• Down syndrome cell adhesion molecule like 1 is a protein in humans that is encoded by the DSCAML1 gene. (wikipedia.org)
  • The L1CAM gene provides instructions for producing the L1 cell adhesion molecule protein (shortened to L1 protein), which is found throughout the nervous system. (medlineplus.gov)
  • L1CAM gene mutations that cause L1 syndrome lead to an L1 protein that cannot facilitate cell-cell adhesion or participate in various neuronal functions. (medlineplus.gov)
  • Other mutations change the structure of the protein, impairing the protein's ability to interact with other proteins at the cell surface or preventing the protein from reaching the cell surface where it is needed. (medlineplus.gov)
  • Neuroligin 4 X-linked (NLGN4X) is an X-linked postsynaptic scaffolding protein, with functional role in excitatory synapsis development and maintenance, that has been associated with neuropsychiatric disorders such as intellectual disability, autism spectrum disorders (ASD), anxiety, attention deficit hyperactivity disorder (ADHD), and Tourette's syndrome. (nih.gov)
  • Full length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell. (origene.com)
  • Dr Matthias Soller has secured a BBSRC grant on RNA splicing using Drosophila Down Syndrome Cell Adhesion Molecule as a model membrane protein. (birmingham.ac.uk)
  • In hypermobility type of Ehlers-Danlos syndrome , haploinsufficiency (where one copy is unable to produce the protein in sufficient quantity) due to a 30-kb deletion of tenascin-X (TNXB) gene is responsible for the disease. (dorak.info)
  • Neuroligin3 is a transmembrane scaffolding protein and cell adhesion molecule. (antibodiesinc.com)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • Myelin protein zero is produced by specialized cells called Schwann cells, which wrap around and insulate peripheral nerves. (medlineplus.gov)
  • This protein is an adhesion molecule, which means it acts like molecular glue. (medlineplus.gov)
  • Many of the MPZ gene mutations that cause Charcot-Marie-Tooth syndrome change single protein building blocks (amino acids) in myelin protein zero. (medlineplus.gov)
  • The product of the PIGA gene is required for the synthesis of anchor protein known as GPI- anchor that ties other proteins to the cell surface. (aacc.org)
  • In normal red blood cells, the small blue arrows attached to the red blood cells surface represent the GPI-anchor needed for the expression of CD59 complement regulatory protein. (aacc.org)
  • FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
  • Led by Dr Maria Luz Fernandez at the University of Connecticut, USA, the research team suggested that consumption of grapes may help protect heart health in people with metabolic syndrome by improving vascular functions. (nutraingredients.com)
  • Zhang WJ, Frei B. Albumin selectively inhibits TNFα-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. (ijmedicine.com)
  • Elevated circulating levels of some endothelial adhesion molecules including e-selectin, intercellular adhesion molecule-1 (icam-1), and vascular cell adhesion molecule-1 (vcam-1) may reflect structural microvascular changes related to the pathophysiological processes of impaired insulin action and secretion. (najms.com)
  • dhBBR and Di-MeBBR reduced expression of EMMPRIN, CD68, and NFκB p65, and Di-MeBBR also reduced expression of matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in aortic plaques. (biomedcentral.com)
  • Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). (cdc.gov)
  • Intercellular adhesion molecule-1 polymorphisms in patients with Behçet disease: a meta-analysis. (cdc.gov)
  • This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. (origene.com)
  • Neuronal excitation is also influenced by the amounts of neurotransmitter receptors and signaling molecules retained at particular synaptic sites. (frontiersin.org)
  • Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
  • These receptors are present on phagocytic cells, mast cells, and lung epithelial and smooth muscle cells. (medscape.com)
  • 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
  • The L1CAM gene (MIM No. 308840) encodes a neural cell adhesion molecule involved in cell adhesion dynamics and the generation of transmembrane signals at tyrosine kinase receptors. (biomedcentral.com)
  • Recent studies revealed a key role for PSD- 95, a scaffolding molecule enriched at glutamatergic synapses, in modulation of clustering of several neurotransmitter receptors, adhesion molecules, ion channels, cytoskeletal elements and signaling molecules at postsynaptic sites. (frontiersin.org)
  • The postsynaptic compartment of excitatory synapses is characterized by an electron-dense region, referred to as the postsynaptic density (PSD), attributable to the high density of neurotransmitter receptors and associated molecules at these sites. (frontiersin.org)
  • Hematopoietic cells contain more than a dozen different GPI-anchored proteins including adhesion molecules, enzymes, and receptors. (aacc.org)
  • L1 is a transmembrane adhesion molecule with extracellular immunoglobulin and fibronection III-like domains ( Schachner, 1991 ). (jneurosci.org)
  • L1 syndrome is caused by mutations in the L1CAM gene. (medlineplus.gov)
  • Clinical significance of L1CAM expression and its biological role in the progression of oral squamous cell carcinoma. (nih.gov)
  • DSCAM interacts with other cell adhesion molecules to prevent their running amok. (jax.org)
  • The researchers focused on DSCAM's self-avoidance function in the mouse retina, but DSCAM and members of the cadherin superfamily have also emerged as key contributors to a variety of neurodevelopmental disorders, including autism, schizophrenia, bipolar disease, Down syndrome and intellectual disability. (jax.org)
  • The team plans further investigation of the cell types in which DSCAM functions and the molecular mechanisms by which DSCAM masks adhesion, to advance understanding of normal development as well as the potential mechanisms underlying neurodevelopmental disorders. (jax.org)
  • Makoto Sato and colleagues from Kanazawa University now present results showing that, in the fly brain, neurons from one lineage project their axons to different columns, and that this mechanism is regulated by the gene Dscam (Down syndrome cell adhesion molecule). (technologynetworks.com)
  • One gene of interest is Down Syndrome Cell Adhesion Molecule ( Dscam ), which functions in neural development. (boisestate.edu)
  • Cell adhesion molecules (CAMs) make a kind of "cell" call, sending connecting signals between neurons. (jax.org)
  • where it attaches (binds) to proteins on neighboring neurons to help the cells stick to one another (cell-cell adhesion). (medlineplus.gov)
  • In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)
  • L1 has been localized to growth cones and processes of postmitotic developing neurons, where it mediates cell adhesion, neurite outgrowth, and axon bundling. (jneurosci.org)
  • Disruption in L1-mediated cell adhesion could lead to the loss of neurons (cell-death) or the abnormal wiring of neural connections, either of which could lead to cognitive deficits that may be lifelong. (nih.gov)
  • It is involved in cell-cell interactions in neurons and in other cell types. (antibodiesinc.com)
  • The brain's structure has columnar features, which are hypothesized to arise from nerve cells (neurons) stemming from the same parent cell, initially forming radial units. (technologynetworks.com)
  • it involves neuroblasts (neural stem-like cells) that produce radially oriented and clonally related groups of neurons. (technologynetworks.com)
  • aPL activate endothelial cells (ECs) by up-regulating adhesion molecules, IL-6 production and modulating prostaglandin metabolism. (europa.eu)
  • OVDs can create and preserve surgical space, pressurize the anterior chamber in the presence of an open wound, partition spaces, protect the corneal endothelial cells from fluid turbulence, and facilitate surgery. (lww.com)
  • Serum albumin is a specific inhibitor of apoptosis in human endothelial cells. (ijmedicine.com)
  • These mutations typically lead to severe cases of L1 syndrome, often HSAS. (medlineplus.gov)
  • These mutations typically lead to less severe cases of L1 syndrome, usually MASA syndrome or the other milder forms of this condition. (medlineplus.gov)
  • In humans, mutations in the L1 cell adhesion molecule are associated with a neurological syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation, adducted thumbs, spasticity, and hydrocephalus. (jneurosci.org)
  • Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). (origene.com)
  • Early in his career, when Dr. Charness was investigating the interaction between alcohol and the developing nervous system, he noted that the neuropathology observed in individuals with fetal alcohol spectrum disorder (FASD) strongly resembled that seen in individuals with various genetic syndromes attributable to mutations in the gene encoding the L1 neural cell adhesion molecule. (nih.gov)
  • In addition, the DNA in our own cells undergoes an estimated 30 new mutations during our lifetime, either through mistakes during DNA copying or cell division or, more often, because of damage from the environment. (dorak.info)
  • Mutations in this gene may be associated with autism and Asperger syndrome. (antibodiesinc.com)
  • Several mutations in the MPZ gene cause other forms of Charcot-Marie-Tooth disease known as type 2I, type 2J, and dominant intermediate D. These forms of Charcot-Marie-Tooth disease, which often do not become evident until adulthood, affect the specialized outgrowths from nerve cells (axons) that transmit impulses to muscles and other nerve cells. (medlineplus.gov)
  • Mutations can arise de novo or in the setting of acquired bone marrow (BM) failure syndromes. (aacc.org)
  • Consumption of polyphenol-rich grape may offer heart health benefits for men with metabolic syndrome, according to new research data. (nutraingredients.com)
  • The study - published in the Journal of Nutrition - evaluates the effects of grape polyphenols in people with metabolic syndrome (MetS) - revealing that consumption of a freeze dried whole-grape powder led to reductions in blood pressure, improved blood flow and reduced inflammation. (nutraingredients.com)
  • Metabolic syndrome refers to a cluster of conditions including high blood pressure, raised blood sugar level, excess body fat around the waist or low HDL (the good cholesterol) and increased blood triglycerides - all of which are known to significantly increase the risk for heart disease, stroke and diabetes. (nutraingredients.com)
  • This further supports the accumulating evidence that grapes can positively influence heart health, and extends it to men with metabolic syndrome. (nutraingredients.com)
  • The randomized, placebo-controlled, crossover study, recruited 24 men between the age of 30 and 70 years - all of whom had metabolic syndrome. (nutraingredients.com)
  • Early endothelial dysfunction is a common antecedent of the metabolic or insulin resistance syndrome and may thus play an etiologic role in the pathogenesis of type 2 diabetes mellitus and associated complications. (najms.com)
  • Elevated levels of soluble cellular adhesion molecules have been related to insulin resistance and other metabolic syndrome components. (najms.com)
  • Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). (cdc.gov)
  • The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
  • An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. (embl.de)
  • Leukocyte adhesion deficiency type I is caused by a mutation in the common chain of the β2 integrin family CD18. (lu.se)
  • The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. (embl.de)
  • We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. (embl.de)
  • Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
  • This occurs in insects thanks to Dscam1 (Down syndrome cell adhesion molecule 1). (jax.org)
  • Binding of Dscam1 with identical isoforms results in a repulsive signal, which is important for certain self-avoidance mechanisms within cells. (technologynetworks.com)
  • Dscam1 can develop nearly 20,000 variants, but when two identical Dscam1 molecules bind, they lead to a repulsive signal known to control self-avoidance in certain dendritic processes -- dendrites are branch-like extensions of nerve cells. (technologynetworks.com)
  • Among aPL, anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) have been shown to induce NF-kappaB nuclear translocation leading to a pro-inflammatory endothelial cell phenotype and thereby inducing acute phase proteins, such as serum amyloid A (SAA). (europa.eu)
  • A 2-year-old child with a history of infantile pre-B cell acute lymphoblastic leukemia (ALL) was admitted to hospital with nausea and vomiting after 3 weeks of upper respiratory tract symptoms. (cdc.gov)
  • Later, the International Committee on Taxonomy of Viruses (ICTV) officially named the virus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). (biomedcentral.com)
  • Most patients have a comparatively good prognosis, and a few quickly progress to acute respiratory distress syndrome (ARDS), sepsis shock, and multiple organ failure, which heralds a poor prognosis. (biomedcentral.com)
  • Coronary atherosclerotic disease involves the epicardial coronary arteries and may manifest as an acute or chronic coronary syndrome. (ijmedicine.com)
  • Acute coronary syndrome (ACS) arises from atherosclerotic plaque rupture leading to coronary thrombosis and/or spasm. (ijmedicine.com)
  • Giugliano RP, Cannon CP, Braunwald E. NonST-Segment elevation acute coronary syndrome (non-st-segment elevation myocardial infarction and unstable angina). (ijmedicine.com)
  • Libby P. Molecular bases of the acute coronary syndromes. (ijmedicine.com)
  • Low serum albumin levels and in-hospital adverse outcomes in acute coronary syndrome. (ijmedicine.com)
  • Prognostic significance of serum albumin in patients with acute coronary syndrome. (ijmedicine.com)
  • As a result, we identified a large number of genes encoding N. lugens pattern recognition proteins, modulation proteins in the prophenoloxidase (proPO) activating cascade, immune effectors, and the signal transduction molecules involved in the immune pathways, including the Toll, Immune deficiency (Imd) and Janus kinase signal transducers and activators of transcription (JAK-STAT) pathways. (biomedcentral.com)
  • The genome- and transcriptome-wide analysis of immune-related genes including pattern recognition and modulation molecules, immune effectors, and the signal transduction molecules involved in the immune pathways is an important step in determining the overall architecture and functional network of the immune components in N. lugens . (biomedcentral.com)
  • PCS (n = 17), PCS/CFS (n = 13), and healthy controls (HC, n = 14) were screened for serum anti-endothelial cell autoantibodies (AECAs) and dysregulated cytokines. (mdpi.com)
  • Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
  • This process is thought to be regulated by molecules that regulate synapse number, morphology and strength. (frontiersin.org)
  • In this review we will highlight mechanisms that control targeting of PSD-95 at the synapse, and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic structure and strength. (frontiersin.org)
  • With a donor of the endogenous acetyl radical (ACR575a), we showcased its capability in precise and continuous modulation of the cell redox homeostasis from signaling to stress, and induction of a local oxidative burst to promote differentiation of neural stem cells (NSCs). (bvsalud.org)
  • A new screening method that can test the effectiveness of therapeutic molecules designed to 'glue' proteins together in the body has been developed at the University of Birmingham and the University of Leicester. (birmingham.ac.uk)
  • In PNH patients these two complement regulatory proteins are absent or partially expressed on red blood cells. (aacc.org)
  • L1 is critical in neural development as this molecule guides newly developed nerve cells to their proper locations within the brain. (nih.gov)
  • Axons or nerve fibers are long protrusions of nerve cells, the function of which is to conduct electrical signals. (technologynetworks.com)
  • It plays a role in tightly packing the myelin around nerve cells (myelin compaction). (medlineplus.gov)
  • CD59 also called membrane inhibitor of reactive lysis (MIRL) forms defensive shield for red blood cells to inhibit the assembly of the membrane attack complex. (aacc.org)
  • [ 3 ] Thus, it enhances and prolongs antigen signaling on B cells. (medscape.com)
  • Behçet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity. (cdc.gov)
  • Family members with L1 syndrome caused by the same mutation may have different forms of the condition. (medlineplus.gov)
  • Paroxysmal nocturnal hemoglobinuria or PNH is a rare benign clonal acquired hematopoietic stem-cell (HSC) disorder that results from somatic mutation of the X- linked phosphatidylinositol glycan class A gene known as the PIGA gene. (aacc.org)
  • [ 8 ] Deficiency of CD18 on phagocytic cells causes LAD type 1 (see Table 2). (medscape.com)
  • displays a reduced size of the corticospinal tract and decreased axonal association with nonmyelinating Schwann cells. (jneurosci.org)
  • Disruption of these functions likely impedes the growth and development of the brain, leading to the signs and symptoms of L1 syndrome. (medlineplus.gov)
  • Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. (medlineplus.gov)
  • As a result, peripheral nerves cannot trigger muscle movement or relay information from sensory cells back to the brain, leading to the weakness and sensory problems characteristic of Charcot-Marie-Tooth disease. (medlineplus.gov)
  • One of nature's strategies is extreme molecular diversity, like giving each neuron a unique cell phone number or bar code. (jax.org)
  • We will use primary ECs and endothelial cell lines to determine the molecular events by which anti-beta2-GPI antibodies and SAA i n presence and absence of LXA4 affect the transcriptional regulation of target genes (such as IL-6, IL-8, tissue factor). (europa.eu)
  • An animal model would help illuminate the normal function of L1 and facilitate progress in defining the molecular basis of CRASH syndrome. (jneurosci.org)
  • These conditions vary in severity and include, from most severe to least, X-linked hydrocephalus with stenosis of the aqueduct of Sylvius (HSAS), MASA syndrome, spastic paraplegia type 1, and X-linked complicated corpus callosum agenesis. (medlineplus.gov)
  • Circulating levels of endothelial adhesion molecules appear to have clinically significant prognostic value beyond inflammatory marker-crp in predicting future risk of type 2 diabetes. (najms.com)
  • [ 6 ] HELLP syndrome is a severe form of preeclampsia and involves hemolytic anemia, elevated liver function tests (LFTs), and low platelet count. (medscape.com)
  • Phagocytosis is an ancient, highly conserved process in all multicellular organisms, through which the host can protect itself against invading microorganisms and environmental particles, as well as remove self-apoptotic cells/cell debris to maintain tissue homeostasis. (frontiersin.org)
  • More specifically, he found that alcohol inhibits L1-mediated cell adhesion by interacting with an alcohol binding pocket in the L1 extracellular domain. (nih.gov)
  • Most single gene disorders can be investigated by prenatal diagnosis using DNA extracted from cells obtained from amniocentesis at 16-18 weeks' gestation or chorionic villus sampling (CVS) at about 10-12 weeks' gestation. (dorak.info)
  • Small peptides containing the RGD sequence can modulate a variety of cell adhesion invents associated with thrombosis, inflammation, and tumor metastasis. (embl.de)
  • Antiphospholipid syndrome (APS) is an autoimmune disease, characterized by recurrent thrombosis in presence of circulating antiphospholipid antibodies (aPL). (europa.eu)
  • The cer is about 2%-5% and as high as 26% in most common complications include renal small-cell lung carcinoma [ 5 ]. (who.int)
  • The conditions that make up L1 syndrome were once thought to be distinct disorders, but since they were found to share a genetic cause, they are now considered to be part of the same syndrome. (medlineplus.gov)
  • In Cri-Du-Chat syndrome (5p deletion), the genetic basis of the phenotype is haploinsufficiency for the telomerase reverse transcriptase gene ( TERT ), which is included in the deleted part of chromosome 5. (dorak.info)
  • The hypothesis asserts that in the early stages of development, the cerebral cortex forms as an assembly of interacting 'columns', or 'radial units', with each unit originating from a stem cell layer containing neural stem cells. (technologynetworks.com)
  • MASA syndrome is also named for the characteristic features of the condition, which are intellectual disability (mental retardation) that can range from mild to moderate, delayed speech (aphasia), spasticity, and adducted thumbs. (medlineplus.gov)
  • C3b and C4b bind to CR1, which is present on various phagocytes and also on erythrocytes and B cells. (medscape.com)
  • Neutrophils are unable to aggregate and do not bind to intercellular adhesion molecules on endhothelial cells. (lu.se)
  • A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS) including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic Fatigue Syndrome (PCS/CFS). (mdpi.com)
  • The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. (degruyter.com)
  • Pulmonary function tests should be obtained in patients with hypocomplementemic urticarial vasculitis syndrome (HUVS) to assess for chronic obstructive pulmonary disease. (medscape.com)
  • As a result, PNH is characterized by continuous destruction of PNH red blood cells due to vulnerability to complement mediated lysis. (aacc.org)
  • Normal red blood cells can resist the effect of complement activation by the expression of CD59. (aacc.org)
  • As we mentioned, hemolysis is due to complement activation of vulnerable red blood cells. (aacc.org)
  • Otherwise, the POI was not significantly correlated with the peripheral blood white blood cell (WBC) count, monocyte percentage (M%) or haemoglobin (HGB) content. (biomedcentral.com)
  • CR2 binds C3dg, and C3d is present on B cells and dendritic cells (see the Table 1). (medscape.com)
  • 00:02:50;15 I mean, just look at this really spectacular dendritic arbor of a Purkinje cell. (ibiology.org)
  • Therefore, we investigated the effects of patients' sera on endothelia cells (ECs) in vitro. (mdpi.com)
  • Patients with hypocomplementemic urticarial vasculitis syndrome, and less commonly in those with systemic lupus erythematosus, often have circulating anti-C1q antibodies with concomitant low levels of C1q. (medscape.com)
  • The patients were studied genetically for Fragile X syndrome, followed by whole exome sequencing and analysis of intellectual disability-related genes variants. (biomedcentral.com)
  • Objectif principal : étude rétrospective monocentrique de la perméabilité primaire d'une FAV proximale mise en place en première intention chez des patients insuffisants rénaux chroniques âgés de 75 ans ou plus. (nephrologuemarseille.fr)
  • Multiple myeloma (MM) is a cancer of the The largest series, 23 patients with lepto- plasma cells. (who.int)
  • This deficiency is seen in white blood cells and red blood cells. (aacc.org)
  • Genes to Cells. (elsevierpure.com)
  • We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. (stowers.org)
  • We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. (stowers.org)
  • Expression of each cluster's gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq. (stowers.org)
  • Cell surface EMMPRIN expression was measured by flow cytometry and Western blotting, and phospho-(p)-p38, p-JNK, nuclear NFκB p65, and phospho-p65 were measured by Western blotting. (biomedcentral.com)
  • Macrophages and foam cells secret a variety of inflammatory factors, which attract more monocytes to infiltrate into the subendothelial space, propagate inflammatory response and subsequently advance atherosclerotic plaques [ 4 ]. (biomedcentral.com)
  • Subsequent literature regarding this newly recognized (but of course not truly new) "mast cell activation syndrome" (MCAS) included case reports as well as formal studies (mostly relatively small scale), reviews, and various proposals for formal diagnostic criteria. (degruyter.com)