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  • inhibition
  • Our data suggest that strategies aimed at the inhibition of syndecan-4 will be of great value for the treatment of cartilage damage in osteoarthritis. (nih.gov)
  • Here, the authors used the human tumour necrosis factor α (TNFα) transgenic (hTNFtg) mouse, to analyse the expression and function of syndecan-4 in chronic-destructive-arthritis and answer the question whether inhibition of syndecan-4 by specific antibodies may prevent cartilage-estruction and/or improve the phenotype after onset of the disease in this animal model of human rheumatoid arthritis. (bmj.com)
  • More importantly, My data suggest that inhibition of syndecan-4 can not only prevent cartilage damage, but also reduces the severity after onset of the disease. (bmj.com)
  • angiogenesis
  • Here, we show that the secreted metalloprotease ADAMTS1, involved in angiogenesis and inflammatory processes, cleaves the ectodomain of syndecan-4. (nih.gov)
  • Among many interesting phenotypes in syndecan-4 null is mice is arterial hypertension (lack of Akt activation leads to suppressed NO production) and defective tumor but not ischemic angiogenesis. (yale.edu)
  • Immunohistochemistry
  • Methods Expression of syndecan-4 was investigated by immunohistochemistry in the hind-paws of 8-/12-week-old hTNFtg mice and wild type controls. (bmj.com)
  • Results As seen in immunohistochemistry, there was a strong expression of syndecan-4 in the synovial membranes of hTNFtg mice, whereas only negligible staining for syndecan-4 was found in synovial tissues of wild type animals. (bmj.com)
  • interaction
  • Furthermore, syndecan-4 and calcineurin colocalized (proximity ligation assay) suggesting a possible interaction. (ahajournals.org)
  • Syndecan-4 controls the activation of ADAMTS-5 through direct interaction with the protease and through regulating mitogen-activated protein kinase (MAPK)-dependent synthesis of matrix metalloproteinase-3 (MMP-3). (nih.gov)
  • focal
  • This is consistent with the codistribution of syndecan-4 with the alpha isoform of protein kinase C in focal adhesions. (nih.gov)
  • osteoarthritis
  • The mechanisms of ADAMTS-5 activation and their links to the pathogenesis of osteoarthritis remain poorly understood, but syndecans have been shown to be involved in the activation of ADAMTS-4 (ref. 3). (nih.gov)
  • Here we show that syndecan-4 is specifically induced in type X collagen-producing chondrocytes both in human osteoarthritis and in murine models of the disease. (nih.gov)
  • regulate
  • Syndecan-4 is known to regulate thrombin activity ( 18 , 19 ), and OPN function is regulated by thrombin cleavage ( 12 , 14 , 17 , 20 ). (rupress.org)
  • regulator
  • Thus, syndecan-4 is a critical intrinsic regulator of inflammatory reactions via its effects on OPN function and is a potential novel therapeutic tool for treating inflammatory diseases. (rupress.org)
  • Thus, we show that syndecan-4 is a critical intrinsic regulator of inflammatory reactions through the regulation of OPN functions. (rupress.org)
  • Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. (bioaimscientific.com)
  • expression
  • However, treatments that targeted the cytoplasmic region of syndecan-4, including ectopic expression of its mutant truncated with the cytoplasmic domains and treatment with protein kinase Calpha inhibitor Gö6976, did not influence the TNIIIA2 activity. (sigmaaldrich.com)
  • In addition, synovial fibroblasts were isolated and analysed for syndecan-4-expression by reverse transcriptase PCR. (bmj.com)
  • These responses required both syndecan-4 binding and signaling, as evidenced by silencing syndecan-4 expression and by overexpressing a syndecan-4 mutant lacking the intracellular domain, respectively. (biologists.org)
  • The aim of this study was to investigate the gene expression and location of decorin, syndecan-1 and syndecan-4 in the healthy breast during the menstrual cycle. (biomedcentral.com)
  • pathway
  • Recently we discovered that in addition to its role in FGF signaling syndecan-4 controls formation of mTOR complex 2 and activation of the Akt pathway (Partovian et a l Mol Cell '08). (yale.edu)
  • regulation
  • Regulation of inositol phospholipid binding and signaling through syndecan-4. (nih.gov)
  • In turn, lipid binding stabilizes the syndecan in oligomeric form, with subsequent binding and activation of protein kinase C. The specificity of phospholipid binding and its potential regulation are investigated here. (nih.gov)
  • Over the years my lab has demonstrated that syndecan-4 plays a critical role in regulation of FGF signaling (Horowitz, JCB '02 and many others) and that this involves regulation of its trafficking to the plasma membrane rafts and endocytosis among other events (Tkachenko JBC '02, JCS '04, Circ Res '06). (yale.edu)