AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Antibodies, Antineutrophil CytoplasmicVasculitisWegener GranulomatosisAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisMyeloblastinSyndromeAntibodiesAntibody SpecificityPeroxidaseAntibodies, ViralChurg-Strauss SyndromeAntibodies, MonoclonalAntibodies, BacterialMicroscopic PolyangiitisPropylthiouracilFluorescent Antibody Technique, IndirectAutoantibodiesGlomerulonephritisVasculitis, Leukocytoclastic, CutaneousAntithyroid AgentsAntibody FormationAntibodies, NeutralizingFluorescent Antibody TechniqueNeutrophilsSerine EndopeptidasesPolyarteritis NodosaAntibodies, AntinuclearEnzyme-Linked Immunosorbent AssayAntibody AffinityDown SyndromeImmunoglobulin GMetabolic Syndrome XAntibodies, Anti-IdiotypicAntibodies, FungalBinding Sites, AntibodyColitis, UlcerativeImmunosuppressive AgentsHIV AntibodiesAutoimmune DiseasesEndocarditis, Subacute BacterialEpitopesBiological MarkersAutoantigensAntibodies, NeoplasmPurpura, Schoenlein-HenochAntibodies, ProtozoanAntibodies, Monoclonal, Murine-DerivedPrednisoloneImmune SeraNeutrophil ActivationLysosomal-Associated Membrane Protein 2Cross ReactionsSjogren's SyndromeGraves DiseaseNephrotic SyndromeCyclophosphamideEosinophilia-Myalgia SyndromeMethimazoleFixativesNose DiseasesImmunoglobulin MRespiratory BurstMolecular Sequence DataLung DiseasesPlasma ExchangeCathepsin GSensitivity and SpecificityRecurrenceFocal InfectionMethylprednisoloneNeutralization TestsHemoptysisScleritisAmino Acid SequenceProctocolectomy, RestorativeBiopsyAntigen-Antibody ReactionsPancreatic ElastaseAntibodies, BispecificTreatment OutcomeDrug ContaminationMice, Inbred BALB CTurner SyndromeTime FactorsSingle-Chain AntibodiesAntibodies, BlockingLupus Erythematosus, SystemicFollow-Up StudiesRemission InductionAntigen-Antibody ComplexCholangitis, SclerosingNeutropeniaImmunoglobulin Fab FragmentsAntiphospholipid SyndromeMyelodysplastic SyndromesAbnormalities, MultipleAntibodies, HeterophileKidneyAntibodies, CatalyticCrohn Disease
ANCAVasculitisComplementAntigensAntinuclear antibodiesGranulomatosisAutoantibodiesNephroticSerumClinicalBasement-membraneTherapeutic antibodiesRenalGlomerulonephritisCOVID-19 VaccinationMonoclonal antibodyTiterEosinophiliaPrevalenceProteinaseAntigenSjogren'sManifestationsAntiphospholipid syndromeIntravenousConjugatesDisordersNeurologicIgG1PeripheralDermatomyositisInflammationMultisystemReactInflammatory diseasesSymptomsAcuteChronicImmune-mediatedDescribeSevereDiseasesUncommon
ANCA18
  • Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis. (pneumotox.com)
  • Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy. (pneumotox.com)
  • Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe. (pneumotox.com)
  • Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism. (pneumotox.com)
  • GPA is one of the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic disorders. (medscape.com)
  • Thus, a patient can have "severe" disease in the lungs in the presence of antineutrophil cytoplasmic antibody (ANCA)-associated diffuse alveolar hemorrhage with mild extrapulmonary involvement [ 8 ]. (medilib.ir)
  • Blood tests that look for certain antibodies - such as the anti-neutrophil cytoplasmic antibody (ANCA) test - can help diagnose vasculitis. (worldwidefaqs.com)
  • What is ANCA (Anti neutrophil cytoplasmic antibodies)? (umqaa.com)
  • Besides neutropenia, other findings include anti-neutrophil cytoplasmic antibody (ANCA), antinuclear antibody (ANA), anti-double-stranded DNA (dsDNA), anti-human neutrophil elastase (HNE), and anti-myeloperoxidase antibodies. (kevinmd.com)
  • Because antineutrophil cytoplasmic auto-antibodies (ANCA) can be detected in the serum (liquid and a cellular part of the blood) in up to 40% of the patients, it is also considered one of the three ANCA-associated vasculitides, along with granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis. (vasculitisfoundation.org)
  • Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is a common primary small-vessel vasculitis, characterized by necrotizing inflammation of small vessels and the presence in the patient's serum of ANCA antibodies [2] . (ucalgary.ca)
  • ANCA antibodies are a group of antibodies that are directed against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes. (ucalgary.ca)
  • Savage CO. Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. (ucalgary.ca)
  • Warm?CALM: Café aulait macules?cANCA: Cytoplasmic pattern of ANCA?CAP: Community-acquired pneumonia?cap. (kuwaitpharmacy.com)
  • Antineutrophil cytoplasmic antibody (ANCA) vasculitis can result in various symptoms depending on the organ or body part affected. (medicinenet.com)
  • Antineutrophilic cytoplasmic antibody (ANCA)-linked vasculitides are a diverse collection of uncommon autoimmune diseases that result in blood vessel inflammation with varying symptoms. (medicinenet.com)
  • Drug-induced vasculitis and renal-limited vasculitis are other conditions linked to ANCA. (medicinenet.com)
  • The diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is based on the presence of ANCA, clinical symptoms, and a biopsy of the frequently affected organs such as the kidneys and nasal mucosa or the lungs (which are infrequently affected). (medicinenet.com)
Vasculitis20
  • We describe the case of an elderly woman who developed anti-neutrophil cytoplasmic antibody-associated vasculitis with pulmonary renal syndrome approximately 3 weeks after the first dose of COVID-19 mRNA vaccination (Moderna). (frontiersin.org)
  • An increasing number of studies has also supported a possible link between COVID-19 vaccination and the rapid development of de novo or relapsed glomerular diseases, such as anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). (frontiersin.org)
  • Fraticelli P, Kafyeke A, Mattioli M, Martino GP, Murri M, Gabrielli A. Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib. (wjgnet.com)
  • Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after COVID-19 Vaccination. (pneumotox.com)
  • Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. (pneumotox.com)
  • Propylthiouracil-induced lupus-like or vasculitis syndrome. (pneumotox.com)
  • Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole. (pneumotox.com)
  • PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease. (pneumotox.com)
  • Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue. (pneumotox.com)
  • Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies. (pneumotox.com)
  • Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (pneumotox.com)
  • [1] Hearing loss, headache, arthralgia, fever, arthritis, and myalgias are the most common systemic symptoms of Cogan syndrome, and up to 15% of patients develop vasculitis. (aao.org)
  • Randomized trial of cyclophosphamide versus methotrexate for induc tion of remission in early systemic antineutrophil cytoplasmic antibody the management of granulomatosis with polyangiitis continues associated vasculitis. (ehd.org)
  • Here we describe 4 cases of new onset or relapsing antineutrophil cytoplasmic antibodies associated vasculitis occurring in timely association with influenza vaccination. (sanevax.org)
  • See "Pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis" . (medilib.ir)
  • Cryogloblinemia is a vasculitis of small blood vessels that is caused by deposition of immune complexes: large aggregates of antibodies and the other proteins they are bound to. (vasculitisfoundation.org)
  • Churg-Strauss Syndrome (CSS), now also referred to by its medically more accurate term eosinophilic granulomatosis with polyangiitis (EGPA), is a rare systemic vasculitis (inflammation in the wall of blood vessels of the body), predominantly affecting small-sized vessels. (vasculitisfoundation.org)
  • Proteinase 3 antineutrophil cytoplasmic antibody-associated vasculitis consistent with granulomatosis with polyangiitis. (ocu-radiology.jp)
  • Secondary vasculitis may be triggered by an infection, a drug, or a toxin or may occur as part of another inflammatory disorder or cancer. (merckmanuals.com)
  • 16. Jha S , Naidu G, Sharma A. Is rituximab "The Wonder Drug" for antineutrophil cytoplasmic antibody- associated vasculitis? (org.np)
Complement2
  • Serologic testing for enterovirus showed an 8-fold increase in enterovirus antibody titration by complement fixation between days 3 and 11. (cdc.gov)
  • This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
Antigens3
  • Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a relapsing and remitting course. (medscape.com)
  • Although the ocular pathogenesis of Cogan syndrome is not fully understood, it has been postulated to be an autoimmune disease in which autoantibodies target corneal, inner ear, and endothelial antigens. (aao.org)
  • The majority of cases are primary and related to auto-antibodies against podocyte antigens, most notably phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) though newer antigens continue to be discovered [ 1 ]. (biomedcentral.com)
Antinuclear antibodies1
  • A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynauds phenomenon and positivity of antinuclear antibodies. (lookformedical.com)
Granulomatosis2
Autoantibodies2
Nephrotic9
Serum3
  • Gross hematuria, heavy proteinuria, acute renal failure (serum creatinine up to 6.5 mg/dL), and hemoptysis coupled with a marked increase in serum anti-myeloperoxidase-O antibody were observed. (frontiersin.org)
  • However, most drugs act as haptens, binding covalently to serum or cell-bound proteins, including peptides embedded in major histocompatibility complex (MHC) molecules. (merckmanuals.com)
  • As these produce antibodies, serum immunoglobulin levels tend not to fall dramatically. (dermnetnz.org)
Clinical10
  • When the Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the ACR SLE classification criteria in 2012, they classified a person as having SLE in the presence of biopsy-proven lupus nephritis with ANA or anti-dsDNA antibodies or if 4 of the diagnostic criteria, including at least 1 clinical and 1 immunologic criterion, have been satisfied. (medscape.com)
  • Sepsis and Septic Shock Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. (msdmanuals.com)
  • Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)
  • GlobalData's Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). (pharmaceutical-technology.com)
  • The clinical picture evolved rapidly into a syndrome indistinguishable from axonal Guillain-Barré syndrome. (sanevax.org)
  • Initially defined independently by 2 researchers in the late 19th century as Wernicke's encephalopathy and Korsakoff syndrome, respectively, the syndrome was finally termed Wernicke-Korsakoff due to the shared etiologic, clinical, and histopathologic characteristics indicated by the former nomenclature. (psychiatrist.com)
  • The clinical efficacy of MZB as an immunosuppressant for renal transplantation was investigated in various Japanese institutions during the period from 1978 to 1982, and in 1984, MZB was approved by the Japanese Ministry of Health, Labour and Welfare as a drug indicated for the prevention of rejection in renal transplantation [ 2 , 3 ]. (hindawi.com)
  • We compared the clinical features and survival of patients with SSc-ILD to those with ILD associated with other CTD (non-SSc CTD-ILD), including RA, SLE, PM/DM, Sjögren's syndrome, and MCTD. (jrheum.org)
  • In the field of immunodiagnostics, antibodies are used to quantify clinical biomarkers in complex biological samples like blood (Wild, 2013). (trea.com)
  • There hasn't yet been what we would consider a proven "disease-modifying" drug, meaning a drug that you can introduce that actually changes the clinical course of the disease. (medscape.com)
Basement-membrane1
  • Test results for antinuclear factors, antiglomerular basement-membrane antibodies, and antineutrophil cytoplasmic antibodies were negative. (cdc.gov)
Therapeutic antibodies1
  • Some protein and large polypeptide drugs (eg, insulin , therapeutic antibodies) can directly stimulate antibody production. (merckmanuals.com)
Renal1
  • In addition to its approval for the prevention of rejection after renal transplantation, MZB has been approved in Japan for the treatment of lupus nephritis (1990), rheumatoid arthritis (1992), and primary nephritic syndrome (1995), and in these diseases, it has often been used in combination with corticosteroids and/or anti-inflammatory drugs [ 4 ]. (hindawi.com)
Glomerulonephritis4
  • One study found that 12% of HAE patients had at one of the following autoimmune conditions: glomerulonephritis, Sjogren's syndrome, irritable bowel disease, thyroiditis, systemic lupus erythematosus, rheumatoid arthritis, drug induced lupus, pernicious anemia, juvenile RA with IgA deficiency, or sicca syndrome. (mastattack.org)
  • Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in a patient with a predisposition to autoimmune abnormalities. (pneumotox.com)
  • Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment. (pneumotox.com)
  • Vyvgart is indicated for the treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive and membranous glomerulonephritis (membranous nephropathy), lupus nephritis and Sjogren's syndrome and COVID-19 mediated postural orthostatic tachycardia syndrome. (pharmaceutical-technology.com)
COVID-19 Vaccination1
  • We analyzed multisystem inflammatory syndrome in children cases by reported COVID-19 vaccination status (2-dose primary series vs. no vaccination). (cdc.gov)
Monoclonal antibody3
  • Results of testing for respiratory syncytial virus, influenza virus, parainfluenza virus, and adenovirus by IFA and ELISA, which used specific monoclonal antibody, were all negative. (cdc.gov)
  • 4 ). In addition, on day 3, MRC-5 cell culture showed a specific cytopathic effect, which was confirmed as enterovirus by indirect IFA that used enterovirus mouse monoclonal antibody (Novocastra, Newcastle, UK) and fluorescein isothiocyanate-conjugated AffiniPure Goat Anti-Mouse (Jackson Immuno-Research, West Grove, PA, USA). (cdc.gov)
  • Rituximab is an immunoglobulin G1 (IgG1) kappa monoclonal antibody composed of a murine (mouse) variable region (Fab portion) that is fused onto a human constant region (Fc portion). (dermnetnz.org)
Titer2
  • The ACR/EULAR classification requires an antinuclear antibody (ANA) titer of at least 1:80 on HEp-2 cells or an equivalent positive test at least once. (medscape.com)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
Eosinophilia1
  • Idiopathic hypereosinophilic syndrome (HES) is a rare disorder characterized by peripheral eosinophilia exceeding 1500/mm 3 , a chronic course, absence of secondary causes, and signs and symptoms of eosinophil-mediated tissue injury. (wjgnet.com)
Prevalence2
  • RA patients are more likely to have thyroid-related antibodies, and some studies indicate an increased prevalence of thyroid diseases in RA. (springer.com)
  • [ 1 ] Although the prevalence of MAI infection has increased following the epidemic of acquired immunodeficiency syndrome (AIDS), MAI infection remains a rare cause of skin disease. (medscape.com)
Proteinase1
  • AAV is an autoimmune disorder characterized by small vascular inflammation, which predominantly occurs in the kidneys and in the presence of anti-neutrophil cytoplasmic antibodies and either anti-myeloperoxidase or anti-proteinase 3 antibodies ( 6 , 7 ). (frontiersin.org)
Antigen6
  • Serologic tests for hepatitis B surface antigen and anti-hepatitis C antibodies were negative. (journalmc.org)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com.cn)
  • The complex formed by the binding of antigen and antibody molecules. (lookformedical.com)
  • The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. (lookformedical.com)
  • Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. (lookformedical.com)
  • Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction. (lookformedical.com)
Sjogren's1
Manifestations2
  • [6] [7] Cogan syndrome can also lead to cardiovascular complications such as aortitis, as well as gastrointestinal and neurologic manifestations. (aao.org)
  • Patients with the atypical form of Cogan syndrome typically present with inflammatory ocular manifestations, such as episcleritis and choroiditis, with or without interstitial keratitis along with audiovestibular symptoms that are different from the Meniere-like symptoms seen in the typical form of Cogan syndrome. (aao.org)
Antiphospholipid syndrome1
  • 21. Sharma A, Naidu GSRSNK, Chattopadhyay A, Acharya N, Jha S , Jain S. Novel CECR1 gene mutations causing deficiency of adenosine deaminase 2, mimicking antiphospholipid syndrome. (org.np)
Intravenous2
Conjugates2
  • Specifically, the invention provides novel antibody conjugates suitable for use in Discrete Fluorescence Quenching Displacement Immunoassays and methods for producing these antibody conjugates. (trea.com)
  • The invention further relates to the use the novel antibody conjugates, and a kit comprising the same. (trea.com)
Disorders3
  • The impact of endocrine disorders on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS) is reviewed. (springer.com)
  • Capsule?CAPD: Continuous ambulatory peritoneal dialysis?Caps: Capsules?CAPS: Cryopyrin-Associated Periodic Syndromes disorders?CAPTIA Syph G: ?CAPTIA Syph M: ?CAST: Cardiac arrhythmia suppression trials?CAT: Computerized axial tomography?Cataplasm. (kuwaitpharmacy.com)
  • Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (bvsalud.org)
Neurologic1
  • Wernicke-Korsakoff syndrome is one of the neurologic complications that may emerge due to thiamine deficiency. (psychiatrist.com)
IgG11
Peripheral1
  • The classic form of Cogan syndrome is characterized by a nonsyphilitic, peripheral subepithelial keratitis that evolves rapidly into an interstitial keratitis with possible vascularization in the later stages of the disease. (aao.org)
Dermatomyositis1
  • CTD associated with ILD include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis and dermatomyositis (PM/DM), Sjögren's syndrome, and mixed connective tissue disease (MCTD) 4 . (jrheum.org)
Inflammation2
  • Removing antibodies may reduce inflammation in the kidney tissues. (medlineplus.gov)
  • [4] Cogan syndrome is characterized by recurrent ocular inflammation as well as hearing loss that can lead to deafness if left untreated. (aao.org)
Multisystem1
  • Multisystem inflammatory syndrome in children occurs after SARS-CoV-2 infection in vaccinated persons, but may be less severe. (cdc.gov)
React2
  • about the same percentage of patients react to structurally unrelated antibiotics (eg, sulfa drugs). (merckmanuals.com)
  • Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies. (lookformedical.com)
Inflammatory diseases1
  • Also occurs in inflammatory diseases such as sarcoidosis, Sjogren syndrome, IgG4-related diseases, and tubulointerstitial nephritis with uveitis (TINU) syndrome. (bmj.com)
Symptoms2
  • [2] The classic form of Cogan syndrome is diagnosed when a patient develops vestibular auditory symptoms within two years of ocular symptoms. (aao.org)
  • Symptoms and signs of drug allergies vary by patient and drug, and a single drug may cause different reactions in different patients. (merckmanuals.com)
Acute6
  • The global pandemic caused by severe acute respiratory syndrome coronavirus 2 has led to a significant loss of life, as well as severe disruptions to economies and social activities worldwide. (frontiersin.org)
  • Coronavirus disease of 2019 (COVID-19) infection will progress to acute respiratory distress syndrome in approximately 15-30% of hospitalized patients ( 1 ). (frontiersin.org)
  • On day 3, acute respiratory distress syndrome developed, and the patient required mechanical ventilation. (cdc.gov)
  • Timeline of disease course, treatments, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) tests, antibody tests, and Vero E6 cell line culture from day 0 to day 240. (ajtmh.org)
  • Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. (ocu-radiology.jp)
  • 8. Watari T, Branch J, Suganami Y, Ofuchi H, Kitagawa I. Characteristics of drug overdose patients transported to an acute suburban hospital in the Kanagawa region, Japan. (bedsidebootcamp.com)
Chronic2
  • Secondary causes include systemic diseases such as systemic lupus erythematosus and IgG4-related disease, solid tumor malignancies, chronic infections, and drugs. (biomedcentral.com)
  • Despite the high recovery rates that may be ensured with early treatment interventions, undiagnosed cases may result in the subacute/chronic dementia Korsakoff syndrome. (psychiatrist.com)
Immune-mediated1
  • Drug hypersensitivity is an immune-mediated reaction to a drug. (merckmanuals.com)
Describe1
  • In fact, these 2 syndromes describe the different phases of the single disease. (psychiatrist.com)
Severe1
  • The characteristics of MZB, which differentiate it from AZT, are the lack oncogenicity shown in animal experiments and association with a low incidence of severe adverse drug reactions, for example, myelosuppression and hepatotoxicity, clinically [ 1 - 3 ]. (hindawi.com)
Diseases3
  • Medscape Drugs & Diseases. (medscape.com)
  • Hypothyroidism contributes to the increased risk for cardiovascular diseases and metabolic syndrome in RA patients and may be correlated with RA disease activity and response to treatment. (springer.com)
  • Cushing syndrome in the rheumatic diseases is mainly secondary to glucocorticoid treatment. (springer.com)
Uncommon1
  • Cogan's syndrome (also Cogan syndrome) is an uncommon disease seen mostly in young adults that can severely affect vision and hearing. (aao.org)