Synaptic contacts fundamental for long term memory. Medical search. Frequent questions

It is this trait to retain and form memories that is associated with neural plasticity and therefore many of the functions individuals perform on a daily basis. (wikipedia.org)
Learn how our guest speaker uses a novel approach to explore synaptic plasticity. (bruker.com)
Attendees will learn how the use of multiphoton glutamate uncaging can mimic synaptic release and uncover the mechanisms of spike-timing-dependent plasticity. (bruker.com)
We use several preparations including primary cultures of dissociated neurons to understand the role of Ng in events of synaptic plasticity, such as those associated with hebbian plasticity (Long Term Potentiation -LTP- and Long Term Depression -LTD) and homeostatic plasticity (synaptic scaling). (uam.es)
i) Investigate local protein synthesis in neurons that underlies spine morphogenesis and synaptic plasticity. (unist.ac.kr)
In this review we will focus on studies that attempt to uncover the role of synaptic plasticity in the regulation of whole-animal behavior by learning and memory. (simplyautomatic.com)
The first focuses on the roles played by synaptic plasticity, especially in long-term depression in the cerebellum in motor learning, and its regulatory mechanism. (simplyautomatic.com)
learning and memory at all levels of analysis ranging from molecular biology to synaptic and neural plasticity and behavior. (simplyautomatic.com)
Studying protein synthesis in presynaptic terminals will advance our basic understanding of synaptic function and plasticity and will provide critical insights into the early mechanisms underlying NDs. (ru.nl)
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. (ncbs.res.in)
2017. The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster. . (ncbs.res.in)
This is underlined by a wealth of studies including from our group that synaptic adhesion proteins can modulate synaptic plasticity and impact memory processes. (yale.edu)
Award recognizes professor's synaptic plasticity research, its translation to potential amblyopia and autism treatments, and his career of mentorship. (mit.edu)
Recognizing his research advancing understanding of how the brain changes with experience by altering the strength of connections among neurons, a phenomenon called "synaptic plasticity," the Society for Neuroscience (SfN) recently named Mark Bear , Picower Professor at MIT, a co-recipient of the 2023 Julius Axelrod Prize . (mit.edu)
Synaptic strength and plasticity are fundamental parameters for routing information throughout the brain and storing memories. (pasteur.fr)
In 1996, you discovered that local protein synthesis in dendrites has a crucial role for synaptic plasticity. (embo.org)
In the 1990s, we were studying mechanisms of synaptic plasticity, the strengthening and weakening of synapses. (embo.org)
We also developed an appreciation for the protein demands of neurons: the processes we were studying are fundamental for their ongoing maintenance, not just used for plasticity. (embo.org)

The sign and magnitude of the change in synaptic strength depend on the relative timing between spikes of two connected neurons (the pre- and postsynaptic neurons). (bruker.com)
These findings suggest that the functional specificity and structural arrangement of synaptic inputs, distributed or forming micro-clusters in the dendrites of pyramidal neurons, are fundamental for guiding the rules for sensory perception, affecting the STDP learning rule, learning and memory, and ultimately cognition. (bruker.com)
How synapses form to wire neurons into networks is a fundamental question of neuroscience. (yale.edu)
The number of dendrites-i.e., the branches of neurons that make synaptic connections-also increases, as does the number of synapses (Klintsova & Greenough, 1999). (encyclopedia.com)
It has long been believed that the number of neurons does not increase after birth, but some studies have shown that in adult rodents and primates new neurons are formed after damage (Rakic, 2002). (encyclopedia.com)
Glanzman, a cellular neuroscientist, and his colleagues report that they have eliminated, or at least substantially weakened, a long-term memory in both the marine snail known as Aplysia and neurons in a Petri dish. (scienceblog.com)
They are the first scientists to show that long-term memory can be erased at a connection between just two neurons. (scienceblog.com)
Josselyn is fascinated by fundamental questions about memory, including how individual neurons "decide" to become part of a particular memory, called an engram. (natureknowsproducts.com)
Using a genetic tweak in mice to increase levels of a protein called CREB, she was able to increase the excitability of particular neurons, and found that thisinfluenced where in the brain a memory was encoded. (natureknowsproducts.com)
To prove that the neurons actually encoded this, she turned off the brain cells that had lit up during memory formation, selectively killing them with a toxin. (natureknowsproducts.com)
Because the memory capacity of neurons is dependent upon synapse size, this eight percent difference turned out to be a key number the team could then plug into their algorithmic models of the brain to measure how much information could potentially be stored in synaptic connections. (worldhealth.net)
In particular, layer V neurons, being the main target of processed outputs leaving the hippocampal formation and sending their axons to cortical regions, play an important role in the consolidation and replay of memories, which involve hippocampal-neocortical communications. (lsuhsc.edu)
Despite their fundamental role in the consolidation and replay of memories, very little is known about the integrative features of these neurons. (lsuhsc.edu)
Using these techniques, we are currently studying the properties of the synaptic inputs and how they are integrated with voltage-dependent currents, the initiation of active processes in the dendrites (i.e. dendritic spikes) and their impact on the somatic output in hippocampal CA1 neurons and neurons of the deep layers of the entorhinal cortex. (lsuhsc.edu)

Despite this predominant role in long-term information storage, synapses are composed of molecules (i.e. (ru.nl)
Analyzing synaptic changes in vivo, we have applied proteomic studies of synapses in mouse models with altered synaptogenesis to dissect signaling pathways. (yale.edu)
When I did the research part of my M.D./Ph.D., I was working on understanding how the protein CaM kinase II potentiates calcium signaling and, through its autophosphorylation, provides cells and especially neuronal synapses with an important "molecular memory. (asbmb.org)
As a postdoc, I wanted to learn more about the nuts and bolts of synapses and moved to study the biochemistry of proteins responsible for synaptic vesicle trafficking. (asbmb.org)
Picower Professor Mark Bear has made fundamental discoveries about how connections among brain cells, or synapses, change with experience. (mit.edu)
Unlike electrical connections within manufactured electrical circuits, "synapses are diverse in terms of their efficiency of communication (synaptic strength), and are extremely plastic", explains David DiGregorio, Head of the Synapse and Circuit Dynamics Laboratory at the Institut Pasteur (CNRS - UMR3571). (pasteur.fr)
Calcium is a universal signaling molecule in all cells, and for synapses in the brain is responsible for the release of chemical neurotransmitters from synaptic vesicles. (pasteur.fr)
But Tom Bartol, a Salk staff scientist, had an idea: if they could measure the difference between two very similar synapses such as these, they might glean insight into synaptic sizes, which so far had only been classified in the field as small, medium and large. (worldhealth.net)

In this case the 'other force' would be the affinity among existing domains, ie autocatalysis writ - really - large, already confirmed in terms of neuronal functional complexes, abstractions, molecular complexes in life etc. (otoom.net)
Fourth, we analyze how synaptic aberrations contribute to brain disorders and how the maturation of neuronal connectivity can be supported. (yale.edu)
It turns out the neuronal equivalent of additive increase is called long-term potentiation. (neurosciencenews.com)

Its availability and activity are locally regulated by proteins such as neurogranin (Ng), very abundant in the post-synaptic environment, which sequesters CaM in a Ca+2 and phosphorylation dependent manner. (uam.es)
RNA and proteins) with half-lives several order of magnitude shorter than memories themselves 1-3 . (ru.nl)
Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance. (ru.nl)
Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains. (ncbs.res.in)
My long-term overall interest is in the cell biology of molecular machines, with a particular interest in understanding how proteins regulate the structure and organization of membranes, both inside and outside the cell. (asbmb.org)
They discovered that the long-term memory for sensitization in the marine snail can be erased by inhibiting the activity of a specific protein kinase - a class of molecules that modifies proteins by chemically adding to them a phosphate (an inorganic chemical), which changes the proteins' structure and activity. (scienceblog.com)
Researchers at the Institut Pasteur studied the structural organization of synaptic proteins and their influence on the strength of interneuronal communication. (pasteur.fr)
However, the proximity between calcium channel proteins and the synaptic vesicle proteins on which Ca2+ act is critical for regulating the strength and precision of communication. (pasteur.fr)
Thus by studying the nanoscale organization of synaptic proteins we can decipher the molecular code regulating different types of synaptic communication," sums up David DiGregorio. (pasteur.fr)
Until recently, scientists knew that the distance between synaptic proteins must be important, but had little information about the actual two-dimensional nanoscale topographical arrangement of calcium channels and synaptic vesicles, and how it related to the strength and efficiency of synaptic communication. (pasteur.fr)
We hypothesized that the different spatial distribution of these proteins was related to the diversity of synaptic function. (pasteur.fr)
For the first time we show how diversity in the two-dimensional nanotopography of synaptic proteins drives diversity of synaptic strength and its differential modulation by pharmacological compounds. (pasteur.fr)
The dogma was that short-term memories could be elicited without new proteins. (embo.org)
SMOC1 and SPON1 proteins associated with Aß plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. (cdc.gov)
We found 32 dementia-associated plasma proteins that were involved in proteostasis, immunity, synaptic function, and extracellular matrix organization. (cdc.gov)

They are also the preferential site for the induction of long-term potentiation (LTP) and long-term depression (LTD) thought to be the underlying mechanisms for learning and memory in the brain. (bruker.com)
A stimulus with learned relevance elicits a stronger response in these systems, suggesting that this positive potentiation is one piece of the puzzle that is the memory trace. (technologynetworks.com)
He and his students showed that NMDA receptors trigger long‐term depression (LTD) as well as long‐term potentiation (LTP) in the cortex, that the properties of LTD and LTP are themselves 'metaplastic' and depend on the recent history of cortical activity, and that these bidirectional synaptic modifications and metaplasticity are essential for development of the visual cortex. (mit.edu)

A neuron with extremely polarized structures requires proper distribution and transport of mitochondria in different locations - cell body, axons, and dendrites - in response to physiological needs and synaptic activity. (unist.ac.kr)
Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function, Neuron , November 20, 2019. (pasteur.fr)
It occurs when one neuron fires closely after another, which strengthens their synaptic connection and makes it slightly more likely the first will trigger the second in the future. (neurosciencenews.com)

An in-depth knowledge of the molecular basis of synaptic regulation is fundamental to decipher the mechanisms involved in the formation of memories. (uam.es)
Our long-term goal is to better understand the fundamental molecular and cellular mechanisms that underlie cognitive functions. (unist.ac.kr)
The Role of Experience, Learning, & Memory Major topics for weeks 8 through 12 include the effects of experience on animal behavior, the mechanisms of learning and memory for the relations between different events, the basic laws and mechanisms of association formation, the assessment of value and the function of reinforcement. (simplyautomatic.com)
His lab's demonstration of LTD in the hippocampus was paradigm‐shifting, opening the door to numerous studies of the fundamental molecular mechanisms of synaptic modification. (mit.edu)
The amygdala plays a key role in forming new fear-related memories, which tend to form quickly-making mouse experiments that use electric shocks or loud noises a popular way to investigate the mechanisms of memory formation and retrieval. (natureknowsproducts.com)
We are focused on understanding basic cell biological synaptic mechanisms, but there has been an interesting convergence of many neurodevelopmental and some neurodegenerative disorders on the synapse. (embo.org)
However, further research has shown that other regions of the body-such as the hippocampus, a brain area important for regulating memory-contain timekeeping mechanisms of their own that may respond to stimuli other than light. (smithsonianmag.com)
By elucidating the mechanisms of dendritic integration in the entorhinal cortex, these studies will increase our knowledge of memory processing. (lsuhsc.edu)

This approach reveals insights into the location and structural organization of dendritic spines and has useful implications for learning, memory, and cognition. (bruker.com)
Learning involves "a change in the content or organization of long term memory and/or behavior. (simplyautomatic.com)
Long-Term Knowledge Organization: Spaced repetition contributes to long-term knowledge organization by promoting systematic review and categorization of information. (knowlesti.jp)
These studies can reveal how the sub-synaptic organization and dynamics of the cleft contribute to synaptic functions. (yale.edu)

(1) information flow through neural circuits that is necessary to produce complex behaviour and (2) activity-driven synaptic remodelling for memory storage . (ru.nl)

David DiGregorio's team recently combined fluorescence imaging, computational modeling, and electron microscopy, showing in particular that the number of presynaptic calcium channels (CaV) does not correlate with synaptic strength, and that different nanoscale CaV-synaptic vesicle arrangements explain functional differences. (pasteur.fr)

Synaptic activity triggers intracellular calcium (Ca+2) oscillations that locally modulate several signaling pathways. (uam.es)
In contrast to these systems, long-range inhibitory pathways are much sparser and less numerous, but mounting evidence suggests that they can still have surprisingly robust effects on network function and behavior," says Prof. Dr. Johannes Letzkus, Professor at the University of Freiburg and former Research Group Leader at the Max Planck Institute for Brain. (technologynetworks.com)
Optimized Knowledge Retention: Spaced repetition optimizes knowledge retention by reinforcing memory pathways at strategic intervals. (knowlesti.jp)

As fundamental as the neurotransmitters are, there's another class of master molecules that, over the past 15 years, has dramatically changed our understanding of connections in the brain. (additudemag.com)

Memories are encoded by long-term changes in synaptic efficiency and connectivity. (uam.es)
Neurological Efficiency: Spaced repetition improves neurological efficiency by strengthening synaptic connections. (knowlesti.jp)

Lipids are major components of the brain, required for signaling, metabolism, trafficking and homeostasis, making lipid research fundamental to studying neurological disorders. (sanbio.nl)

And it spurs the development of new nerve cells from stem cells in the hippocampus, an area of the brain related to memory and learning. (additudemag.com)
Once it became clear to researchers that BDNF was present in the hippocampus, the area of the brain related to memory and learning, they set out to test whether it was a necessary ingredient in the process. (additudemag.com)
On the one hand, we investigate hippocampus-dependent memory processes. (yale.edu)
The hippocampus, tucked deep inside the brain's temporal lobes, is where such memories are formed and indexed. (natureknowsproducts.com)
Through an ongoing process called memory consolidation-which happens over the course of weeks in humans, as they sleep and dream-memories initially encoded in the hippocampus are transferred for long-term storage to the wrinkly neural tissue of the neocortex, on the brain's surface. (natureknowsproducts.com)
We investigated this feature selection process in the hippocampus during memory acquisition and subsequent consolidation. (nature.com)
Thus, while the hippocampus comprehensively encodes the real-time sensory environment, it implements a flexible filtering mechanism to maximize the utility of memories destined for long-term storage. (nature.com)
The Salk team, while building a 3D reconstruction of rat hippocampus tissue (the memory center of the brain), noticed something unusual. (worldhealth.net)
So the hippocampus, the part of the brain which is so essential for learning and memory, is actually following when the food is available. (smithsonianmag.com)

More specifically, Dr. Araya is passionate about dendritic computations, and how dendritic spines control the processing, storage, and integration of synaptic inputs. (bruker.com)
We set out to determine whether such inputs might be present in neocortex, and if so, how they might uniquely contribute to memory. (technologynetworks.com)

This finding is driving a paradigm shift in our understanding of synaptic function. (ru.nl)

Moreover, a mechanistic understanding of memory has implications that can range from the treatment of memory and anxiety disorders to the development of artificial intelligence and efficient hardware and software design. (technologynetworks.com)
The research has important potential implications for the treatment of post-traumatic stress disorder, as well as drug addiction, in which memory plays an important role, and perhaps Alzheimer's disease and other long-term memory disorders. (scienceblog.com)

The brain's ability to remodel itself forms the basis of the brain's capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. (wikipedia.org)
Spines can undergo structural remodeling that is tightly coupled with synaptic function. (bruker.com)
In this viewpoint, we advocate that deep learning can be further enhanced by incorporating and tightly integrating five fundamental principles of neural circuit design and function: optimizing the system to environmental need and making it robust to environmental noise, customizing learning to context, modularizing the system, learning without supervision, and learning using reinforcement strategies. (jneurosci.org)
Nootropics, often referred to as 'smart drugs' or cognitive enhancers, represent a fascinating array of compounds designed to possibly augment cognitive function, memory, creativity, and overall brain health. (99purity.com)
That means the memory function of the brain is affected by food, and late eating produces an internal misalignment in the body. (smithsonianmag.com)

Investigating the dynamics of the synaptic proteome homeostasis is fundamental for our deeper understanding of the synapse operation in healthy and diseased brains. (ru.nl)
The way it works is that an electrical signal shoots down the axon, the outgoing branch, until it reaches the synapse, where a neurotransmitter carries the message across the synaptic gap in chemical form. (additudemag.com)
This integration enables mechanistic insights into synapse development and the profound disease relevance of synaptic biology. (yale.edu)
Select trans-synaptic interactions are now known to guide synapse development and we have identified and characterized synaptogenic cell adhesion molecules. (yale.edu)
In addition, we can erase the long-term change at a single synapse that underlies long-term memory in the snail. (scienceblog.com)

hence, it is the biological basis for learning and the formation of new memories. (wikipedia.org)
Abstract Cognitive functions such as learning and memory are of fundamental biological importance and diseases that affect these functions are among the most challenging biomedical problems of our time. (neurodegenerationresearch.eu)
The point is to reduce the problem so we can study on a fundamental biological level how PKM is maintaining long-term memory," Glanzman said. (scienceblog.com)

This conclusion is explored using two-photon (2P) glutamate uncaging that mimics synaptic release. (bruker.com)
Their finding that LTD is impacted in several developmental disorders led to the insight that excess protein synthesis downstream of the glutamate receptor mGlu5 is a core driver of the synaptic, circuit, and behavioral dysfunction seen in Fragile X Syndrome, the most common form of inherited intellectual disability and a leading monogenic cause of autism. (mit.edu)

Regularly revisiting information strengthens memory traces, making them more resistant to forgetting and interference. (knowlesti.jp)

Two-photon calcium imaging of CA3 axonal projections to CA1 combined with simultaneous local field potential recordings revealed that CA3 projections that encode behaviourally informative sensory stimuli were selectively recruited during the memory replay events that underlie hippocampal memory consolidation 5 . (nature.com)

Learning how to manipulate specific engrams in this way could yield revolutionary applications not only for memory disorders but also depression-for example, by restoring positive memories-and addiction, by eliminating pleasurable memories of using alcohol or drugs. (natureknowsproducts.com)
This is called long-term depression. (neurosciencenews.com)

To form memories, the brain must make connections between sensory "bottom-up" signals from the environment and internally generated "top-down" signals that convey information about past experiences and current goals. (technologynetworks.com)

Their work provides the first functional analysis of how long-range inhibition shapes information processing in the neocortex. (technologynetworks.com)

2. What role does sleep play in promoting the formation of new synaptic connections in the brain? (upenn.edu)
Zone of uncertainty" in the brain influences its ability to form new memories. (technologynetworks.com)
The neocortex is the largest and most complex part of the brain and has long been considered the ultimate storage site for long-term memories. (technologynetworks.com)
Researchers at the University of Freiburg Medical School led by Prof. Dr. Johannes Letzkus and the Max Planck Institute for Brain Research have discovered that a little-studied area of the brain, the "zone of uncertainty" or "zona incerta," communicates with the neocortex in unconventional ways to rapidly control memory formation. (technologynetworks.com)
The signals identified in this study are likely critical not only for memory, but also for a number of additional brain functions, such as attention. (technologynetworks.com)
Memory is one of the most fundamental functions of the brain, enabling people to learn from experience and remember the past. (technologynetworks.com)
How does a specific learning and memory system in the mammalian brain gain control of behavior? (simplyautomatic.com)
In the mouse brain it is common for dendrites to extend over hundreds of micrometers and for axons to be tens of millimeters long. (ru.nl)
In a long term, large study of brain changes that occur with age in these monkeys, we have shown that normal brain aging is associated with a significant downregulation of Klotho expression. (neurodegenerationresearch.eu)
Whatever part of the brain was taken away, there was always a trace of memory (Lashley, 1950). (encyclopedia.com)
Almost all the processes that are involved in memory in the snail also have been shown to be involved in memory in the brains of mammals," said Glanzman, who added that the human brain is far too complicated to study directly. (scienceblog.com)
It is possible to watch a memory forming in the brain. (natureknowsproducts.com)
Memory is a fundamental building block of what constitutes humanity," says Alcino Silva , professor of psychology at UCLA's Brain Research Institute. (natureknowsproducts.com)
Salk researchers and collaborators have achieved critical insight into the size of neural connections, putting the memory capacity of the brain far higher than common estimates. (worldhealth.net)
Our memories and thoughts are the result of patterns of electrical and chemical activity in the brain. (worldhealth.net)
While I had hoped to learn fundamental principles about how the brain is organized from these detailed reconstructions, I have been truly amazed at the precision obtained in the analyses of this report. (worldhealth.net)
I believe this will give me, as a researcher into fundamental brain processes, insight into the real-world issues that need to be addressed. (mcgill.ca)

In recent years, researchers have begun to identify a number of such top-down projection systems, all of which share a number of common features: They signal through synaptic excitation, the standard way of sending information between cortical regions, and they also exhibit a common regime for memory encoding. (technologynetworks.com)
Eichenbaum, H. A cortical-hippocampal system for declarative memory. (nature.com)

Scientists do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory. (unist.ac.kr)

But most research that looks at memory-and the fear of losing it-studies declarative memory. (natureknowsproducts.com)

Work in the Kayser Lab stands to connect this fundamental behavior - sleep - to both pathogenesis and treatment of neuropsychiatric disease. (upenn.edu)

Specifically, the lab studied how stress affects the amygdala, a question of relevance for stress-induced disorders and the long-term consequences of stress. (mcgill.ca)

This innovative textbook is the first to integrate learning and memory, behaviour, and cognition. (simplyautomatic.com)

If marine snails are attacked by a predator, the attack heightens their sensitivity to environmental stimuli - a "fundamental form of learning that is necessary for survival and is very robust in the marine snail," Glanzman said. (scienceblog.com)

Inflamed and dysfunctional NTS and other key brainstem nuclei may play a pivotal role in triggering memory and cognitive dysfunction in OSA. (hindawi.com)

3 Serious developments in the field have occurred in recent memory, thanks to significant advances in MS and biobanking. (sanbio.nl)

2022. Local translation provides the asymmetric distribution of CaMKII required for associative memory formation. . (ncbs.res.in)
We propose that utility-dependent recruitment of sensory experience during memory consolidation is a general coding principle for associative learning. (nature.com)

4) We recently demonstrated that increased Klotho levels are associated with enhanced cognitive functions in mice and humans and can prevent synaptic and cognitive impairments in a transgenic mouse model (hAPP mice from line J20) that simulates key aspects of Alzheimer's disease (AD). (neurodegenerationresearch.eu)
We recently demonstrated that elevating levels of the pleotropic protein Klotho enhances cognitive functions in mice and humans, and can prevent synaptic and cognitive impairments in a transgenic mouse model that simulates key aspects of Alzheimer's disease. (neurodegenerationresearch.eu)

The Tolman-Eichenbaum machine: unifying space and relational memory through generalization in the hippocampal formation. (nature.com)
Information processing and memory formation. (lsuhsc.edu)

Memory is one of the most fundamental mental processes. (simplyautomatic.com)

Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception. (medscape.com)

Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. (nature.com)

Buzsaki, G. Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning. (nature.com)

One of the consistent things we see in people who have disruptions in their circadian rhythms is memory deficits," says Christopher Colwell , a professor of psychiatry at the UCLA School of Medicine and co-author of the study. (smithsonianmag.com)
For years, his team has investigated how disruptions to the sleep/wake cycle have an impact on learning and memory. (smithsonianmag.com)

Once it is activated, PKM's continual activity maintains a memory until PKM degrades. (scienceblog.com)
Glanzman decided to study PKM in the marine snail, which has simple forms of learning and a simple nervous system, so that he could understand in precise detail how PKM's activity maintains a long-term memory, a process that is not well understood. (scienceblog.com)

Independent research is fundamental to level H5 study and also equips students with confidence to source and evaluate information relevant to the core course topics. (oxfordcollege.ac)
Josselyn's work is part of a new wave of research in neuroscience, aided by a convergence of increasingly powerful technologies, that seeks to reveal how memories are made, lost and might be restored. (natureknowsproducts.com)
From the perspective of a fundamental researcher, not only will this integration provide the direction for basic research, but also allows us to better understand the diverse ways in which brains work to solve the problems of daily life. (mcgill.ca)
Your nocturnal noshing may not only be bad for physical health, it could also be detrimental to learning and memory, according to the latest neuroscientific research. (smithsonianmag.com)
Please describe briefly and in simple terms your research discovery. (hopkinsmedicine.org)

Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila. (upenn.edu)

This includes both memory of events (episodic, or autobiographical memory) and more general facts (semantic memory). (natureknowsproducts.com)

It could hardly be more timely, as the world's population rapidly ages and Alzheimer's disease and other forms of dementia threaten to erode the memories of millions of people. (natureknowsproducts.com)

By contrast, axons encoding uninformative, peripatetic sensory cues were notably suppressed during memory replay. (nature.com)

Upsetting memories such as images, thoughts, or flashbacks may haunt the person, and nightmares may be frequent. (wikipedia.org)
Could veterans of war, rape victims and other people who have seen horrific crimes someday have the traumatic memories that haunt them weakened in their brains? (scienceblog.com)

Anatomy33

Organisms6

Diseases4

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology19

Phenomena and Processes15

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care3

Plasticity18

Neurons14

Synapses8

Neuronal3

Proteins15

Potentiation3

Neuron3

Mechanisms8

Organization4

Neural circuits1

Vesicle1

Pathways3

Neurotransmitters1

Efficiency2

Neurological disorders1

Hippocampus9

Inputs2

Paradigm shift1

Implications2

Function5

Synapse5

Biological3

Glutamate2

Strengthens1

Axonal1

Depression2

Form memories1

Functional1

Brain17

Cortical2

Protein synthesis1

Declarative memory1

Behavior1

Relevance1

Behaviour1

Stimuli1

Dysfunction1

Advances1

Associative2

Cognitive functions2

Formation2

Processes1

Principles1

Crucial1

Hippocampal1

Disruptions2

Activity2

Research5

Drosophila1

Episodic1

Alzheimer's1

Sensory1

Haunt2