• Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
  • Bosset JF, Collette L, Calais G. Chemotherapy with preoperative radiotherapy in rectal cancer. (novapublishers.com)
  • [15] The field of virotherapy was nearly abandoned for a time, as the technology required to modify viruses didn't exist whereas chemotherapy and radiotherapy technology enjoyed early success. (privacytools.io)
  • Our results revealed that gemcitabine and cisplatin-induced severe body weight loss and skeletal muscle atrophy in the mice with cancer were greatly attenuated after AC extract administration. (oncotarget.com)
  • Sulforaphane protects against cisplatin-induced nephrotoxicity. (weeksmd.com)
  • Ingestion of SEB produces profound gastrointestinal (GI) symptoms, including anorexia, nausea, vomiting, and diarrhea, which are believed to be mediated through the release of cytokines from T cells in the lamina propria of the intestines. (medscape.com)
  • One study stated that medical marijuana can help children with seizures and chemotherapy-induced nausea. (healthline.com)
  • Performance status is often used as a measure to determine whether a person can receive chemotherapy, or whether dose reduction is required. (worldsbest.rehab)
  • Most patients receive chemotherapy on an outpatient basis and are admitted to the hospital if they develop fever and neutropenia, obvious infection, or some other complication. (medscape.com)
  • This article reviews the activity of against specific threats provided that a safe vaccine exists that humoral immunity against several biological agents, discusses can induce a protective response. (cdc.gov)
  • Apparently, the goal seems to center around frightening or inducing enough guilt that everyone would begin to demand the vaccine as soon as it is available. (newmediaexplorer.org)
  • FluMist contains live (attenuated) influenza viruses that replicate in the nasopharynx of the vaccine recipient. (newmediaexplorer.org)
  • 100° F."[6] These symptoms are nearly identical to those the flu vaccine is designed to prevent. (newmediaexplorer.org)
  • Varicella vaccine is a live attenuated viral vaccine. (vaccinesafety.edu)
  • Measles, Mumps, and Rubella (MMR) Vaccine The measles/mumps/rubella vaccines (MMR vaccines) effectively protect against all 3 infections ( measles, mumps, rubella). (msdmanuals.com)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of paclitaxel and oxaliplatin treatment of cancer (70-90% of patients receiving these drugs). (painchannels.com)
  • iii) To design and pharmacologically validate lead compounds that attenuate paclitaxel and oxaliplatin CIPN sensory symptoms. (painchannels.com)
  • Paclitaxel triggers anti-mitotic actions by impeding the cell cycle in the late Everolimus mTOR inhibitor stages of mitosis, backing microtubule formation, and eventually inducing apoptosis. (gp120-inhibitors.com)
  • In this study, we investigated whether combined treatment with the ethonolic extract of AC ameliorates cachexia symptoms, especially muscle wasting, in lung tumor-bearing mice treated with chemotherapy. (oncotarget.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • Thus, the best available treatments against PDAC (that is, chemotherapy) are less effective under tumor-associated conditions. (nature.com)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
  • Patients with grade 2+ skin toxicity mostly suffer from skin disintegrity and symptoms caused by inflammation in the irradiated areas. (biomedcentral.com)
  • Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
  • In a human clinical trial, he had a group of cancer patients go on short fasts before and then soon after undergoing chemotherapy. (coconutresearchcenter.org)
  • In the past, many clinical efforts have been made to attenuate skin toxicity in radiation therapy or to delay its onset, but in many countries there is no "gold standard" in skin care during and after radiation treatment. (biomedcentral.com)
  • Adenoviruses, particularly, have shown to be safe, inducing only mild adverse side effects in clinical trials, making them a great candidate for further clinical development. (helsinki.fi)
  • The diagnosis of chemotherapy-induced oral mucositis is based on clinical findings and the chronology of the development of lesions. (medscape.com)
  • Chemotherapy induced peripheral neuropathy (CIPN) is a frequent, disabling side effect of anticancer drugs. (painchannels.com)
  • Patients undergoing chemotherapy with cisplatin (CIS) develop neuropathy in addition to other symptoms such as, anxiety, depression, muscle wasting and body weight loss. (mdpi.com)
  • The chemotherapeutic agent used, dosing schedule, type of cancer, and presence of additional medical complications make a difference to the occurrence and severity of chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • As the underlying cellular mechanisms remain incompletely understood pharmacotherapies for chemotherapy-induced neuropathy are limited. (gp120-inhibitors.com)
  • Gabapentin, amytriptyline and opioids are used to treat chemotherapy-induced neuropathy. (gp120-inhibitors.com)
  • More recently, Zimmerman and Zimmerman (1990/1991) concluded that 'cannabis mutagenicity remains unclear', but argued that there was evidence that 'cannabinoids induce chromosome aberrations in both in vivo and in vitro studies' (p19). (druglibrary.org)
  • Cannabinoids curb neuropathic pain induced by traumatic nerve damage, harmful insults and metabolic changes. (gp120-inhibitors.com)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
  • Thapsigargin marketed ER stress protein mimicked ER stress-induced cardiomyocyte contractile anomalies including despondent top shortening and maximal speed of shortening/relengthening aswell as extended relengthening duration, the result which was abrogated with the autophagy inhibitor 3-methyladenine as well as the ALDH2 activator Alda-1. (health-e-nc.org)
  • Oddly enough, Alda-1-induced beneficial impact against ER tension was obliterated by autophagy inducer rapamycin, Akt inhibitor AktI and mTOR inhibitor RAD001. (health-e-nc.org)
  • These data recommend a beneficial function of ALDH2 against ER stress-induced cardiac anomalies perhaps through autophagy decrease. (health-e-nc.org)
  • In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. (biomedcentral.com)
  • Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
  • To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)
  • Aetna considers laboratory testing medically necessary for heavy metal poisoning (e.g., arsenic, cadmium, copper, gold, iron, mercury) for members with specific signs and symptoms of heavy metal toxicity and/or a history of likely exposure to heavy metals. (aetna.com)
  • Aetna considers laboratory testing for manganese medically necessary for persons with specific signs and symptoms of manganese toxicity (dyscoordination, loss of balance, confusion) who have a history of likely exposure to high levels of manganese (e.g., occupational exposures to manganese aerosols or dust in the welding or steel industries, exposure to high levels of manganese in contaminated drinking water, suspected manganese toxicity in persons on chronic total parenteral nutrition). (aetna.com)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • Unlike vaccines, which require time to induce pro- tective immunity and depend on the host's ability to mount an immune response, passive antibody can the- oretically confer protection regardless of the immune status of the host. (cdc.gov)
  • Varicella and ZVL are live attenuated vaccines and are thus contraindicated during pregnancy. (vaccinesafety.edu)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (worldsbest.rehab)
  • Taken together, these results demonstrated that the AC extract has a protective effect against chemotherapy-induced muscle atrophy mainly by attenuating muscle proteolysis, pro-inflammatory cytokine production, and anorexia, and activating IGF-1-dependent protein synthesis. (oncotarget.com)
  • Authors Štefan Toth and colleagues at Pavol Jozef Safarik University and Louis Pasteur University Hospital in Slovakia concluded that, "Our study has shown that the triple combination (combination of CoQ10 and omega-3 PUFA together with statins) should have a higher protective effect than the dual combination and could attenuate the muscle adverse effects of statin therapy. (lifeextension.com)
  • These same adaptive survival pathways protect pancreatic cancer cells against chemotherapy 7 . (nature.com)
  • Vaccination studies have established a direct cor- botulism is largely supportive, although prompt administration relation between antibody titer to PA and survival after lethal of an antitoxin may reduce the severity of symptoms by neu- challenge with virulent anthrax spores (7,8). (cdc.gov)
  • 39-40 Radiation-induced erythema multiforme may occur when phenytoin is given prophylactically to neurosurgical patients who are receiving whole-brain therapy and systemic steroids. (wikipedia.org)
  • Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
  • Attended video-PSG excluded RBD showing REM sleep with atonia and without increased phasic EMG activity, and diagnosed with severe obstructive sleep apnea (OSA) with an apnea-hypopnea index of 30.1 demonstrating that the reported abnormal sleep behaviors occurred only during respiratory event-induced arousals. (go.jp)
  • Vital signs and respiratory symptoms were also observed. (researchgate.net)
  • It begins 5-10 days after the initiation of chemotherapy and lasts 7-14 days. (medscape.com)
  • May 25, 2023 - NIH-funded research effort identifies most common symptoms, potential subgroups, and initial symptom-based scoring system - with aim of improving future diagnostics and treatment. (nih.gov)
  • Patients receiving chemotherapy are instructed to increase protein and calorie intake. (coconutresearchcenter.org)
  • Christopher Lengner and colleagues at the University of Pennsylvania studied how certain mouse intestinal stem cells responded to calorie restriction and radiation-induced injury. (lifeextension.com)
  • 131-2 Radiation dermatitis occurs to some degree in most patients receiving radiation therapy, with or without chemotherapy. (wikipedia.org)
  • Protects Against Malaria - Ginger root and ginger oil are effective against yellow fever and malaria as they have mosquito repelling qualities. (motherjai.com)
  • The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. (curehunter.com)
  • It quickly addresses hay fever symptoms, flu and colds. (safeserenespace.com)
  • Symptoms of primary infection with VZV, also known as chickenpox, include mild fever, malaise and a generalized vesicular rash. (vaccinesafety.edu)
  • It usually begins with mild constitutional symptoms (eg, fever. (msdmanuals.com)
  • Longo found that short-term fasting before and just after undergoing chemotherapy could greatly reduce the side effects associated with the therapy. (coconutresearchcenter.org)
  • This symptomatology greatly weakens patients and may even lead to adjournment of chemotherapy. (mdpi.com)
  • Skeletal muscle atrophy, the most characteristic feature of cancer cachexia, often occurs in patients with cancer undergoing chemotherapy. (oncotarget.com)
  • Patients suffering CIPN complain of somatosensory symptoms, including paresthesia and pain that drastically affects their quality of life. (painchannels.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • The Effects of Melatonin on the Descending Pain Inhibitory System and Neural Plasticity Markers in Breast Cancer Patients Receiving Chemotherapy: Randomized, Double-Blinded, Placebo-Controlled Trial is het volledige studierapport vrij in te zien. (kanker-actueel.nl)
  • Van de studie Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial is alleen het abstract vrij in te zien. (kanker-actueel.nl)
  • On the other hand, their therapeutic use for other purposes would be limited in patients with impaired immune systems, a restriction which would potentially preclude their use as anti-emetic agents in cancer chemotherapy, or as appetite stimulants and mood enhancers in patients with AIDS. (druglibrary.org)
  • Pneumonitis: Monitor patients for signs and symptoms of pneumonitis and treat appropriately. (drugs.com)
  • The immune system involves a host of cells, biological structures, and processes that protect us from disease and ill health caused by microorganisms, parasites, toxic chemicals, and diseased cells (cancer). (coconutresearchcenter.org)
  • Chemotherapy itself is very harsh on the body and causes significant collateral damage, including immune suppression by inducing DNA damage and cell death in both peripheral blood and bone marrow (disrupting stem cell development), which often results in long-term impairment to the immune system. (coconutresearchcenter.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • Oil-free hydroethanolic pumpkin seed extract could be beneficial for benign prostatic hyperplasia related symptoms. (greenmedinfo.com)
  • A significant decrease in insulin-like growth factor 1 (IGF-1) expression and formation was observed in the atrophying muscle of the conventional chemotherapy treatment group (CGC), and this decrease was markedly reversed by AC treatment. (oncotarget.com)
  • Rather than dealing with the symptoms of the aging-related diseases, it is necessary to preventively act on the process of aging itself [ 3, 9 ]. (iospress.com)
  • Clinicians should be aware that symptoms of AFM can initially be subtle and often mimic other neurologic diseases with targeted treatments. (cdc.gov)
  • 1 According to Longo, fasting causes cells to rapidly switch to a protected mode with changes in levels of glucose, IGF-1, protein kinase A (PKA), and many other proteins and molecules, protecting the cells from various toxins, including chemotherapy drugs. (coconutresearchcenter.org)
  • Results showed that adolescent cannabis users were at greater risk for severe CUD, which increased their vulnerability to poorer mental health symptoms, including depression, anxiety, and psychotic-like symptoms. (csequence.com)
  • The authors concluded: "Adolescent cannabis users have greater psychotic like symptoms than adult cannabis users and adolescent controls, through an additive effect…However, adolescents have an amplified risk of severe CUD relative to adults, which in combination with being young, augments symptoms of mental ill health. (csequence.com)
  • He showed that short-term fasting provided complete protection to mice against the side effects of high-dose chemotherapy. (coconutresearchcenter.org)
  • However, it hasn't been used in combination with chemotherapy because of its weight-loss effect and lack of nutrition at a time when the body is in desperate need of nourishment to support immune function. (coconutresearchcenter.org)
  • The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
  • Our results suggest that 3,4-DAP treatment is effective for weakness and autonomic symptoms, but may be ineffective for ataxia of PCD. (go.jp)
  • The EORTC Core Quality of Life Questionnaire (EORTC QLQ-C30) is a three-item subscale evaluating the symptoms of fatigue, weakness, and lack of energy. (medscape.com)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
  • The purpose of this study was to evaluate whether SFN induces a cytoprotective effect on the CDDP-induced nephrotoxicity. (weeksmd.com)
  • The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes. (weeksmd.com)
  • Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. (hindawi.com)
  • De Deense onderzoekers onderzochten of melatonine het risico op depressieve symptomen bij vrouwen met borstkanker kon verlagen in een periode van drie maanden na de operatie en beoordeelden het effect van melatonine op de volgende subjectieve parameters: angst, slaap, algemeen welzijn, vermoeidheid, pijn en slaperigheid. (kanker-actueel.nl)
  • Aung HH, Mehendale SR, Wang CZ, Xie JT, McEntee E. Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. (novapublishers.com)
  • Preincubation of LLC-PK1 cells with 0.5-5 microM SFN by 24 h was able to prevent, in a concentration-dependent way, CDDP-induced cell death. (weeksmd.com)
  • In animal research, he found that fasting for 48 hours or longer protects normal, healthy mammalian cells, but not cancer cells from chemotherapy. (coconutresearchcenter.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • Radiation burns are often discussed in the same context as radiation-induced cancer due to the ability of ionizing radiation to interact with and damage DNA, occasionally inducing a cell to become cancerous. (wikipedia.org)
  • This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment. (kanker-actueel.nl)
  • Adenoviruses can be genetically modified to increase their infectivity or improve the anti-cancer immune responses induced by the virus, e.g., through the expression of immunostimulatory molecules. (helsinki.fi)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
  • See Cancer Chemotherapy: Keys to Diagnosing Common Toxicities, a Critical Images slideshow, to help recognize some of the more common complications of chemotherapy. (medscape.com)
  • Scotté also highlighted the importance of psychological factors, citing depression, psychosocial stress before treatment, negative attention to symptoms, and fear of relapse as key features in the development of cancer-related fatigue. (medscape.com)
  • This article proposes a biological defense initiative based on developing, producing, and stockpiling specific antibody reagents that can be used to protect the population against biological warfare threats. (cdc.gov)
  • Unfortunately, inducing a the advantages and disadvantages of an antibody-based protective response by vaccination may take longer than the defense strategy, and proposes stockpiling specific antibodies time between exposure and onset of disease. (cdc.gov)
  • In addition, to assess fatigue, the diagnostic process consists of documenting the start, type, and duration of the fatigue, as well as the presence of attenuating factors and interference with activities of daily living and leisure activities. (medscape.com)
  • For example, era but was largely abandoned with the advent of antimicrobial smallpox virus would not be considered a useful biological chemotherapy (2,3). (cdc.gov)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Vrouwen, 30-75 jaar, die een operatie ondergingen voor borstkanker en zonder tekenen van depressie op Major Depression Inventory (MDI) werden 1 week voor de operatie opgenomen en ontvingen 6 mg orale melatonine of placebo gedurende 3 maanden. (kanker-actueel.nl)
  • However, none of the drugs has been shown to totally attenuate neuropathic pain. (gp120-inhibitors.com)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase). (weeksmd.com)
  • Aetna does not consider screening for heavy metal poisoning medically necessary for members with only vague, ill-defined symptoms (e.g., dysphoria, fatigue, malaise, and vague pain) and no history of likely heavy metal exposure. (aetna.com)
  • Aetna considers laboratory testing for manganese experimental and investigational persons with vague, ill-defined symptoms (e.g., dysphoria, fatigue, malaise, and vague pain) without a history of manganese exposure, and for all other indications. (aetna.com)
  • The MD Anderson Symptom Inventory (13 items) assesses fatigue, sleep disorders, and drowsiness. (medscape.com)