AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowTransplantation, HomologousBone Marrow CellsLiver TransplantationGraft vs Host DiseaseTransplantation, AutologousHematopoietic Stem Cell TransplantationKidney TransplantationWhole-Body IrradiationBone and BonesAnemia, AplasticTransplantation ConditioningLiving DonorsLeukemiaTissue and Organ ProcurementTransplantation ChimeraTreatment OutcomeRetrospective StudiesTissue DonorsGraft SurvivalBusulfanBone Marrow PurgingHistocompatibility TestingHematopoietic Stem CellsHistocompatibilityCyclophosphamideTransplantation, IsogeneicBone Marrow DiseasesHematopoiesisRecurrenceSyndromeCombined Modality TherapyMice, Inbred C57BLRadiation ChimeraLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBone Marrow ExaminationLeukemia, Myeloid, AcuteImmunosuppressive AgentsRemission InductionTime FactorsHematologic NeoplasmsGraft RejectionPrecursor Cell Lymphoblastic Leukemia-LymphomaHepatic Veno-Occlusive DiseaseBone RemodelingBone Marrow NeoplasmsTransplantation ImmunologyLeukemia, MyeloidGraft vs Host ReactionImmunosuppressionLymphocyte DepletionStem Cell TransplantationAcute DiseaseLymphoma, Non-HodgkinLeukocyte TransfusionMyelodysplastic SyndromesHeart TransplantationSevere Combined ImmunodeficiencyT-LymphocytesChimeraSurvival AnalysisColony-Forming Units AssayHLA AntigensLung TransplantationCyclosporineHematologic DiseasesActuarial AnalysisBone DensityLymphocyte TransfusionNuclear FamilyAntineoplastic Combined Chemotherapy ProtocolsFollow-Up StudiesCarmustineOrgan TransplantationPancytopeniaCell DifferentiationGraft vs Tumor EffectSurvival RateLeukocyte CountGraft vs Leukemia EffectCytarabineCytomegalovirus InfectionsSpleenBone ResorptionGranulocyte Colony-Stimulating FactorMelphalanMice, Inbred BALB CDisease-Free SurvivalEtoposideFlow CytometryLymphomaMultiple MyelomaFatal OutcomeCells, CulturedPrognosisMice, KnockoutHodgkin DiseaseAntigens, CD34Infection
LymphomaTransplantLeukemiaHematologyMultiple MyelomaBiopsyAutologousPeripheral blood stemHematopoietic cellDisordersOncologyDiseasesAplastic anaemiaHematologic malignanciesDisease Control and PreventionCord Blood TransplantationPediatricHypocellular boneChemotherapyCurativeCancersBloodPathophysiologyComplicationsUndergoneCancer syndromesCytokine releasePulmonaryFellowshipHospitalOncologistResearch CentreFailureExpertiseSymptomsClinicalRemissionDonorLungSurvival
Lymphoma6
Transplant9
  • Patients between 16-40 years of age were enrolled between October 2012 and June 2015 at 8 participating transplant centers. (ashpublications.org)
  • Departmental bone marrow transplant services offer essential medical expertise and complementary services to patients with complex health conditions. (tasmc.org.il)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • The Koru Hospital Bone Marrow Transplant Center is a state-of-the-art medical facility that offers advanced stem cell therapy for a range of hematological disorders. (koruhastanesi.com)
  • At the Koru Hospital Bone Marrow Transplant Center, we provide comprehensive care to our patients, from pre-transplant evaluation to post-transplant follow-up care. (koruhastanesi.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
  • Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. (mcw.edu)
  • Currently the only curative treatment remains bone marrow transplant. (crct-inserm.fr)
Leukemia9
Hematology4
  • Dr. Seth Maliske specializes in hematology, oncology and blood and bone marrow transplants. (sanfordhealth.org)
  • She specializes in pediatric hematology and has particular expertise in the care of children undergoing stem cell transplantation for noncancerous disorders, such as sickle cell anemia, aplastic anemia and thalassemia. (choa.org)
  • Dr. Mapara graduated from the University of Heidelberg Medical School/Germany, and received his post-graduate training in Internal Medicine and Hematology/Oncology at the Universities of Heidelberg and the University Medical Center Charite of the Humboldt University of Berlin in Germany. (columbia.edu)
  • Unlike allogenic bone marrow transplantation, where you use cells from the immune system of another person to fight the cancer and run the risk of the donor immune system attacking patient's organs, CAR-T therapy uses the patient's own cells," said Dr. Gerhard Hildebrandt , division chief of Hematology and Blood and Marrow Transplantation at UK. (uky.edu)
Multiple Myeloma2
  • BMT is used in combination with chemotherapy as a treatment for multiple myeloma, a cancer that affects the plasma cells in bone marrow. (koruhastanesi.com)
  • Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial Lancet Oncology 21 (10): 1317-1330,2020. (pennmedicine.org)
Biopsy4
Autologous4
  • After lethal irradiation, the five animals were given 15-27 X 10(6) autologous marrow cells (3.2-4.4 X 10(6) cells/kg) containing 65-91% CD34+ cells. (nih.gov)
  • The Pediatric Hemato-oncology Department performs a full array of bone marrow transplants (BMT) for children, sourced by self-donated (autologous) marrow, peripheral blood donations and donations from related or unrelated donors (allogeneic). (tasmc.org.il)
  • He was treated with chemotherapy (8 R-CHOP protocols) with partial response, followed by high-dose chemotherapy and autologous hematopoietic stem cell transplantation, with a complete response, and was stable for the previous 4 years. (spandidos-publications.com)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
Peripheral blood stem2
Hematopoietic cell3
  • Hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) is potentially curative, yet applied sparingly in adults due in part to limited donor availability and to concerns about safety. (ashpublications.org)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)
Disorders11
  • The Dana-Dwek Children's Hospital Pediatric Hemato-oncology and Bone Marrow Transplantation Department treats infants, children, and adolescents suffering from acute and chronic blood diseases and from malignant hematological and non-hematological disorders. (tasmc.org.il)
  • There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
  • Allogeneic BMT is used as a curative therapy for MDS, a group of disorders that affect the production of blood cells in bone marrow. (koruhastanesi.com)
  • Cord blood transplantation is used to treat certain genetic disorders that affect the production of blood cells, such as sickle cell anemia and thalassemia. (koruhastanesi.com)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • Dr. Arnold is a Pediatric Hematologist/Oncologist at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Associate Professor of Pediatrics at Emory University School of Medicine. (choa.org)
  • Bone Marrow Failure Syndromes are a group of blood disorders. (petermac.org)
  • The 'Inherited Bone Marrow Disorders' panel test comes into play here. (petermac.org)
  • Platelet disorders - immune thrombocytopenic purpura (ITP), Glanzmann's thrombasthenia, Bernard Soulier syndrome. (apollohospitals.com)
  • Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)
Oncology2
  • Neupogen therapy should only be given in collaboration with an oncology centre which has experience in G-CSF treatment and haematology and has the necessary diagnostic facilities. (medicines.org.uk)
  • The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
Diseases7
  • A hyperinflammatory 'cytokine storm' state termed macrophage activation syndrome (MAS), culminating from a complex interplay of genetics, immunodeficiency, infectious triggers and dominant innate immune effector responses, can develop across disparate entities including systemic juvenile idiopathic arthritis (sJIA) and its counterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers and cancer immunotherapy. (nature.com)
  • Primary immunological deficiencies, such as severe combined immune deficiency syndromes, antibody deficits, complement deficiency, phagocytic cell abnormalities, or other impairments in innate immunity, as well as acquired immune deficiency, are diseases that primarily affect the immune system. (bayshorehealthcentre.com)
  • Auto-inflammatory syndromes, for example, are diseases associated with autoimmune responses to self-antigens. (bayshorehealthcentre.com)
  • In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
  • National Center for Infectious Diseases. (cdc.gov)
  • These diseases can often cause bone marrow failure and lung disease. (childrenshospital.org)
  • The condition often shares the features of a variety of autoimmune diseases, such as lichen planus, Sjögren's syndrome, systemic lupus erythematosus or primary biliary cirrhosis [12, 13]. (bvsalud.org)
Aplastic anaemia2
Hematologic malignancies2
Disease Control and Prevention4
  • A portion of the specimen was centrifuged at 2,000 rpm for 10 min, *Centers for Disease Control and Prevention, Atlanta, Georgia, and the pellet was processed for standard EM. (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Cord Blood Transplantation2
Pediatric4
  • Hematological investigations and diagnostics including bone marrow testing and spinal taps: These tests are performed pain-free with the help of the Tel Aviv Sourasky Medical Center's Dream Service (pediatric service that helps children undergo treatment and testing under sedation). (tasmc.org.il)
  • Improving survival rates after pediatric bone marrow transplantation will likely result in greater numbers of early and late renal complications. (ectrx.org)
  • We designed a retrospective study to evaluate the incidence of renal involvement on 120 bone marrow recipients referred to the pediatric nephrology outpatient clinic between 2003 and 2005. (ectrx.org)
  • GATA2 syndrome is characterized by progression to MDS and AML in pediatric and young adulthood (80% by 40 years of age) after the acquisition of secondary mutations. (crct-inserm.fr)
Hypocellular bone2
Chemotherapy2
Curative1
Cancers9
  • The most common types of bone cancers are osteosarcoma, Ewing sarcoma, chondrosarcoma and chordoma. (cuanschutz.edu)
  • Some types of blood cancers start in the blood-forming cells of the bone marrow but not the bone itself. (cuanschutz.edu)
  • Those cancers are not discussed on this page and do not classify as bone cancer. (cuanschutz.edu)
  • Many other cancers can spread ( metastasize ) to the bone, when that occurs, they are not classified as bone cancer but are named for where they began, such as lung cancer that has metastasized to the bone. (cuanschutz.edu)
  • Bone cancers account for less than 0.2% of all cancers in the United States. (cuanschutz.edu)
  • Our clinical partnership with UCHealth has produced survival rates higher than the state average for all stages of bone and joint cancers . (cuanschutz.edu)
  • Bone cancers in children and teenagers include osteosarcoma and Ewing sarcoma. (cuanschutz.edu)
  • Myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML) are cancers caused by dysfunction of the bone marrow characterized by multiplication of a category of immature white blood cells, called "blasts", by a multi-stage process. (crct-inserm.fr)
  • Several other immunotherapies targeted at various blood cancers are in the pipeline for the cancer center. (uky.edu)
Blood14
Pathophysiology2
Complications2
  • High early mortality rates and a high rate of complications in Wiskott-Aldrich syndrome suggest frequent monitoring by a clinical immunologist is essential. (medscape.com)
  • These complications were found in 4 cases (3 female and 1 male) including membranous nephropathy (n=2), hemolytic uremic syndrome (n=1) and cyclosporine nephrotoxicity (n=1). (ectrx.org)
Undergone2
Cancer syndromes2
  • Mutations in DNA repair genes disrupt the maintenance of DNA integrity and predispose to hereditary cancer syndromes. (bmj.com)
  • Like BRCA1 and BRCA2, there are other genes that have been linked to cancer syndromes. (livemint.com)
Cytokine release3
  • Many scenarios, including infection, aberrant immunity, cancer and cancer immunotherapy, are associated with cytokine storm, also known as cytokine release syndrome (CRS) or hypercytokinaemia. (nature.com)
  • Participants were divided into the cytokine release syndrome (CRS) group (n = 60) and the non-CRS group (n = 11) to further analyze the relationship between hypoalbuminemia and CRS. (bvsalud.org)
  • The most significant side effect is cytokine release syndrome, a general inflammatory response in the body and toxicity to the brain. (uky.edu)
Pulmonary4
  • Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
  • Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)
  • In general, admit a patient with Wiskott-Aldrich syndrome (WAS) with bleeding or pulmonary infection because the extent of bleeding may be difficult to ascertain or bleeding may be difficult to control. (medscape.com)
  • These findings may have important implications for the diagnosis and treatment of pulmonary alveolar proteinosis syndromes in humans. (nih.gov)
Fellowship1
  • In addition, he completed a research fellowship at the Transplantation Biology Research Center of the Massachusetts General Hospital at the Harvard Medical School in Boston. (columbia.edu)
Hospital5
  • pinyin: Táiběi Róngmín Zǒngyī Yuàn) is a national first-class medical center and a teaching hospital that provides tertiary patient care, undergraduate medical education programs and residency programs in Taiwan. (wikipedia.org)
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine has been named No. 10 among cancer centers nationally by U.S. News & World Report. (wustl.edu)
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is expanding proton therapy for patients by adding the latest, most innovative technology to its S. Lee Kling Proton Therapy Center with the addition of. (wustl.edu)
  • METHODS: This study was conducted from May 2021 to December 2021 among patients undergoing CAR-T cell therapy at the Bone Marrow Transplantation Center in The First Affiliated Hospital of Zhejiang University School of Medicine. (bvsalud.org)
  • Vijay Haribhakti , consultant surgical oncologist, Jaslok Hospital and Research Centre, Mumbai, worries about Jolie's decision and the impact it can have. (livemint.com)
Oncologist1
  • Your oncologist will be able to identify potential trials for which bone cancer is eligible. (cuanschutz.edu)
Research Centre1
  • Research Centre, Riyadh, Saudi Arabia. (who.int)
Failure7
Expertise1
  • p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
Symptoms3
  • The symptoms are so severe that most people with Chediak-Higashi syndrome die at an early age (before 7 years). (lu.se)
  • The team next sequenced CECR1 from 4 patients from other centers who had symptoms of the syndrome. (nih.gov)
  • The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
Clinical8
  • Urinary excretion of HS, DS, and/or CS occurs, and the quantity may vary based on the diagnostic spectrum of clinical severity of Sly syndrome. (medscape.com)
  • Building a Texas-based center for neuroblastoma clinical research. (alexslemonade.org)
  • Candotti F. Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome. (medscape.com)
  • A 3-year-old girl came to NIH's Clinical Center about a decade ago with fevers, skin rash, and strokes that left her severely disabled. (nih.gov)
  • There are numerous clinical trials being conducted by CU Cancer Center members at any time, including trials that enroll bone sarcomas. (cuanschutz.edu)
  • The clinical and functional effects of TERT variants in myelodysplastic syndrome. (harvard.edu)
  • 8 - 10 While most studies have been performed with hATG, more recently, rabbit-derived ATG (rATG) has been introduced into clinical practice, particularly in organ transplantation. (haematologica.org)
  • Based on our clinical observations and the data from this project, we will be able to individualize the monitoring of patients according to the type of GATA2 mutation by offering appropriate clinical monitoring, a better definition of the time of allogeneic transplantation as well as appropriate genetic counseling to children and families. (crct-inserm.fr)
Remission1
Donor3
Lung1
Survival1
  • The five-year survival rate for bone cancer - the percentage of people who live at least five years after the disease is found -varies by the specific type of cancer. (cuanschutz.edu)