Pulmonary EmphysemaEmphysemaSubcutaneous EmphysemaMediastinal Emphysemaalpha 1-Antitrypsin DeficiencyPancreatic ElastaseLungPulmonary Disease, Chronic ObstructiveTomography, X-Ray ComputedRespiratory Function TestsPneumonectomySmokingSmokeForced Expiratory VolumeMatrix Metalloproteinase 12alpha 1-AntitrypsinTotal Lung CapacityPulmonary AlveoliSeverity of Illness IndexLung Volume MeasurementsHeliumVital CapacityPulmonary Diffusing CapacityBronchitisSpirometryResidual VolumeBronchitis, ChronicSymptom AssessmentAirway ObstructionPulmonary Heart DiseaseDepressionPulmonary FibrosisDyspneaElastinRadiography, ThoracicBronchoalveolar Lavage FluidQuestionnairesTreatment OutcomeBronchographyLung ComplianceFollow-Up StudiesBronchoscopyTime FactorsRisk FactorsQuality of LifeCoal MiningPrevalenceLung DiseasesBehavioral SymptomsLung Diseases, ObstructiveProspective StudiesAsthmaPsychiatric Status Rating ScalesDisease Models, AnimalRespiratory MechanicsLeukocyte ElastasePneumoconiosisTobaccoPneumoniaRetrospective StudiesDiaphragmRespiratory Tract DiseasesOccupational DiseasesRadiographic Image Interpretation, Computer-AssistedComorbidityChronic DiseasePneumopericardiumPhenotypeDesmosineCross-Sectional StudiesReproducibility of ResultsFunctional Residual CapacityAffective SymptomsExercise ToleranceLongitudinal StudiesCohort StudiesSpiritualismPulmonary Surfactant-Associated Protein DAirway ResistanceMice, Inbred C57BLCoughAnxietyRespiration DisordersBronchiCase-Control StudiesOrbital DiseasesDepressive DisorderAge FactorsBronchiolesDisease ProgressionBronchodilator AgentsSensitivity and SpecificityMacrophages, AlveolarSerpin E2Analysis of VariancePapainBronchoalveolar LavageOxygen Inhalation Therapy