• Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant diagnostic challenge given similar histomorphology. (eurekamag.com)
  • Although the presence of a t(X;18) rearrangement or expression of TLE1 can help confirm the diagnosis of synovial sarcoma, negative results for these tests are not diagnostic of malignant peripheral nerve sheath tumor. (eurekamag.com)
  • The goal of the present study was to determine the diagnostic utility of SOX10 to discriminate between synovial sarcoma and malignant peripheral nerve sheath tumor. (eurekamag.com)
  • Forty-eight cases of malignant peripheral nerve sheath tumor, all from patients with documented neurofibromatosis, and 97 cases of genetically confirmed synovial sarcoma, including 4 intraneural synovial sarcomas, were immunohistochemically stained for SOX10. (eurekamag.com)
  • Therefore, SOX10 is a specific (93%), albeit not very sensitive (67%), diagnostic marker to support a diagnosis of malignant peripheral nerve sheath tumor over synovial sarcoma. (eurekamag.com)
  • The differential diagnosis includes anaplastic Wilms' tumor renal synovial sarcomas malignant mesenchymomas ectomesenchymomas Because of the rarity of this tumour, optimal treatment is as yet unknown. (wikipedia.org)
  • Synovial chondromatosis with malignant degeneration to chondrosarcoma. (medscape.com)
  • Malignant transformation of synovial chondromatosis of the shoulder to chondrosarcoma. (medscape.com)
  • Primary synovial chondromatosis: a reassessment of malignant potential in 155 cases. (medscape.com)
  • Indeed, the identification of histotype-specific (pathognomonic) gene alterations is of paramount importance in the differential diagnosis among sarcoma variants, between malignant and benign mimics, as well as between sarcoma and other tumor types ( 1 - 3 ). (frontiersin.org)
  • Three patients had malignant fibrous histiocytoma, two patients had myxoid liposarcoma, one patient had synovial sarcoma, and one had extraskeletal chondrosarcoma. (biomedcentral.com)
  • The biopsy should be placed in line with the incision for definitive tumor resection to allow en-bloc resection of the biopsy tract. (medscape.com)
  • Hum Pathol 61:205-209 Wu MK, Cotter MB, Pears J, McDermott MB, Fabian MR, Foulkes WD, O'Sullivan MJ (2016) Tumor progression in DICER1-mutated cystic nephroma-witnessing the genesis of anaplastic sarcoma of the kidney. (wikipedia.org)
  • In the diagnosis of sarcomas, tumor cell morphology (shape, pattern of growth, microenvironment contexture) and the expression of differentiation markers represent the most important factors, but molecular investigations are increasingly employed to complement these pathological assessments. (frontiersin.org)
  • Brachytherapy, interstitial tumor bed irradiation, following conservative surgery has been shown to provide excellent local control and limb preservation in patients with soft tissue sarcomas (STS), whereas little is known about the tolerance of peripheral nerves to brachytherapy. (biomedcentral.com)
  • Success in the management of soft tissue sarcomas (STS) is often limited by the extension of lesions to neurovascular structures, because of the difficulty in dissecting the neurovascular bundle from the tumor without compromising the function and local recurrence of residual lesions. (biomedcentral.com)
  • We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
  • Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States. (nih.gov)
  • Extremely rare synovial chondrosarcoma arising from the elbow joint: case report and review of the literature. (medscape.com)
  • Benign synovial disorders. (medscape.com)
  • Giant cell tumors(GCT) are uncommon and benign tumors originating due to proliferation of the tendon synovial sheath. (jocr.co.in)
  • The distinction is further complicated by similar immunophenotype and especially by occasional synovial sarcomas that present as intraneural tumors. (eurekamag.com)
  • Solitary fibrous tumors (SFTs) must be carefully distinguished from other entities, such as synovial sarcoma and angiosarcoma, which have a worse prognosis and different treatment course. (medscape.com)
  • Usefulness of NKX2.2 Immunohistochemistry for Distinguishing Ewing Sarcoma from Other Sinonasal Small Round Blue Cell Tumors. (nih.gov)
  • Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. (nih.gov)
  • The term "sarcoma" identifies a heterogeneous group of rare tumors comprising over 60 different histologic variants ( 1 ). (frontiersin.org)
  • Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma. (nih.gov)
  • ScientificWorldJournal 9:97-101 Arabi H, Al-Maghraby H, Yamani A, Yousef Y, Huwait H (2016) Anaplastic sarcoma of the kidney: A rare unique renal neoplasm. (wikipedia.org)
  • Mod Pathol Yoshida M, Hamanoue S, Seki M, Tanaka M, Yoshida K, Goto H, Ogawa S, Takita J, Tanaka Y (2016) Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities. (wikipedia.org)
  • Int J Surg Pathol 24(6):556-561 Wu MK, Vujanic GM, Fahiminiya S, Watanabe N, Thorner PS, O'Sullivan MJ, Fabian MR, Foulkes WD (2017) Anaplastic sarcomas of the kidney are characterized by DICER1 mutations. (wikipedia.org)
  • Hum Pathol 53:114-120 Vujanić GM, Kelsey A, Perlman EJ, Sandstedt B, Beckwith JB (2007) Anaplastic sarcoma of the kidney: a clinicopathologic study of 20 cases of a new entity with polyphenotypic features. (wikipedia.org)
  • Kirchhoff C, Buhmann S, Braunstein V, Weiler V, Mutschler W, Biberthaler P. Synovial chondromatosis of the long biceps tendon sheath in a child: a case report and review of the literature. (medscape.com)
  • Conventional HPCs and SFTs have a better prognosis than some older studies may suggest, in that these studies may have inadvertently included sarcomas with HPC-like features. (medscape.com)
  • Crettenand F, Martin D, Cherix S, Demartines N, Matter M. Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma. (jcancer.org)
  • Extensive surgery is often required for advanced soft tissue sarcoma (STS) of the limb. (jcancer.org)
  • A phase II study of gemcitabine and docetaxel combination in relapsed metastatic or unresectable locally advanced synovial sarcoma. (nih.gov)
  • Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. (jcancer.org)
  • The diffuse type demonstrates more extensive involvement of the synovial membrane and capsule while the local form is less aggressive and is being confined to a distinct area of the synovium [3] . (jocr.co.in)
  • Significantly increased standardized uptake value in the peripheral rim of the lesion on 2-[ 18 F]fluoro-2 deoxy-D glucose positron emission tomography imaging, mimicking a soft tissue sarcoma, should be recognized as a potential diagnostic pitfall in cases of chronic expanding hematoma. (biomedcentral.com)
  • 2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)
  • Due to their rarity and heterogeneity, the accuracy of sarcoma diagnosis remains challenging. (frontiersin.org)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
  • Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
  • Antiangiogenic approaches for the treatment of advanced synovial sarcomas. (nih.gov)
  • Different NGS approaches, including anchored multiplex PCR and hybrid capture-based panels, were employed to profile a large set of sarcomas of different histotypes. (frontiersin.org)
  • The analysis confirmed the reliability of NGS RNA-based approaches in detecting sarcoma-specific rearrangements. (frontiersin.org)
  • The typical history of a patient with primary synovial chondromatosis of the knee is that of a middle-aged man with monoarticular pain, swelling, and stiffness with or without mechanical symptoms in the knee. (medscape.com)
  • The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
  • Variably present are palpable loose bodies in synovial recesses, tenderness along the medial or lateral joint line, and decreased patellar mobility. (medscape.com)
  • Prognostic factors and treatment of patients with advanced synovial sarcoma: A single-center experience. (nih.gov)
  • Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
  • Soft tissue sarcomas (STS) are tumours arising from connective tissues, with an incidence of about 5 per 100'000 [ 1 ]. (jcancer.org)
  • The lesion exhibited significantly increased FDG uptake on FDG-PET, mimicking the characteristics of a soft tissue sarcoma accompanied by hematoma. (biomedcentral.com)
  • In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
  • Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
  • 56 synovial sarcoma cases were selected for this study. (biomedcentral.com)
  • Despite an increasing interest for radical lymph node dissection as part of treatment for sarcomas, there is currently no study on a standardized population in which radical lymph node dissection was performed systematically. (jcancer.org)
  • Synovial osteochondromatosis: a histopathological study of thirty cases. (medscape.com)
  • It remains to be determined whether SOX10-positive cells in intraneural synovial sarcoma represent entrapped Schwann cells, synovial sarcoma cells or both. (eurekamag.com)
  • A synovial sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment. (nih.gov)
  • Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma. (nih.gov)
  • Bynum CK, Tasto J. Arthroscopic treatment of synovial disorders in the shoulder, elbow, and ankle. (medscape.com)
  • This work describes the set-up of a shared platform among the laboratories of the Alleanza Contro il Cancro (ACC) Italian Research Network for the identification of fusion transcripts in sarcomas by using Next Generation Sequencing (NGS). (frontiersin.org)
  • In particular, about one third of all sarcomas presents pathognomonic chromosome rearrangements (translocations, deletions, insertions) that result in fusion genes and corresponding expression of fusion transcripts ( 4 ). (frontiersin.org)
  • Kerimoglu S, Aynaci O, Saraçoglu M, Cobanoglu U. Synovial chondromatosis of the subtalar joint: a case report and review of the literature. (medscape.com)
  • Abdelwahab IF, Contractor D, Bianchi S, Hermann G, Hoch B. Synovial chondromatosis of the lumbar spine with compressive myelopathy: a case report with review of the literature. (medscape.com)
  • Chiang CH, Jou IM, Wang PH, Chern TC, Huang MT. Synovial osteochondromatosis of the second metatarsophalangeal joint: a case report. (medscape.com)