as the call goes out for green innovation and climate change technologies, there is an important lesson to learn from an ammonia synthesis patent which marks its 100th anniversary this year: some inventions may be a double-edged sword. (wipo.int)
  • Ammonia synthesis exponentially increased harvests and will continue to do so for years to come. (wipo.int)
  • Following his discovery of ammonia synthesis, he had spent World War I working on poison gas research, earning the title "father of chemical warfare. (wipo.int)
  • Moving forward one hundred years and even the positive application of ammonia synthesis has repercussions. (wipo.int)
  • A number of different scenarios for future nitrogen fertilizer use and the challenges likely to be faced by what has been called "our nitrogen economy" over the next hundred years are discussed in the article, "How a century of ammonia synthesis changed the world," published in the September 28, 2008, issue of Nature Geoscience . (wipo.int)
  • total synthesis , semisynthesis , and methodology . (wikipedia.org)
  • A total synthesis is the complete chemical synthesis of complex organic molecules from simple, commercially available petrochemical or natural precursors. (wikipedia.org)
  • [2] Total synthesis may be accomplished either via a linear or convergent approach. (wikipedia.org)
  • 2017). soundgen: Parametric Voice Synthesis . (lu.se)
  • The Intergovernmental Panel on Climate Change (IPCC) is finalizing its Sixth Assessment cycle , during which the IPCC has produced the Assessment reports of its three Working Groups, three Special Reports, a refinement to the Methodology Report and the Synthesis report. (ipcc.ch)
  • Reactive synthesis from temporal logic specifications provides a methodology to automatically construct a system implementation from a declarative specification of correctness. (springer.com)
  • Total syntheses (see above) are sometimes used to showcase the new methodology and demonstrate its value in a real-world application. (wikipedia.org)
  • The proprietary methodology renders processing ten times faster than in classical synthesis while simultaneously circumventing the limitations caused by the formation of by-products or intermediates to which traditional SPPS approaches are subject. (prweb.com)
  • Cubism can evoke in our minds the methodology of research synthesis conducted via systematic reviews and meta-analysis. (cdc.gov)
  • The Speech Synthesis Markup Language Specification is one of these standards and is designed to provide a rich, XML-based markup language for assisting the generation of synthetic speech in Web and other applications. (w3.org)
  • This document is a specification for a Speech Synthesis Markup Language. (w3.org)
  • There is some variance in the use of terminology in the speech synthesis community. (w3.org)
  • The design and standardization process has followed from the Speech Synthesis Markup Requirements for Voice Markup Languages published December 23, 1999 by the W3C Voice Browser Working Group. (w3.org)
  • provide predictable control of voice output across platforms and across speech synthesis implementations. (w3.org)
  • The syntheses feature a palladium-catalyzed hydrocarbonylative lactonization to install the 6,6-fused bicyclic ring system and a Dreiding-Schmidt reaction to build the oxaspirolactone moiety of these target molecules. (acs.org)
  • Our group has previously demonstrated the successful synthesis of boron nanotube through CVD reaction, and proposed a mechanism involving the physical templating of boron nanotubes. (aiche.org)
  • [2] Most often, each step in a synthesis refers to a separate reaction taking place to modify the starting compound. (wikipedia.org)
  • Each step of a synthesis involves a chemical reaction and reagents . (wikipedia.org)
  • Thus, the release reaction and prostaglandin synthesis act to consolidate the initial hemostatic plug by promoting the participation of other platelets in the growing hemostatic plug. (medscape.com)
  • Our chemical total syntheses of these Abies sesquiterpenoids have enabled (i) the validation of beshanzuenone C's weak PTP1B inhibiting potency, (ii) identification of new synthetic analogs with promising and selective protein tyrosine phosphatase SHP2 inhibiting potency, and (iii) preparation of azide-tagged probe molecules for target identification via a chemoproteomic approach. (acs.org)
  • Herein, the synthesis of a new scaffold useful for the preparation of peptidyl-AOMKs is reported and it is demonstrated that the new synthetic probes bearing a 4-functionalized 2,6-dimethylbenzoate efficiently inhibit cysteine proteases like cathepsin B. (thieme-connect.com)
  • To support the Synthesis Report writing process, the SYR TSU organizes various meetings including Core Writing Team meetings. (ipcc.ch)
  • The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. (wiley-vch.de)
  • Hydrolases in Organic Synthesis - Regio- and Stereoselective Biotransformations. (thieme-connect.com)
  • This article is about artificial synthesis of organic compounds . (wikipedia.org)
  • For the journal, see Organic Syntheses . (wikipedia.org)
  • Organic synthesis is a special branch of chemical synthesis and is concerned with the intentional construction of organic compounds . (wikipedia.org)
  • [1] Organic molecules are often more complex than inorganic compounds, and their synthesis has developed into one of the most important branches of organic chemistry . (wikipedia.org)
  • Robert Burns Woodward , who received the 1965 Nobel Prize for Chemistry for several total syntheses [4] (e.g., his 1954 synthesis of strychnine [5] ), is regarded as the father of modern organic synthesis. (wikipedia.org)
  • Professor Maguire underlined the central importance of organic synthesis to the field of chemical biology and the interfaces with drug development and process development. (soci.org)
  • Dr Nick Gathergood, Dublin City University, added that EuCheMS has belatedly recognised organic synthesis as a strategically important subject and it will henceforth have a much higher profile at European level. (soci.org)
  • We describe herein the first total syntheses of these Abies sesquiterpenoids relying on the sustainable and inexpensive chiral pool molecule (+)-carvone. (acs.org)
  • [17] Historically, total syntheses targeted racemic mixtures, mixtures of both possible enantiomers , after which the racemic mixture might then be separated via chiral resolution . (wikipedia.org)
  • Expertise in synthesis allows researchers to attack interdisciplinary problems, to grapple with mechanistic problems and hence design superior processes. (soci.org)
  • The essential role of the markup language is to provide authors of synthesizable content a standard way to control aspects of speech such as pronunciation, volume, pitch, rate, etc. across different synthesis-capable platforms. (w3.org)
  • The carbon -based SACs exhibit excellent activity and selectivity (≈68%) for the synthesis of substituted quinolines by a three-component oxidative cyclization , affording a wide assortment of quinolines (23 examples) from anilines and acetophenones feedstock in an efficient, atom-economical manner. (bvsalud.org)
  • is a component for the Amphion/NAV system (synthesis of state estimation software) which automatically generates and displays explanations for each piece of the synthesized code, thus effectively achieving traceability between code and specification. (aaai.org)
  • The HiScribe SP6 RNA Synthesis Kit is designed for the in vitro transcription of RNA using SP6 RNA Polymerase. (neb.com)
  • RNA synthesized from this kit is suitable for many applications including RNA structure and function studies, ribozyme biochemistry, probes for RNase protection or gel shift assays, hybridization-based blots, anti-sense RNA or RNAi experiments, microarray analysis, microinjection, sgRNA synthesis and in vitro translation studies. (neb.com)
  • In this paper, we will describe three techniques which enhance the capabilities of a synthesis tool with respect to generation of explanations, certificates, and simulation data. (aaai.org)
  • Low-cost, globally distributed DNA synthesis capabilities increase the risk that malicious actors may exploit this technology to produce dangerous biological agents, with potentially catastrophic consequences. (nti.org)
  • Developing tools to advance universal DNA synthesis screening in countries around the world to prevent the misuse of this technology and help safeguard modern bioscience. (nti.org)
  • Title : Moving Knowledge into Action: Developing the Rapid Synthesis and Translation Process Within the Interactive Systems Framework Personal Author(s) : Thigpen, Sally;Puddy, Richard W.;Singer, Helen Harber;Hall, Diane M. (cdc.gov)
  • The HiScribe SP6 RNA Synthesis Kit from NEB is faster and achieves higher yields for RNAs of various lengths. (neb.com)
  • The various enzymes and pathways involved in the synthesis of cellular phosphoinositides will be discussed. (nih.gov)
  • One must learn concepts (e.g., elements of research synthesis, the technology), repeat the behaviors (e.g., use relevant software, operate the machine), and practice relentlessly. (cdc.gov)
  • bio report describes the status of benchtop DNA synthesis devices, explains the risks for biosecurity, and recommends action and oversight by governments, industry, and the scientific community. (nti.org)
  • In research synthesis, clinical and public health professionals examine the scientific literature on a certain topic from multiple years and perspectives. (cdc.gov)
  • Research synthesis allows for examining scientific studies of diagnostic tools, therapies, interventions, programs, or policies as part of a continuum, with the past flowing into the present and the present influencing the future. (cdc.gov)
  • Just as art can help the public understand history, clinical and public health professionals can use research synthesis as a scientific tool to enhance medicine and public health. (cdc.gov)
  • For specific domains (e.g., data analysis, planning and scheduling, or state estimation), automated program synthesis systems have been developed which are capable of producing hundreds of lines of non-trivial code. (aaai.org)
  • In this paper, we discuss an extension of the AB system (synthesis of data analysis programs) for the automatic generation of code annotations which can be handled by a verification condition generator and an automated theorem prover. (aaai.org)
  • Figure H.5 shows the result of the analysis/synthesis process using phase information and applied to a piano tone. (stanford.edu)
  • Through the U.S. Geological Survey's Powell Center for Analysis and Synthesis, we brought together a group of scientists to elucidate mechanisms underlying amphibian declines in North America and Europe. (usgs.gov)
  • Tools for sound synthesis and acoustic analysis. (lu.se)
  • The capacity for protein synthesis was tested by radiolabeling cultures with 3H-leucine and analyzing the resultant autoradiograms. (jneurosci.org)
  • Isolated growth cones displayed incorporation of 3H-leucine that was inhibited by treatment with the protein synthesis inhibitors anisomycin and pactamycin, indicating that ribosomal-dependent translation occurs in growth cones. (jneurosci.org)
  • Ultrastructural analyses of growth cones demonstrated the presence of polyribosomes, the machinery for protein synthesis. (jneurosci.org)
  • Taken together, these studies reveal a capacity for protein synthesis confined totally to the neuronal growth cone proper. (jneurosci.org)
  • By 2015, someone will have used protein synthesis techniques to build a million copies of an 8 bit binary adder. (foresight.org)
  • By 2015, someone will have used protein synthesis techniques to build a million marginally reliable copies of a 256 state finite state machine. (foresight.org)
  • After completing this course on XST Synthesis Options you will be able to describe an approach to using XST synthesis options to obtain higher performance and gain timing closure, use XST to get the most out of your HDL. (xilinx.com)
  • The conditions for each step of a synthesis are designed to give an adequate yield of pure product with as few steps as possible. (wikipedia.org)
  • A single synthesis tool cannot create the best results for all architectures. (latticesemi.com)
  • Synthesis quality of results (QoR) is affected by the design snapshot after the HDL parsing, the tool flow, and the order in which the optimizations executed. (latticesemi.com)
  • Lattice Synthesis Engine (LSE) is a logic-synthesis tool designed specifically to produce the best possible results for Lattice's FPGAs. (latticesemi.com)
  • This mechanism will be a tool that DNA providers can use to screen DNA synthesis orders, and it will be incorporated into benchtop DNA synthesis devices. (nti.org)
  • The list below represents a synthesis of some of the common themes regarding teaching about risk and resilience. (carleton.edu)
  • for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. (thieme-connect.com)
  • To promote evidence-based programs and policies, the primary single-study articles and research synthesis published in this journal can remind us that we can learn from art and science to conduct, value, and apply evidence-based medicine and public health. (cdc.gov)
  • The title comes from a series of discussions between short-lived Evol member Rubén Patiño and Roc Jiménez de Cisneros about digital synthesis techniques. (boomkat.com)
  • The synthesis is done one frame at a time. (stanford.edu)
  • Until recently there were no large-scale syntheses of long-term time series data to test hypotheses about the generality of factors driving population dynamics at broad spatial scales. (usgs.gov)
  • Moreover, as the cost of DNA synthesis continues to decline over time, the fixed costs of screening orders is placing a growing financial burden on commercial providers and straining the viability of the voluntary screening model. (nti.org)
  • However, safeguards for DNA synthesis technology-to ensure that providers do not inadvertently sell the building blocks of dangerous pathogens to malicious actors-have not kept pace with growing global demand for this service and declining costs. (nti.org)
  • Providing efficient, affordable tools for screening DNA orders is critically important for safeguarding DNA synthesis technology, and it could help universalize screening practices globally. (nti.org)
  • The synthesis of proteins in growth cones could afford a mechanism for the alteration of growth cone structure or function. (jneurosci.org)
  • Develop an international Common Mechanism to enable effective, efficient screening of DNA synthesis orders and customers. (nti.org)
  • To preserve safe and secure global access to DNA synthesis services, NTI is working with the World Economic Forum (WEF) to develop an international Common Mechanism for DNA synthesis screening. (nti.org)
  • Some syntheses are feasible on a research or academic level, but not for industry level production. (wikipedia.org)
  • DNA synthesis is a service that is widely used in bioscience research in laboratories around the world. (nti.org)
  • Synthesis of clinical or public health research, conducted by combining results of several studies, explores the relationship between an intervention or an exposure and a health outcome from perspectives different from and in addition to those examined in a single study. (cdc.gov)
  • Research synthesis creates a dialogue among clinical and public health professionals about its role in evidence-based medicine and public health. (cdc.gov)
  • The synthesis step has the most potential to improve the quality of results in FPGA design. (latticesemi.com)
  • This is an effective way to quickly analyze the post-synthesis results. (latticesemi.com)
  • Congenital bile acid synthesis defect type 1 is a disorder characterized by cholestasis, a condition that impairs the production and release of a digestive fluid called bile from liver cells. (medlineplus.gov)
  • As a result, cholesterol and other fats build up in the liver and fat-soluble vitamins are not absorbed, which contribute to the signs and symptoms of congenital bile acid synthesis defect type 1. (medlineplus.gov)
  • Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. (medlineplus.gov)
  • Serum albumin levels are dependent on the rate of synthesis, the amount secreted from the liver cell, the distribution in body fluids, and the level of degradation. (medscape.com)
  • Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). (medscape.com)