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  • nerve cells
  • By illuminating how nerve cells are connected to each other, we are closer to understanding what organizational steps go awry in synaptic disorders that impair brain development," said senior author Thomas Biederer, PhD, from the Department of Neuroscience at Tufts University School of Medicine. (tufts.edu)
  • protein
  • When you see how many different proteins and different varieties of the same protein reside in the cleft, the numbers for each individual element is likely to be small, meaning that you can't use statistical mechanics but must use sociology instead. (wordpress.com)
  • small
  • The synaptic cleft is so small ( under 400 Angstroms - 40 nanoMeters ) that it can't be seen with the light microscope ( the smallest wavelength of visible light 3,900 Angstroms - 390 nanoMeters). (wordpress.com)
  • diverse
  • Taken together, the results support the novel concept that the synaptic cleft is comprised of structurally and molecularly diverse sub-compartments, and that its components can be dynamic. (tufts.edu)
  • The stuff in the synaptic cleft is so diverse, and so intimately involved with itself and the membranes on either side what what is needed for comprehension is not a chemist but a sociologist. (wordpress.com)
  • memory
  • Among the behavioral alterations that the researchers suspect may be related to the structure and dynamics of the synaptic cleft is the ability to learn and access memory, as well as an increased risk for drug addiction. (tufts.edu)
  • make
  • Mutations in the proteins that make up the cleft increase vulnerability to developmental disorders, notably autism spectrum disorders. (tufts.edu)