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  • Gene
  • The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. (nih.gov)
  • Deleting the gene for synaptotagmin (syt(null)) strongly suppresses synaptic transmission in every species examined, showing that synaptotagmin is central in the synaptic vesicle cycle. (nih.gov)
  • All but one known subtype are recessive disorders, which means that a child will have to have two copies of the abnormal gene (one from each parent) in order to develop the disease. (malacards.org)
  • We conducted transcriptomic profiling of two Leishmania species and the human macrophage over the course of intracellular infection by using high-throughput RNA sequencing to characterize the global gene expression changes and reprogramming events that underlie the interactions between the pathogen and its host. (asm.org)
  • BoNT
  • This results were also confirmed that BoNT/B bound specifically to recombinant rat synaptotagmins I and II.Scatchard plot analysis showed a single class of binding site with dissociation constants of 0.23 and 2.3 nM for synaptotagmin II and synaptotagmin I,respectively. (nii.ac.jp)
  • The high-affinity binding of BoNT/B was specifically inhibited by a monoclonal antibody recognizing with the amino-terminal region of synaptotagmin II.Although the precise structure of the complex of synaptotagmin and gangliosides remains to be established, these findings indicate that synaptotagmin is a potential candidate acting as BoNT/B protein receptor. (nii.ac.jp)
  • Although botulinum neurotoxin serotype A (BoNT/A) products are common treatments for various disorders, there is only one commercial BoNT/B product, whose low potency, likely stemming from low affinity toward its human receptor synaptotagmin 2 (hSyt2), has limited its therapeutic usefulness. (sciencemag.org)
  • mutations
  • Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. (antikoerper-online.de)
  • Analysis of point mutations in the complexin-1 C terminus identified two single amino-acid substitutions that impaired clamping without altering the activation function of complexin-1. (jneurosci.org)
  • secretory
  • After IgE-dependent stimulation, they secrete a variety of pharmacologically active products that are stored in secretory granules ( 2 ). (jimmunol.org)
  • interaction
  • In vitro work has implicated a conserved basic residue at the tip of loop 3 of the Ca 2+ -binding pocket in both C 2 domains in coordinating this electrostatic interaction with anionic membranes. (jneurosci.org)
  • protein kinase
  • These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl-heidelberg.de)
  • vivo
  • But there has been no direct evidence that any of the Ca(2+)-binding sites within synaptotagmin are required in vivo. (nih.gov)
  • respectively
  • αON-S and αOFF-S RGCs establish preferential connectivity with type-6 and type-2 bipolars in control conditions, respectively. (arvojournals.org)
  • sensitivity
  • We have extensively characterized the two strains and found divergent behavioral profiles for cocaine-related behaviors including initial locomotor sensitivity to cocaine. (easychair.org)