Dentate gyrus (DG) granule cells carrying homozygous mutation of L100P exhibit decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic plasticity. (biomedcentral.com)
TSP binds to α2δ‐1 to drive the formation of excitatory synapses during development, suggesting that overactivation of this pathway may lead to exuberant excitatory synaptogenesis and network hyperexcitability seen in DCMs. (eneuro.org)
We find that LTP of monosynaptic responses evoked by selective stimulation of excitatory associational fibers is substantially reduced in slices of anterior piriform cortex (APC) from Fmr1 KO mice, compared with wild-type (WT) controls. (jneurosci.org)
Electrophysiological characterization of synaptic transmission in slices from the mPFC indicated an age-related decrease in glutamatergic transmission. (jneurosci.org)
Hippocampal3
These results indicated that Cdk5/p35 in excitatory neurons is important for the hippocampal synaptic plasticity and associative memory retention. (biomedcentral.com)
In the present study, we created mice in which the p35 gene was deleted in hippocampal excitatory neurons (CaMKII-Cre p35cKO) or GABAergic inhibitory neurons (Dlx-Cre p35cKO). (biomedcentral.com)
Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. (biomedcentral.com)
Hippocampus7
CreER-p35cKO mice show reduced dendritic spine density in CA1 pyramidal neurons and impaired LTD induction in the hippocampus with impairment in spatial learning and memory and reduced anxiety-like behavior [ 11 ]. (biomedcentral.com)
Our results indicated that the activation of cyclinD1-CDK4 is required for short-term synaptic plasticity and mGluR-dependent LTD, and suggested that this cyclin-dependent kinase may have different roles during the postnatal development in mice hippocampus area CA1. (biomedcentral.com)
All of them are present in the hippocampus, where they participate in the regulation of synaptic functionality and gene transcription [ 12 - 14 ]. (biomedcentral.com)
In this study, we initiated to investigate the potential functions of cyclinD1-CDK4 in neuronal plasticity during the postnatal development in mice hippocampus area CA1. (biomedcentral.com)
Input-output curves and paired-pulse plasticity were not significantly altered in KO compared with WT mice in either the olfactory cortex or hippocampus. (jneurosci.org)
This impairment of LTP in the piriform cortex is age dependent, appearing only in mice at least 6 months of age, and selective, because it is not observed in the CA1 field of hippocampus. (jneurosci.org)
Together with previous work indicating that redox state mediates senescent physiology in the hippocampus, the results indicate that redox changes contribute to senescent synaptic function in vulnerable brain regions involved in age-related cognitive decline. (jneurosci.org)
Neurons4
Since these mice had p35 deletion in all cells, it was impossible to separate and analyze its functions in excitatory and inhibitory neurons. (biomedcentral.com)
Using behavioral and electrophysiological analyses, we investigate whether the p35/Cdk5 activity is involved in associative memorylearning in excitatory or inhibitory neurons. (biomedcentral.com)
The expression and translocation of cyclinD1-CDK4 in post-mitotic neurons indicate that they may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity. (biomedcentral.com)
The present results suggest that the expression of cell cycle-related markers may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity. (biomedcentral.com)
Spine1
it appears that FMRP plays an important role in spine maturation or plasticity ( Bagni and Greenough, 2005 ). (jneurosci.org)
Mechanisms1
In this study, we further analyzed the cognitive and affective behaviors of L100P homozygotes and their WT littermates, and explored the underlying synaptic mechanisms as well. (biomedcentral.com)
Responses3
Postsynaptic responses to patterned burst stimulation in KO mice showing impaired LTP were not significantly different from those in WT mice, suggesting that the LTP deficit was not caused by alterations in circuit properties. (jneurosci.org)
Fmr1 KO mice exhibit hyperactivity in open field tests, heightened seizure susceptibility, exaggerated responses to sensory stimulation, normal fear conditioning, and mild impairments in spatial learning tasks ( Kooy, 2003 ). (jneurosci.org)
In particular, a robust decrease in N -methyl- d -aspartate receptor (NMDAR)-mediated synaptic responses in the mPFC was correlated with several measures of attention. (jneurosci.org)
Function3
Synaptic function and plasticity were studied in mice lacking the fragile X mental retardation protein (FMRP), a model for the fragile X mental retardation syndrome. (jneurosci.org)
Here, we used mice with a genetic deletion of α2δ‐1 to determine how α2δ‐1 contributes to cell death, elevated excitatory synapse number, and in vitro network function after FL and to examine the molecular specificity of GBP's effects. (eneuro.org)
The decrease in NMDAR function was due in part to an altered redox state as bath application of the reducing agent, dithiothreitol, increased the NMDAR component of the synaptic response to a greater extent in middle-age animals. (jneurosci.org)
The results indicate that FMRP deficiency is associated with an age-dependent and region-selective impairment in long-term synaptic plasticity. (jneurosci.org)
Found1
On the other hand, Li and colleagues ( 2002 ) found that synaptic potentials recorded in layer IV/V of frontal neocortex in response to white matter stimulation showed greatly diminished LTP in Fmr1 KO mice. (jneurosci.org)
α2δ-1 signaling drives apoptotic cell death, anatomic reorganization, excitatory synaptogenesis, astrocytosis, and network hyperexcitability in a model of insult-induced cortical malformation known as freeze lesion (FL). (eneuro.org)
Fndc5/irisin was reduced in hippocampus of BCAS mice, forced expression hippocampal Fndc5 or bilateral intrahippocampal injection of recombinant irisin respectively improved hippocampal synaptic plasticity or inflammatory microenvironment, and then alleviated the cognitive impairments. (biomedcentral.com)
Impairments1
The impairments in both short-term presynaptic and long-term plasticity were worse in the rats in which early post-TBI seizures were induced than those in which later post-TBI seizures were induced. (oncotarget.com)
Stratum radiatum1
Double-labeling immunogold analysis with BK channel and glutamate receptor antibodies indicated that BK channels are targeted to the presynaptic membrane facing the synaptic cleft in terminals of Schaffer collaterals in stratum radiatum. (jneurosci.org)
Irisin1
Here, we investigated the activity and efficacy of Fndc5/irisin in experimental VaD, further explored whether the potential effects of LIPUS on VaD is related to Fndc5/irisin. (biomedcentral.com)
Presynaptic7
Electrophysiological (ePhys) studies including paired-pulse stimulation for short-term presynaptic plasticity and long-term potentiation (LTP) of CA1 Schaffer collateral synapses of the hippocampus for post-synaptic function survey were followed at post-event 1 hour, 3 and 7 days respectively. (oncotarget.com)
Our data indicates that synaptic plasticity (i.e., both presynaptic and postsynaptic) suppression occurs in TBI followed by a seizure and that the interval between the TBI and seizure is an important factor in the severity of the resulting deficits. (oncotarget.com)
Whole-cell, intracellular, and field-potential recordings from CA1 pyramidal cells showed that the presynaptic BK channels are activated by calcium influx and can contribute to repolarization of the presynaptic action potential (AP) and negative feedback control of Ca 2+ influx and transmitter release. (jneurosci.org)
This was observed in the presence of 4-aminopyridine (4-AP, 40-100 μ m ), which broadened the presynaptic compound action potential. (jneurosci.org)
In contrast, the presynaptic BK channels did not contribute significantly to regulation of action potentials or transmitter release under basal experimental conditions, i.e., without 4-AP, even at high stimulation frequencies. (jneurosci.org)
In particular, it is not known whether functional BK channels exist in presynaptic terminals and whether they contribute to presynaptic action potential (AP) repolarization and control of transmitter release in the CNS. (jneurosci.org)
However, with the limited resolution of LM it was not possible to determine whether BK channels are located in the presynaptic or postsynaptic membrane, nor was it possible to determine their distribution with respect to the synaptic cleft and release sites. (jneurosci.org)
Schaffer1
To determine the precise effects of post-traumatic seizure activity on hippocampal processes, we induced seizures at various intervals after traumatic brain injury (TBI) and analyzed plasticity at CA1 Schaffer collateral synapses. (oncotarget.com)
Rats2
At the same time, SD rats were injected with LPS (830 μg/Kg) intraperitoneally, and Open field test, Novel Objective Recognition test, Fear condition test were used to detect cognitive function. (biomedcentral.com)
The same molecular technics, behavioral and electrophysiological tests were used to examine whether metformin could alleviate the LPS-associated neuronal damage, as well as synaptic plasticity, and behavioral alterations in SD rats. (biomedcentral.com)
Cognitive1
At the same time, LPS injection in rat triggers cognitive impairment through activation of NF-κB signaling pathway, and metformin administration alleviates the LPS-induced memory dysfunction and improves synaptic plasticity. (biomedcentral.com)
Mechanism2
The anti-T2DM mechanism of TFH has been elaborated from comprehensive perspectives, including target prediction, metabolites, potential metabolic pathways, and so on. (bvsalud.org)
Such a mechanism may regulate transmission during variations in the intra-terminal calcium concentration ([Ca 2+ ] i ) or membrane potential, and could provide an "emergency brake" under conditions that cause excessive depolarization and Ca 2+ accumulation in the terminals, e.g., brain ischemia or epilepsy. (jneurosci.org)
Early1
Finally, prophylactic infusion of levetiracetam for one week after FPI reduced the synaptic plasticity deficits in early post-TBI seizure animals. (oncotarget.com)
Studies1
While further studies will be necessary to determine the degree to which cleavage of ICAM-5 in particular contributes to MMP dependent LTP our data support an growing body of literature suggesting that MMPs are essential mediators of synaptic plasticity. (healthandwellnesssource.org)