• Recently, insulinoma-associated protein 1 (INSM1) has been identified as a novel neuroendocrine marker that is more sensitive than chromogranin, synaptophysin, and CD56 in pulmonary neuroendocrine tumors. (gastrores.org)
  • We studied this marker in conjunction with chromogranin, synaptophysin, and CD56 in 36 appendiceal AdexGCCs (21 primaries, 15 metastatic). (gastrores.org)
  • Primary and metastatic AdexGCCs showed no difference in INSM1, chromogranin, synaptophysin, or CD56 staining. (gastrores.org)
  • Immunohistochemically, the tumor was positive for chromogranin A, CD56, and synaptophysin, and a diagnosis of paraganglioma of the urinary bladder was confirmed. (biomedcentral.com)
  • In this study, we assessed the sensitivity and specificity of CD56 in the diagnosis of SCC of the uterine cervix compared with those of chromogranin and synaptophysin. (elsevierpure.com)
  • Twenty-two (88%) of 25 SCCs of the uterine cervix labeled with CD56 in a predominantly membranous and diffuse pattern, whereas 16 of 25 (64%) stained with synaptophysin in a predominantly diffuse pattern and 8 of 25 (32%) showed predominantly focal immunoreactivity for chromogranin. (elsevierpure.com)
  • Furthermore the cells were negative for CD56, chromogranin and synaptophysin. (biomedcentral.com)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
  • Conventional neuroendocrine markers, such as chromogranin and synaptophysin, however, are often negative or focally positive in these tumors [ 2 , 3 ]. (gastrores.org)
  • Tumor cells are immunoreactive for chromogranin, synaptophysin, neuron-specific enolase or other neuroendocrine markers. (pathologyoutlines.com)
  • MCC express both neuroendocrine (neuron-specific enolase, synaptophysin, chromogranin) and cytokeratin markers (cytokeratin 20, as a paranuclear dot, CAM 5.2) and is negative for S100 and the common leukocyte antigen ( 2 ). (ispub.com)
  • Clinico-pathologic data including overall survival, proliferation rate and diagnostic markers (synaptophysin, chromogranin A, Mib-1, TTF-1) were recorded. (biomedcentral.com)
  • In LNCaP cells and xenografted tumors, overexpression of miR-652 increased markers of NED, including chromogranin A, neuron specific enolase, and synaptophysin. (oncotarget.com)
  • Available sections were immunostained for keratin (OSCAR and AE1/AE3 antibodies), desmin, neurofilament protein, glial fibrillary acidic protein, synaptophysin, and chromogranin A. Not all cases could be tested for all markers. (elsevierpure.com)
  • INSM1 exhibits low expression in AdexGCCs and is expressed by a lower proportion of tumor cells compared to chromogranin and synaptophysin. (gastrores.org)
  • We have seen in consultation a number of malignant melanomas with anomalous expression of keratin, other intermediate filaments, or synaptophysin, and therefore studied a large group of primary and metastatic melanomas to determine the frequency of these events. (elsevierpure.com)
  • Stains for keratin, synaptophysin, and chromogranin were negative. (elsevierpure.com)
  • The Ki‑67 positivity index was 75%, and the thyroid transcription factor‑1, NapsinA, p40, nuclear protein in testis, CD34, Sal‑like protein 4, SRY‑box transcription factor 2 and synaptophysin were negative. (spandidos-publications.com)
  • The tumors were screened for neural differentiation with an antibody panel consisting of neuron-specific enolase, S100 protein, Leu-7, chromogranin, synaptophysin, and neurofilament. (nih.gov)
  • In contrast, conventional carcinoids are often diffusely positive for chromogranin and synaptophysin, with abundant electron-dense granules on electron microscopy [ 4 ]. (gastrores.org)
  • The histological examination from the FNA sample revealed a scarce specimen for evaluation, with columnar epithelial cells with mild atypia, positive for CK7 and 19, negative for p53, chromogranin A and synaptophysin. (spg.pt)
  • Carcinoids were smaller in size and had higher synaptophysin and chromogranin A, but lower TTF-1 expressions. (biomedcentral.com)
  • Results The En bloc and R0 resection rates were 100 % (14/14) and 92.9 % (13/14), respectively. (thieme-connect.com)
  • 18. Synaptophysin and chromogranin A expression analysis in human tumors. (nih.gov)
  • These tumors are comprised of cells that express neuroendocrine proteins such as synaptophysin and chromogranin. (itmig.org)
  • Glomus tumors are positive for smooth muscle actin and negative for pan-cytokeratin, CAM5.2, synaptophysin and chromogranin. (pulmonarypath.org)
  • Are positive for neuroendocrine immunohistochemical markers like INSM1, synaptophysin and chromogranin and can be positive for PAX8 (polyclonal). (papsociety.com)