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Mitochondrial Proton-Translocating ATPasesBacterial Proton-Translocating ATPasesProton-Translocating ATPasesProtein SubunitsVitamin UMolecular Sequence DataAmino Acid SequenceAnthranilate SynthaseGlutaminaseMacromolecular SubstancesGlucosyltransferasesBase SequenceIntegrin alpha5MitochondriaReceptors, NicotinicProtein Phosphatase 2DNA, MitochondrialReceptors, GABA-AMutationEscherichia coliRNA, MessengerPhosphorylationCitrate (si)-SynthaseCells, CulturedSignal TransductionReverse Transcriptase Polymerase Chain ReactionGlycogen Synthasealpha 1-AntitrypsinGlycogen Synthase Kinase 3Thymidylate SynthaseNitric Oxide Synthase Type IKineticsCloning, MolecularBinding SitesReceptors, Adrenergic, alphaProtein BindingHypoxia-Inducible Factor 1, alpha SubunitRecombinant ProteinsNitric OxideSequence Homology, Amino AcidEnzyme InhibitorsProtein Conformationalpha7 Nicotinic Acetylcholine ReceptorProtein Structure, TertiaryTryptophan SynthaseModels, MolecularElectrophoresis, Polyacrylamide GelTransfectionBlotting, WesternMolecular WeightCell LineIntegrin alpha6Mutagenesis, Site-DirectedTranscription, GeneticIntegrin alpha3beta1Integrin alpha4Malate SynthaseIsoenzymesGlutamate SynthaseCattleEnzyme ActivationIntegrin alpha5beta1Sequence AlignmentGene ExpressionGene Expression RegulationRats, Sprague-DawleyHydroxymethylglutaryl-CoA SynthaseDNA PrimersRecombinant Fusion ProteinsDose-Response Relationship, DrugMice, Inbred C57BLDNA, ComplementaryThromboxane-A SynthaseAmino Acid OxidoreductasesSubstrate SpecificityIntegrinsMice, KnockoutSaccharomyces cerevisiaeIntegrin alpha4beta1ArginineInterleukin-1alphaIntegrin alpha2beta1DNAMultienzyme ComplexesAlkyl and Aryl TransferasesReceptors, Adrenergic, alpha-1Integrin alpha1beta1CatalysisPeptide FragmentsStructure-Activity RelationshipPromoter Regions, GeneticReceptors, Adrenergic, alpha-2Integrin alpha6beta1DNA-Binding ProteinsTime FactorsLiverDimerizationIntegrin alpha6beta4Integrin alpha ChainsATP Synthetase Complexes
Tryptophan synthaseATPaseEpsilonEnzymePhosphate synthaseInducible nitric oxide syTrpAMitochondrial membrane ATPCatalytic coreProtein subunitMRNAStalkATP5F1ADeltaBetaMembraneProtonMutationsLocusSynthesisAtpAInitiation factorProteinsActivatorComplexBiosynthesisConsists0006Amino acidsReceptorSymbolDomainComplementKinase
Tryptophan synthase3
ATPase5
  • The protein is a subunit of the catalytic portion of the F1Fo ATPase, also known as Complex V, which consists of 14 nuclear and 2 mitochondrial -encoded subunits. (wikipedia.org)
  • In the F-ATPase from Geobacillus stearothermophilus, conformational changes in the ε-subunit are influenced by intracellular ATP concentration and membrane potential. (rcsb.org)
  • Complex V, also called F1F0 ATPase or ATP synthase is extremely conserved through evolution and can be found in plants, fungi, bacteria, and animals. (thermofisher.com)
  • The ATP synthase enzyme is a transmembrane protein responsible for driving the reversible reaction from ADP + phosphate to ATP, in oxidative phosphorylation, and as a proton pumping ATPase. (thermofisher.com)
  • H+-transporting two-sector ATPase, C subunit family protein [Arabidopsi. (yeastrc.org)
Epsilon2
  • The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. (wikipedia.org)
  • ATP synthase epsilon chain OS=Coxiella burnetii (strain RSA 493 / Nine Mile phase I) GN=atpC PE=3 SV. (yeastrc.org)
Enzyme7
  • Background ATP synthase is the universal enzyme that synthesizes ATP from ADP and phosphate using the energy stored in a transmembrane ion gradient. (agrisera.com)
  • ATP synthase F1 subunit alpha, mitochondrial is an enzyme that in humans is encoded by the ATP5F1A gene. (wikipedia.org)
  • However, in the Escherichia coli enzyme, there is no evidence that such ATP binding to the ε-subunit is mechanistically important for modulating the enzyme's hydrolytic activity. (rcsb.org)
  • In a form with a mutated ε-subunit unable to bind ATP, the enzyme remains inactive and the ε-subunit is down. (rcsb.org)
  • Therefore, neither the γ-subunit nor the regulatory ATP bound to the ε-subunit is involved in the inhibitory mechanism of this particular enzyme. (rcsb.org)
  • The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. (thermofisher.com)
  • The SUCLA2 and SUCLG1 genes each provide instructions for making one part (subunit) of an enzyme called succinate-CoA ligase. (medlineplus.gov)
Phosphate synthase2
  • 18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)
  • 1594\1533\BAB40956.2\Avena sativa\Avena sativa MIP mRNA for myo-inositol-1-phosphate synthase,complete cds. (or.jp)
Inducible nitric oxide sy2
  • PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)
  • The expression and activity of inducible nitric oxide synthase, an intracellular marker of M1, were increased by MWCNTs. (cdc.gov)
TrpA1
  • In particular, the intrinsically low catalytic activity of the alpha-subunit TrpA is stimulated several hundredfold through the interaction with the beta-subunit TrpB1. (uni-regensburg.de)
Mitochondrial membrane ATP2
  • Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. (joplink.net)
  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. (joplink.net)
Catalytic core3
  • Subunits alpha and beta form the catalytic core in F1. (joplink.net)
  • ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. (wikipedia.org)
  • This gene encodes the alpha subunit of the catalytic core. (wikipedia.org)
Protein subunit1
  • The work supports a role for chemical modification in the recognition and subsequent degradation of a key protein subunit of PSII by a bacterial-type protease, suggesting that tryptophan oxidation of components of the photosynthetic apparatus after high light stress plays a critical role in initiating the PSII repair system. (elifesciences.org)
MRNA2
Stalk3
  • During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (joplink.net)
  • Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (joplink.net)
  • The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. (thermofisher.com)
ATP5F1A1
  • As an alpha subunit, ATP5F1A is contained within the catalytic F1 portion of the complex. (wikipedia.org)
Delta1
  • Among these proteins , calmodulin, ATP synthase mitochondrial subunits alpha and delta, malate dehydrogenase and sperm equatorial segment protein 1 were shown to be linked with sperm fertility. (rsc.org)
Beta2
  • The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression. (joplink.net)
  • If viewed from the synaptic cleft, the protein will look like a pseudo-symmetrical rosette shown in the picture below composed of 10 different alpha and 4 different beta subunits. (proteopedia.org)
Membrane2
  • AtpA is the largest subunit of the membrane-extrinsic ATP synthase subcomplex. (agrisera.com)
  • Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. (wikipedia.org)
Proton1
  • The proton channel consists of three main subunits (a, b, c). (wikipedia.org)
Mutations1
  • Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease. (thermofisher.com)
Locus1
  • the second locus, on chromosome 3, controls synthesis of the β subunit. (medscape.com)
Synthesis1
  • GMP synthase catalyses the synthesis of GMP from XMP. (embl.de)
AtpA1
  • The Recombinant Ureaplasma parvum serovar 3 ATP synthase subunit alpha (atpA), partial is a α- or alpha protein sometimes glycoprotein present in blood. (gentaur.com)
Initiation factor1
  • 39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)
Proteins2
  • Alpha enolase was significantly down-regulated in the ERCR− group, while two other proteins , isocitrate dehydrogenase and triosephosphate isomerase, were up-regulated in ERCR− in comparison to ERCR+. (rsc.org)
  • Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
Activator1
  • Since N -acetylglutamate (NAG) is the allosteric activator of carbamoylphosphate synthase, the entry step into the urea cycle, decreased ureagenesis occurs with accumulation of free ammonia. (medscape.com)
Complex1
  • To determine whether this bridging sulfide is catalytically relevant and to further explore the mechanism of the C-cluster, we obtained crystal structures of the 310 kDa bifunctional CODH/acetyl-CoA synthase complex from Moorella thermoacetica bound both with a substrate H(2)O/OH(-) molecule and with a cyanide inhibitor. (rcsb.org)
Biosynthesis1
  • NAD+ synthase ( EC 6.3.5.1 ) catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide and is induced by stress factors such as heat shock and glucose limitation. (embl.de)
Consists1
00061
  • 7524) oxaloacetate decarboxylase alpha subunit CP001857 CDS Arcpr_0006 complement(7556. (go.jp)
Amino acids1
  • In PSII subunits, photo-oxidative modifications of several amino acids such as Trp have been indeed documented, whereas the linkage between such modifications and D1 degradation remains elusive. (elifesciences.org)
Receptor1
  • There must be 5 molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. (proteopedia.org)
Symbol1
  • The gene ATP synthase, subunit b is referred to in FlyBase by the symbol Dmel\ATPsyn-b (CG8189, FBgn. (yeastrc.org)
Domain2
  • 38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
  • the E-value for the NAD_synthase domain shown below is 2.8e-10. (embl.de)
Complement3
  • 15406) siroheme synthase CP001857 CDS Arcpr_0016 complement(15403. (go.jp)
  • 20325) RNase P subunit p30 CP001857 CDS Arcpr_0023 complement(20322. (go.jp)
  • complement C8 alpha chain [Source:HGNC. (gsea-msigdb.org)
Kinase1
  • L'analyse d'image des cartes appariées a permis d'identifier sept protéines qui étaient soit surexprimées, soit sous-exprimées : le récepteur de la protéine kinase C activée, la tubuline alpha (×2), la prostaglandine F2-alpha synthase, la protéine disulfide isomérase, une protéine du transport vésiculaire et une protéine hypothétique. (who.int)