• However, more studies are necessary to examine this drug's efficacy in both the prophylaxis and treatment of NSAID-induced ulceration. (hindawi.com)
  • Finally, all people older than 50 years who, for the first time, show symptoms suggestive of a stomach acid-related disorder, and anyone of any age with 'alarm' features such as vomiting, bleeding, anemia, an abdominal mass, unexplained weight loss, or trouble swallowing should have an endoscopy to identify the cause quickly and to rule out cancer. (medbroadcast.com)
  • The 13% absolute risk reduction (ARR) means that 8 patients would need to be treated (NNT) with short-term misoprostol (rather than placebo) to prevent 1 additional patient from developing a gastric ulcer, 95% CI 4 to 112. (acpjc.org)
  • This leads us to consider whether misoprostol is cost-effective and whether we need to target high-risk patients for therapy. (acpjc.org)
  • We then randomly reassigned 732 patients in whom treatment was successful to maintenance therapy with 20 mg of omeprazole daily, 200 microg of misoprostol twice daily, or placebo for six months. (nih.gov)
  • At eight weeks, treatment was successful in 76 percent of the patients given 20 mg of omeprazole (233 of 308), 75 percent of those given 40 mg of omeprazole (237 of 315), and 71 percent of those given misoprostol (212 of 298). (nih.gov)
  • Zafirlukast is an asthma used to decrease the occurrence of chronic asthmatic symptoms in patients 5. (bad-drug.net)
  • Millions of patients use NSAIDs for the relief of various types of arthritis pain, stiffness, and related symptoms. (biomedcentral.com)
  • Gastrointestinal bleeding, ulceration, and perforation have occurred in NSAID-treated patients receiving misoprostol . (idealsecimsistemi.com)
  • Patients were approximately Mifepristone and Misoprostol - Safe2ChooseMifepristone and Misoprostol . (idealsecimsistemi.com)
  • Selective NSAIDs such as cyclo-oxygenase (COX)-2 inhibitors were first introduced with the purpose of providing symptomatic pain relief along with lesser gastrointestinal risk. (biomedcentral.com)
  • More important, although misoprostol has been shown to reduce serious adverse events, the NNT is 264 to prevent a single complication ( 2 ). (acpjc.org)
  • Although the probability that any given individual user of an NSAID will suffer a serious gastrointestinal complication is fairly low, widespread patient exposure can translate into a major national health burden. (biomedcentral.com)
  • Misoprostol is a water-soluble, viscous liquid that contains approximately equal amounts of two diastereomers. (rxlist.com)