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  • NFAT
  • The Ca 2+ /calmodulin-activated phosphatase calcineurin (CaN) plays a central role in the pathology-related changes of astroglial cells mainly through activation of the inflammation-related transcription factors Nuclear Factor of Activated T-cells (NFAT) and Nuclear Factor kB (NF-kB). (operamedphys.org)
  • Evidence from murine and cell line models has implicated calcineurin-nuclear factor of activated T-lymphocytes (NFAT) signaling pathway, a Ca 2+ /calmodulin-dependent major proinflammatory pathway, in the pathogenesis of these diseases. (hindawi.com)
  • This review further highlights the need to characterize better all factors determining the outcome of calcineurin/NFAT signaling in diseases and the downstream targets mediating the beneficial and detrimental effects. (hindawi.com)
  • Altered calcineurin/NFAT activation is increasingly linked to pathological features of neurodegenerative diseases such as amyotrophic lateral sclerosis, Huntington's, Parkinson's, and Alzheimer's diseases, characterized by massive synaptic dysfunction, glial activation, and neuronal death in some regions of the brain [ 26 - 29 ]. (hindawi.com)
  • isoform
  • Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. (abcam.com)
  • Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway. (springer.com)
  • Dudek
  • Serena M. Dudek, Ph.D. is best known for her seminal work describing Long-term synaptic Depression (LTD) in the hippocampus. (moluna.de)
  • phenotype
  • An activity-regulated cytoskeleton-associated protein (Arc/Arg-3.1) has recently emerged as an attractive candidate effector molecule/immediate early gene product ( 13 , 14 ), whose induction may correlate, at least in part, with the induced synaptic alteration phenotype ( 15 - 18 ). (pnas.org)
  • vivo
  • The neuronal immediate early gene Arc / Arg-3.1 is widely used as one of the most reliable molecular markers for intense synaptic activity in vivo. (pnas.org)
  • growth
  • Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. (abcam.com)
  • pathways
  • Ongoing research in the lab is focused on 2D human induced pluripotent stem cell (hiPSC)-derived cultures and 3D cerebral organoid models of neurodegenerative and neurodevelopmental disease and aberrant redox/S-nitrosylation pathways leading to synaptic damage. (scripps.edu)
  • pathway
  • for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). (wikiversity.org)
  • Here we identify a novel MHCI signaling pathway that involves the inhibition of a known synapse-promoting factor, the insulin receptor. (jneurosci.org)
  • excitatory synapses
  • Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. (uniprot.org)
  • terminals
  • Circadian remodeling of the small ventral lateral neuron (sLNv) dorsal terminals was first described at the peak and trough levels of pigment-dispersing factor (PDF) immunoreactivity, that is at zeitgeber time 2 (ZT2) and ZT14 (2 hr after lights ON and lights OFF, respectively), as well as their counterparts under constant darkness (DD) (circadian time 2 [CTand CT14). (sdbonline.org)