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  • vesicle
  • Key events during the synaptic vesicle cycle-such as exocytosis and endocytosis-require formation and disassembly of protein complexes. (aspetjournals.org)
  • Therefore, it is not surprising that subtle alterations in synaptic vesicle cycle-associated proteins directly or indirectly contribute to pathophysiology seen in several neurologic and psychiatric diseases. (aspetjournals.org)
  • In contrast to the increasing number of examples in which presynaptic dysfunction causes neurologic symptoms or cognitive deficits associated with multiple brain disorders, synaptic vesicle-recycling machinery remains an underexplored drug target. (aspetjournals.org)
  • At least two pathways are involved, one that relies on the recycling of synaptic vesicle 2 (SV2) system and one that does not. (wikipedia.org)
  • They are thought to fine-tune the synaptic vesicle cycle. (wikipedia.org)
  • Hair cells is capable of one action potential propagation for one vesicle release. (wikipedia.org)
  • One vesicle release from the presynaptic hair cell onto the postsynaptic bouton is enough to create an action potential in the auditory afferent cells. (wikipedia.org)
  • neural
  • We explain why the membrane potential near threshold is sensitive to properties of the afferent noise and show how this shapes the neural response. (frontiersin.org)
  • Often the impact of the signal on the neural dynamics can be assumed to be small compared to the entire synaptic barrage so that a linear approximation of the response is justified. (frontiersin.org)
  • transient
  • Hyperforin and adhyperforin are wide-spectrum inhibitors of the reuptake of serotonin, norepinephrine, dopamine, glutamate, GABA, glycine, and choline, and they exert these effects by binding to and activating the transient receptor potential cation channel TRPC6. (wikipedia.org)
  • frequency
  • SGTX blocks orthodromic transmission, as evidenced by the fact that the synaptic potential is strongly depressed with application of the toxin and the block intensifies as stimulus frequency increases. (wikipedia.org)
  • spikes
  • We find that temporal discretization of spikes times amplifies the effects of finite synaptic weights. (beds.ac.uk)
  • According to the conventional view of signal processing, graded changes of membrane potential at the dendrite are converted into a sequence of spikes. (wiley.com)
  • Although a tight temporal coupling between pre- and postsynaptic spikes exists, the timing between these spikes is also affected by graded potential changes. (wiley.com)