Gene DosageSynapsesSynaptic TransmissionDosage Compensation, GeneticHippocampusNeuronal PlasticityDendritic SpinesExcitatory Postsynaptic PotentialsNeuronsLong-Term PotentiationNerve Tissue ProteinsPresynaptic TerminalsReceptors, AMPAMutationMice, KnockoutMice, TransgenicNeuromuscular JunctionPhenotypeMiniature Postsynaptic PotentialsMice, Inbred C57BLDendritesSynaptic VesiclesReceptors, N-Methyl-D-AspartatePatch-Clamp TechniquesDosage FormsBrainSynapsinsVesicle-Associated Membrane Protein 1AldicarbCell Adhesion Molecules, NeuronalDisease Models, AnimalExcitatory Amino Acid AgentsGene DuplicationHeterozygoteX Chromosome InactivationCA1 Region, HippocampalPost-Synaptic DensityGene Expression RegulationAnimals, NewbornRats, Sprague-DawleyCells, CulturedDrosophilaGlutamic AcidAllelesMembrane ProteinsParathionDrosophila ProteinsLong-Term Synaptic DepressionGuanylate KinaseSynaptic PotentialsMice, Mutant StrainsDown SyndromeElectric StimulationReceptors, GlutamateMolecular Sequence DataX ChromosomeTrisomyBrain-Derived Neurotrophic FactorPyramidal CellsSynaptophysinNeurotransmitter AgentsAlzheimer DiseaseCerebral CortexElectrophysiologySynaptic MembranesChromosomes, Human, Pair 21HaploinsufficiencyInhibitory Postsynaptic PotentialsSynaptosomesHomozygoteSignal TransductionRNA, MessengerCorticotrophsGene Expression Regulation, DevelopmentalGene DeletionGenotypeAneuploidyBase SequenceN-MethylaspartateMemoryExcitatory Amino Acid AntagonistsGenes, FungalDiazinonReceptor, trkBGenesSaccharomyces cerevisiaeMidline Thalamic NucleiDrosophila melanogasterOrgan Culture TechniquesMaze LearningVesicular Glutamate Transport Protein 1Amyloid beta-PeptidesVesicular Inhibitory Amino Acid Transport ProteinsPlasmidsChromosome MappingAmyloid beta-Protein PrecursorAnimals, Genetically ModifiedGene ExpressionTime FactorsPolyploidy